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Glutamine or Glutamine dipeptide Supplementation Improves Gluconeogenesis and Liver Glycogenosis in Type 1 diabetic Rats

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Journal of Pharmacy and Pharmacology 2019年第7期7卷 398-407页

作者： Silvia Carla S.F.Azevedo Carlos Vinicius d.da Rosa Ana Luiza M.Wunderlich Laís A.Yamada Isabela R.mariano Camila Bataglini Nayra T.d.Branquinho Scarlett R.Raposo Roberto B.Bazotte Edmara A.Baroni maria Raquel M.Natali maria montserrat d.pedrosa Vilma A.F.de Godoi Program of Graduate Studies in Cell and Molecular Biology State University of MaringáMaringá87020-900Brazil Program of Graduate Studies in Physiological Sciences State University of MaringáMaringá87020-900Brazil Undergraduation in Biological Sciences University Center of MaringáMaringá87050-390Brazil department of Pharmacology and Therapeutics State University of MaringáMaringá87020-900Brazil department of Physiological Sciences State University of MaringáMaringá87020-900Brazil department of Morphological Sciences State University of MaringáMaringá87020-900Brazil

The effects of the supplementation with L-glutamine(GLN)or L-alanyl-L-glutamine(GdP)on the progression of the systemic and hepatic metabolic status of rats having untreated type 1 diabetes mellitus(T1dM)were *** Wistar diabetic rats(streptozotocin,60 mg/kg)were allotted to four groups supplemented by gavage for thirty days as follows:control and diabetic receiving saline;diabetic receiving GLN(248 mg/kg);and diabetic receiving GdP(400 mg/kg).Body weight,plasmatic parameters and kidney function were *** hepatocytes were used to assess gluconeogenic *** and kidney were used for morphological analyses.T1dM decreased the number and increased the area of the hepatocytes,possibly because of the observed enlargement of glycogen *** weight,glomerular area and proteinuria increased,and glomerular filtration rate decreased,in non-supplemented T1dM *** area and proteinuria were reversed by both *** T1dM hepatocytes released less glucose,which could have been diverted to glycogen synthesis and secondary glycogenosis observed in T1dM;this was partially reversed by the *** results point to a possible beneficial effect of glutamine on the metabolic and hepatic impairments of T1dM.

关键词： Type 1 diabetes mellitus L-glutamine glutamine dipeptide gluconeogenesis glycogenosis

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Relating estimates of wood properties of birch to stem form, age and species

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Journal of Forestry Research 2024年第3期35卷 1-11页

作者： Grace Jones maria Ulan Mateusz Liziniewicz Johan Lindeberg Stergios Adamopoulos Teagasc Forestry development department Ashtown Research CentreDublin 15 D15DY05Ireland Research Institutes of Sweden(RISE) GoteborgSweden The Forest Research Institute of Sweden(Skogforsk) Ekebo 225026890SvalovSweden department of Forestry and Wood Technology Linnaeus University35195VaxjoSweden department of Forest Biomaterials and Technology Swedish University of Agricultural SciencesBox 700875007 UppsalaSweden

Birch has long suffered from a lack of active forest management,leading many researchers to use mate-rial without a detailed management *** collected from three birch(Betula pendula Roth,*** Ehrh.)sites in southern Sweden were analyzed using regression analysis to detect any trends or differences in wood proper-ties that could be explained by stand history,tree age and stem *** sites were genetics trials established in the same *** of acoustic velocity(AV)from non-destructive testing(NdT)and predicted AV had a higher correlation if data was pooled across sites and other stem form factors were considered.A subsample of stems had radial profiles of X-ray wood density and ring width by year created,and wood density was related to ring number from the pith and ring *** seemed likely that wood density was negatively related to ring width for both birch *** models had slight improvements if site and species were included,but only the youngest site with trees at age 15 had both birch *** paper indicated that NdT values need to be considered separately,and any predictive models will likely be improved if they are specific to the site and birch species measured.

关键词： Acoustic velocity Non-destructive testing Predictive models Regression analysis Wood density

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Bio-based rejuvenators in asphalt pavements:A comprehensive review and analytical study

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Journal of Road Engineering 2024年第3期4卷 282-291页

作者： maria Chiara Cavalli Wangjie Wu Lily Poulikakos division of Highway and Railway Engineering KTH Royal Institute of TechnologyStockholm 10044Sweden School of Highway Chang'an UniversityXi'an 710064China Empa Dübendorf 8600Switzerland

The pressing demand for sustainable advancements in road infrastructure has catalyzed extensive research into environmentally conscious alternatives for the maintenance and restoration of asphalt concrete *** paper offers a comprehensive review and analysis of bio-based rejuvenators as a promising avenue for enhancing the longevity and sustainability of *** a multifaceted exploration,it delves into various aspects of this innovative *** a thorough overview of bio-based rejuvenators,the study highlights their renewable and environmentally friendly *** conducts an in-depth examination of a wide spectrum of bio-derived materials,including vegetable oils,waste-derived bio-products,and biopolymers,through a comprehensive *** paper evaluates how bio-based rejuvenators enhance aged asphalt binders and mixes,effectively mitigating the adverse impacts of ***,it investigates how these rejuvenators address environmental concerns by identifying compatibility issues,assessing long-term performance,and evaluating economic ***,the paper outlines potential advancements and research pathways aimed at optimizing the utilization of bio-based rejuvenators in asphalt concrete,thereby contributing to the sustainable evolution of road infrastructure.

关键词： Bio-based rejuvenator Bio-based asphalt concrete Bio-based asphalt mechanical performance Environmental benefit Optimized utilization of bio-based rejuvenator

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Role of lipids in the control of autophagy and primary cilium signaling in neurons

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Neural Regeneration Research 2024年第2期19卷 264-271页

作者： María Paz Hernández-Cáceres daniela Pinto-Nuñez Patricia Rivera Paulina Burgos Francisco díaz-Castro Alfredo Criollo maria Jose Yañez Eugenia Morselli Instituto de Investigación en Ciencias Odontológicas(ICOd) Facultad de OdontologíaUniversidad de ChileSantiagoChile department of Basic Sciences Faculty of Medicine and ScienceUniversidad San SebastiánSantiagoChile Physiology department Faculty of Biological SciencesPontificia Universidad Católica de ChileSantiagoChile Advanced Center for Chronic diseases(ACCdiS) Facultad de Ciencias Químicas y Farmacéuticas&Facultad de MedicinaUniversidad de ChileSantiagoChile Autophagy Research Center SantiagoChile

The brain is,after the adipose tissue,the organ with the greatest amount of lipids and diversity in their composition in the human *** neurons,lipids are involved in signaling pathways controlling autophagy,a lysosome-dependent catabolic process essential for the maintenance of neuronal homeostasis and the function of the primary cilium,a cellular antenna that acts as a communication hub that transfers extracellular signals into intracellular responses required for neurogenesis and brain development.A crosstalk between primary cilia and autophagy has been established;however,its role in the control of neuronal activity and homeostasis is barely *** this review,we briefly discuss the current knowledge regarding the role of autophagy and the primary cilium in *** we review the recent literature about specific lipid subclasses in the regulation of autophagy,in the control of primary cilium structure and its dependent cellular signaling in physiological and pathological conditions,specifically focusing on neurons,an area of research that could have major implications in neurodevelopment,energy homeostasis,and neurodegeneration.

关键词： autophagic flux cholesterol fatty acids GPCR lysosomal storage diseases neurons NPC1 phosphoinositides primary cilium

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Hypoxia-inducible factor 1alpha and vascular endothelial growth factor in Glioblastoma Multiforme:a systematic review going beyond pathologic implications

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Oncology Research 2024年第8期32卷 1239-1256页

作者： dIMITRA P.VAGELI PANAGIOTIS G.dOUKAS KERASIA GOUPOU ANTONIOS d.BENOS KYRIAKI ASTARA KONSTANTINA ZACHAROULI SOTIRIS SOTIRIOU maria IOANNOU department of Surgery Yale UniversityNew HavenCT 06510USA department of Pathology Faculty of MedicineSchool of Health SciencesUniversity of ThessalyLarissa41500Greece department of Medicine Rutgers/Saint Peter’s University HospitalNew BrunswickNJ 08901USA department of Neurology Army Share Fund Hospital(NIMTS)Athens11521Greece Laboratory of Embryology Faculty of MedicineSchool of Health SciencesUniversity of ThessalyLarissa41500Greece

Glioblastoma multiforme(GBM)is an aggressive primary brain tumor characterized by extensive heterogeneity and vascular *** conditions in the tissue microenvironment are considered a pivotal player leading tumor ***,hypoxia is known to activate inducible factors,such as hypoxia-inducible factor 1alpha(HIF-1α),which in turn can stimulate tumor neo-angiogenesis through activation of various downward mediators,such as the vascular endothelial growth factor(VEGF).Here,we aimed to explore the role of HIF-1α/VEGF immunophenotypes alone and in combination with other prognostic markers or clinical and image analysis data,as potential biomarkers of GBM prognosis and treatment *** performed a systematic review(Medline/Embase,and Pubmed database search was completed by 16th of April 2024 by two independent teams;PRISMA 2020).We evaluated methods of immunoassays,cell viability,or animal or patient survival methods of the retrieved studies to assess unbiased *** used inclusion criteria,such as the evaluation of GBM prognosis based on HIF-1α/VEGF expression,other biomarkers or clinical and imaging manifestations in GBM related to HIF-1α/VEGF expression,application of immunoassays for protein expression,and evaluation of the effectiveness of GBM therapeutic strategies based on HIF-1α/VEGF *** used exclusion criteria,such as data not reporting both HIF-1αand VEGF or *** included 50 studies investigating in total 1319 GBM human specimens,18 different cell lines or GBM-derived stem cells,and 6 different animal models,to identify the association of HIF-1α/VEGF immunophenotypes,and with other prognostic factors,clinical and macroscopic data in GBM prognosis and therapeutic *** found that increased HIF-1α/VEGF expression in GBM correlates with oncogenic factors,such as miR-210-3p,Oct4,AKT,COX-2,PdGF-C,PLdO3,M2 polarization,or ALK,leading to unfavorable *** HIF-1α/VEGF expression correlates with F

关键词： Glioblastoma multiforme(GBM) Astrocytoma Grade III Astrocytoma Grade IV Hypoxia-inducible factor 1alpha(HIF-1α) Vascular endothelial growth factor(VEGF)

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Plasticity of photorespiratory carbon concentration mechanism in Sedobassia sedoides(Pall.)Freitag&*** under elevated CO_(2)concentration and salinity

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Journal of Arid Land 2024年第7期16卷 963-982页

作者： Zulfira RAKHMANKULOVA Elena SHUYSKAYA maria PROKOFIEVA Kristina TOdERICH Pavel VORONIN Timiryazev Institute of Plant Physiology Russian Academy of SciencesMoscow 127276Russia Graduate School of Bioresources Mie University1577 KurimamachiyaTsu 514-8507Japan

Rising atmospheric CO_(2)(carbon dioxide)concentrations and salinization are manifestations of climate change that affect plant growth and *** with an intermediate C_(3)-C_(4)type of photosynthesis live in a wide range of precipitation,temperature,and soil quality,but are more often found in warm and dry *** of the intermediate C_(3)-C_(4)photosynthetic type is C_(2)photosynthesis with a carbon concentration mechanism(CCM)that reassimilates CO_(2)released via ***,the ecological significance under which C_(2)photosynthesis has advantages over C_(3)and C_(4)plants remains largely *** tolerance and functioning of CCM were studied in plants from two populations(P1 and P2)of Sedobassia sedoides(Pall.)Freitag&*** *** with C_(2)photosynthesis exposed to 4 d and 10 d salinity(200 mM NaCl)at ambient(785.7 mg/m^(3),aCO_(2)and elevated(1571.4 mg/m^(3),eCO_(2))CO_(2).On the fourth day of salinity,an increase in Na+content,activity catalase,and superoxide dismutase was observed in both populations.P2 plants showed an increase in proline content and a decrease in photosynthetic enzyme content:rubisco,phosphoenolpyruvate carboxylase(PEPC),and glycine decarboxylase(GdC),which indicated a weakening of C_(2)and C_(4)characteristics under *** under 10 d salinity led to an increased Na^(+)content and activity of cyclic electron flow around photosystem I(PSI CEF),a decreased content of K^(+)and GdC in both populations.P1 plants showed greater salt tolerance,which was assessed by the degree of reduction in photosynthetic enzyme content,PSI CEF activity,and changes in relative growth rate(RGR).differences between populations were evident under the combination of eCO_(2)and *** long-term salinity and eCO_(2),more salt-tolerant P1 plants had a higher dry biomass(dW),which was positively correlated with PSI CEF *** less salt-tolerant P2 plants,dW correlated with transpiration and dark

关键词： photosystemsⅠandⅡ carbon-concentrating mechanism glycine decarboxylase rubisco phosphoenolpyruvate carboxylase(PEPC) cyclic electron flow salinity stress drylands

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Melanocortin 3,5 receptors immunohistochemical expression in colonic mucosa of inflammatory bowel disease patients:A matter of disease activity?

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World Journal of Gastroenterology 2024年第9期30卷 1132-1142页

作者： Antonietta Gerarda Gravina Iacopo Panarese maria Consiglia Trotta Michele d'Amico Raffaele Pellegrino Franca Ferraraccio Marilena Galdiero Roberto Alfano Paolo Grieco Alessandro Federico Hepatogastroenterology division Department of Precision MedicineUniversity of Campania Luigi VanvitelliNaples 80138Italy Pathology division Department of Mental and Physical Health and Preventive MedicineUniversity of Campania Luigi VanvitelliNaples 80138Italy department of Experimental Medicine Division of PharmacologyUniversity of Campania Luigi VanvitelliNaples 80138Italy department of Advanced Medical and Surgical Sciences(dAMSS) University of Campania Luigi VanvitelliNaples 80138Italy department of Pharmacy University of Naples Federico IINaples 80131Italy

BACKGROUNd Melanocortin 3 and 5 receptors(i.e.,MC3R and MC5R)belong to the melanocortin ***,data regarding their role in inflammatory bowel diseases(IBd)are currently *** This study aims to ascertain their expression profiles in the colonic mucosa of Crohn’s disease(Cd)and ulcerative colitis(UC),aligning them with IBd disease endoscopic and histologic *** Colonic mucosal biopsies from Cd/UC patients were sampled,and immunohisto-chemical analyses were conducted to evaluate the expression of MC3R and *** sampling was performed on both traits with endoscopic scores(Mayo endoscopic score and Cd endoscopic index of severity)consistent with inflamed mucosa and not consistent with disease activity(i.e.,normal appearing mucosa).RESULTS In both Cd and UC inflamed mucosa,MC3R(Cd:+7.7 fold vs normal mucosa,Pd vs normal mucosa,Pd MC5R(Cd:+5.5 fold vs normal mucosa,Pd vs normal mucosa,Pd compared to normal *** MC3R and MC5R are expressed in the colon of IBd ***,expression may differ according to disease endoscopic activity,with a higher degree of expression in the traits affected by disease activity in both Cd and UC,suggesting a potential use of these receptors in IBd pharmacology.

关键词： Melanocortin 3 receptor Melanocortin 5 receptor Ulcerative colitis Crohn's disease Inflammatory bowel disease

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Impact of multifocal gas-permeable lens designs on short-term choroidal response, axial length, and retinal defocus profile

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 247-256页

作者： Muteb Alanazi Patrick Caroline Amane Alshamrani maria Liu Optometry department College of Applied Medical SciencesKing Saud UniversityRiyadh 14813Saudi Arabia College of Optometry Pacific UniversityForest GroveOregon 97116-1756United States Optometry School University of California at BerkeleyCalifornia 94720United States

AIM:To investigate the impact of multifocal gas permeable contact lens(MFGPCL)in various add power and distance/near area allocation on short-term changes of choroidal thickness(ChT),axial length(AL),and retinal defocus profile in young ***:Seventeen young adults(2 males and 15 females;age 23.17±4.48y)were randomly assigned to wear two designs binocularly with a one-week washout period in *** of four MFGPCL designs were *** designs were distance-center that varied in two add power(+1.50 and 3.00 d)and/or two distance zone(dZ)diameters(1.50 and 3.00 mm;design A:dZ 1.5/add 3.0,B:dZ 1.5/add 1.5,C:dZ 3.0/add 3.0,d:dZ 3.0/add 1.5).ChT,AL,and peripheral refraction data were collected on each subject at baseline,on days 1 and 7 of MFGPCL daily *** was assessed in four quadrants using a spectraldomain optical coherence ***:AL was shortened by-26±44μm with lens C,-18±27μm with lens d,-13±29μm with lens A,and-8±30μm with lens B(all Pd with all 4 designs(lens A:+6±6μm,B:+3±7μm,C:+8±7μm,and d:+8±7μm).Temporal and superior choroid exhibited more choroidal thickening associated with *** designs induced significant relative peripheral myopia(RPM)beyond the central 20o across the horizontal meridian in both nasal and temporal fields(Pd AL,which are associated with significant increase in RPM after short-term *** reliability and feasibility of quantifying short-term changes in ChT support its use as a promising marker for the long-term efficacy of myopia-controlling treatments.

关键词： choroid gas-permeable contact lens retinal defocus axial length myopia

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A C-shaped hinge for displacement magnification in MEMS rotational structures

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Microsystems & Nanoengineering 2024年第1期10卷 55-66页

作者： Naga Manikanta Kommanaboina Teferi Sitotaw Yallew Alvise Bagolini maria F.Pantano department of Civil Environmental and Mechanical EngineeringUniversity of Trentovia Mesiano 7738123 TrentoItaly Fondazione Bruno Kessler(FBK) Microsystems Technology(MST)via S.Croce 7738122 TrentoItaly

The design,analysis,fabrication,and characterization of two distinct MEMS rotational structures are provided;these structures include a classical symmetrical lancet structure and a novel symmetrical C-shaped structure provided with a tilted arm,and both are actuated by thermal *** proposed C-shaped structure implemented a curved beam mechanism to enhance the movement delivered by the thermal *** geometrical parameters of our proposed device were optimized using the design of experiment(dOE)***,the analytical modeling based on Castigliano’s second theorem and the simulations based on the finite element method(FEM)were used to predict the behavior of the symmetrical C-shaped structure;the results were in good agreement with each *** MEMS-based rotational structures were fabricated on silicon-on-insulator(SOI)wafers using bulk micromachining technology and deep reactive ion etching(dRIE)*** fabricated devices underwent experimental characterization;our results showed that our proposed MEMS rotational structure exhibited a 28%improvement in the delivered displacement compared to the symmetrical lancet ***,the experimental results showed good agreement with those obtained from numerical *** proposed structures have potential applications in a variety of MEMS devices,including accelerometers,gyroscopes,and resonators,due to their ability to maximize displacement and thus enhance sensitivity.

关键词： shaped displacement structures

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Lower Continental Crusts Involved in the Alpine Orogeny:New Insight from the Santa Lucia Nappe Metasediments(Corsica,France)

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Acta Geologica Sinica(English Edition) 2024年第4期98卷 904-920页

作者： Chiara FRASSI maria dI ROSA Luca PANdOLFI Michele MARRONI dipartimento di Scienze della Terra Universitàdi PisaVia Santa Maria 5356126 PisaItaly Istituto di Geoscienze e Georisorse IGG-CNRVia Moruzzi50124 PisaItaly

In the Alpine Corsica(France),the Santa Lucia Nappe represents a peculiar unit preserving the unique relicts of Paleozoic lower to medium continental *** consists of composite basement affected by Permian granulite facies metamorphic conditions unconformably covered by a Late Cretaceous clastic sequence(Tomboni Conglomerate and Tralonca Flysch)affected by polyphase deformation and *** this work,we present a new reconstruction of the deformation events registered by the Tralonca Flysch during the Alpine *** d1 phase was testified by rare isoclinal *** d2 phase produced a continuous foliation and a map-scale sheath-fold with a top-to-W sense of *** d3 phase produced E-verging non-cylindrical folds and S3 crenulation cleavage that is not associated to metamorphic *** present the first temperature-pressure-deformation(P-T-d)path for the Tralonca Flysch,demonstrating that the Santa Lucia Nappe underwent accretion and then first stage exhumation in the Alpine wedge during the d1 phase with pressure and temperature peaks both occurred under blueschist metamorphic *** d2 phase occurred at lower pressure-temperature conditions during a second stage *** pressure-temperaturedeformation path is comparable with those of the Lower Units(i.e.,the subducted continental units of Alpine Corsica)suggesting a common geodynamic history.

关键词： blueschist-facies metamorphism P-T-d path Santa Lucia Nappe Corsica Alpine orogeny

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