检索结果-南通市图书馆

Increased hepatic expression of insulin-like growth factor-Ⅰreceptor in chronic hepatitis C

World Journal of Gastroenterology 2006年第24期12卷 3821-3828页

作者： José Tadeu Stefano maria lúcia Corr(e|^)a-giannella Cristiane maria Freitas Ribeiro Ven(a|^)ncio Avancini Ferreira Alves Paulo Celso Bosco Massarollo Marcel Cerqueira Cesar Machado Daniel giannella-Neto laboratory for Cellular and Molecular Endocrinology University of Sao Paulo Medical School Brazil laboratory for Cellular and Molecular Endocrinology University of Sao Paulo Medical School Diabetes UnitDivision of EndocrinologyBrazil Department of Pathology Santa Casa de Misericórdia de Sao Paulo Brazil Department of Pathology University of Sao Paulo Medical School Brazil laboratory for Experimental Surgery University of Sao Paulo Medical School Brazil

AIM： Although increased insulin-like growth factor-I receptor （IGF-IR） gene expression has been reported in hepatocellular carcinoma, studies assessing IGF-IR in chronic hepatitis C （CHC） and cirrhosis are scarce. We therefore aimed to evaluate IGF-IR and IGF-I rnRNA expression in liver from patient with CHC. METHODS： IGF-IR and IGF-I rnRNA content were determined by semi-quantitative RT-PCR and IGF-IR protein expression was determined by immunohistochemistry in hepatic tissue obtained from patients with CHC before （34 patients） and after （10 patients） therapy with interferon-α and ribavirin. RESUlTS： An increase of IGF-IR rnRNA content was observed in hepatic tissue obtained from all CHC patients as well as from 6 cadaveric liver donors following orthopic transplantation （an attempt to evaluate normal livers） in comparison to normal liver, while no relevant modifications were detected in IGF-I mRNA content. The irnrnunohistochemical results showed that the raise in IGF-IR rnRNA content was related both to ductular reaction and to increased IGF-IR expression in hepatocytes. A decrease in IGF-IR rnRNA content was observed in patients who achieved sustained virological response after therapy, suggesting an improvement in hepatic damage. CONClUSION： The up-regulation of IGF-IR expression in hepatocytes of patients with CHC could constitute an attempt to stimulate hepatocyte regeneration. Considering that liver is the organ with the highest levels of IGF-I, our finding of increased IGF-IR expression after both acute and chronic hepatic damage highlights the need for additional studies to elucidate the role of IGF-I in liver regeneration.

关键词： Chronic hepatitis C Insulin-like growth factorI Insulin-like growth factor I receptor Ductular reaction Hepatocyte regeneration Ischemia-reperfusion

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Native and exotic seed dispersal by the stone marten(Martes foina):implications for the regeneration of a relict climactic forest in central Portugal

引用

Integrative Zoology 2019年第3期14卷 280-292页

作者： lúcia PEREIRA Ana VASQUES Paula MAIA maria João RAMOS PEREIRA Carlos FONSECA Milena MATOS CESAM-Centre for Environmental and Marine Studies-Wildlife Research Unit Department of BiologyUniversity of AveiroAveiroPortugal CESAM-Centre for Environmental and Marine Studies-Department of Environment and Planning University of AveiroAveiroPortugal Erasmus University College Life Sciences DepartmentRotterdamthe Netherlands Institute of Biosciences PPGBANDepartment of ZoologyUniversidade Federal do Rio Grande do SulBrazil Bioliving Association FrossosAlbergaria-a-VelhaPortugal

The stone marten(Martes foina)is a carnivorous mammal that often consumes fleshy fruits,thus potentially promoting seed *** present study was developed in Bussaco National Forest,central Portugal,and aimed to assess the potential role of the stone marten in dispersing native and exotic plants in different forest landscape *** from stone marten scats and fleshy fruits were collected monthly and were thereafter identified and sowed in a nursery,following a randomized experimental *** emergence was monitored *** linear models were used to test for differences in time and success of emergence between seeds from scats and fruits of 3 native species(Rubus ulmifolius,Arbutus unedo and Celtis australis)and 1 exotic plant species with invasive behavior(Prunus laurocerasus).Fruit consumption by the stone martens significantly increased and accelerated the germination of the native *** but had no effect on the other 2 native species or on the invasive *** suggested that stone martens contribute to gene flow and forest regeneration by dispersing native plant ***,although the germination was not enhanced in the invasive species,the preference of stone martens for these fruits may potentially contribute to the proliferation of *** study represents a contribution to better understanding the fauna and flora interactions,enabling for a more conscious and effective decision-making in forest management.

关键词： germination invasive species Martes foina Prunus laurocerasus relict climactic forest

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Assessment of vascular invasion in gastric cancer: A comparative study

引用

World Journal of Gastroenterology 2013年第24期19卷 3761-3769页

作者： letícia Trivellato Gresta Ismael Alves Rodrigues-Júnior lúcia Porto Fonseca de Castro Geovanni Dantas Cassali Mnica maria Demas lva-res Cabral Department of Anatomic Pathology and Medicine University Federal of Minas GeraisBelo Horizonte 30130-100 Brazil Institute of Biological Sciences University Federal of Minas GeraisBelo Horizonte 31270-901 Brazil

AIM: To evaluate and compare detection of lymphatic and blood vessel invasion (lVI and BVI) by hematox-ylin-eosin (HE) and immunohistochemistry (IHC) in gastric cancer specimens, and to correlate with lymph node status. METHODS: IHC using D2-40 (a lymphatic endothelial marker) and CD34 (a pan-endothelial marker) was performed to study lVI and BVI in surgical specimens froma consecutive series of 95 primary gastric cancer cases. The results of the IHC study were compared with the detection by HE using McNemar test and kappa index. The morphologic features of the tumors and the presence of lVI and BVI were related to the presence of lymph node metastasis. A χ2 test was performed to obtain associations between lVI and BVI and other prognostic factors for gastric cancer. RESUlTS: The detection rate of lVI was considerably higher than that of BVI. The IHC study identified eight false-positive cases and 13 false-negative cases for lVI, and 24 false-positive cases and 10 false-negative cases for BVI. The average Kappa value determined was moderate for lVI (k=0.50) and low for BVI (k=0.20). Both lVI and BVI were statistically associated with the presence of lymph node metastasis (HE: P=0.001, P=0.013, and IHC: P=0.001, P=0.019). The mor-phologic features associated with lVI were location of the tumor in the distal third of the stomach (P=0.039), Borrmann's macroscopic type (P=0.001), organ inva-sion (P=0.03) and the depth of tumor invasion (P=0.001). The presence of BVI was related only to the depth of tumor invasion (P=0.003). CONClUSION: The immunohistochemical identification of lymphatic and blood vessels is useful for increasing the accuracy of the diagnosis of vessel invasion and for predicting lymph node metastasis.

关键词： Gastric cancer Tumour-node-metastesis staging lymph node metastasis Predictive factor lymphatic vessel invasion Blood vessel invasion Immunohistochemistry CD34 D2-40

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Incorporation of phenolic extracts from different by-products in yoghurts to create fortified and sustainable foods

引用

Food Bioscience 2023年第1期51卷 816-826页

作者： Sara M.Ferreira lúcia Santos lEPABE-laboratory for Process Engineering EnvironmentBiotechnology and EnergyFaculty of EngineeringUniversity of PortoRua Dr.Roberto Frias4200-465PortoPortugal AliCE-Associate laboratory in Chemical Engineering Faculty of EngineeringUniversity of PortoRua Dr.Roberto Frias4200-465PortoPortugal

This work aimed to study and compare the effect of the incorporation of agro-industrial by-products(chestnut shell,grapeseed,and pomegranate peel)into yoghurts to fortify them while assessing their potential to replace synthetic *** each by-product,phenolic extracts were obtained and *** extracts demonstrated antioxidant and antibacterial properties,and the capacity to inhibitα-*** shell extract stood out regarding antioxidant capacity,displaying values of 1128 and 972 mgT_(rolox•gextract)^(-1),for the assays with DPPH and ABTS,*** yoghurts were produced(negative control,positive control with 0.1%of sorbic acid,two for each extract with 0.1%and 0.2%of extract,a mixture of extracts and a mixture of extracts with sorbic acid),and stored at 4℃.The incorporation of the extracts into the yoghurts maintained their physical-chemical properties and microbiological *** samples inhibited the growth of Escherichia coli and Staphylococcus *** analysis proved that higher concentrations of extract had similar results to synthetic *** results showed the viability to fortify yoghurts with the incorporation of by-product extracts,developing a value-added ***,revealed the possibility of these extracts replacing synthetic preservatives and antioxidants.

关键词： Antioxidants By-products Sustainability Circular economy Fortified foods Yoghurts Preservatives

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Vulnerability Assessment Framework for Cultural Heritage Sites:The Case of the Roman Ruins of Tróia

引用

International Journal of Disaster Risk Science 2023年第1期14卷 26-40页

作者： Marvin Ravan maria João Revez Inês Vaz Pinto Patrícia Brum Joern Birkmann Institute of Spatial and Regional Planning(IREUS) University of Stuttgart70569StuttgartGermany Nova Conservação S.A1200-872LisbonPortugal Troia Resort 7570-789CarvalhalGDLPortugal

This article contributes to developing an indicator-based vulnerability assessment framework for cultural heritage *** provides a vulnerability index for heritage sites potentially exposed to multiple hazards,including sudden-onset and slow-onset hazards,while considering climate change *** determining particular criteria and indicators,the Cultural Heritage Vulnerability Index incorporates structural and non-structural factors of the heritage site and its local and national *** assessment procedure was applied to the case of the Roman Ruins of Tróia in *** findings highlight those areas of sensitivity(e.g.,the existing deterioration patterns and types of foundation)and coping and adaptive capacities(e.g.,institutional setting and response plan)that significantly contribute to the level of vulnerability and *** results of vulnerability assessment will further enable determining priorities and developing risk mitigation and preparedness measures,in particular reducing structural sensitivity and promoting coping capacities.

关键词： Climate change Coping capacity Cultural heritage Risk assessment Roman Ruins of Tróia Vulnerability assessment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Myostatin gene promoter:structure,conservation and importance as a target for muscle modulation

引用

Journal of Animal Science and Biotechnology 2019年第2期10卷 255-273页

作者： Carla Vermeulen Carvalho Grade Carolina Stefano Mantovani lúcia Elvira Alvares Universidade Federal da Integracao latino-Americana UNILAInstituto Latino-Americano de Ciências da Vida e da NaturezaAvenida Tarquínio Joslin dos Santos1000Foz do IguacuPR CEP 85870-901Brazil Departamento de Bioquímica e Biologia Tecidual Universidade Estadual de Campinas-UNICAMPRua Monteiro Lobato255CampinasSP CEP 13083-862Brazil.

Myostatin(MSTN) is one of the key factors regulating myogenesis. Because of its role as a negative regulator of muscle mass deposition, much interest has been given to its protein and, in recent years, several studies have analysed MSTN gene regulation. This review discusses the MSTN gene promoter, focusing on its structure in several animal species, both vertebrate and invertebrate. We report the important binding sites considering their degree of phylogenetic conservation and roles they play in the promoter activity. Finally, we discuss recent studies focusing on MSTN gene regulation via promoter manipulation and the potential applications they have both in medicine and agriculture.

关键词： CAAT box E-box Gene promoter Myogenesis Myostatin SNP Transcription factors TATA box

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Agmatine as a novel candidate for rapid-onset antidepressant response

引用

World Journal of Psychiatry 2021年第11期11卷 981-996页

作者： Ana Paula Valverde Anderson Camargo Ana lúcia S Rodrigues Department of Biochemistry Campus UniversitárioCenter for Biological SciencesUniversidade Federal de Santa CatarinaFlorianópolisSC 88040900Brazil

Major depressive disorder(MDD)is a disabling and highly prevalent mood disorder as well as a common cause of *** stress,inflammation,and intestinal dysbiosis have all been shown to play crucial roles in the pathophysiology of *** conventional antidepressants are widely used in the clinic,they can take weeks to months to produce therapeutic *** discovery that ketamine promotes fast and sustaining antidepressant responses is one of the most important breakthroughs in the pharmacotherapy of ***,the adverse psychomimetic/dissociative and neurotoxic effects of ketamine discourage its chronic ***,agmatine,an endogenous glutamatergic modulator,has been postulated to elicit fast behavioral and synaptogenic effects by stimulating the mechanistic target of rapamycin complex 1 signaling pathway,similar to ***,recent evidence has demonstrated that the modulation of the NlR family pyrin domain containing 3 inflammasome and gut microbiota,which have been shown to play a crucial role in the pathophysiology of MDD,may also participate in the antidepressant-like effects of both ketamine and *** review seeks to provide evidence about the mechanisms that may underlie the fast antidepressant-like responses of agmatine in preclinical *** the anti-inflammatory properties of agmatine,it may also be further investigated as a useful compound for the management of MDD associated with a pro-inflammatory ***,the fast antidepressant-like response of agmatine noted in animal models should be investigated in clinical studies.

关键词： Agmatine Fast-acting antidepressants Ketamine Major depressive disorder Microbiota-gut-brain axis Neuroinflammation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Association between the CYBA and NOX4 genes of NADPH oxidase and its relationship with metabolic syndrome in non-alcoholic fatty liver disease in Brazilian population

引用

Hepatobiliary & Pancreatic Diseases International 2018年第4期17卷 330-335页

作者： Fabiola Rabelo Jose Tadeu Stefano Ana Mercedes Cavaleiro Rodrigo Vieira Costa lima Daniel Ferraz de Campos Mazo Flair Jose Carrilho maria lúcia Correa-giannellac Claudia P.Oliveiraa Departamento de Gastroenterologia Faculdade de Medicina FMUSPUniversidade de Sao PauloSao PauloSPBrazil Hospital das Clinicas HCFMUSP Departamento de GastroenterologiaLIM07Faculdade de MedicinaUniversidade de Sao PauloSao PauloSPBrazil laboratório de Carboidratos e Radioimunensaio LIM18Hospital das Clinicas HCFMUSP(LIM07)Faculdade de MedicinaUniversidade de Sao PauloSao PauloBrazil Programa de Pos-Graduacao em Medicina Universidade Nove de Julho(UNINOVE)Sao PauloBrazil

Background: Oxidative stress has been implicated in the progression of severe forms of non-alcoholic fatty liver disease(NAFlD). NADPH oxidase produces reactive oxygen species. In the present study, we investigated for the first time two single nucleotide polymorphisms(SNPs) in the regulatory region of genes encoding NADPH oxidase 4(NOX4) and p22 phox(CYBA) in ***: A total of 207 biopsy-proven NAFlD patients [simple steatosis(n = 27); nonalcoholic steatohepatitis(NASH)(n = 180)] were evaluated. Genomic DNA was extracted from peripheral blood cells, and polymorphisms in CYBA(unregistered) and NOX4(rs3017887) were determined by direct sequencing of ***: Associations of CYBA-675 T/A with high-density lipoprotein(HDl)(TT vs TA vs AA; P lycerides(TGl)(TT vs XA; P ly in NASH patients. For polymorphisms in the NOX4 gene, NOX4(rs3017887) CA + AA genotypes was significant associated with alanine aminotransferase(AlT)(CA + AA vs CC; P = 0.02). However, there was no association of SNPs in the CYBA and NOX4 genes encoding the NADPH oxidase system proteins and the presence of NASH. Regarding the clinical results, it was observed that the most advanced degrees of fibrosis occurred in patients diagnosed with type 2 diabetes mellitus(66.9% vs 37.5%, P lucose and insulin levels increased significantly in the presence of ***: There were associations between the presence of the allele A in the NOX4 SNP and a higher concentration of AlT in the NAFlD population; between the presence of the AA genotype in the polymorphism of the CYBA-675 T/A CYBA gene and a higher level of TGl and lower HDl in NASH patients. The presence of metabolic syndrome was associated with advanced degrees of fibrosis in NAFlD patients.

关键词： Non-alcoholic fatty liver disease Nonalcoholic steatohepatitis Genetic polymorphism Metabolic syndrome

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

High prevalence of vitamin A deficiency in Crohn's disease patients according to serum retinol levels and the relative dose-response test

引用

World Journal of Gastroenterology 2015年第5期21卷 1614-1620页

作者： Márcia Soares-Mota Tianny A Silva luanda M Gomes Marco AS Pinto laura MC Mendon?a maria lúcia F Farias Tiago Nunes Andrea Ramalho Cyrla Zaltman Instituto de Nutricao Josué de Castro Federal University of Rio de JaneiroRio de Janeiro 21941-913Brazil Departamento de Clínica Médica Hospital Universitário Clementino Fraga FilhoFederal University of Rio de JaneiroRio de Janeiro 21941-901Brazil Nutrition and Immunology Chair ZIEL Research Center for Nutrition and Food SciencesTechnical University of MünchenFreising-Weihenstephan80333 MünchenGermany

AIM:To assess the vitamin A status of patients with Crohn's disease(CD) by evaluating serum retinol levels and the relative dose response(RDR) test(liver retinol stores).METHODS:Vitamin A nutritional status was measured by serum retinol obtained by high performance liquid chromatography and the RDR test for evaluation of the hepatic *** composition was performed by densitometry by dual-energy X-ray *** A dietary intake was assessed from a semiquantitative food frequency ***:This study included 38 CD patients and 33 *** serum retinol concentrations were detected in 29% of CD patients vs 15% in controls(P ls,which indicated inadequate hepatic vitamin A stores(P ls with hypovitaminosis A had lower BMI and body fat compared with those without this *** was no association between vitamin A deficiency and its dietary intake,ileal location,presence of disease activity and prior bowel ***:Patients with CD have higher prevalence of vitamin A deficiency,as assessed by two independent methods.

关键词： Crohn's disease Vitamin A Serum retinol Relative dose response test Body composition

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cardiovascular rehabilitation in patients aged 70-year-old or older:benefits on functional capacity,physical activity and metabolic profile in younger *** patients

引用

Journal of Geriatric Cardiology 2020年第9期17卷 544-553页

作者： Marta Fontes-Oliveira maria Trêpa Patrícia Rodrigues Preza Fernandes Sandra Magalhães Sofia Cabral Mário Santos Severo Torres Cardiology Department University Hospital Centre of PortoPortoPortugal Cardiac Rehabilitation Unit Cardiology DepartmentUniversity Hospital Centre of PortoPortoPortugal Pulmonary Vascular Disease Unit University Hospital Centre of PortoPortoPortugal

Background The benefits of exercise-based cardiac rehabilitation(EBCR)programs in post-acute myocardial infarction(AMI)patients have been *** aim was to assess the impact of EBCR in³70-years-old *** post-AMI *** We retrospectively evaluated patients who underwent a supervised EBCR protocol,twice a week during 6-12 *** evaluated changes in several outcomes based on pre-and post-CRP *** Of a total of 1607 patients,333(21%)were³*** the EBCR,an overall improvement on functional capacity,daily physical activity,lipid profile,body mass index,glycated hemoglobin(HbA1c),N-terminal pro-brain natriuretic peptide(NT-pro-BNP)and C-reactive protein was observed in both younger and older patients(Plder patients showed a smaller benefit on the increment of daily physical activity and lipid profile improvement,but a larger reduction in *** the multivariate analysis,only improvements on daily physical activity and HbA1c were dependent on *** As their younger counterparts,older patients,significantly improved functional capacity,metabolic parameters and level of daily physical activity after EBCR.

关键词： Aging Cardiovascular prevention Exercise-based cardiac rehabilitation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：