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CYP2E1 immunoglobulin G4 subclass antibodies after desflurane anesthesia

World Journal of Hepatology 2014年第5期6卷 340-346页

作者： Chrysanthi Batistaki George Michalopoulos Paraskevi Matsota Tzortzis Nomikos Konstantinos Kalimeris maria Riga maria nakou Georgia Kostopanagiotou 2~(nd) Department of Anesthesiology School of Medicine University of Athens "Attikon" University Hospital 12462 Athens Greece Department of Gastroenterology "Tzaneion" Peripheral General Hospital 18536 Piraeus Greece Department of Nutrition and Dietetics Harokopio University 17671 Athens Greece

AIM: To investigate CYP2E1 IgG4 autoantibody levels and liver biochemical markers in adult patients after anesthesia with desflurane. METHODS: Forty patients who were > 18 years old and undergoing elective surgery under general anes-thesia with desflurane were studied. Alpha-glutathione-S-transferase(aGST) and IgG4 antibodies againstCYP2E1 were measured preoperatively and 96 h post-operatively, as well as complete blood count, prothrom-bin time(PT), activated partial thromboplastin time(aPTT), international normalized ratio(INR), aspartate aminotransferase(SGOT), alanine aminotransferase(SGPT), g-glutamyl-transpeptidase(gGT), alkaline phosphatase, total serum proteins, albumin and bili-rubin. A separate group of 8 patients who received re-gional anesthesia was also studied for calibration of the methodology used for CYP2E1 IgG4 and aGST measure-ments. Student's t-test and the Mann-Whitney U test were used for comparison of the continuous variables, and Fisher's exact test was used for the categorical variables. All tests were two-tailed, with statistical sig-nificance set as P 0.1). The mean aGST differences were statistically elevated in men by 2.15 ng/mL compared to women when adjusted for BMI, duration of anesthe-sia, number of times anesthesia w

关键词： Drug-induced-liver injury Desflurane Anesthesia Hepatotoxicity CYP2E1 IgG4

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Liposarcoma of the stomach: A rare case report

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World Journal of Gastroenterology 2007年第30期13卷 4154-4155页

作者： Konstantinos Tepetes Gregory Christodoulidis Michael E Spyridakis maria nakou George Koukoulis Konstantinos Hatzitheofilou General Surgery Department University Hospital of Larissa Larissa Greece Pathology Department University Hospital of Larissa Larissa Greece

Liposarcoma is the most common soft tissue sarcoma and accounts for 15%-20% of all mesenchymal malignancies. The tumor occurs most frequently in the limbs, retroperitoneum and rarely has a visceral location. We report a case of a gastric liposarcoma in a male patient. A 68 years old male patient was admitted to hospital for abdominal discomfort and fullness lasting for a month. He reported rare episodes of vomiting. The CT examination revealed a large epigastric mass （8 cm × 4 cm） involving the lesser curvature of the stomach, in contact with the pancreas and gallbladder. Fatty areas within the mass were evident. A total gastrectomy together with cholecystectomy was performed. The histopathological diagnosis was a well differentiated liposarcoma. The patient did not undergo any adjuvant treatment, he is under close follow up and two years later he is disease free. We report this case due to the rarity of this tumor in the stomach （nine cases reported in the literature）.

关键词： Gastric liposarcoma Lipoblasts CT diagnosis Total gastrectomy Well-differentiated type

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