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Motivations for and barriers to innovation in non-profit organizations: The case of nursing homes in Northern Portugal

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International Journal of Innovation Studies 2024年第1期8卷 25-44页

作者： Ana Rita Gonçalves Lopes Aldina Isabel de Azevedo Correia Alexandra maria da Silva braga Center for Research and Innovation in Business Sciences and Information Systems School of Management and TechnologyPolitecnico do PortoRua do Curral-Margaride4610-156 FelgueirasPortugal

To contribute to the empirical literature on innovation in non-profit organizations,this study examines innovation in Private Social Solidarity Institutions with social responses for the elderly in Northern *** enriches the literature by clarifying the concept of innovation applied to non-profit organizations,which represents a perspective different from the business ***,it is important to support the innovation decisionmaking process in similar non-profit *** this study,the population was surveyed through questionnaires based on the PUBLIN research project,which has already been applied in different countries,and the targets were employees of organizations with social responses for the *** sample is small,with 28 respondent institutions and 51 employees,but it is representative,as it includes institutions from all districts in Northern *** study employed a quantitative approach,particularly factor analysis,multiple linear regression,and correlation analyses,using scales already applied in other dimensions of the social sector,to understand the effect of each innovation dimension/determinant on creativity and innovation in nonprofit *** results show that in these organizations with social responses for the elderly,learning orientation,risk-taking,and job satisfaction have a positive impact on innovation.

关键词： Determinants of innovation non-profit organizations social responses for the elderly Northern Portugal

Clinicopathological Description of a Chronic Lymphocytic Leukemia in a Dog

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Open Journal of Veterinary Medicine 2024年第7期14卷 155-162页

作者： maria Clara Boni Raffi Giovanna Valverde Magalhães Barbosa Alana Carolina Capais Rodrigues Sheila Canevese Rahal John P. Kastelic luíz Guilherme Dercore Benevenuto Iolanda Simões braga Beatriz Poloni Batista Felipe César Da Silva Brasileiro Fernanda Barthelson Carvalho de Moura Priscylla Tatiana Chalfun Guimarães Okamoto Regina Kiomi Takahira Alessandra Melchert Noeme Sousa Rocha Department of Veterinary Clinics School of Veterinary Medicine and Animal Science So Paulo State UniversityUNESP Botucatu SP Brazil Independent Veterinary Practitioner Department of Veterinary Surgery and Animal Reproduction School of Veterinary Medicine and Animal Science So Paulo State UniversityUNESP Botucatu SP Brazil Faculty of Veterinary Medicine University of Calgary Calgary Canada

Hematopoietic tumors are associated with diagnostic and therapeutic challenges and a poor prognosis. Furthermore, their pathophysiology in dogs is not well understood. Chronic lymphocytic leukemia has been rarely reported in golden retrievers, perhaps due to difficulties in diagnosis and care. An 8-year-old spayed female golden retriever was referred to our hospital with a 2-month history of fatigue, weakness, and selective appetite. The dog was diagnosed with chronic lymphocytic leukemia based on blood smear evaluation. Despite treatment, the dog deteriorated and the owners opted for euthanasia. Histopathological examination revealed atypical lymphocytes in the spleen, extramedullary hematopoiesis in the spleen and liver, bone marrow depletion, moderate neutrophilic myocarditis, and acute renal tubular necrosis. In an immunohistochemical panel, cells in the spleen and bone marrow were positive for anti-CD20, anti-CD45, anti-CD3, anti-IBA-1, anti-Ki67, anti-MUM-1, and anti-PAX-5. In conclusion, the leukemia diagnosis was confirmed through reactive histiocytosis, marked extramedullary hematopoiesis, and other clinical and laboratory findings. Herein, we report a case of chronic lymphocytic leukemia in a female dog with clinical, laboratory, and necroscopy findings.

关键词： Canine Cancer Neoplasia Therapeutics

FeedEfficiencyService: An architecture for the comparison of data from multiple studies related to dairy cattle feed efficiency indices

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Information Processing in Agriculture 2022年第3期9卷 378-396页

作者： Heitor Magaldi Linhares Regina braga Wagner Antonio Arbex mariana Magalhaes Campos Fernanda Campos Jose maria N.David Victor Stroele Programa de Pos-Graduacao em Ciencia da Computacao Universidade Federal de Juiz de ForaCampus UniversitarioRua JoseLourenco Kelmers/n-Sao PedroJuiz de ForaMinas Gerais 36036-900Brasil Brazilian Agricultural Research Corporation-Embrapa Av.Eugenio do Nascimento610-AeroportoJuiz de Fora-MGMinas Gerais 36038-330Brasil

The increased demand for food worldwide,the reduced land availability for livestock pro-duction,the increasing cost of animal feed and the need for mitigating livestock-related greenhouse gas emissions have driven the search for animal feeding systems that proves more *** tackle this problem,we propose the use of computational support to help researchers compare data on feed efficiency,therefore improving economic and environ-mental *** a solution,we present an integrative architecture capable of combining heterogeneous data from multiple experiments related to dairy cattle feed efficiency *** proposed architecture,called FeedEfficiencyService,classifies animals according to feed efficiency indices and allows visualizations through ontologies and inference *** results obtained from a case study with researchers from the Brazilian Agri-cultural Research Corporation–Dairy Cattle(EMBRAPA)demonstrate that this architecture is a supporting tool in their daily work *** researchers highlighted the importance of the proposed architecture as it allows analyzing animal data,comparing experiments,having reliable data analyses,and standardizing and organizing data from *** novelty of our approach is the use of ontologies and inference engines to enable the discovery of new knowledge and new relationships between data from feed efficiency-related *** store such data,relationships,and analyses of results in an inte-grated *** solution ensures unified access to the processing history and data from diverse experiments,including those conducted at external research centers.

关键词： Dairy Cattle

Scoping review on vector-borne diseases in urban areas:transmission dynamics,vectorial capacity and co-infection

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Infectious Diseases of Poverty 2018年第1期7卷 916-939页

作者： Marcus Eder Fanny Cortes Noemia Teixeira de Siqueira Filha Giovanny Vinicius Araujo de Franca Stephanie Degroote Cynthia braga Valery Ridde Celina maria Turchi Martelli Public Health England Sierra Leone Country Office FreetownSierra Leone Aggeu Magalhaes Institute(IAM)/Oswaldo Cruz Foundation(Fiocruz) Avenida Professor Moraes Regos/n.Cidade Universitaria.CEP 50RecifePernambuco 740-465Brazil Universidade de Pernambuco(UPE) RecifePernambucoBrazil Liverpool School Of Tropical Medicine(LSTM) LondonUK Secretariat of Health Surveillance Ministry of HealthBrasiliaBrazil University of Montreal School of Public Health(ESPUM) MontrealQuebecCanada IRD(French Institute For Research on Sustainable Development) CEPED(IRD-UniversiteParis Descartes)Universites Paris Sorbonne CitesERL INSERM SAGESUDParisFrance

Background:Transmission dynamics,vectorial capacity,and co-infections have substantial impacts on vector-borne diseases(VBDs)affecting urban and suburban *** key factors can provide insight into priority research areas and offer suggestions for potential *** body:Through a scoping review,we identify knowledge gaps on transmission dynamics,vectorial capacity,and co-infections regarding VBDs in urban ***-reviewed and grey literature published between 2000 and 2016 was *** screened abstracts and full texts to select *** an extraction grid,we retrieved general data,results,lessons learned and recommendations,future research avenues,and practice *** classified studies by VBD and country/continent and identified relevant knowledge *** 773 articles selected for full-text screening,50 were included in the review:23 based on research in the Americas,15 in Asia,10 in Africa,and one each in Europe and *** largest body of evidence concerning VBD epidemiology in urban areas concerned dengue and *** arboviruses covered included chikungunya and West Nile virus,other parasitic diseases such as leishmaniasis and trypanosomiasis,and bacterial rickettsiosis and *** articles retrieved in our review combined transmission dynamics and vectorial capacity;only two combined transmission dynamics and *** review identified significant knowledge gaps on the role of asymptomatic individuals,the effects of co-infection and other host factors,and the impacts of climatic,environmental,and socioeconomic factors on VBD transmission in urban *** included the trade-off from narrowing the search strategy(missing out on classical modelling studies),a lack of studies on co-infections,most studies being only descriptive,and few offering concrete public health *** research is needed on transmission risk in homes and workplaces,given increasingly dynamic and mobil

关键词： Arboviruses Disease vectors Coinfection Urban population Epidemiology Review

Muscle Loss in Cancer Patients: Pathophysiology and Impact on the Outcome

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Journal of Nutritional Oncology 2016年第1期1卷 15-20页

作者： maria Chiara salandini Nicolo Pecorelli Paola De Nardi Marco braga Department of Surgery Vita-Salute San Raffaele University Milan 20132 Italy

A generalized loss of skeletal muscle can be associated with malnutrition, cancer, inflammation or neurodegenerative processes. Most cancer patients undergoing surgery are sarcopenic although only a minority of them suffer from severe weight loss. The cancer stage is a major determinant of sarcopenia, while nutritional factors seem to be less important. In cancer patients sarcopenia has been associated with a worse physical performance, a reduced response to chemotherapy and radiotherapy, a higher postoperative morbidity rate, and a reduced life expectancy.

关键词： Cancer Cachexia sarcopenia Visceral fat Body composition

Chemical composition, antiparasitic and cytotoxic activities of aqueous extracts of Ziziphus joazeiro Mart

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Asian Pacific Journal of Tropical Biomedicine 2019年第5期9卷 222-226页

作者： Jacqueline Cosmo ANDrade Ana Raquel Pereira da Silva Ant?nia Thassya lucas dos santos maria Audilene Freitas Yedda maria Lobo Soares de Matos maria Flaviana Bezerra Morais braga Camila Fonseca Bezerra maria Isabeli Pereira Gon?alo maria Celeste Vega Gomez Míriam Rolóm Cathia Coronel Paulo Riceli Vasconcelos Ribeiro Edy Sousa de Brito Henrique Douglas Melo Coutinho Microbiology and Molecular Biology Laboratory Biological Chemistry Department Regional University of Cariri-URCA Bioassays Laboratory-LABIO Federal University of Cariri-UFCA Brejo Santo University campus (CE) Center for the Development of Scientific Research Moisés Bertoni Foundation/Díaz Gill Laboratories Natural Products Chemistry Multiuser Laboratory LMQPN Embrapa Tropical Agroindustry

Objective: To compare the in vitro antiparasitic activity of aqueous extracts from Ziziphus joazeiro leaves and stem bark against Trypanosoma cruzi, Leishmania braziliensis, and Leishmania infantum, as well as to evaluate its cytotoxicity in mammalian cells, in addition to identifying the chemical composition of the extracts. Methods: Ziziphus joazeiro leaf and stem bark aqueous extracts were prepared by cold extraction maceration and subjected to ultra-efficient liquid chromatography coupled to a quadrupole/time of flight system. The susceptibility assays used Trypanosoma cruzi CLB5 strains and promastigote forms of Leishmania braziliensis and Leishmania infantum for antiparasitic activity of the extracts. Moreover, mammalian fibroblasts NCTC clone 929 were used for cytotoxicity analysis. Results: Terpenoid compounds, flavonoids and phenolic acid were identified in extracts. The stem bark aqueous extracts presented more significant results in terms of antiparasitic activity compared with the leaf aqueous extracts, especially against Leishmania braziliensis and Leishmania infantum promastigote forms with an IC50 luation showed moderate toxicity of the stem bark aqueous extracts, which is relevant information for the rational use of this plant part since it is widely used by the population. Conclusions: These preliminary results may contribute to the formulation of new therapeutic agents against this group of neglected diseases, so further investigations are required to delineate the mechanisms of action mainly of the aqueous extract of stem bark of Ziziphus joazeiro.

关键词： Antiepimastigote Antipromastigote UPLC-MS-ESI-QTOF

Characterization and Modification of a Clay Mineral Used in Adsorption Tests

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Journal of Minerals and Materials Characterization and Engineering 2015年第4期3卷 277-288页

作者： Natália Costa Dias Patrícia Arns Steiner maria Cristina Borba braga Water Resources and Environmental Engineering Post-Graduate Program Department of Hydraulics and Sani-tation Parana Federal University Curitiba Brazil

Clay minerals are widespread in natural systems and have been widely used for the removal of pollutants. In this study, natural expanded vermiculite was used in adsorption tests to remove ammonium nitrogen from landfill leachate. The modification of vermiculite was carried out using NaOH and HCl, and for both modifications the best concentration was 0.1 mol/L. The results produced by XRD (X-ray diffraction) showed that Al replaced K after modification of the vermiculite using HCl and that Mg and Na replaced K after modification using NaOH. It was observed that the adsorption capacity increased as the percentage in mass of K diminished. The Langmuir is the isotherm that presents the best fit of the data, and the values of RL (the Langmuir coefficient) suggest that the adsorption is linear. The thermodynamic parameters indicate that the process is spontaneous and endothermic, that there is a high affinity between the adsorbate and the adsorbent, and that physical adsorption is prevalent.

关键词： Adsorption Isotherms Adsorption Thermodynamics Clay Minerals Expanded Vermiculite Landfill Leachate Vermiculite

Large ferro-pyro-phototronic effect in 0.5Ba(Zr_(0.2)Ti_(0.8))O_(3)-0.5(Ba_(0.7)Ca_(0.3))TiO_(3)thin films integrated on silicon for photodetection

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Carbon Energy 2023年第6期5卷 1-10页

作者： JoséP.B.Silva Katarzyna Gwozdz luís S.Marques Mario Pereira maria J.M.Gomes Judith L.MacManus‐Driscoll Robert L.Z.Hoye Centre of Physics of Universities of Minho and Porto(CF‐UM‐UP) University of MinhoBragaPortugal Laboratory of Physics for Materials and Emergent Technologies LapMETUniversity of MinhoBragaPortugal Department of Quantum Technologies Faculty of Fundamental Problems of TechnologyWroclaw University of Science and TechnologyWroclawPoland Department of Materials Science and Metallurgy CambridgeUK Inorganic Chemistry Laboratory Department of ChemistryUniversity of OxfordOxfordUK Department of Materials Imperial College LondonLondonUK

Coupling together the ferroelectric,pyroelectric,and photovoltaic characteristics within a single material is a novel way to improve the performance of *** this work,we take advantage of the triple multifunctionality shown by 0.5Ba(Zr_(0.2)Ti_(0.8))O_(3)-0.5(Ba_(0.7)Ca_(0.3))TiO_(3)(BCZT),as demonstrated in an Al/Si/SiOx/BCZT/ITO thin-film *** Si/SiOx acts as an n-type layer to form a metal-ferroelectric-insulator-semiconductor heterostructure with the BCZT,and with Al and ITO as *** photo-response of the device,with excitation from a violet laser(405 nm wavelength),is carefully investigated,and it is shown that the photodetector performance is invariant with the chopper frequency owing to the pyro-phototronic effect,which corresponds to the coupling together of the pyroelectric and photovoltaic ***,the photodetector performance was significantly better than that of the devices operating based only on the pyro-phototronic effect by a factor of 4,due to the presence of ferroelectricity in the ***,after a poling voltage of−15 V,for a laser power density of 230mW/cm^(2)and at a chopper frequency of 400Hz,optimized responsivity,detectivity,and sensitivity values of 13.1mA/W,1.7×10^(10)Jones,and 26.9,respectively,are ***,ultrafast rise and fall times of 2.4 and 1.5μs,respectively,are obtained,which are 35,000 and 36,000 times faster rise and fall responses,respectively,than previous reports of devices with the ferro-pyro-phototronic *** is understood based on the much faster ferroelectric switching in ferroelectric thin films owing to the predominant 180°domains in a single direction out of plane.

关键词： ferroelectric ferro-pyro-phototronic effect photodetector polarization-controlled response

Robot-assisted adrenalectomy:Step-by-step technique and surgical outcomes at a high-volume robotic center

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Asian Journal of Urology 2023年第4期10卷 475-481页

作者： Federico Piramide Carlo Andrea Bravi Marco Paciotti luca sarchi luigi Nocera Adele Piro maria Peraire Lores Eleonora Balestrazzi Angelo Mottaran Rui farinha Hubert Nicolas Pieter De Backer Frederiek D'hondt Peter Schatteman Ruben De Groote Geert De Naeyer Alexandre Mottrie Department of Urology Onze-Lieve-VrouwziekenhuisAalstBelgium ORSI Academy GhentBelgium Department of Oncology Division of UrologyUniversity of TurinSan Luigi Gonzaga HospitalTurinItaly Department of Urology Humanitas Research Hospital-IRCCSRozzanoItaly Department of Urology ASST Santi Paolo e CarloUniversity of MilanMilanItaly Unit of Urology Division of Experimental OncologyUrological Research InstituteIRCCS San Raffaele Scientific InstituteVita-Salute San Raffaele UniversityMilanItaly Department of Urology Ospedale Policlinico e Nuovo Ospedale Civile S.Agostino Estense ModenaUniversity of Modena and Reggio EmiliaModenaItaly Division of Urology IRCCS Azienda Ospedaliero-Universitaria di BolognaBolognaItaly Urological Department La CitadelleLiègeBelgium

Objective In the last years,robotic surgery was introduced in several different settings with good perioperative ***,its role in the management of adrenal masses is still *** order to provide a contribution to this field,we described our step-by-step technique for robotic adrenalectomy(RA)and related modifications according to the type of adrenal mass *** We retrospectively analyzed 27 consecutive patients who underwent RA at Onze-Lieve-Vrouw hospital(Aalst,Belgium)between January 2009 and October ***,intra-and post-operative,and pathological data were retrieved from our prospectively maintained institutional *** variables are summarized as median and interquartile range(IQR).Categorical variables are reported as frequencies(percentages).Results Twenty-seven patients underwent RA were included in the *** age,body mass index,and Charlson's comorbidity index were 61(IQR:49-71)years,26(IQR:24-29)kg/m^(2),and 2(IQR:0-3),respectively,and 16(59.3%)patients were *** tumor size at computed tomography scan was 6.0(IQR:3.5-8.0)*** operative time and blood loss were 105(IQR:82-120)min and 175(IQR:94-250)mL,*** intraoperative complications were *** postoperative complications rate was 11.1%,with a postoperative transfusion rate of 3.7%.A total of 10(37.0%)patients harbored malignant adrenal *** them,3(11.1%)had adrenocortical carcinoma,6(22.2%)secondary metastasis,and 1(3.7%)malignant pheochromocytoma on final pathological *** 1(10.0%)patient had positive surgical *** We described our step-by-step technique for RA,which can be safely performed even in case of high challenging settings as malignant tumors,pheochromocytoma,and large *** standardization of perioperative protocol should be encouraged to maximize the outcomes of this complex surgical procedure.

关键词： Robotics Adrenalectomy Pheochromocytoma Malignant Surgical technique