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Major Elements Geochemistry of Sedimentary Rocks from CorumbataíFormation, Santa Gertrudes Ceramic Pole, São Paulo, Brazil

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Geomaterials 2014年第1期4卷 11-17页

作者： maria Margarita torres Moreno Rogers Raphael da Rocha Letícia Hirata Godoy Ceramica Rochaforte Rio Claro Brazil Department of Petrology and Metalogeny Institute of Geosciences and Exact Sciences Paulista State University Rio Claro Brazil

We conducted a geochemical study of the major elements of 29 clay samples from 10 mining fronts, which are used for ceramic coatings at Santa Gertrudes Ceramic Pole, São Paulo, Brazil. This region is considered as the biggest ceramic pole in Latin America. The mines are located in Corumbataí Formation (Paraná Sedimentary Basin) and are mined in bench system. The samples were analyzed as a whole and along each profile to evaluate the variation of the concentration of major elements and weathering effects. The results show a differentiation into three groups: 1) carbonate clays;2) lower portion samples;3) upper portion samples, and properties that allow obtaining useful information about the use and selection of raw materials to the formulation of ceramic masses and for quality control of raw materials in order to achieve products of similar quality.

关键词： Clay Minerals Raw Material Ceramic Coatings Weathering

Obesity is associated with the Arg389Gly ADRB1 but not with the Trp64Arg ADRB3 polymorphism in children from San Luis Potosí and León,México

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The Journal of Biomedical Research 2017年第1期31卷 40-46页

作者： Celia Aradillas-García Miguel Cruz Elva Perez-Luque maria E.Garay-Sevilla Juan M.Malacara Aduna R Jesús Peralta Ana Burguete-García Jorge A.Alegría-torres Faculty of Medicine of the Autonomous University of San Luis Potosi MéxicoCIACYT-Facuity of MedicineC.P. 78210 San Luis Potosi S.L.P. México Medical Research Unit in Biochemistry Hospital de EspecialidadesCentro Medico Nacional Siglo XXI del Instituto Mexicano del Seguro SocialMexico City C.P 06720 Mexico Department of Medical Sciences Campus LeónUniversity of Guanajuato.LeónC.P.37320.México Chronic Infection and Cancer Division Research Center on Infectious DiseasesInstituto Nacional de Salud PublicaC.P.62100CuernavacaMorelosMéxico Department of Pharmacy Campus GuanajuatoUniversity of GuanajuatoNoria Alta C.P.36050GuanajuatoMéxico

This research was designed to analyze the possible associations of Arg389 Gly ADRB1 and Trp64 Arg ADRB3polymorphisms in children with obesity.A cross-sectional study included 1,046 school-age Mexican participants（6-12 years old） from the cities of San Luis Potosi and *** were classified as non-obese or obese according to their body mass index（BMI） percentile;obese children had a BMI≥95th percentile for sex and *** data were *** were detected using TaqMan qPCR assay.A logistic regression analysis was used to calculate the risk of obesity based on *** were found between groups where obese children had a significant increase in systolic and diastolic blood pressure,fasting plasma glucose,insulin,HOMAIR,LDL-cholesterol,triglycerides,and lower HDL-cholesterol compared with the normal weight group（P 〈 0.05）.The distribution of allele frequency in the population was Arg = 87.4 and Gly = 12.6（Hardy Weinberg equilibrium x^2= 3.16,P = 0.07）;Trp = 81.5 and Arg= 18.5（Hardy Weinberg equilibrium x^2 = 2.2,P = 0.14） for ADRB1 and ADRB3,*** though no different frequencies of Arg389 Gly polymoiphism between groups were found（P = 0.08）,children carriers of one Gly389,ADRB1 allele had a risk for obesity of OR = 1.40（95%CI,1.03-1.90,P =0.03） after adjustment for age and *** other association was found for Trp64 Arg ADRB3 *** the Arg389 Gly ADRB1 polymorphism was associated with risk for obesity in Mexican children.

关键词： childhood obesity β-adrenergic receptor(ADRB) gene polymorphisms Mexican children

3D additive manufactured composite scaffolds with antibiotic-loaded lamellar fillers for bone infection prevention and tissue regeneration

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Bioactive Materials 2021年第4期6卷 1073-1082页

作者： María C´amara-torres Stacy Duarte Ravi Sinha Ainhoa Egizabal Noelia´Alvarez maria Bastianini Michele Sisani Paolo Scopece Marco Scatto Alessandro Bonetto Antonio Marcomini Alberto Sanchez Alessandro Patelli Carlos Mota Lorenzo Moroni Maastricht University MERLN Institute for Technology-Inspired Regenerative MedicineComplex Tissue Regeneration DepartmentUniversiteitssingel 406229ERMaastrichtthe Netherlands TECNALIA Basque Research and Technology Alliance(BRTA)Mikeletegi Pasealekua 220009Donostia-San SebastianSpain Prolabin&Tefarm S.r.l. Via Dell’Acciaio906134PerugiaItaly d Nadir S.r.l.Via Torino155/b30172VeniceItaly Department of Environmental Sciences Informatics and StatisticsCa’Foscari University of VeniceDorsoduro 324630172VeniceItaly Department of Physics and Astronomy Padova UniversityVia Marzolo835131PadovaItaly

Bone infections following open bone fracture or implant surgery remain a challenge in the orthopedics *** order to avoid high doses of systemic drug administration,optimized local antibiotic release from scaffolds is required.3D additive manufactured(AM)scaffolds made with biodegradable polymers are ideal to support bone healing in non-union scenarios and can be given antimicrobial properties by the incorporation of *** this study,ciprofloxacin and gentamicin intercalated in the interlamellar spaces of magnesium aluminum layered double hydroxides(MgAl)andα-zirconium phosphates(ZrP),respectively,are dispersed within a thermoplastic polymer by melt compounding and subsequently processed via high temperature melt extrusion AM(~190◦C)into 3D *** inorganic fillers enable a sustained antibiotics release through the polymer matrix,controlled by antibiotics counterions exchange or pH ***,both antibiotics retain their functionality after the manufacturing process at high temperatures,as verified by their activity against both Gram+and Gram-bacterial ***,scaffolds loaded with filler-antibiotic do not impair human mesenchymal stromal cells osteogenic differentiation,allowing matrix mineralization and the expression of relevant osteogenic ***,these results suggest the possibility of fabricating dual functionality 3D scaffolds via high temperature melt extrusion for bone regeneration and infection prevention.

关键词： Melt extrusion additive manufacturing Antibiotic delivery Lamellar inorganic fillers Bone infection Bone regeneration Human mesenchymal stromal cells

Anatomophysiological relationships and clinical considerations of taste and smell loss in patients with COVID-19

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World Journal of Virology 2022年第5期11卷 362-374页

作者： maria Fernanda Rossi Vigliar Karina torres Pomini Daniela Vieira Buchaim Rogerio Leone Buchaim Biological Sciences Bauru School of DentistryUniversity of São PauloBauru 17012901São PauloBrazil University of Marilia Marilia 17525902São PauloBrazil University Center of Adamantina Adamantina 17800000São PauloBrazil Faculty of Veterinary Medicine and Animal Science University of São PauloSão Paulo 05508270São PauloBrazil

BACKGROUND There are numerous conflicting discussions about the outbreak of the new coronavirus 2019(COVID-19).AIM To present some anatomical and physiological considerations about two of the symptoms reported by patients:The loss or reduction of smell and *** The loss or reduction of smell and taste is presented in a peculiar way,with some cases of persistence even after *** this,it was searched in three databases,PubMed/MEDLINE,Web of Science,and Scopus,using the following keywords:"Smell","Taste","Smell AND COVID-19","Taste AND COVID-19",with no publication time restriction,only in English with full text available,excluding also brief communications,letters to the editor,editorials,reviews,comments,and conference *** The search found 776 articles in the PubMed/MEDLINE database,1018 in the Web of Science database,and 552 in the Scopus database,from which duplicates were removed(104 articles).Finally,17 studies were selected for detailed analysis within the eligibility criteria,with titles and abstracts related to central nervous system lesions responsible for smell and *** review suggests that viral mechanisms of action may be related to lesions both at the local level and at the level of the central nervous system,lasting up to 3 to 4 *** is considered persistent if it exceeds this period,as reported in one case in this *** are still few studies about the treatment,and among those addressed in this review,only two studies reported possible treatments and emphasized the scarcity of data,with the best option being treatments that do not cause harm,such as gustatory and olfactory physiotherapy CONCLUSION Given the scarcity of data,this review emphasizes the importance of prevention,through the correct use of personal protective equipment by health professionals and respect for local behavioral *** is also emphasized,through five studies,that there is a predominance of such symptoms in patients with COVID-

关键词： SARS-CoV-2 COVID-19 Coronavirus Olfactory nerve Smell Taste

Integrity and resilience in the face of multiple crises:commentary from Puerto Rico

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Forensic Sciences Research 2021年第3期6卷 316-319页

作者： Richard J.Noel Jr Jose A.torres-Ruiz Department of Basic Sciences School of MedicinePonce Health Sciences UniversityPoncePRUSA Office of the Chancellor Ponce Health Sciences UniversityPoncePRUSA

Since 2010,the population of Puerto Rico has declined by 11.8%and is currently 3.3 million peo-ple[1].This worrisome trend is a result of a pleth-ora of island-wide challenges spanning financial difficulties,natural disasters,and *** over a decade of economic hardship and debt,incapacitating hurricanes,Irma and maria,destroyed large swaths of the island in *** still recovering from that disaster,a magnitude 6.4 earthquake centered about 5 miles off the south-western coast on January 7,2020,destroying build-ings and roads in southwestern Puerto *** event,and subsequent aftershocks that continue until today,further aggravate an already stressed *** the mix,viral epidemics have brought fur-ther economic,social,and health-related *** Rico was the centre of the 2016-2017 Zika virus infections,representing over 85%of the US infections in 2016[2].

关键词： island disaster southwestern

Proposed Relief Map of the Suitability of the Maranhão River Basin, Brazil, for Anthropogenic Use

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Journal of Geographic Information System 2016年第3期8卷 351-360页

作者： Valdir A. Steinke Ercilia torres Steinke Mario Diniz Araujo Neto maria Ligia Cassol Pinto University of Brasilia Brasília Brazil

In this paper, we proposed a method for mapping the suitability of land for intensive anthropogenic use in the Maranhao River Basin, in the state of Goiás, Brazil. We analyzed existing 1:250,000 maps of the local geology, drainage system topography and geomorphological features. We generated new information based on our analysis, including a compilation of basic morphometric data and a map of the slopes in the basin, which we used to construct the geomorphological suitability map of the watershed. Our results indicate that 40% of the study area can support intensive anthropogenic use;the remaining 60% of the basin area is categorized as “fragile” regarding the expansion of intensive land use.

关键词： Morphometry GIS Environmental Management Suitability of the Watershed Land Use Policy

Cadaveric bone marrow mesenchymal stem cells:first experience treating a patient with large severe burns

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Burns & Trauma 2015年第2期3卷 74-82页

作者： Eduardo Mansilla Gustavo H.Marín Mirta Berges Silvia Scafatti Jaime Rivas Andrea Núñez Martin Menvielle Roberto Lamonega Cecilia Gardiner Hugo Drago Flavio Sturla mercedes Portas Silvia Bossi maria Victoria Castuma Sandra Peña Luengas Gustavo Roque Karina Martire Jose maria Tau Gabriel Orlandi Adrian Tarditti Tissue Engineering Regenerative Medicine and Cell Therapies LaboratoryCUCAIBAProvince of Buenos Aires Ministry of HealthTransplantation ProgramLa PlataProvince of Buenos AiresArgentina Burns and Plastic Surgery Department San Martín HospitalProvince of Buenos Aires Ministry of HealthLa PlataProvince of Buenos AiresArgentina Burns Hospital Buenos Aires CityArgentina Department of Chemistry Mayaguez CampusUniversity of Puerto RicoMayaguezPuerto RicoUSA.

Background:In January 2005,Rasulov et *** published"First experience in the use of bone marrow mesenchymal stem cells(MSCs)for the treatment of a patient with deep skin burns".Here,we present the first ever treated patient with cadaveric bone marrow mesenchymal stem cells(CMSCs)in the history of ***:A young man,who severely burned 60%of his total body surface with 30%of full-thickness burns while working with a grass trimmer that exploded,was involved in the *** were obtained from the bone marrow of a cadaver donor in a routine procurement procedure of CUCAIBA,the Province of Buenos Aires,Argentina,Ministry of Health,Transplantation Agency,cultured,expanded,and applied on the burned surfaces using a fibrin spray after early ***:So far,our preliminary experience and our early results have been very impressive showing an outstanding safety data as well as some impressive good results in the use of ***:Based on al this,we think that improvements in the use of stem cells for burns might be possible in the near future and a lot of time as well as many lives could be saved by many other research teams all over the *** will probably be a real scientific opportunity in Regenerative Medicine as well as in Transplantation.

关键词： Burns Cadaveric Transplantation Skin regeneration Mesenchymal stem cells

Review: Surgical Treatment of Type 2 Diabetes

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Pharmacology & Pharmacy 2014年第1期5卷 24-29页

作者： maria Dolores Hellin Gil Pedro Pujante Alarcon Alfonso Lopez Ruiz maria Angeles Ibanez Alicia Hernandez torres Ana Belen Hernandez Cascales Nutrition Service Hospital University Virgen de la Arrixaca de MurciaMurciaSpain Endocrinology and Nutrition Service Hos-pital University Virgen de la Arrixaca de MurciaMurciaSpain Community Pharmacy Bullas(Murcia)Spain Health Center Mar-iano Yago Yecla(Murcia)Spain Infectious Internal Medicine Hospital University Virgen de la Arrixaca de MurciaMurciaSpain

In the last decades we have witnessed a significant increase in the incidence of type 2 diabetes mellitus, and obesity in parallel. So 90% of patients with Diabetes Mellitus type 2 (DM2) are obese. Changes in lifestyle (diet and exercise), behavioral therapies or the use of certain anti-obesity drugs have shown a limited effect and are not maintained over time. Currently, bariatric surgery is the most effective anti-obesity treatment, which is durable and resolves associated comorbidities. The surgical treatment of obesity for the modification of the anatomy of the digestive system is to produce gastric capacity constraints alone or associate with varying degrees of intestinal malabsorption and reduce body weight, improve and maintain the comorbidities associated weight loss by reduced food intake alone or in combination with malabsorption of this. The development of these surgical techniques has occurred in stages. With these techniques, setting to bariatric surgery is an effective, safe and proven procedure for the treatment of obesity and its complications especially DM2, as their post surgery referral mechanisms provide us with information for potential therapeutic treatment aimed at optimizing the control DM2 patients metabolic obese. In this review, we expose the evidence in treatment of DM2 with bariatric surgery and the actual hypothesis trying to explain how it is possible.

关键词： DM2 Bariatric Surgery Gastric Bypass

Bispecific sigma-1 receptor antagonism and mu-opioid receptor partial agonism:WLB-73502,an analgesic with improved efficacy and safety profile compared to strong opioids

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Acta Pharmaceutica Sinica B 2023年第1期13卷 82-99页

作者： Alba Vidal-torres Begoña Fernández-Pastor Mónica García Eva Ayet Anna Cabot Javier Burgueño Xavier Monroy Bertrand Aubel Xavier Codony Luz Romero Rosalía Pascual maria Teresa Serafini Gregorio Encina Carmen Almansa Daniel Zamanillo Manuel Merlos JoséMiguel Vela WeLab Barcelona Parc Cientific de BarcelonaBarcelona 08028Spain

Opioids are the most effective painkillers,but their benefit-risk balance often hinder their therapeutic ***-73502 is a dual,bispecific compound that binds sigma-1(S1R)and mu-opioid(MOR)***-73502 is an antagonist at the *** behaved as a partial MOR agonist at the G-protein pathway and produced no/unsignificantβ-arrestin-2 recruitment,thus demonstrating low intrinsic efficacy on MOR at both signalling *** its partial MOR agonism,WLB-73502exerted full antinociceptive efficacy,with potency superior to morphine and similar to oxycodone against nociceptive,inflammatory and osteoarthritis pain,and superior to both morphine and oxycodone against neuropathic ***-73502 crosses the blood-brain barrier and binds brain S1R and MOR to an extent consistent with its antinociceptive *** to morphine and oxycodone,tolerance to its antinociceptive effect did not develop after repeated 4-week ***,contrary to opioid comparators,WLB-73502 did not inhibit gastrointestinal transit or respiratory function in rats at doses inducing full efficacy,and it was devoid of proemetic effect(retching and vomiting)in ferrets at potentially effective ***-73502 benefits from its bivalent S1R antagonist and partial MOR agonist nature to provide an improved antinociceptive and safety profile respect to strong opioid therapy.

关键词： WLB-73502 Sigma-1 receptor Mu-opioid receptor Biased agonist Analgesic activity Chronic pain Neuropathic pain Safety