检索结果-南通市图书馆

World Journal of Hepatology 2017年第6期9卷 333-342页

作者： Sirio Fiorino maria letizia bacchi-reggiani Paolo Leandri Elisabetta Loggi Pietro Andreone Unità Operativa di Medicina Interna C Ospedale Maggiore Unità Operativa Malattie Cardiovascolari Azienda Ospedaliero Universitaria di BolognaPoliclinico Sant’Orsola-Malpighi Dipartimento di Scienze Mediche e Chirurgiche Azienda Ospedaliero Universitaria di BolognaPoliclinico Sant’Orsola-Malpighi

AIM To assess vitamin E efficacy,defined as its ability to induce hepatitis B e antigen(HBeAg) seroconversion,in children with HBeAg-positive persistent *** In July 2016,we extracted articles published in MEDLINE and the Cochrane Library using the following search terms:"chronic hepatitis B","children","childhood","therapy","treatment","vitamin E","tocopherols","tocotrienols".Only randomized controlled trials(RCTs) published in English language were *** Three RCTs met inclusion criteria and were considered in the present ***,23/122 children in the treatment group underwent HBeAg seroconversion vs 3/74 in the control group(OR=3.96,95%CI:1.18-13.25,P=0.025).CONCLUSION Although our meta-analysis has several limits,including the very small number of available studies and enrolled children with HBeAg positivity-related hepatitis,it suggests that vitamin E use may enhance the probability to induce HBeAg seroconversion in these *** well designed and adequately sized trials are required to confirm or deny these very preliminary results.

关键词： Hepatitis B Pediatric hepatology Viral hepatitis Immunology

How to select elderly colorectal cancer patients for surgery: a pilot study in an Italian academic medical center

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Biology & Medicine 2015年第4期12卷 302-307页

作者： Giampaolo Ugolini Francesco Pasini Federico Ghignone Davide Zattoni maria letizia bacchi reggiani Daniele Parlanti Isacco Montroni Department of Medical and Surgical Sciences University of Bologna S.Orsola Malpighi Hospital

Objective: Cancer is one of the most common diagnoses in elderly patients. Of all types of abdominal cancer, colorectal cancer(CRC) is undoubtedly the most frequent. Median age at diagnosis is approximately 70 years old worldwide. Due to the multiple comorbidities affecting elderly people, frailty evaluation is very important in order to avoid over- or undertreatment. This pilot study was designed to investigate the variables capable of predicting the long-term risk of mortality and living situation after surgery for ***: Patients with 70 years old and older undergoing elective surgery for CRC were prospectively enrolled in the study. The patients were preoperatively screened using 11 internationally-validated-frailty-assessment tests. The endpoints of the study were long-term mortality and living situation. The data were analyzed using univariate Cox proportional-hazard regression analysis to verify the predictive value of score indices in order to identify possible risk ***: Forty-six patients were studied. The median follow-up time after surgery was 4.6 years(range, 2.9-5.7 years) and no patients were lost to follow-up. The overall mortality rate was 39%. Four of the patients who survived(4/28, 14%) lost their functional autonomy. The preoperative impaired Timed Up and Go(TUG), Eastern Cooperative Group Performance Status(ECOG PS), Instrumental Activities of Daily Living(IADLs), Vulnerable Elders Survey(VES-13) scoring systems were significantly associated with increased long term mortality ***: Simplified frailty-assessing tools should be routinely used in elderly cancer patients before treatment in order to stratify patient risk. The TUG, ECOG-PS, IADLs and VES-13 scoring systems are potentially able to predict long-term mortality and disability. Additional studies will be needed to confirm the preliminary data in order to improve management strategies for oncogeriatric surgical patients.

关键词： Elderly geriatric assessment surgical oncology risk assessment screening tools colorectal cancer(CRC)

Effect of a triage course on quality of rating triage codes in a group of university nursing students:a before-after observational study

在线全文

学校读者我要写书评

暂无评论

World Journal of Emergency Medicine 2013年第1期4卷 20-25页

作者： Nicola Parenti maria letizia bacchi reggiani Diego Sangiorgi Vito Serventi Leopoldo Sarli University of Parma Italy University of Bologna Italy

BACKGROUND:Most current triage tools have been tested among hospital nurses groups but there are not similar studies in university *** this study we analyzed if a course on a new fourlevel triage model,triage emergency method(TEM),could improve the quality of rating in a group of nursing ***:This observational study was conducted with paper scenarios at the University of Parma,*** students were assigned a triage level to 105 paper scenarios before and after a course on triage and *** used weighted kappa statistics to measure the inter-rater reliability of TEM and assessed its validity by comparing the students' predictions with the triage code rating of a reference standard(a panel of five experts in the new triage method).RESULTS:Inter-rater reliability was K=0.42(95%Cl:0.37-0.46) before the course on TEM,and K=0.61(95%CI:0.56-0.67) *** accuracy of students' triage rating for the reference standard triage code was good:81%(95%Cl:71-90).After the TEM course,the proportion of cases assigned to each acuity triage level was similar for the student group and the panel of ***:Among the group of nursing students,a brief course on triage and on a new inhospital triage method seems to improve the quality of rating *** new triage method shows good inter-rater reliability for rating triage acuity and good accuracy in predicting the triage code rating of the reference standard.

关键词： Emergency Reliability Triage Triage system Validity

MicroRNAs as possible biomarkers for diagnosis and prognosis of hepatitis b- and c-related-hepatocellularcarcinoma

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2016年第15期22卷 3907-3936页

作者： Sirio Fiorino maria letizia bacchi-reggiani Michela Visani Giorgia Acquaviva Adele Fornelli Michele Masetti Andrea Tura Fabio Grizzi Matteo Zanello Laura Mastrangelo Raffaele Lombardi Luca Di Tommaso Arrigo Bondi Sergio Sabbatani Andrea Domanico Carlo Fabbri Paolo Leandri Annalisa Pession Elio Jovine Dario de Biase Unita Operativa di Medicina C Ospedale Maggiore 40133 Bologna Italy Dipartimento di Medicina Sperimentale Istituto di Cardiologia Policlinico S. Orsola-Malpighi Universita degli Studi di Bologna 40138 BolognaItaly Dipartimento di Farmacia e Biotecnologie Universita di Bologna 40139 Bologna Italy Dipartimento di Medicina Sperimentale Universita di Bologna Ospedale Bellaria 40139 Bologna Italy Servizio di Anatomia Patologica Ospedale Maggiore 40133 Bologna Italy Unita Operativa di Chirurgia A Ospedale Maggiore 40133 Bologna Italy CNR Institute of Neuroscience Padova Italy 35121 Padova Italy Humanitas Clinical and Research Center 20089 Rozzano Milano Italy Istituto di Malattie Infettive Policlinico S. Orsola-Malpighi Universita degli Studi di Bologna 40138 Bologna Italy Unita Operativa di Medicina Interna A Ospedale Maggiore 40133 Bologna Italy Unita Operativa di Endoscopia Digestiva Ospedale Maggiore 40133 Bologna Italy

Aim of the present review is to summarize the current knowledge about the potential relationship between mi RNAs and hepatitis B virus(HBV)-hepatitis C virus(HCV) related liver diseases. A systematic computerbased search of published articles, according to the Preferred Reporting Items for Systematic reviews and Meta-Analysis Statement, was performed to identify relevant studies on usefulness of serum/plasma/urine mi RNAs, as noninvasive biomarkers for early detection of HBV and HCV-induced hepatocellular carcinoma(HCC) development, as well as for its prognostic evaluation. The used Medical Subject Headings terms and keywords were: "HBV", "HCV", "hepatocellular carcinoma", "micro RNAs", "mi RNAs", "diagnosis", "prognosis", "therapy", "treatment". Some serum/plasma mi RNAs, including mi R-21, mi R-122, mi-125a/b, mi R-199a/b, mi R-221, mi R-222, mi R-223, mi R-224 might serve as biomarkers for early diagnosis/prognosis of HCC, but, to date, not definitive results or well-defined panels of mi RNAs have been obtained. More well-designed studies, focusing on populations of different geographical areas and involving larger series of patients, should be carried out to improve our knowledge on the potential role of mi RNAs for HCC early detection and prognosis.

关键词： Hepatitis B virus Hepatitis C virus Hepatocellular carcinomas Liver diseases MicroRNAs Review

Balloon aortic valvuloplasty as a bridge-to-decision in high risk patients with aortic stenosis： a new paradigm for the heart team decision making

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2016年第6期13卷 475-482页

作者： Francesco Saia Carolina Moretti Gianni Dall'Ara Cristina Ciuca Nevio Taglieri Alessandra Berardini Pamela Gallo Marina Cannizzo Matteo Chiarabelli Niccolo Ramponi Linda Taffani maria letizia bacchi-reggiani Cinzia Marrozzini Claudio Rapezzi Antonio Marzocchi Cardio-Thoraco-Vascular Department University Hospital of Bologna Bologna Italy

Background Whilst the majority of the patients with severe aortic stenosis can be directly addressed to surgical aortic valve replace- ment （AVR） or transcatheter aortic valve implantation （TAVI）, in some instances additional information may be needed to complete the diagnostic workout. We evaluated the role of balloon aortic valvuloplasty （BAV） as a bridge-to-decision （BTD） in selected high-risk patients. Methods Between 2007 and 2012, the heart team in our Institution required BTD BAV in 202 patients. Very low left ventricular ejection fraction, mitral regurgitation grade 〉 3, frailty, hemodynamic instability, serious comorbidity, or a combination of these factors were the main drivers for this strategy. We evaluated how BAV influenced the final treatment strategy in the whole patient group and in each specific subgroup. Results Mean logistic European System for Cardiac Operative Risk Evaluation （EuroSCORE） was 23.5%±15.3%, age 81 ± 7 years. In-hospital mortality was 4.5%, cerebrovascular accident 1% and overall vascular complications 4% （0.5% major; 3.5% minor）. Of the 193 patients with BTD BAV who survived and received a second heart team evaluation, 72.6% were finally deemed eligible for definitive treatment （25.4% for AVR; 47.2% for TAVI）： 96.7% of patients with left ventricular ejection fraction recovery; 70.5% of patients with mitral regurgitation reduction; 75.7% of patients who underwent BAV in clinical hemodynamic instability; 69.2% of frail patients and 68% of patients who presented serious comorbidities. Conclusions Balloon aortic valvuloplasty can be considered as bridge-to- decision in high-risk patients with severe aortic stenosis who cannot be immediate candidates for definitive transcatheter or surgical treatment.

关键词： Aortic valve replacement Aortic valve stenosis Heart team Mitral valve regurgitation Transcatheter aortic valve implantation

Benefits of Biochars and NPK Fertilizers for Soil Quality and Growth of Cowpea (Vigna unguiculata L. Walp.) in an Acid Arenosol

在线全文

学校读者我要写书评

暂无评论

Pedosphere 2019年第3期29卷 311-333页

作者： Rogerio Borguete Alves RAFAEL maria Luisa FERNANDEZ-MARCOS Stefania COCCO maria letizia RUELLO Flavio FORNASIER Giuseppe CORTI Department of Rural Engineering Faculty of Agronomy and Forestry Engineering Universidade Eduardo Mondlane Maputo 257 (Mozambique) Department of Agriculture Food and Environmental Sciences Univ er sit a Politecnica delle Marche Ancona 60131 (Italy) Department of Soil Science and Agricultural Chemistry Universidad de Santiago de Compostela Lugo 27002 (Spain) Department of Materials Environmental Sciences and Urban Planning Universita Politecnica delle Marche Ancona 60131 (Italy) Centro di Ricerca Viticoltura ed Enologia Gorizia 34170 (Italy) Instituto de Biodiv ersidade Agraria e Desenvolvimento Rural Universidad de Santiago de Compostela Lugo 27002 (Spain)

Fertilization is required for optimum plant growth, particularly in unfertile soils, while optimizing nutrient use effciency is an alternative to reduce inorganic fertilizer needs and reduce environmental problems caused by nutrient leaching. This study investigated soil properties and cowpea yield responses to biochars(BCs) made from different feedstocks, baby corn peel biochar(BC1), branches of mango tree biochar(BC2), and rice husk biochar(BC3), applied in combination with nitrogen-phosphorus-potassium(NPK) *** experiment was conducted in a greenhouse, using an acid sandy soil(Arenosol) that was submitted for 70 d to the following eight treatments: i) control;ii) full dose of NPK(a commercial compound fertilizer(12-24-12 of N-P2O5-K2O)+ urea(46% N));iii) BC1+ half dose of NPK;iv) BC1 + full dose of NPK;v) BC2 + half dose of NPK;vi) BC2 + full dose of NPK;vii) BC3 + half dose of NPK;and viii) BC3 + full dose of NPK. All biochars were applied at a rate of 0.9%(weight/weight), and each type of biochar was combined with half and full doses of NPK fertilizers. Soil pH increased significantly(P < 0.05) in treatments with BC1 and BC2,while cation exchange capacity(CEC) and available P were higher in the treatments with BC1;BC1 and BC2 also induced higher activity of enzymes related to the P cycle and higher cowpea yield. Similar soil properties and cowpea yield parameters were obtained with the full and half doses of NPK fertilizers for each type of biochar used. In conclusion, biochars in the combination with NPK fertilizers improved soil chemistry and enzymatic activities, allowing reduced fertilizer application and food production costs in the acid soil studied.

关键词： acid soil nutrient use effciency organic amendment plant growth potential enzyme activity soil fertility soil pH

Increased phosphorus availability to corn resulting from the simultaneous applications of phosphate rock, calcareous rock, and biochar to an acid sandy soil

在线全文

学校读者我要写书评

暂无评论

Pedosphere 2020年第6期30卷 719-733页

作者： Rogério Borguete Alves RAFAEL maria Luisa FERNÁNDEZ-MARCOS Stefania COCCO maria letizia RUELLO Flavio FORNASIER Giuseppe CORTI Department of Rural Engineering Faculty of Agronomy and Forestry EngineeringUniversidade Eduardo MondlaneMaputo 257Mozambique Department of Agriculture Food and Environmental SciencesUniversitàPolitecnica delle MarcheAncona 60131Italy Department of Soil Science and Agricultural Chemistry Universidad de Santiago de CompostelaLugo 27002Spain Department of Materials Environmental Sciences and Urban PlanningUniversitàPolitecnica delle MarcheAncona 60131Italy Consiglio per la Ricerca e la Sperimentazione in Agricoltura Centro di Ricerca per lo Studio delle Relazioni tra Pianta e Suolo(C.R.E.A.-R.P.S.)Gorizia 34170Italy Instituto de Biodiversidade Agraria e Desenvolvemento Rural Universidad de Santiago de CompostelaLugo 27002Spain

Phosphorus(P)deficiency is one of the main constraints on crop production in Arenosols(acid sandy soil).The high cost of P fertilizers may represent an insurmountable obstacle in many poor countries,leaving the exploitation of their own calcareous and phosphate rocks as the only low-cost and long-term *** is suggested to have positive effects on soil properties;however,there is no published research on the synergistic effects of biochar and rocky materials in modifying soil *** aim of this study was to investigate the chemical and biochemical responses of an acid Arenosol treated with phosphate rock(PR),calcareous rock(CR),and biochar(BC),and the implications for corn yield.A soil from Marracuene District,Mozambique was used,where corn was grown for 90 d with the soil treated with:no addition(control),water-soluble zinc phosphite fertilizer(WSP),PR,WSP+CR,WSP+BC,WSP+CR+BC,PR+BC,and PR+CR+*** was produced by pyrolysis of babycorn peels for 4 h at 450?C and applied at 11 g *** soil pHH2 Oincreased from about 4.54 in the control to 7.38 in the PR+CR+BC *** oxidizable organic carbon,cation exchange capacity,and available P were higher in the treatments containing BC than in the *** treatments containing CR and/or BC led to the highest activities of alkaline phosphomonoesterase,phosphodiesterase,andα-glucosidase,which increased P availability and gave the greatest biomass and *** suggest that biochar provides additional soluble P and supplies adsorption sites for phosphate,preventing its evolution to unavailable ***,PR applied together with BC contributed to an 840%yield increase compared to the *** treatments containing WSP and BC facilitated phosphite oxidation to phosphate and increased crop yield.

关键词： Arenosols available P enzyme activity phosphite oxidation soil fertility

Ticagrelor therapy and atrioventricular block:Do we need to worry?

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2017年第5期5卷 178-182页

作者： Elia De maria Ambra Borghi letizia Modonesi Stefano Cappelli Cardiology Unit Ramazzini Hospital

Ticagrelor is a potent,direct P2Y12 antagonist with rapid onset of action and intense platelet inhibition,indicated in patients with acute coronary syndromes(ACS).This drug is usually well tolerated,but some patients experience serious adverse effects:Major bleeding;gastrointestinal disturbances;dyspnoea;ventricular pauses > 3 *** the unexpected high incidence of bradyarrhythmias,a PLATO substudy monitored this side effect,showing that ticagrelor was associated with an increase in the rate of sinus bradycardia and sinus arrest compared to *** side effect was usually transient,asymptomatic and not associated with higher incidence of severe atrioventricular(AV) block or pacemaker needs.A panel of experts from Food and Drug Administration did not consider bradyarrhythmias a serious problem in clinical practice and,accordingly,current labeling of the drug does not give any precaution or contraindication regarding this ***,recently some articles have described ACS patients with high-degree,life-threatening,AV block requiring drug discontinuation and,in some cases,pacemaker *** this paper,we describe and discuss five published case reports of severe AV block following ticagrelor therapy and two other cases managed in our *** analysis of literature suggests that,although rarely,ticagrelor can be associated with lifethreatening AV *** and careful monitoring are required especially in patients with already compromised conduction system and/or treated with AV blocking *** studies,with long-term rhythm monitoring,would help to define the outcome of patients at higher risk of developing this complication.

关键词： Ticagrelor Atrioventricular block

Recent advances concerning polyurethane in leather applications:an overview of conventional and greener solutions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Collagen and Leather 2023年第1期5卷 1-15页

作者： Jize Liu Federica Recupido Giuseppe Cesare Lama maria Oliviero letizia Verdolotti Marino Lavorgna Institute for Polymers Composites and Biomaterials(IPCB-CNR)Piazzale Enrico Fermi 180055 Portici(Naples)Italy

Leather is one of the most popular products across globe and holds a significant place in the economy,while the pollution,associated to traditional leather industry,is far away on the"green chemistry"*** this sense,polyurethanes,which exhibit tunable chemical structures by selecting suitable precursors,can fit specific requirements,and the developments of green strategies make them important candidates for leather *** mini review briefly outlines the recent development of conventional(petrol-based)and sustainable polyurethanes in the leather industry,including their design and properties,in applications such as synthetic leather and surface-finishing(coatings/binders).Finally,outlooks of the future tendency,including more environmental-friendly strategies,bio-sourced/recycled materials and development of high-value multifunctional leather materials,are also here proposed.

关键词： Conventional leather Artificial leather polyurethane-synthetic leather polyurethane-based binders polyurethane-based-materials Polyurethane-based-coatings

Coupling of bioelectrochemical toluene oxidation and trichloroethene reductive dechlorination for single-stage treatment of groundwater containing multiple contaminants

在线全文

学校读者我要写书评

暂无评论

Environmental Science and Ecotechnology 2022年第3期11卷 32-39页

作者： Carolina Cruz Viggi Matteo Tucci Marco Resitano Simona Crognale maria letizia Di Franca Simona Rossetti Federico Aulenta Water Research Institute(IRSA) National Research Council(CNR)Via Salaria Km 2930000015MonterotondoRMItaly

Bioremediation of groundwater contaminated by a mixture of aromatic hydrocarbons and chlorinated solvents is typically challenged because these contaminants are degraded via distinctive oxidative and reductive pathways,thus requiring different amendments and redox ***,we provided the proof-of-concept of a single-stage treatment of synthetic groundwater containing toluene and trichloroethene(TCE)in a tubular bioelectrochemical reactor,known as a“bioelectric well”.Toluene was degraded by a microbial bioanode(up to 150 mmol L^(-1) d^(-1))with a polarized graphite anode(t0.2 V ***)serving as the terminal electron *** electric current deriving from microbially-driven toluene oxidation resulted in(abiotic)hydrogen production(at a stainless-steel cathode),which sustained the reductive dechlorination of TCE to less-chlorinated intermediates(i.e.,cis-DCE,VC,and ETH),at a maximum rate of 500 meq L^(-1) d^(-1),in the bulk of the reactor.A phylogenetic and functional genebased analysis of the“bioelectric well”confirmed the establishment of a microbiome harboring the metabolic potential for anaerobic toluene oxidation and TCE reductive ***,Toluene degradation and current generation were found to be rate-limited by external mass transport phenomena,thus indicating the existing potential for further process optimization.

关键词： Bioelectric well Dehalococcoides mccartyi Electrobioremediation Groundwater remediation Toluene Trichloroethene