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Toxic hepatitis in occupational exposure to solvents

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World Journal of Gastroenterology 2012年第22期18卷 2756-2766页

作者： Giulia Malaguarnera Emanuela Cataudella maria giordano Giuseppe Nunnari Giuseppe Chisari mariano Malaguarnera Research Centre "The Great Senescence" University of Catania Department of Infective Diseases Hospital "Garibaldi di Nesima" University of Catania Microbiology and Clinical Microbiology Department of Biomedical Science Hospital Policlinico University of Catania

The liver is the main organ responsible for the metabolism of drugs and toxic chemicals, and so is the primary target organ for many organic solvents. Work activities with hepatotoxins exposures are numerous and, moreover, organic solvents are used in various industrial processes. Organic solvents used in different industrial processes may be associated with hepatotoxicity. Several factors contribute to liver toxicity; among these are: species differences, nutritional condition, genetic factors, interaction with medications in use, alcohol abuse and interaction, and age. This review addresses the mechanisms of hepatotoxicity. The main pathogenic mechanisms responsible for functional and organic damage caused by solvents are: inflammation, dysfunction of cytochrome P450, mitochondrial dysfunction and oxidative stress. The health impact of exposure to solvents in the workplace remains an interesting and worrying question for professional health work.

关键词：有机溶剂毒性肝炎职业暴露细胞色素P450 工业生产过程职业卫生工作药物使用致病机制

Plasmon hybridization engineering in self-organized anisotropic metasurfaces

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Nano Research 2018年第7期11卷 3943-3956页

作者： maria C. giordano Stefano Longhi Matteo Barelli Andrea Mazzanti Francesco Buatier de Mongeot Giuseppe Della Valle Dipartimento di Fisica Universita di Genova Via Dodecaneso 33 Genova I-16146 Italy Dipartimento di Fisica and IFN-CNR Politecnico di Milano Piazza L. da Vinci 32 Milano 1-20133 Italy

The engineering of self-organized plasmonic metasurfaces is demonstrated using a maskless technique with defocused ion-beam sputtering and kinetically controlled deposition. The proposed reliable, cost-effective, and controllable approach enables large-area （order of square centimeter） sub-wavelength periodic patterning with close-packed gold nanostrips. A multi-level variant of the method leads to high-resolution manufacturing of vertically stacked nanostrip dimer arrays, without resorting to lithographic approaches. The design of these self-organized metasurfaces is optimized by employing plasmon hybridization methods. In particular, preliminary results on the so-called gap-plasmon configuration of the nanostrip dimers, implementing magnetic dipole resonance in the near-infrared range, are reported. This resonance offers a superior sensitivity and field enhancement, compared with the more conventional electric dipole resonance. The translational invariance of the nanostrip configuration leads to a high filling factor of the hot spots. These advanced features make the large-area metasurface based on gap-plasmon nanostrip dimers very attractive for surface-enhanced linear and nonlinear spectroscopy （e.g., surface-enhanced Raman scattering） and plasmon-enhanced photon harvesting in solar and photovoltaic cells.

关键词： metasurfaces self-organization gold nanostructures plasmon hybridization gap plasmon resonances

L-carnitine supplementation improves hematological pattern in patients affected by HCV treated with Peg interferon-α 2b plus ribavirin

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World Journal of Gastroenterology 2011年第39期17卷 4414-4420页

作者： Michele Malaguarnera Marco Vacante maria giordano Massimo Motta Gaetano Bertino Manuela Pennisi Sergio Neri mariano Malaguarnera Giovanni Li Volti Fabio Galvano Department of Biological Chemistry Medical Chemistry and Molecular BiologyUniversity of Catania Department of Internal Medicine and Systemic Disease University of Catania Research Center"The Great Senescence" University of Catania

AIM:To evaluate the efficacy of L-carnitine on alleviating anemia,thrombocytopenia and leukopenia,and minimizing dose reductions in patients with chronic hepatitis C virus(HCV)in treatment with Interferonα(IFN-α)plus ***:Sixty-nine patients with chronic hepatitis C were enrolled in the study and divided into two *** A(n=35)received Peg-IFN-α2b plus ribavirin plus L-carnitine,and group B(n=34)received Peg-IFN-αand ribavirin for 12 *** patients underwent laboratory investigations including:red cell count,he-moglobin,white cell count,platelets,bilirubin,alanine aminotransferase(ALT),aspartate aminotransferase(AST),and ***:After 12 mo in group A compared to group B we observed significant differences in AST 108.8 vs 76.8(IU/L;P44%)and the non responders were 12 vs 15(40%vs25%),while the relapsers were 3 vs 5(10%vs3.57,n5%CI=0.65-1n.3,Pn0.001).CONCLUSION:L-carnitine supplementations modulate erythropoiesis,leucopoiesis and thrombocytopoiesis,and may be useful in patients treated for HCV.L-carni-tine treatment offers the possibility of achieving a sustained virological response while preventing overtreatment.

关键词：丙型肝炎病毒 PEG 干扰素患者治疗肉碱病毒唑血小板减少

A giant scrotal pendulous fibroma mimicking a supernumerary testis

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Asian Journal of Andrology 2024年第2期26卷 227-228页

作者： Luigi Quaresima Rocco Francesco Delle Fave giordano Polisini Daniela Fasanella Willy Giannubilo Urology Division Civitanova Marche HospitalCivitanova Marche 62012Italy Department of Clinical and Specialist Sciences Division of UrologyPolytechnic University of the Marche Region Medical SchoolAncona 60126Italy Department of Life Health and Environmental SciencesUniversity of L'AquilaL'Aquila 67100Italy

DearEditor,Pendulous fibroma,also called acrochordon,is a benign skin neoplasm,originating from the ***,small in size,it can arise from any point of the dermis(frequently from the axillary area,inguinal region,eyelid,or neck),and in some cases,it can be *** fibromas are more frequent in obese subjects,and most of the time,they are sporadic,although sometimes,they can be observed in Birt-Hogg-Dube *** some rare cases,they can reach considerable ***,they are associated with diabetes mellitus,obesity,and intestinal ***,the pedicle undergoes torsion,causing pain and ischemic necrosis of the fibroma,which requires rapid removal of the *** present a case of giant pendulous fibroma of the *** patient has given his consent to the publication of his clinical information and photographic images in an anonymous form.

关键词： frequent obesity clinical

Markers of bile duct tumors

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World Journal of Gastrointestinal Oncology 2011年第4期3卷 49-59页

作者： Giulia Malaguarnera maria giordano Isabella Paladina Alessandra Rando Mario Uccello Francesco Basile Antonio Biondi Santo Carnazzo Innocenza Alessandria Clorinda Mazzarino Department of Biomedical Science University of Catania Departments of Senescence Urologicaland Neurological SciencesUniversity of Catania Department of General Surgery University Medical School of CataniaHospital Vittorio Emanuele Department of General Surgery University Medical School of Catania Department of Internal Medicine University Medical School of CataniaHospital Cannizzaro

Biliary tract carcinomas are relatively rare,representing less than 1%of ***,their incidence has increased in Japan and in industrialized countries like the *** tract tumors have a poor prognosis and a high mortality rate because they are usually detected late in the course of the disease;therapeutic treatment options are often limited and of minimal *** studies have shown the importance of serum and molecularmarkers in the diagnosis and follow up of biliary tract *** review aims to introduce the main features of the most important serum and molecular markers of biliary tree *** considerable tumor markers are cancer antigen 125,carbohydrate antigen 19-9,carcinoembryonic antigen,chromogranin A,mucin 1,mucin 5,alpha-fetoprotein,claudins and cytokeratins.

关键词： Bile duct tumors Cholangiocarcinoma Tumor markers Carbohydrate antigen 19-9 Chromogranin A

Gut microbiota in alcoholic liver disease: Pathogenetic role and therapeutic perspectives

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World Journal of Gastroenterology 2014年第44期20卷 16639-16648页

作者： Giulia Malaguarnera maria giordano Giuseppe Nunnari Gaetano Bertino Michele Malaguarnera Department of Clinical and Molecular Biomedicine Section of Pharmacology and Biochemistry Research Centre "The Great Senescence" University of Catania Cannizzaro Hospital Infective Diseases Department of Clinical and Molecular Biomedicine Garibaldi Hospital of Nesima Hepatology Unit Department of Medical and Pediatric Science University of Catania

Alcoholic liver disease(ALD) is the commonest cause of cirrhosis in many Western countries and it has a high rate of morbidity and mortality. The pathogenesis is characterized by complex interactions between metabolic intermediates of alcohol. Bacterial intestinal flora is itself responsible for production of endogenous ethanol through the fermentation of carbohydrates. The intestinal metabolism of alcohol produces a high concentration of toxic acetaldehyde that modifies gut permeability and microbiota equilibrium. Furthermore it causes direct hepatocyte damage. In patients who consume alcohol over a long period, there is a modification of gut microbiota and, in particular, an increment of Gram negative bacteria. This causes endotoxemia and hyperactivation of the immune system. Endotoxin is a constituent of Gram negative bacteria cell walls. Two types of receptors, cluster of differentiation 14 and Toll-like receptors-4, present on Kupffer cells, recognize endotoxins. Several studies have demonstrated the importance of gut-liver axis and new treatments have been studied in recent years to reduce progression of ALD modifying gut microbiota. It has focused attention on antibiotics, prebiotics, probiotics and synbiotics.

关键词： Alcoholic liver disease Bacterial transloca-tion D

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如何建立游戏治疗关系

Endozepine-4 levels are increased in hepatic coma

作者： (美)maria giordano，(美)Garry Landreth，(美)Leslie Jones

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World Journal of Gastroenterology 2015年第30期21卷 9103-9110页

作者： Giulia Malaguarnera Marco Vacante Filippo Drago Gaetano Bertino Massimo Motta maria giordano Michele Malaguarnera Research Center "The Great Senescence" Hospital of Cannizzaro University of Catania Department of Clinical and Experimental Medicine University of Catania Department of Biomedical and Biotechnological Sciences Section of PharmacologySchool of MedicineUniversity of Catania Gerontology and Bone Metabolic Disease Section Department of Medical SciencesUniversity of Torino

AIM:To evaluate the serum levels of endozepine-4,their relation with ammonia serum levels,the grading of coma and the severity of cirrhosis,in patients with hepatic coma. METHODS:In this study we included 20 subjects with Hepatic coma,20 subjects with minimal hepatic encephalopathy(MHE) and 20 subjects control. All subjects underwent blood analysis,Child Pugh and Model for End- stage liver disease(MELD) assessment,endozepine-4 analysis. RESULTS:Subjects with hepatic coma showed significant difference in endozepine-4(P < 0.001) and NH3 levels(P < 0.001) compared both to MHE and controls patients. Between NH3 and endozepine-4 we observed a significant correlation(P = 0.009; Pearson correlation 0.570). There was a significant correlation between endozepine-4 and MELD(P = 0.017; Pearsoncorrelation = 0.529). In our study blood ammonia concentration was noted to be raised in patients with hepatic coma,with the highest ammonia levels being found in those who were comatose. We also found a high correlation between endozepine-4 and ammonia(P < 0.001). In patients with grade Ⅳ hepatic coma,endozepine levels were significantly higher compared to other groups. CONCLUSION:This study suggests that an increased level of endozepine in subjects with higher levels of MELD was observed. In conclusion,data concerning involvement of the GABA-ergic system in HE coma could be explained by stage-specific alterations.

关键词： Endozepine-4 Hepatic encephalopathy Hepatic coma Cirrhosis, Benzodiazepine Peripheralbenzodiazepine receptor Model for End - stage liverdisease Glutamate-related neurotoxicity which in turnmay alter the γ-aminobutyric acid

Knowledge,management,and complications of sepsis and septic shock:A significant therapeutic challenge in the intensive care unit

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Journal of Acute Disease 2024年第2期13卷 53-59页

作者： Jakub Mizera Adrian Bystroń Karolina Matuszewska Justyna Pilch Ugo giordano Wroclaw Medical University wyb.Ludwika Pasteura 150-367 WrocławPoland

Sepsis and septic shock are life-threatening conditions that are globally responsible for almost 20%of mortality,especially in low and middle-income *** review was conducted on PubMed and Google Scholar databases with keywords sepsis,septic shock,sepsis management,and sepsis *** published up to July 2023 in English were *** and management should be carried out without unnecessary *** between various medical specialties including intensive care doctors,neurologists,hepatologists,cardiologists,and pediatric doctors is needed if a child is *** strategies have to be implemented in low and middle-income countries to decrease the sepsis incidence and reduce mortality in the population.

关键词： Sepsis Septic shock Management Complications Diagnosis Review