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Presepsin as a biomarker of bacterial translocation and an indicator for the prescription of probiotics in cirrhosis

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World Journal of Hepatology 2024年第5期16卷 822-831页

作者： Irina Efremova Roman Maslennikov Elena Poluektova Oleg Medvedev Anna Kudryavtseva George Krasnov maria fedorova Filipp Romanikhin maria Zharkova Oxana Zolnikova Gyunay Bagieva Vladimir Ivashkin Department of Internal Medicine Gastroenterology and HepatologySechenov UniversityMoscow 119435Russia Department of Scientific Scientific Community for the Promotion of the Clinical Study of the Human MicrobiomeMoscow 119435Russia Department of Pharmacology Lomonosov Moscow State UniversityMoscow 119192Russia Department of Post-Genomic Research Laboratory Engelhardt Institute of Molecular BiologyRussian Academy of SciencesMoscow 119991Russia

BACKGROUND The gut–liver axis and bacterial translocation are important in cirrhosis,but there is no available universal biomarker of cellular bacterial translocation,for which presepsin may be a *** To evaluate the relationship of the blood presepsin levels with the state of the gut microbiota in cirrhosis in the absence of obvious *** This study included 48 patients with Child–Pugh cirrhosis classes B and C and 15 healthy *** fecal microbiome was assessed using 16S rRNA gene *** levels of presepsin were measured.A total of 22 patients received a probiotic(Saccharomyces boulardii)for 3 *** Presepsin levels were higher in patients with cirrhosis than in healthy individuals[342(91-2875)vs 120(102-141)pg/mL;P=0.048].Patients with elevated presepsin levels accounted for 56.3%of all included *** had lower levels of serum albumin and higher levels of serum total bilirubin and overall severity of cirrhosis as assessed using the Child–Pugh *** with elevated presepsin levels had an increased abundance of the main taxa responsible for bacterial translocation,namely Bacilli and Proteobacteria(including the main class Gammaproteobacteria and the minor taxa Xanthobacteraceae and Stenotrophomonas),and a low abundance of bacteria from the family Lachnospiraceae(including the minor genus Fusicatenibacter),which produce short-chain fatty acids that have a positive effect on intestinal barrier *** presepsin level directly correlated with the relative abundance of Bacilli,Proteobacteria,and inversely correlated with the abundance of Lachnospiraceae and *** 3 months of taking the probiotic,the severity of cirrhosis on the Child–Pugh scale decreased significantly only in the group with elevated presepsin levels[from 9(8-11)to 7(6-9);P=0.004],while there were no significant changes in the group with normal presepsin levels[from 8(7-8)to 7(6-8);P=0.123].A high level of presepsin

关键词： Dysbiosis Gut Intestinal permeability Leaky gut Gut-liver axis Liver Microbiota

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Gut Microbiota and Cytokine Profile in Cirrhosis

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Journal of Clinical and Translational Hepatology 2024年第8期12卷 689-700页

作者： Irina Efremova Roman Maslennikov Anna Kudryavtseva Anastasia Avdeeva George Krasnov Mikhail Diatroptov Vyacheslav Bakhitov Salekh Aliev Natalia Sedova maria fedorova Elena Poluektova Oxana Zolnikova Nariman Aliev Anna Levshina Vladimir Ivashkin Department of Internal Medicine Gastroenterology and HepatologySechenov UniversityMoscowRussia Post-Genomic Research Laboratory Engelhardt Institute of Molecular BiologyRussian Academy of SciencesMoscowRussia V.A.Nasonova Research Institute of Rheumatology MoscowRussia Consultative and Diagnostic Center 2 of the Moscow Health Department MoscowRussia First Hospital Surgery Department Pirogov Russian National Research Medical UniversityMoscowRussia Department of Clinical Laboratory Diagnostics FGBOU DPO“Russian Medical Academy of Continuing Professional Education of the Ministry of Health of the Russian Federation”MoscowRussia The Interregional Public Organization“Scientific Community for the Promotion of the Clinical Study” MoscowRussia

Background and Aims:Gut dysbiosis and abnormal cytokine profiles are common in *** study aimed to evaluate the correlations between ***:In the blood plasma of cirrhosis patients and controls,27 cytokines were examined using a multiplex *** plasma levels of nitrites(stable metabolites of the endothelial dysfunction biomarker nitric oxide)and lipopolysaccharide(LPS)were *** fecal microbiota was assessed by 16S rRNA gene ***:Levels of IL-1b,IL-2,IL-6,IL-13,IP-10,IFN-g,TNF-a,LPS,and nitrites were higher in cirrhosis patients than in controls,while levels of IL-4,IL-7,and PDGF-BB were *** LPS level was directly correlated with the levels of IL-1b,IL1-Ra,IL-9,IL-17,PDGF-BB,IL-6,TNF-a,and *** nitrite level was significantly directly correlated with the levels of TNF-a,GM-CSF,IL-17,and IL-12,and inversely correlated with the IL-7 ***-a levels were directly correlated with ascites severity and the abundance of Negativicutes,Enterobacteriaceae,Veillonellaceae,and Klebsiella,while inversely correlated with the abundance of Firmicutes,Clostridia,and ***-g levels were directly correlated with the abundance of Bacteroidaceae,Lactobacillaceae,Bacteroides,and Megasphaera,and inversely correlated with the abundance of Verrucomicrobiota,Akkermansiaceae,Coriobacteriaceae,Akkermansia,Collinsella,and ***-1b levels were directly correlated with the abundance of Comamonadaceae and Enterobacteriaceae and inversely correlated with the abundance of Marinifilaceae and ***-6 levels were directly correlated with the abundance of Enterobacteriaceae,hepatic encephalopathy,and ascites severity,and inversely correlated with the abundance of Peptostreptococcaceae,Streptococcaceae,and ***:The abundance of harmful gut microbiota taxa and endotoxinemia directly correlates with the levels of proinflammatory cytokines.

关键词： Endotoxin Leaky gut Gut microbiome Systemic inflammation Gut-liver axis Endotoxemia

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Peculiarities of Calculating Bridges with Seismic Isolation Including Spherical Bearings and Hydraulic Dampers in Russia

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Journal of Civil Engineering and Architecture 2015年第4期9卷 401-409页

作者： Natalia V. Durseneva Andrey V. Indeykin Inna O. Kuznetsova Alexander M. Uzdin maria fedorova Theoretical Mechanics Department St-Petersburg State Railway Transport University St-Petersburg 190031 Russia Faculty of Mathematics and Mechanics St-Petersburg State University St-Petersburg 191119 Russia

The peculiarities of calculating isolated structures with spherical bearings are analyzed in this paper. Some of peculiarities are caused by the lack of data at the moment when engineering solutions had to be made, Other peculiarities are connected with physical peculiarities of the device behaviour. To provide the analysis of structure hehaviour under the condition of the lack of input information, two types of design models of seismic protection devices were considered. They are the dampers linearization and the modelling of real dampers by dry friction ones. The dampers linearization makes it possible to use the existing software for calculating linear strongly-damped systems. To calculate structures with dry friction dampers, a new software was worked out. In this case, the structure is described as a piecewise-linear system of a relay-type. The investigations of the structure oscillations take into account both horizontal and vertical components of earthquake input. Under this condition, horizontal oscillation equations of structures are the MaRie-Hill ones. The input and structure parameters which caused the structure instability are estimated. To exclude the structure instability, high damping devices should be used. These methods were used for seismic resistant analysis of bridges with spherical bearings and hydraulic dampers applied in Sochi.

关键词： Seismic isolation spherical bearings hydraulic dampers calculations.

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Brentuximab Vedotin Monotherapy and Combined with Low Dose Donor Lymphocyte Infusion to Control Minimal Residual Disease and Sustain Clinical Remission in a Child with Relapsed Anaplastic Large Cell Lymphoma

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Journal of Cancer Therapy 2017年第8期8卷 683-690页

作者： Alina S.fedorova maria V.Stegantseva Nina V.Minakovskaya Olga V.Aleinikova Clinical Research Department Belarusian Research Center for Pediatric OncologyHematology and ImmunologyMinsk RegionBelarus Laboratory of Genetic Biotechnology Belarusian Research Center for Pediatric OncologyHematology and ImmunologyMinsk RegionBelarus Department of Bone Marrow Transplantation Belarusian Research Center for Pediatric OncologyHematology and ImmunologyMinsk RegionBelarus

Minimal residual disease (MRD) appears to have a strong negative predictive value for disease recurrence in children with anaplastic large cell lymphoma (ALCL). Brentuximab vedotin (BV) can be a therapeutic option for MRD-positive patients to achieve molecular remission and to decrease risk of subsequent relapse. We here report a 4-year-old child with ALCL progression during relapse treatment who received BV as a bridging therapy before haploidentical hematopoietic stem-cell transplantation, and as a maintenance therapy post-transplant alone or combined with simultaneous low dose donor-lymphocyte infusions. MRD monitoring showed a complete molecular response and reflected both BV efficiency and graft-versus-lymphoma effect.

关键词： Anaplastic Large Cell Lymphoma Relapse Brentuximab Vedotin Donor Lymphocyte Infusion Minimal Residual Disease

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Experimental Investigation of Solid Fuel Combustion Process in a Hybrid Porous Reactor

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Journal of Energy and Power Engineering 2017年第9期11卷 589-596页

作者： Vojislav Jovicic Nataliia fedorova Ana Zbogar-Rasic Mario Toledo Torres Antonio Delgado Institute of Fluid Mechanics (LSTM) Friedrich-Alexander University of Erlangen-Nuremberg Erlangen D-91058 Germany Erlangen Graduate School in Advanced Optical Technologies (SA OT) Erlangen D-91058 Germany Department of Mechanical Engineering Technical University Federico Santa Maria Valparaiso 05101 Chile

One of the most significant human-made methane emission sources is the MSW （municipal solid waste）, deposited on sanitary landfills and open dumps. Within this work, an alternative MSW treatment concept is presented, which could provide a relatively clean waste/biomass-to-energy transformation. The proposed procedure comprises of a combustion and a gasification （or pyrolysis） step, which are consecutively taking place in a two-stage hybrid porous reactor system. The core of the system is two packed bed reactors, in which solid fuel （waste or biomass） is mixed with inert ceramic particles of similar size. This paper overviews the initial experimental investigation of the combustion step of a hybrid mixture, composed of wood pellets （fuel） and alumina balls （inert ceramic particles） in a 250 ram-high batch reactor. The temperature profile along the reactor, the concentration of CO and the flame front propagation velocity were measured as a function of the ceramic particle size （11 and 20 mrn）, the inert-to-fuel mass ratio （0：1, 2：1, 3：1） and the airflow rate （30, 42, 60 1/min）. Experiments indicate that an increase of the mass ratio of inert-to-fuel material and a decrease of the inert ceramic particles size lead to a decrease of the maximum temperature of the packed hybrid bed. Measured CO concentrations showed strong dependence on the inert ceramic particle size, i.e. the particle size reduction from 20 to 11 mm resulted in a significant reduction of CO-emission peaks. The maximum flame front propagation velocity of 0.2 mm/sec was detected for the airflow of 42 1/min, the particle size of 20 mm and the mass ratio of 3：1.

关键词： Combustion allothermal gasification MSW hybrid filtration combustion packed bed.

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