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A Single Case of Two Synchronous Metastatic Tumours

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Journal of Cancer Therapy 2019年第8期10卷 671-676页

作者： Filipa Pereira Tiago Alpoim maria leitao Manuela Machado Medical Oncology Department IPO PortoPortoPortugal

The incidence of multiple primary tumours increases with age and due to multiple other factors as environmental and genetic predisposition. The authors describe a case of a 77-year-old female patient with diagnosis in September 2009 of colon mucinous adenocarcinoma. She was submitted to surgery, considered R1 and adjuvant chemotherapy. Six months after treatment she had abdominal recurrence on a nodular lesion in peritoneal fat. The patient was submitted to surgery and did multiple courses of systemic treatment. She underwent cytoreductive surgery with hyperthermic chemotherapy, too. In December 2014 she presented a nodular lesion on the bladder and after excision, the histology confirmed a high-grade transitional cell carcinoma and she maintains treatment with endovesical BCG instillations. After that, she had no evidence of peritoneal disease progression. Besides the bad prognosis associated to peritoneal disease, our case report describes a long survival (5 years with no disease progression) in a patient with high risk at diagnosis to peritoneal recurrence. This case shows the importance of multimodal approach and the impact of locoregional treatment in localized metastatic disease.

关键词： Colon Cancer Bladder Cancer Multiple Primary Neoplasms Synchronous

Retrorectal Cystic Hamartoma with Malignant Transformation

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Journal of Cancer Therapy 2020年第1期11卷 18-25页

作者： Andreia Cruz Sarah Lopes maria leitao Sonia Carvalho Olga Sousa Manuela Machado Medical Oncology Department Portuguese Institute of OncologyIPO PortoPortugal Pathology Department IPO PortoPortugal Radiotherapy Department IPO PortoPortugal

Retrorectal cystic hamartomas are rare congenital lesions that can undergo malignant transformation, and adenocarcinoma is the most frequently described histological type. The authors describe a case of a 53-year-old female patient with a localized well-differentiated adenocarcinoma that developed in a retrorectal cystic hamartoma. The patient was submitted to surgery (a Kraske procedure), with an R1 resection, followed by adjuvant radio-chemotherapy. After 23 months of follow up, the patient remains free from disease recurrence. Given the rarity of this entity, this case allows us to reflect on the differential diagnosis, therapeutic approach and patients’ follow-up.

关键词： Retrorectal Cystic Hamartoma Tailgut Cyst Presacral Malignant Transformation Adenocarcinoma

A New Era in the Adjuvant Treatment of Pancreatic Adenocarcinoma

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Journal of Cancer Therapy 2019年第12期10卷 915-919页

作者： Manuela Machado maria leitao Mário Fontes e Sousa Magalhaes e Helena Oncologia Medica IPO PortoPortoPortugal Oncologia Medica Centro Hospitalar Lisboa Ocidental(CHLO)LisboaPortugal Oncologia Medica Unidade Local de Saude de MatosinhosHospital Pedro HispanoMatosinhosPortugal

Pancreatic adenocarcinoma is currently a major public health problem, being the 7th cause of death worldwide. Incidence is increasing and unfortunately nowadays the incidence is almost overlapping to mortality. The cornerstone of curative treatment is still surgery, but adjuvant treatment is critical to decreasing the risk of recurrence.

关键词： Pancreatic Adenocarcinoma Adjuvant Chemotherapy Positive Clinical Trials

Oral Health and Self-Perception in the Elderly

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Health 2014年第21期6卷 3045-3053页

作者： Walda Viana Brígido de Moura Iris do Ceu Clara Costa Fábia Barbosa de Andrade Tainara Lorena dos Santos Ferreira Andréa Silvia Walter de Aguiar Gabriela Eugenio de Sousa Furtado maria Eneide leitao de Almeida Department of Dentistry Federal University of Ceará(UFC)FortalezaBrazil Department of Dentistry Federal University of Rio Grande do Norte(UFRN)NatalBrazil Faculty of Health Sciences of Trairi(FACISA) Federal University of Rio Grande do Norte(UFRN)Santa CruzBrazil

Background: Investigating self-perception of oral health among the elderly may contribute towards changing public health and assistance policies in the area. Methods: The present study assessed the oral health status (tooth decay, need for treatment, periodontal status, use of and need for dental prosthesis, soft tissue alterations and self-perception of oral health) of 102 elderly people from two community groups in Fortaleza, Ceará State, Brazil. Results: Mean age was 69.9 years and 82.4% were female. Mean DMFT was 30.17 with a predominant missing component;63.7% were edentulous. Regarding prosthesis, 29.4% and 67.6% of elderly patients did not use upper and lower dentures respectively, while 66.7% and 78.4% required some type of upper and lower prosthesis respectively. Among valid sextants, 44.3% presented dental calculus and 34.3% presented loss of attachment from 6 to 8 mm. Soft tissue alterations were found in 58.8%. Despite of precarious clinical conditions and dental treatment needs, good oral health perception was found (49%), as well as satisfaction with the appearance of teeth and gums (60.8%). Conclusion: Subjects displayed unsatisfactory oral health conditions, accumulated over time and resulting from the lack of policies favoring this age group. There is a need for oral rehabilitation that enables the recovery of function and esthetics among the elderly, restoring their self-esteem and improving social interaction.

关键词： Oral Health The Elderly Epidemiology Self-Image

Common bean SNP alleles and candidate genes affecting photosynthesis under contrasting water regimes

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Horticulture Research 2021年第1期8卷 110-123页

作者： Susana Trindade leitao maria Catarina Bicho Priscila Pereira maria Joao Paulo Marcos Malosetti Susana de Sousa Araujo Fred van Eeuwijk maria Carlota Vaz Patto Instituto de Tecnologia Quimica e Biológica Antonio Xavier Universidade Nova de LisboaOeirasPortugal Wageningen University&Research WageningenThe Netherlands Present address:Instituto Superior de Agronomia Universidade de LisboaLisboaPortugal Present address:Nunhems Vegetable Seeds NunhemThe Netherlands Present address:Association BLC3-Technology and Innovation Campus Centre Bio R&D UnitOliveira do HospitalLisboaPortugal

Water deficit is a major worldwide constraint to common bean(Phaseolus vulgaris L.)production,being photosynthesis one of the most affected physiological *** gain insights into the genetic basis of the photosynthetic response of common bean under water-limited conditions,a collection of 158 Portuguese accessions was grown under both well-watered and water-deficit *** gas-exchange parameters were measured and photosynthetic pigments *** same collection was genotyped using SNP arrays,and SNP-trait associations tested considering a linear mixed model accounting for the genetic relatedness among accessions.A total of 133 SNP-trait associations were identified for net CO 2 assimilation rate,transpiration rate,stomatal conductance,and chlorophylls a and b,carotenes,and xanthophyll *** of these associations were detected under water-deficit and 43 under well-watered conditions,with only two associations common to both *** candidate genes revealed that stomatal regulation,protein translocation across membranes,redox mechanisms,hormone,and osmotic stress signaling were the most relevant processes involved in common bean response to water-limited *** candidates are now preferential targets for common bean water-deficit-tolerance ***,new sources of water-deficit tolerance of Andean,Mesoamerican,and admixed origin were detected as accessions valuable for breeding,and not yet explored.

关键词： breeding water assimilation

Shared and tailored common bean transcriptomic responses to combined fusarium wilt and water deficit

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Horticulture Research 2021年第1期8卷 2163-2180页

作者： Susana T.leitao Carmen Santos Susana de Sousa Araujo Diego Rubiales maria Carlota Vaz Patto Instituto de Tecnologia Quimica e Biologica Antonio Xavier Universidade Nova de LisboaOeirasPortugal Association BLC3-Technology and Innovation Campus Centre Bio R&D UnitLagares da BeiraPortugal Institute for Sustainable Agriculture CSICCordobaSpain

Common bean(Phaseolus vulgaris L.),one of the most consumed food legumes worldwide,is threatened by two main constraints that are found frequently together in nature,water deficit(WD)and fusarium wilt(Fop).To understand the shared and unique responses of common bean to Fop and WD,we analyzed the transcriptomic changes and phenotypic responses in two accessions,one resistant and one susceptible to both stresses,exposed to single and combined *** responses(photosynthetic performance and pigments quantification)and disease progression were also *** combined FopWD imposition negatively affected the photosynthetic performance and increased the susceptible accession disease *** susceptible accession revealed a higher level of transcriptional changes than the resistant one,and WD single stress triggered the highest transcriptional *** 89 differentially expressed genes were identified exclusively in combined stresses for the susceptible accession,35 were identified in the resistant *** genes belong mainly to“stress”,“signaling”,“cell wall”,“hormone metabolism”,and“secondary metabolism”functional *** the up-regulated genes with higher expression in the resistant accession,the cysteine-rich secretory,antigen 5 and Pr-1(CAP)superfamily protein,a ribulose bisphosphate carboxylase family protein,and a chitinase A seem promising targets for multiple stress breeding.

关键词： metabolism assessed stress

Overview of resistant hypertension:A glimpse of the cardiologist's current standpoint

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World Journal of Cardiology 2012年第9期4卷 275-283页

作者： Luis Paiva maria Carmo Cachulo Rui Providencia Sergio Barra Paulo Dinis Antonio leitao-Marques Cardiology Department Coimbra's Hospital and University Centre3041-801 CoimbraPortugal

Hypertension is a major risk factor for cardiovascular disease,resulting in increased incidence of cerebrovascular events,ischaemic heart disease,heart failure,and renal ***,it is one of the most important preventable causes of premature morbidity and *** current knowledge on the management of hypertension and the availability of several effective antihypertensive medications,uncontrolled hypertension remains a common and challenging clinical *** hypertension is a complex condition with multiple contributing factors and overlapping *** there is limited hard evidence regarding resistant hypertension,our understanding of this condition has improved *** article will present an overview of resistant hypertension and highlight recent publications about this topic.

关键词： Hypertension Resistant hypertension Management