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Advances in Infectious Diseases 2022年第1期12卷 90-105页

作者： Mirian Carla Bortolamedi da Silva maria Helena Brandeleiro Werlang Valdir Spada Júnior Guilherme Welter Wendt Ana Paula Vieira Franciele Ani Caovilla Follador Léia Carolina Lucio Cleide Viviane Busanello martins Kérley Braga Pereira Bento Casaril Paulo Cezar Nunes Fortes Lirane Elize Defante Ferreto Post-Graduante Program Health Sciences University of Wester Paraná (UNIOESTE) Francisco Beltr&#227 o Brazil State of the Health of Paraná (SESA-PR) Francisco Beltr&#227 o Brazil

To identify risk factors for A. baumannii infection in patients hospitalized in an Intensive Care Unit (ICU) of a tertiary public hospital in Paraná, Brazil, a retrospective paired case-control study (ratio 1:2) was conducted from January 2018 to December 2020. Patients in the case group were hospitalized in the ICU with A. baumanni (n = 68 cases) and were compared with patients in the control group, without infection by A. baumannii (n = 136). Both were matched by age (±10 years), sex, and ICU stay (±5 days). Conditional multiple logistic regression was used to determine statistically significant risk factors based on the results of bivariate analyses. Mortality was higher in infected (cases) than in non-infected patients (51.5% vs. 39.7%). The incidence and bacterial resistance increased annually. At bivariate analysis, cases had longer hospital stays (median 35 vs. 22 days, p A. baumannii and antimicrobial resistance. There is need for surveillance, and constant evaluation of control actions. Risk factors were colonization, previous hospitalization, and hospitalization time. This is essential for the decision-making of professionals and optimization of prevention, control, and therapeutic management actions.

关键词： Acinetobacter baumannii Risk-Factors Infection Intensive Care

A ConA-like lectin isolated from <i>Canavalia maritima</i>seeds alters the expression of genes related to virulence and biofilm formation in <i>Streptococcus mutans</i>

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Advances in Bioscience and Biotechnology 2013年第12期4卷 1073-7078页

作者： Theodora Thays Arruda Cavalcante Victor Alves Carneiro Cinara Carneiro Neves Humberlania de Sousa Duarte maria Gleiciane de Queiroz martins Francisco Vassiliepe Sousa Arruda Mayron Alves de Vasconcelos Hélcio Silva dos Santos Rodrigo Maranguape da Silva Cunha Benildo Sousa Cavada Edson Holanda Teixeira Biologically Active Molecules Laboratory (Biomol-Lab) Department of Biochemistry and Molecular Biology Federal University of Ceará Forta-leza Brazil Center of Agricultural Science and Biological Acaraú Valley State Uni-versity Sobral Brazil Center of the Exact Sciences and Technology Acaraú Valley State Uni-versity Sobral Brazil Faculty of Dentistry Institute of Applied Theology (INTA) Sobral Brazil Integrate Biomolecules Laboratory (LIBS) Department of Pathology and Legal Medicine Federal University of Ceará Fortaleza Brazil Integrate Biomolecules Laboratory (LIBS) Faculty of Medicine of Sobral Federal University of Ceará Sobral Brazil

Bacteria form biofilms as an adaptive mechanism in response to environmental changes. Streptococcus mutans is the biofilm-forming bacterium that is primarily associated with dental caries. The expression of important genes by bacteria in biofilms is different from that of planktonic cells. Lectins are proteins that bind specifically to carbohydrates and may have important biological activities on bacterial cells, acting as antibacterial and anti-biofilm agents. ConM (Canavalia maritima lectin) is a protein that is able to inhibit the planktonic growth and biofilm formation of S. mutans. In this context, this study aimed to evaluate the effects of ConM and concanavalin A (ConA) on the expression of genes related to virulence and biofilm formation in S. mutans. The results showed that ConM significantly reduced the expression of genes encoding enzymes related to adhesion, formation and regulation of biofilms. On the contrary, ConA did not alter the expression of the genes studied. Because the two lectins have a high degree of similarity, the differences in the actions of ConM and ConA may be explained by the small structural differences in the carbohydrate recognition domain of the lectins.

关键词： Streptococcus mutants Lectin Canavalia maritima Biofilm Expression

Analysis of Nursing Care Concept: Perspective of the Person Submitted to Care

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Open Journal of Nursing 2016年第6期6卷 491-496页

作者： Camila Brasil Moreira Ana Fátima Carvalho Fernandes Míria Conceição Lavinas Santos Altamira Mendonça Félix Gomes Carla Monique lopes Mourão Rosy Denyse Pinheiro de Oliveira Angelica Isabely de Morais Almeida Suzy Ramos Rocha Cláudia Rayanna Silva Mendes Sadrine maria Eufrasino de Pinho Marinna maria de Andrade Costa Jordana Prado Benevides Caroline Batista de Queiroz Aquino Iarlla Silva Ferreira Raquel Vilanova Araujo Department of Nursing Federal University of Ceará Fortaleza Brazil

This study aimed to analyze the concept of nursing care to patients with breast cancer on chemotherapy treatment, according to the perspective of the person submitted to care. The study followed the conceptual analysis methodology proposed by Walker and Avant according to Waldow, and it was developed through consultation to SCOPUS and CINAHL databases. The selection was carried out by inclusion and exclusion criteria, constituting a sample of 7 articles. There have been identified the main uses of the risk concept, defining attributes, antecedents and consequences of the concept. The evaluation of the concept and nursing care to breast cancer patient on chemotherapy treatment allowed a broader understanding of the phenomenon, with emphasis on the skills and competencies in nursing care dispensed to woman on chemotherapy treatment for breast cancer.

关键词： Nursing Breast Neoplasms Analysis Research Nursing Care Chemotherapy

Relationship of Density of Specific Prostate Antigen (DPSA) with Prostate Histopathology: A Comparative Study of Patients Addressed in a School Hospital

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Journal of Biosciences and Medicines 2017年第3期5卷 105-111页

作者： Marcos Benedito Figueiredo Brandã o maria Benedita Figueiredo Brandã o Elias Sobreira Sathler Richard Raphael Borges Tavares Vieira Carolina Cadinelli Vieira Pedro Kozlowsky de Alencar Marcus Vinicius de Mello Pinto Lamara Laguardia Valente Rocha Lina Claudia Pereira lopes Daniel Almeida da Costa Carlos Henrique Diniz Branco Luiz Gioseffi Jannuzzi School Hospital of the Dom Andre Arcoverde Foundation Valen&ccedil a Brazil Universidade Está cio de Sá Rio de Janeiro Brazil The Medical School at the Center of Higher Education of Valenç a Valen&ccedil a Brazil The Cellurare Institute Center of Laser Treatment and Cell Therapy Petr&oacute polis Brazil The Medical School at the Health Sciences Institute of the University Center of Caratinga Caratinga Brazil

Background: The prostate is the site of problems that have great clinical relevance. Beside this, the alterations in their volume can be divided into benign or malignant pathologies, but of multifactorial cause and there is no examination that alone is reliable for the diagnosis. Despite the evolution of the various methods of diagnostic imaging in the evaluation of pelvic diseases, the diagnosis of prostate cancer still requires histological confirmation obtained by transrectal ultrasound guided biopsy, a procedure that is generally safe and well tolerated by the patients. The most common histological type found in prostate biopsies is adenocarcinoma. Methodology: The objective of this study was to study the values of density of the prostate-specific antigen (DPSA) compared to histopathological results of prostate biopsy, patients attended at the Urology Outpatient Clinic of the Luiz Gioseffi Jannuzzi School Hospital from 1999 to 2007, using Exploratory, retrospective and documentary descriptive study. The sample was divided into groups of patients with adenocarcinoma and patients without adenocarcinoma, who presented only benign prostatic hyperplasia. Results: Of the 251 patients undergoing prostate biopsy, 124 were diagnosed with adenocarcinoma and 127 without adenocarcinoma. It was observed in this study that the DPSA was higher in adenocarcinoma than in the cases of patients with prostatic hyperplasia alone, and could therefore be used as an auxiliary tool in both diagnosis and follow-up of patients with adenocarcinoma. Conclusion: In this study, it can be observed that DPSA was higher in patients presenting with adenocarcinoma than in patients presenting only Benign Prostatic Hyperplasia (BPH), reinforcing its promising role to assist in the diagnosis and follow-up of patients with adenocarcinoma.

关键词： Prostate Cancer Adenocarcinoma Benign Prostatic Hyperplasia Prostate Biopsy

Nursing Diagnostics of Nutrition Domain of NANDA International in Hemodialysis Patients

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Open Journal of Nursing 2016年第3期6卷 204-212页

作者： Érida maria Diniz Leite Sama Mikaella de Oliveira maria Isabel da Conceição Dias Fernandes maria das Graças mariano Nunes Cyndi Fernandes de Lima Ana Luisa Brandão de Carvalho Lira Department of Nursing Hospital Academic Onofre Lopes Natal Brasil Department of Nursing University of Rio Grande do Norte Natal Brasil

Introduction: The dialysis causes the loss of the nutrients and the elevation of catabolism, thus, patients in dialysis have at high risk for the loss of body reserves of protein and energy. Objective: To identify nursing diagnoses of nutrition domain of NANDA International in hemodialysis patients and to correlate them to the socioeconomic and clinical data. Design: Cross-sectional study. Setting: Performed in a large university hospital in northeastern Brazil. Participants: The first stage was carried out with 50 patients, selected with the following inclusion criteria: Being hospitalized and undergoing hemodialysis in that hospital;aged 18 years old or over;being conscious and oriented. Exclusion criteria were patients undergoing hemodialysis in that hospital with external service, pregnant women and patients being treated by plasmapheresis. In the second stage, participants were three nursing specialists in nephrology and nursing diagnoses. Methods: The defining characteristics of the nursing diagnoses inserted in the nutrition domain were observed in patients and then these data were judged by nurses, in order to identify diagnoses present in each patient. The Chi-square, Fisher’s exact and Mann-Whitney tests were used in the analysis of the relationship of socioeconomic and clinical data, with an adopted p value of p = 0.001), origin (p = 0.014), religion (p = 0.046) and income (p = 0.039), respectively. Conclusion: The variables that showed significant association were risk of impaired liver function and gender;imbalanced nutrition: More than body requirements and origin requirements;risk for deficient fluid volume and religion;and deficient fluid volume and income.

关键词： Nursing Nursing Diagnosis Risk Groups Nutrition Renal Dialysis

Relationship between Th17 immune response and cancer

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World Journal of Clinical Oncology 2021年第10期12卷 845-867页

作者： Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo lopes Correia Luana Weber lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45083-900BahiaBrazil Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next *** has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer *** Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin *** type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor *** other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 ***(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in ***,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical *** understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets.

关键词： Cancer Immune response Th17 cells Interleukin-17 Tumor microenvironment Pathophysiology

Variables Associated with Cirrhosis Diagnosis in Patients with Chronic Hepatitis C: A Case-Control Study

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Health 2015年第12期7卷 1634-1641页

作者： Gilmar Amorim de Sousa Iris do Céu Clara Costa Dyego Leandro Bezerra de Souza Fabia Barbosa de Andrade Lívia Medeiros Soares Celani Ranna Santos Pessoa Marlon César de Souza Filho Daniel Fernandes Mello de Oliveira Luana lopes de Medeiros Lucila Samara Dantas de Oliveira maria Flávia Monteiro The Integrated Department of Medicine Federal University of Rio Grande do Norte UFRN Natal Brazil The Post-Graduate Program in Collective Health of UFRN Natal Brazil Gastroenterology Program of the University Hospital Onofre lopes/UFRN Natal Brazil The Medical School of UFRN Natal Brazil

The diagnosis of liver cirrhosis in patients with chronic hepatitis C has not always been easy, since the gold standard method is the liver biopsy, which is an invasive procedure with interobserver accuracy problems and there have been reports of complications including records of deaths due to hemoperitoneum. Cirrhosis changes the prognosis of the subject with hepatitis C and requires a different clinical management. This study aimed to identify clinical and laboratory variables associated with the diagnosis of cirrhosis in the ultrasonography of patients infected with hepatitis C. In a case-control study, we evaluated 70 cirrhotic patients with chronic hepatitis C compared to a control group of 70 non-cirrhotic people with positive HCV. The results showed, through logistic regression analysis, that the variables blood donor and professional athlete, adjusted for alcohol consumption, showed OR 0.24 and 0.18, with p values of 0.044 and 0.035, respectively. We conclude that the diagnosis of cirrhosis in patients with chronic hepatitis C remains challenging, but the patients with the condition of blood donor or professional athlete prove to be less likely to cirrhosis in ultrasonography in the initial consultation.

关键词： Cirrhosis Biomakers Fibrosis Hepatitis C Virus Clinical Diagnosis Biopsy Non-Invasive Methods Scores Ultrasonography

Concentrations of Silver Nitrate in the In Vitro Development and Conservation of Passiflora gibertii ***

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American Journal of Plant Sciences 2017年第12期8卷 2944-2955页

作者： Gláucia Amorim Faria Lucas Menezes Felizardo Antonio Flávio Arruda Ferreira Paula Suares Rocha Aline Namie Suzuki Antonio da Silva Souza Tatiana Góes Junghans maria Angélica Pereira de Carvalho Costa Ana Patricia Bastos Peixoto Augusto Ramalho de Morais Beatriz Garcia lopes Tiago Almeida de Oliveira Departmentof Mathematics School of EngineeringSao Paulo State University(Unesp)Ilha SolteiraBrazil Department of Civil Engineering School of EngineeringSao Paulo State University(Unesp)Ilha SolteiraBrazil Laboratory of Environmental Mutagenesis Institute of BiosciencesSao Paulo State University(Unesp)Rio ClaroBrazil Embrapa Cassava and Fruticulture Cruz das AlmasBrazil Center for Agrarian Biological and Environmental SciencesFederal University of the Recôncavo of Bahia(UFRB)Cruz das AlmasBrazil Department of Statistics State University of Paraíba(UEPB)Campina GrandeBrazil Department of Exact Sciences Federal University of Lavras(UFLA)LavrasBrazil

The aim of this study was to evaluate the effects of silver nitrate in the in vitro development and conservation of passion fruit plants. Experiments were carried out at the Laboratory of Culture and Tissues, in the National Cassava and Fruits Research Center (EMBRAPA), using microcuttings of Passiflora gibertii N. E. Br., previously cultivated in vitro. The microcuttings were placed in MS media supplemented with silver nitrate at concentrations of 0, 1, 2, 4 and 8 mg·L-1, and, during 30, 60 and 90 days, the following variables were identified: Shooting length (cm), number of roots, number and coloration of leaves. A completely randomized design with 30 replications in a split-plot scheme was employed. Polynomial regression equations were adjusted in analysis of variance to compare averages of treatments. The obtained results support the assumption of high sensitivity of passion fruit tissues to ethylene, which reflects in the lost of vigor and in the induction of culture senescence by its accumulation. Based on obtained results, and in order to mitigate this problem, it is possible to indicate an addition of 2 mg·L-1?of silver nitrate in culture media, for the micropropagation of passion fruit plant, allowing the controlling of the atmosphere inside the culture test tubes, during the establishment of explants and other steps of the process.

关键词： Passion Fruits Tropical Fruits Plant Propagation Reduced Growth Ethylene

Dried blood spot sampling as an alternative for the improvement of hepatitis B and C diagnosis in key populations

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World Journal of Hepatology 2021年第4期13卷 504-514页

作者： Geane lopes Flores Jakeline Ribeiro Barbosa Helena Medina Cruz Juliana Custódio Miguel Denise Vigo Potsch JoséHenrique Pilotto Danielle Malta Lima JeováKeny Baima Colares Carlos Eduardo Brandão-Mello Marcia maria Amendola Pires Jurema Corrêa da Mota Francisco I Bastos Lia Laura Lewis-Ximenez Livia Melo Villar Viral Hepatitis Laboratory FIOCRUZRio de Janeiro 21040360Brazil Postgraduate Program in Pathology Federal University of CearáFortaleza 60020181CearaBrazil Clementino Fraga Filho Hospital Federal University of Rio de JaneiroRio de Janeiro 21040360Brazil Nova Iguaçu General Hospital Nova Iguaçu 26041061Brazil Molecular Immunology Laboratory Oswaldo Cruz InstituteRio de Janeiro 21040360Brazil Postgraduate Program in Medical Sciences University of FortalezaFortaleza 60811905CearáBrazil Escola de Medicina e Cirurgia Gaffrée&Guinle University HospitalFederal University of Rio de Janeiro StateRio de Janeiro 20270901Brazil Institute of Communication and Information on Science and Technology in Health FIOCRUZRio de Janeiro 21040360Brazil

BACKGROUND To achieve the elimination of hepatitis B and C,there is an urgent need to develop alternative strategies to increase the access of diagnosis,particularly among key populations such as people living with human immunodeficiency virus(HIV),individuals with coagulopathies and chronic kidney disease(CKD)*** To evaluate the use of dried blood spot(DBS)in the detection of hepatitis B virus(HBV)and hepatitis C virus(HCV)*** A total of 430 individuals comprised of people living with HIV,coagulopathies and CKD provided paired serum and DBS ***,anti-HBc and anti-HCV were tested in those samples using a commercial *** and selected behavioral variables were evaluated to assess possible association with HBV and HCV *** Using DBS,HBsAg prevalence varied from 3.9%to 22.1%,anti-HBc rates varied from 25.5%to 45.6%and anti-HCV positivity ranged from 15.9%to 41.2%in key *** of HBV and HCV tests using DBS varied from 88.9%to 100%.The HBsAg assay demonstrated the best performance in CKD and coagulopathy individuals and the anti-HCV test had a sensitivity and specificity of 100%in people living with *** of HBV and HCV detection in DBS varied from 90.2%to 100%.In the CKD group,HBsAg positivity was associated with infrequent use of condoms,and anti-HBc positivity was associated with sharing nail cutters/razors/***-HCV reactivity was positively associated with a history of transplantation and length of time using hemodialysis in both *** people living with HIV,only the male gender was associated with anti-HBc positivity in serum and *** DBS with electrochemiluminescence are useful tools for the diagnosis and prevalence studies of hepatitis B and C among key populations and may increase the opportunity to foster prevention and treatment.

关键词： Dried blood spot Electrochemiluminescence Hepatitis B Hepatitis C Key populations Diagnosis

Challenges in Implementing DVI Best Practice Guidelines Due to the Brumadinho Disaster

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Forensic Medicine and Anatomy Research 2024年第1期12卷 1-12页

作者： Reinaldo Moreira Silva Bruno Diniz Sander Morais Carlos Danilo Ruas Silva Elza Cristina lopes de Oliveira Fernando Pereira Macedo Giovanni Vitral Pinto Guadalupe Dell’Arret Coutinho Higgor Gonçalves Dornelas João Luiz Silva Moreira Laila Evangelista de Almeida Fernandes Marcia Lobão Iannini Patrícia Siqueira Valéria Rosalina Dias e Santos Sordaini maria Caligiorne Instituto de Criminalística Polícia Civil de Minas Gerais Belo Horizonte Brazil

The broke of a tailings dam from Vale S.A. destroyed a gigantic area killing 270 persons in Brumadinho/Brazil. Organizing activities after a mass disaster is a complex process that requires the involvement of many people and resources in the laboratory. To DNA identification of the victims, a daunting work had to be made by DNA laboratory staff in a collaborative effort with many partners. Efforts to implement good practice guidelines in Disaster Victim Identification (DVI) have revealed several important aspects that need to change in the forensic DNA laboratory. This article highlights the challenges of implementing DVI best practice guidelines in resource-poor settings, but with professionals from different sectors engaged in the same goal of briefly identifying victims and helping families and society.

关键词： Disaster Victim Identification DNA Brumadinho