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Endothelial nitric oxide synthase gene polymorphisms are associated with sensitization to seasonal aeroallergens in asthmatic children

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World Journal of Pediatrics 2017年第1期13卷 34-40页

作者： maria iordanidou Emmanouil Paraskakis Anna Tavridou Athanasios Chatzimichael Vangelis G.Manolopoulos Respiratory Unit Department of PediatricsUniversity Hospital of AlexandroupolisAlexandroupolisThraceGreece Laboratory of Pharmacology Medical SchoolDemocritus University of ThraceAlexandroupolisGreece

Background:Childhood asthma phenotype is the consequence of interaction between environment and genetic *** oxide(N01 formation is affected by polymorphisms in nitric oxide synthase(NOS)enzymes,which play a significant role as inflammatory factors in the *** study was undertaken to estimate the correlation of-786C>T and 894G>T polymorphisms of the eNOs gene with the sensitization of asthmatic children to common aeroallergens.

关键词： asthma atopy genetics nitric oxide

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Enhancement of Sister Chromatid Exchanges in Peripheral Blood Lymphocytes of Thyroid Cancer Patients in Vitro

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Journal of Pharmacy and Pharmacology 2015年第4期3卷 173-181页

作者： Kontou maria Dafa Evagelia Trivizaki Antoniou M. Elsa iordanidou Lydia Lialiaris S. Theodore Department of Medicine Laboratory of Genetics Democritus University of Thrace Alexandroupolis 68100 Greece Department of Nuclear Medicine Anticancer Hospital of Pireaus "Metaxa " Athens 18537 Greece

The aim of our study was to determine the chromosomal fragility of thyroid cancer patients in vitro. The cytogenetic methodology used in our study, was the SCEs （sister chromatid exchanges technique）. FPG （fluorescence plus giemsa） method, was used in order to dye chromosomes. PRI （proliferation rate index）, MI （mitotic index）, AGT （average generation time） and PDT （population doubling time） were also counted. CPT-11 （Irinotecan）, an original alkyliotic agent, was used in our experiments as a positive control. Samples from 19 thyroid cancer patients and 13 healthy donors were controlled. The levels of SCEs were analyzed as a quantitative index of genotoxicity and the PRI and the MI were estimated as qualitative indices of cytostaticity and cytotoxicity, respectively. After CPT-11 addition in human lymphocytes cultures, the chromosomes of the cancer patients had a significant increase of the mean SCEs frequency. PRI and MI of treated with CPT- 11 and untreated lymphocytes of thyroid cancer patients were significantly lower than those of healthy donors, The results suggested that peripheral lymphocyte chromosomes of cancer patients are highly fragile and the alkyliotic agents increase their genetic instability. It appears that the increased SCE levels in peripheral blood lymphocyte chromosomes of thyroid cancer patients often result in chromosomal brittleness,

关键词： CPT-11 proliferative rate index mitotic index peripheral lymphocytes genotoxicity cytotoxicity cytostaticity.

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