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Exercise-induced anaphylaxis with an Ayurvedic drug as cofactor:A case report

World Journal of Clinical Cases 2019年第5期7卷 623-627页

作者： Francesca Losa Margherita Deidda Davide Firinu maria luisa di martino maria Pina Barca Stefano Del Giacco Department of Medical Sciences and Public Health and Unit of Allergy and Clinical Immunology University Hospital "Duilio Casula" University of Cagliari

BACKGROUND The practice of Indian Ayurvedic medicine is spreading in Western countries and Shilajit is one of the most used drugs, for its antioxidant activities and immunomodulatory effects. Albeit Shilajit has showed a high degree of safety, it can act as cofactor of anaphylaxis, especially in condition at high risk, such as mast cell activation syndrome(MCAS). We reported this case to sensitize practitioners to investigate to the use of complementary and alternative medicine,in case of exercise-induced anaphylaxis(EIAn).CASE SUMMARY A 43-year-old woman, working as a dance teacher, developed urticaria after ingestion of rice, tuna and Shilajit, which did not respond to intramuscular corticosteroids. Subsequently, she developed dyspnoea and hypotension with loss of consciousness that arose 1 h after sexual activity. The patient did not refer personal history of atopy. Specific IgE for main food allergens resulted negative,with total IgE levels of 14 IU/L. Oral provocation test with Shilajit was not perfomed because the patient refused, but we performed prick-by-prick and patch test that resulted negative. Serum tryptase at the time of anaphylaxis was 20.6 μg/L that fell down to of 10.6 μg/L after therapy, but has remained at the high value after two days and during the follow-up. We performed an analysis of the c-KIT gene in peripheral blood, which was negative. We felt the diagnosis consistent with EIAn in a patient with a possible *** In Western countries the use of drugs from Ayurvedic medicine is more common than in the past. These substances can be cofactors of anaphylaxis in patients with risk factors.

关键词： Indian Ayurvedic medicine Anaphylaxis Exercise-induced anaphylaxis Mast cell activation syndrome Case report

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Lower Continental Crusts Involved in the Alpine Orogeny:New Insight from the Santa Lucia Nappe Metasediments(Corsica,France)

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Acta Geologica Sinica(English Edition) 2024年第4期98卷 904-920页

作者： Chiara FRASSI maria di ROSA Luca PANDOLFI Michele MARRONI dipartimento di Scienze della Terra Universitàdi PisaVia Santa Maria 5356126 PisaItaly Istituto di Geoscienze e Georisorse IGG-CNRVia Moruzzi50124 PisaItaly

In the Alpine Corsica(France),the Santa Lucia Nappe represents a peculiar unit preserving the unique relicts of Paleozoic lower to medium continental *** consists of composite basement affected by Permian granulite facies metamorphic conditions unconformably covered by a Late Cretaceous clastic sequence(Tomboni Conglomerate and Tralonca Flysch)affected by polyphase deformation and *** this work,we present a new reconstruction of the deformation events registered by the Tralonca Flysch during the Alpine *** D1 phase was testified by rare isoclinal *** D2 phase produced a continuous foliation and a map-scale sheath-fold with a top-to-W sense of *** D3 phase produced E-verging non-cylindrical folds and S3 crenulation cleavage that is not associated to metamorphic *** present the first temperature-pressure-deformation(P-T-d)path for the Tralonca Flysch,demonstrating that the Santa Lucia Nappe underwent accretion and then first stage exhumation in the Alpine wedge during the D1 phase with pressure and temperature peaks both occurred under blueschist metamorphic *** D2 phase occurred at lower pressure-temperature conditions during a second stage *** pressure-temperaturedeformation path is comparable with those of the Lower Units(i.e.,the subducted continental units of Alpine Corsica)suggesting a common geodynamic history.

关键词： blueschist-facies metamorphism P-T-d path Santa Lucia Nappe Corsica Alpine orogeny

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Changes in call properties of Boana pulchella (Anura, Hylidae) in response to different noise conditions

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Current Zoology 2024年第4期70卷 548-556页

作者： Pablo Grenat maria Ferrero mariana Baraquet Favio Pollo Manuel Otero Zulma Salinas Nancy Salas Adolfo martino Ecologia Departamento de Ciencias NaturalesFacultad de Ciencias ExactasFisico-Quimicas y NaturalesUniversidad Nacional de Rio CuartoRutaNacional N°36-km601X5804BYARioCuartoArgentina lnstituto de Ciencias de la Tierra Biodiversidad y Ambiente(ICBIA)UNRC-CONICETRuta Nacional N°36-km 601X5804BYARio CuartoArgentina Cátedra de Botanica General Departamento de Recursos Naturales y AmbienteFacultad de AgronomiaUniversidad de Buenos AiresAv.San Martin 4453Buenos AiresArgentina

The increasing expansion of urban areas leads to the emergence of new noisy environments that can affect animal *** play a crucial role in the mating displays of anurans,and the negative impact of anthropogenic noise-induced auditory masking has been reported in several *** investigated the acoustic variation in 96 males(n=971 calls)of the treefrog Boana pulchella across acoustically undis-turbed sites and different noise conditions,associated with urban areas(URBAN)and roads(ROAD),in Central *** analyzed the effect of anthropogenic noise conditions on 6 temporal(call duration[CD],intercall interval,first and second note duration,internote interval,and call rate)and 3 spectral(dominant frequency of first and second note,frequency difference between them)call *** effects of temperature and size on acoustical variables were *** observed differences in all call attributes among the noise conditions,except for intercall *** exposed to URBAN and ROAD exhibited significant changes in CD,dominant frequency of the second note,and fre-quency difference between *** males had longest internote interval,while ROAD individuals displayed increased first and second note duration and call ***,ROAD males exhibited immediate changes in call rate in direct response to passing heavy *** study emphasizes the impact of anthropogenic noise on the acoustic characteristics of *** *** how animals adapt to noisy environments is crucial in mitigating the adverse effects of urbanization on their communication *** investigations should explore whether the observed call adjustments are effective in avoiding or mitigating the negative consequences of anthropogenic noise on reproductive success.

关键词： acoustic communication advertisement call auditory masking noise pollution road traffic noise.

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Genome-wide investigation to assess copy number variants in the Italian local chicken population

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Journal of Animal Science and Biotechnology 2024年第2期15卷 563-577页

作者： Filippo Cendron martino Cassandro Mauro Penasa Department of Agronomy FoodNatural ResourcesAnimals and Environment(DAFNAE)University of PadovaViale Dell’Universita 1635020 LegnaroPDItaly Federazione Delle Associazioni Nazionali di Razza E Specie Via XXIV Maggio 4300187 RomeItaly

Background Copy number variants(CNV)hold significant functional and evolutionary *** ongoing CNV studies aim to elucidate the etiology of human diseases and gain insights into the population structure of ***-density chips have enabled the detection of CNV with increased resolution,leading to the identification of even small *** study aimed to identify CNV in local Italian chicken breeds and investigate their distribution across the *** Copy number variants were mainly distributed across the first six chromosomes and primarily associated with loss type *** majority of CNV in the investigated breeds were of types 0 and 1,and the minimum length of CNV was significantly larger than that reported in previous ***,a high proportion of the length of chromosome 16 was covered by copy number variation regions(CNVR),with the major histocompatibility complex being the likely *** the genes identified within CNVR,only those present in at least five animals across breeds(n=95)were discussed to reduce the focus on redundant *** of these genes have been associated to functional traits in ***,several CNVR on different chromosomes harbor genes related to muscle development,tissue-specific biological processes,heat stress resistance,and immune *** trait loci(QTL)were also analyzed to investigate potential overlapping with the identified CNVR:54 out of the 95 gene-containing regions overlapped with 428 QTL associated to body weight and size,carcass characteristics,egg production,egg components,fat deposition,and feed *** The genomic phenomena reported in this study that can cause changes in the distribution of CNV within the genome over time and the comparison of these differences in CNVR of the local chicken breeds could help in preserving these genetic resources.

关键词： Chicken Copy number variant Conservation Local breed SNP

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Venous Doppler flow patterns,venous congestion,heart disease and renal dysfunction:A complex liaison

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World Journal of Cardiology 2024年第1期16卷 5-9页

作者： Alessio di maria Rossella Siligato Marta Bondanelli Fabio Fabbian Specialized Medicines Renal UnitUniversity Hospital St.Anna of FerraraFerrara I-44124Italy Department of Biomedical DentalMorphological and Functional Imaging SciencesUniversity of MessinaMessina I-98121Italy Department of Medical Sciences University of FerraraFerrara I-44124Italy Department of Medical Sciences University of FerraraFerrara 44124Italy

The World Journal of Cardiology published an article written by Kuwahara et al that we take the pleasure to comment *** focused our attention on venous *** intensive care settings,it is now widely accepted that venous congestion is an important clinical feature worthy of *** venous Doppler profile abnormalities at multiple sites could suggest adequate treatment and monitor its *** dysfunction could trigger or worsen fluid overload in heart disease,and cardio-renal syndrome is a well-characterized spectrum of disorders describing the complex interactions between heart and kidney *** overload and venous congestion,including renal venous hypertension,are major determinants of acute and chronic renal dysfunction arising in heart *** congestion from venous hypertension could be involved in the development of organ injury in several clinical situations,such as critical diseases,congestive heart failure,and chronic kidney *** and abnormal Doppler flow patterns diagnose clinically significant systemic venous *** and nephrologists might use this valuable,noninvasive,bedside diagnostic tool to establish fluid status and guide clinical choices.

关键词： Cardio-renal syndrome Fluid overload Venous congestion Acute kidney injury Ultrasound Doppler flow patterns

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Two big orifices in the second duodenal portion:A case of an atypical double papilla

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Hepatobiliary & Pancreatic diseases International 2024年第1期23卷 83-85页

作者： Salvatore Francesco Vadalàdi Prampero Nikola Panic Marco Massidda Chiara Rocchi Pierluigi maria Rinaldi Ana Malenkovic Milutin Bulajic Gastroenterology and GI Endoscopy Department Mater Olbia HospitalOlbia 07026Italy digestive Endoscopy Unit University Clinic"Dr Dragisa Misovic-Dedinje"Belgrade 11000Serbia Radiology Department Mater Olbia HospitalOlbia 07026Italy

With the advent of endoscopic retrograde cholangiopancreatography(ERCP)in the early 1970s,anatomic anomalies of the Vaterian system were described endoscopically[1].Although the occurrence is rare,the common bile duct(CBD)and the pancreatic duct may fail to coalesce during embryologic *** leads to double major papilla because both ducts open into the duodenum separately[1].In this way the cranial duct communicates with the CBD,while the caudal orifice communicates with the pancreatic duct[2].

关键词： orifice Vater atypical

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Successful treatment of acute liver failure due to Wilson’s disease: Serendipity or fortuity?

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World Journal of Hepatology 2024年第8期16卷 1111-1119页

作者： Valeria Delle Cave Fabiola di Dato Pier Luigi Calvo maria Immacolata Spagnuolo Raffaele Iorio Department of Translational Medical Science Section of PediatricsUniversity of Naples Federico IINaples 80131Italy Pediatric Gastroenterology Unit Regina Margherita Children's HospitalAzienda Ospedaliera-Universitaria Cittàdella Salute e della ScienzaTurin 10126Italy

BACKGROUND Acute liver failure(ALF)may be the first and most dramatic presentation of Wilson’s disease(WD).ALF due to WD(WD-ALF)is difficult to distinguish from other causes of liver disease and is a clear indication for liver *** is no firm recommendation on specific and supportive medical treatment for this *** To critically evaluate the diagnostic and therapeutic management of WD-ALF patients in order to improve their survival with native *** A retrospective analysis of patients with WD-ALF was conducted in two pediatric liver units from 2018 to *** During the study period,16 children(9 males)received a diagnosis of WD and 2 of them presented with *** first was successfully treated with an unconventional combination of low doses of D-penicillamine and zinc plus steroids,and survived without liver *** second,exclusively treated with supportive therapy,needed a hepatotransplant to overcome *** Successful treatment of 1 WD-ALF patient with low-dose D-penicillamine and zinc plus steroids may provide new perspectives for management of this condition,which is currently only treated with liver transplantation.

关键词： Fulminant liver failure Copper Chelator Zinc Steroids Liver transplantation Autoimmune hepatitis Prognostic score 24 hour-urinary copper excretion Native liver

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Laparoscopic central pancreatectomy with gastro-pancreatic anastomosis for symptomatic serous cystadenoma:A case report and literature review

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Laparoscopic, Endoscopic and Robotic Surgery 2024年第2期7卷 87-91页

作者： Giuseppe Frazzetta Antonino Picciurro Angela Maffongelli Irene Vitale Francesco Vitale Daniela Scimeca Michele Amata Anna Calì Ambra Bonaccorso Barbara Scrivo Vincenzo di martino Elisabetta Conte Filippo Mocciaro Roberto di Mitri Pierenrico Marchesa Oncologic Surgery Unit ARNAS Civico HospitalPalermo 90100Italy Gastroenterology Unit ARNAS Civico HospitalPalermo 90100Italy

Surgery for lesions of the proximal part of the pancreatic body or neck can be challenging,and when enucleation is not possible,central pancreatectomy is an *** central pancreatic resection is rarely described worldwide;it is considered a difficult procedure mainly because of the risk of double pancreatic fistula developing at two sites of ***,it seems to be an excellent alternative to distal pancreatectomy or pancreaticoduodenectomy,with the advantages of preserving functioning parenchyma and reducing endocrine and exocrine ***,patients with pancreatic lesions requiring central resection are often managed with the open approach in many hospitals due to the complexity of total laparoscopic central pancreatectomy,which requires advanced laparoscopic skills,expertise and ***,we report a case of a 29-year-old female who underwent total laparoscopic central pancreatic resection with gastro-pancreatic anastomosis for symptomatic serous *** discuss the details of case management and review the relevant literature.

关键词： Laparoscopic Pancreatic surgery Central pancreatectomy Cystadenoma

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Lower limb suspension induces threshold-specific alterations of motor units properties that are reversed by active recovery

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Journal of Sport and Health Science 2024年第2期13卷 264-276页

作者： Giacomo Valli Fabio Sarto Andrea Casolo Alessandro Del Vecchio martino V.Franchi Marco V.Narici Giuseppe De Vito Department of Biomedical Sciences University of PadovaPadova 35131Italy Department Artificial Intelligence in Biomedical Engineering Friedrich-Alexander UniversityErlangen-Nurnberg 91052Germany

Purpose:This study aimed to non-invasively test the hypothesis that(a) short-term lower limb unloading would induce changes in the neural control of force production(based on motor units(MUs) properties) in the vastus lateralis muscle and(b) possible changes are reversed by active recovery(AR).Methods:Ten young males underwent 10 days of unilateral lower limb suspension(ULLS) followed by 21 days of *** ULLS,participants walked exclusively on crutches with the dominant leg suspended in a slightly flexed position(15°-20°) and with the contralateral foot raised by an elevated *** AR was based on resistance exercise(leg press and leg extension) and executed at 70% of each participant’s 1repetition maximum,3 times/*** voluntary isometric contraction(MVC) of knee extensors and MUs properties of the vastus lateralis muscle were measured at baseline,after ULLS,and after *** were identified using high-density electromyography during trapezoidal isometric contractions at 10%,25%,and 50% of the current MVC,and individual MUs were tracked across the 3 data collection ***:We identified 1428 unique MUs,and 270 of them(18.9%) were accurately *** ULLS,MVC decreased by 29.77%,MUs absolute recruitment/derecruitment thresholds were reduced at all contraction intensities(with changes between the 2 variables strongly correlated),while discharge rate was reduced at 10% and 25% but not at 50% *** MVC and MUs properties fully recovered to baseline levels after *** changes were observed in the pool of total as well as tracked ***:Our novel results demonstrate,non-invasively,that 10 days of ULLS affected neural control predominantly by altering the discharge rate of lower-threshold but not of higher-threshold MUs,suggesting a preferential impact of disuse on motoneurons with a lower depolarization ***,after 21 days of AR,the impaired MUs properties were fully restored to baseline levels,highlighting the plas

关键词： disuse High-density EMG Muscle disuse Neural impairment Neuromuscular degeneration

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Hyperkalemia in Patients on Peritoneal dialysis: Clinical Use Experience with New Potassium-Binders

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Open Journal of Nephrology 2024年第3期14卷 324-333页

作者： Gennaro Argentino Mario Iorio Alessandra Antonia Mele Andrea Camocardi Enrica Emanuela Cascone maria Elena Liberti Adelia Sagliocca Andrea Pota Luigi Russo maria luisa Sirico Germano Terzini Michele Cavasso Chiara Mennillo Francesca Nettuno Raffaele Genualdo Giuseppe Surfaro Lucia di Micco UOC Nefrologia e dialisi Ospedale del Mare Naples Italy UOC Chirurgia Generale Ospedale del Mare Naples Italy

Background: Patients with end-stage kidney disease (ESKD) on maintenance dialysis have a high risk of developing hyperkalemia. In addition to traditional approaches, a new option for the management of patients on dialysis includes the use of a potassium binder, sodium zirconium cyclosilicate (SZC). We evaluated the effect and safety of SZC in patients with chronic PD. Objective: To present a case series that illustrates the real-world use of new potassium-binders in hyperkalemic patients on peritoneal dialysis. Methods: This case series collected 9 patients on PD with baseline potassium values > 5.5 mmol/l and who were treated with SZC 5 g once a day. Data were collected at baseline and at 1, 2, and 3 months after initiation of treatment. Results: The median age of patients was 64.5 years and the median duration of observation was 90 ± 5 days. It was observed that median serum potassium decreased (5.8 mmol/l at baseline with a range of 5.8 mmol/L - 6.8 mmol/L versus 4.5 in the third month with a range of 3.6 mmol/L - 5.3 mmol/L) after SZC treatment. Adverse events were observed in 2 (22.2%). The unique adverse event was constipation and presented in 2 patients (22.2%). Constipation was mild and transient during the observation period. No adverse events of special interest were reported. Conclusion: Normokalemia was established and maintained in this series of patients treated with SZC. No episodes of hyper- or hypo-kalemia were observed. SCZ had a good safety profile and was well tolerated over 3 months.

关键词： SZC Sodium Zirconium Cyclosilicate Hyperkalaemia Peritoneal dialysis

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