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This pain drives me crazy:Psychiatric symptoms in women with interstitial cystitis/bladder pain syndrome

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World Journal of Psychiatry 2024年第6期14卷 954-984页

作者： marianna Mazza Stella Margoni Giuseppe Mandracchia Guglielmo Donofrio Alessia Fischetti Georgios D Kotzalidis Giuseppe Marano Alessio Simonetti Delfina Janiri Lorenzo Moccia Ilaria Marcelli Greta Sfratta Domenico De Berardis Ottavia Ferrara Evelina Bernardi Antonio Restaino Francesco maria Lisci Antonio maria D'Onofrio Caterina Brisi Flavia Grisoni Claudia Calderoni Michele Ciliberto Andrea Brugnami Sara Rossi maria Chiara Spera Valeria De Masi Ester maria Marzo Francesca Abate Gianluca Boggio maria Benedetta Anesini Cecilia Falsini Anna Quintano Alberto Torresi Miriam Militenda Giovanni Bartolucci Marco Biscosi Sara Ruggiero Luca Lo Giudice Giulia Mastroeni Elisabetta Benini Luca Di Benedetto Romina Caso Francesco Pesaresi Francesco Traccis Luca Onori Luca Chisari Leonardo Monacelli mariateresa Acanfora eleonora Gaetani Monia Marturano Sara Barbonetti Elettra Specogna Francesca Bardi Emanuela De Chiara Gianmarco Stella Andrea Zanzarri Flavio Tavoletta Arianna Crupi Giulia Battisti Laura Monti Giovanni Camardese Daniela Chieffo Antonio Gasbarrini Giovanni Scambia Gabriele Sani Department of Neurosciences Fondazione Policlinico Universitario A Gemelli IRCCSUniversita Cattolica del Sacro CuoreRome 00168Italy Department of Psychiatry UniversitàCattolica del Sacro CuoreRome 00168Italy Department of Neurosciences Section of PsychiatryFondazione Policlinico Universitario Agostino Gemelli IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy Mental Health NHSASL 4 TeramoTeramo 64100Italy Medical and Surgical Sciences UniversitàCattolica del Sacro CuoreRome 00168Italy Division of Gynecologic Oncology UniversitàCattolica del Sacro CuoreRome 00168Italy UOS Psicologia Clinica Governo ClinicoFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy CEMAD Digestive Disease Center Fondazione Policlinico Universitario A.Gemelli-IRCCSRome 00168Italy Department of Woman and Child Health Catholic UniversityRome 00168Italy UOC Psichiatria Clinica e d’Urgenza Dipartimento di Scienze Dell’InvecchiamentoNeurologicheOrtopediche e Della Testa-colloFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy

BACKGROUND Interstitial cystitis/bladder pain syndrome(IC/BPS)is an at least 6-mo noninfectious bladder inflammation of unknown origin characterized by chronic suprapubic,abdominal,and/or pelvic *** the term cystitis suggests an inflammatory or infectious origin,no definite cause has been *** occurs in both sexes,but women are twice as much *** To systematically review evidence of psychiatric/psychological changes in persons with IC/*** Hypothesizing that particular psychological characteristics could underpin IC/BPS,we investigated in three databases the presence of psychiatric symptoms and/or disorders and/or psychological characteristics in patients with IC/BPS using the following strategy:("interstitial cystitis"OR"bladder pain syndrome")AND("mood disorder"OR depressive OR antidepressant OR depression OR depressed OR hyperthymic OR mania OR manic OR rapid cyclasterisk OR dysthymiasterisk OR dysphoriasterisk).RESULTS On September 27,2023,the PubMed search produced 223 articles,CINAHL 62,and the combined PsycLIT/PsycARTICLES/PsycINFO/Psychology and Behavioral Sciences Collection search *** on *** produced 14 studies,of which none had available *** were peer-reviewed articles reporting psychiatric/psychological symptoms in patients with IC/BPS,i.e.63 articles spanning from 2000 to October *** studies identified depression and anxiety problems in the IC/BPS population,along with sleep problems and the tendency to *** Psychotherapies targeting catastrophizing and life stress emotional awareness and expression reduced perceived pain in women with IC/*** concepts should be considered when implementing treatments aimed at reducing IC/BPS-related pain.

关键词： Interstitial cystitis/bladder pain syndrome Psychiatric symptoms Psychological symptoms Catastrophizing Anxiety Depression

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大陆集团总部

现代装饰 2024年第3期 32-41页

作者： Arsen Aliverdiev(设计) Michael Bertram(设计) Kerstin El-Khawad(设计) Gunter Fleitz(设计) Eva Perez Fons(设计) Lisa Holler(设计) Leticia Hutchings(设计) Peter Ippolito(设计) Christiane Klinner(设计) Susann Kreplin(设计) Frank Lakmann(设计) Tim Lessmann(设计) eleonora Mannisi(设计) Thomas Mura(设计) maria Cristina Orizzonte(设计) Jana Stumpe(设计) Bradley Wheeler(设计) Elisabed Zautashvili(设计) Werner Huthmacher(摄影) Ippolito Fleitz Group(摄影) 不详

“The Future in Motion”是大陆集团的座右铭,而大陆集团的品牌“Continental”则代表着面向未来、可持续发展和团结协作的理念。由于原集团总部的面积不再能满足公司的未来发展,大陆集团决定在德国汉诺威毗邻城市森林的位置新建一座... 详细信息

“The Future in Motion”是大陆集团的座右铭,而大陆集团的品牌“Continental”则代表着面向未来、可持续发展和团结协作的理念。由于原集团总部的面积不再能满足公司的未来发展,大陆集团决定在德国汉诺威毗邻城市森林的位置新建一座总部。新总部的设计以共享办公为概念,可为多达2400名员工提供工作场所。新楼经过五年建设,于2023年12月投入使用。

关键词：集团总部德国汉诺威可持续发展团结协作大陆座右铭

Nonalcoholic fatty liver disease and diabetes

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World Journal of Diabetes 2022年第9期13卷 668-682页

作者： maria Irene Bellini Irene Urciuoli Giovanni Del Gaudio Giorgia Polti Giovanni Iannetti Elena Gangitano eleonora Lori Carla Lubrano Vito Cantisani Salvatore Sorrenti Vito D’Andrea Department of Surgical Sciences Sapienza University of RomeRome 00161Italy Department of Radiological Sciences Oncology and PathologySapienza University of RomeRome 00161Italy Department of Experimental Medicine Section of Medical PhysiopathologyFood Science and EndocrinologySapienza University of RomeRome 00161Italy

Nonalcoholic fatty liver disease(NAFLD)is the most prevalent chronic liver disease in the world and represents a clinical-histopathologic entity where the steatosis component may vary in degree and may or may not have fibrotic *** key concept of NAFLD pathogenesis is excessive triglyceride hepatic accumulation because of an imbalance between free fatty acid influx and *** epidemiological,biochemical,and therapeutic evidence supports the premise that the primary pathophysiological derangement in most patients with NAFLD is insulin resistance;thus the association between diabetes and NAFLD is widely recognized in the *** NAFLD is the hepatic manifestation of a metabolic disease,it is also associated with a higher cardiovascular *** B-mode ultrasound is widely adopted as a first-line imaging modality for hepatic steatosis,although magnetic resonance imaging represents the gold standard noninvasive modality for quantifying the amount of fat in these *** of NAFLD patients depends on the disease severity,ranging from a more benign condition of nonalcoholic fatty liver to nonalcoholic *** from alcohol,a Mediterranean diet,and modification of risk factors are recommended for patients suffering from NAFLD to avoid major cardiovascular events,as per all diabetic *** addition,weight loss induced by bariatric surgery seems to also be effective in improving liver features,together with the benefits for diabetes control or resolution,dyslipidemia,and ***,liver transplantation represents the ultimate treatment for severe nonalcoholic fatty liver disease and is growing rapidly as a main indication in Western *** review offers a comprehensive multidisciplinary approach to NAFLD,highlighting its connection with diabetes.

关键词： Bariatric surgery Diabetes Hepatic steatosis Liver fibrosis Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis

Non-alcoholic fatty liver disease connections with fat-free tissues: A focus on bone and skeletal muscle

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World Journal of Gastroenterology 2017年第10期23卷 1747-1757页

作者： eleonora Poggiogalle Lorenzo maria Donini Andrea Lenzi Claudio Chiesa Lucia Pacifico Department of Experimental Medicine-Medical Pathophysiology Food Science and Endocrinology SectionSapienza University of Rome Institute of Translational Pharmacology National Research Council Policlinico Umberto I Hospital Sapienza University of Rome

The estimates of global incidence and prevalence of non-alcoholic fatty liver disease(NAFLD) are worrisome, due to the parallel burden of obesity and its metabolic complications. Indeed, excess adiposity and insulin resistance represent two of the major risk factors for NAFLD; interestingly, in the last years a growing body of evidence tended to support a novel mechanistic perspective, in which the liver is at the center of a complex interplay involving organs and systems, other than adipose tissue and glucose homeostasis. Bone and the skeletal muscle are fat- free tissues which appeared to be independently associated with NAFLD in several cross-sectional studies. The deterioration of bone mineral density and lean body mass, leading to osteoporosis and sarcopenia, respectively, are age-related processes. The prevalence of NAFLD also increases with age. Beyond physiological aging, the three conditions share some common underlying mechanisms, and their elucidations could be of paramount importance to design more effective treatment strategies for the management of NAFLD. In this review, we provide an overview on epidemiological data as well as on potential contributors to the connections of NAFLD with bone and skeletal muscle.

关键词： Non-alcoholic fatty liver disease Bone Skeletal muscle Osteoporosis Sarcopenia

Acupuncture for breakthrough pain in cancer:A medical record

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World Journal of Acupuncture-Moxibustion 2021年第4期31卷 254-257页

作者： Diana Lalli Flavia Santoboni Riccardo Vallorani Mario Vetrano eleonora Latini Sveva maria Nusca maria Chiara Vulpiani Department of Surgical and Medical Sciences and Translational Medicine Faculty of Medicine and Psychology"Sapienza"University of Romevia di Grottarossa 1035-1039Rome 00189Italy Physical Medicine and Rehabilitation Unit Sant'Andrea University HospitalVia di Grottarossa 1035-1039Rome 00189Italy

Patients with chronic cancer pain frequently suffer from severe pain intensity exacerbations.A 60-years old woman had been experiencing Breakthrough Cancer Pain(BTCP) mostly concentrated on shoulders since the resection of the upper right lung lobe one year before,reason why she underwent Traditional Chinese Medicine treatment(TCM).She was diagnosed with *** strong opioids intake during radiotherapy and chemotherapy,she continued to suffer from pain without benefiting from these *** was treated with somatic and auricular acupuncture and cupping technique for 10 sessions,2-3 sessions per week,30 min per *** five/six sessions of treatment the patient felt much better,relieved from the pain with an improving Numeric rating Scale(NRS) and an important improving of Breakthrough Pain Assessment Tool-BAT and Constant-Murley *** cancer patients,acupuncture could represent an effective treatment option.

关键词： Acupuncture Breakthrough pain Cancer Case report

From bench to bedside: Fecal calprotectin in inflammatory bowel diseases clinical setting

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World Journal of Gastroenterology 2018年第33期24卷 3681-3694页

作者： maria Gloria Mumolo Lorenzo Bertani Linda Ceccarelli Gabriella Laino Giorgia Di Fluri eleonora Albano Gherardo Tapete Francesco Costa Department of General Surgery and Gastroenterology Gastroenterology Unit Azienda Ospedaliero Universitaria Pisana Department of New Technologies and Translational Research in Medicine and Surgery University of Pisa

Fecal calprotectin(FC) has emerged as one of the most useful tools for clinical management of inflammatory bowel diseases(IBD). Many different methods of assessment have been developed and different cutoffs have been suggested for different clinical settings. We carried out a comprehensive literature review of the most relevant FC-related topics: the role of FC in discriminating between IBD and irritable bowel syndrome(IBS) and its use in managing IBD patients In patients with intestinal symptoms, due to the high negative predictive value a normal FC level reliably rules out active IBD. In IBD patients a correlation with both mucosal healing and histology was found, and there is increasing evidence that FC assessment can be helpful in monitoring disease activity and response to therapy as well as in predicting relapse, post-operative recurrence or pouchitis. Recently, its use in the context of a treat-to-target approach led to a better outcome than clinically-based therapy adjustment in patients with early Crohn's disease. In conclusion, FC measurement represents a cheap, safe and reliable test, easy to perform and with a good reproducibility. The main concerns are still related to the choice of the optimal cut-off, both for differentiating IBD from IBS, and for the management of IBD patients.

关键词： Fecal calprotectin Inflammatory bowel diseases Crohn's disease Ulcerative colitis Irritable

Robot-assisted adrenalectomy:Step-by-step technique and surgical outcomes at a high-volume robotic center

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Asian Journal of Urology 2023年第4期10卷 475-481页

作者： Federico Piramide Carlo Andrea Bravi Marco Paciotti Luca Sarchi Luigi Nocera Adele Piro maria Peraire Lores eleonora Balestrazzi Angelo Mottaran Rui Farinha Hubert Nicolas Pieter De Backer Frederiek D'hondt Peter Schatteman Ruben De Groote Geert De Naeyer Alexandre Mottrie Department of Urology Onze-Lieve-VrouwziekenhuisAalstBelgium ORSI Academy GhentBelgium Department of Oncology Division of UrologyUniversity of TurinSan Luigi Gonzaga HospitalTurinItaly Department of Urology Humanitas Research Hospital-IRCCSRozzanoItaly Department of Urology ASST Santi Paolo e CarloUniversity of MilanMilanItaly Unit of Urology Division of Experimental OncologyUrological Research InstituteIRCCS San Raffaele Scientific InstituteVita-Salute San Raffaele UniversityMilanItaly Department of Urology Ospedale Policlinico e Nuovo Ospedale Civile S.Agostino Estense ModenaUniversity of Modena and Reggio EmiliaModenaItaly Division of Urology IRCCS Azienda Ospedaliero-Universitaria di BolognaBolognaItaly Urological Department La CitadelleLiègeBelgium

Objective In the last years,robotic surgery was introduced in several different settings with good perioperative ***,its role in the management of adrenal masses is still *** order to provide a contribution to this field,we described our step-by-step technique for robotic adrenalectomy(RA)and related modifications according to the type of adrenal mass *** We retrospectively analyzed 27 consecutive patients who underwent RA at Onze-Lieve-Vrouw hospital(Aalst,Belgium)between January 2009 and October ***,intra-and post-operative,and pathological data were retrieved from our prospectively maintained institutional *** variables are summarized as median and interquartile range(IQR).Categorical variables are reported as frequencies(percentages).Results Twenty-seven patients underwent RA were included in the *** age,body mass index,and Charlson's comorbidity index were 61(IQR:49-71)years,26(IQR:24-29)kg/m^(2),and 2(IQR:0-3),respectively,and 16(59.3%)patients were *** tumor size at computed tomography scan was 6.0(IQR:3.5-8.0)*** operative time and blood loss were 105(IQR:82-120)min and 175(IQR:94-250)mL,*** intraoperative complications were *** postoperative complications rate was 11.1%,with a postoperative transfusion rate of 3.7%.A total of 10(37.0%)patients harbored malignant adrenal *** them,3(11.1%)had adrenocortical carcinoma,6(22.2%)secondary metastasis,and 1(3.7%)malignant pheochromocytoma on final pathological *** 1(10.0%)patient had positive surgical *** We described our step-by-step technique for RA,which can be safely performed even in case of high challenging settings as malignant tumors,pheochromocytoma,and large *** standardization of perioperative protocol should be encouraged to maximize the outcomes of this complex surgical procedure.

关键词： Robotics Adrenalectomy Pheochromocytoma Malignant Surgical technique

HCV infection, B-cell non-Hodgkin's lymphoma and immunochemotherapy: Evidence and open questions

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World Journal of Gastrointestinal Oncology 2012年第3期4卷 46-53页

作者： maria Christina Cox maria Antonietta Aloe-Spiriti Elena Cavalieri eleonora Alma Elia Gigante Paola Begini Caterina Rebecchini Gianfranco Delle Fave Massimo Marignani Department of Haematology Sant'Andrea Hospital La Sapienza University Department of Gastroenterology and Liver Disease Sant'Andrea Hospital La Sapienza University

There is plenty of data confirming that hepatitis C virus (HCV) infection is a predisposing factor for a B-cell non-Hodgkin's lymphoma (B-NHL) outbreak, while relatively few reports have addressed the role of HCV in affecting B-NHL patients' outcome. HCV infection may influence the short-term outcome of B-NHL because of the emergence of severe hepatic toxicity (HT) during immunochemotherapy. Furthermore, the long term outcome of HCV-related liver disease and patients' quality of life will possibly be affected by Rituximab maintenance, multiple-lines of toxicity during chemotherapy and hematopoietic stem cell transplantation. In this review, data dealing with aggressive and low-grade B-NHL were separately analyzed. The few retrospective papers reporting on aggressive B-NHL patients showed that HCV infection is a risk factor for the outbreak of severe HT during treatment. This adverse event not infrequently leads to the reduction of treatment density and intensity. Existing papers report that low-grade B-NHL patients with HCV infection may have a more widespread disease, more frequent relapses or a lower ORR compared to HCV-negative patients. Notwithstanding, there is no statistical evidence that the prognosis of HCV-positive patients is inferior to that of HCV-negative subjects. HCV-positive prospective studies and longer follow-up are necessary to ascertain if HCV-positive B-NHL patients have inferior outcomes and if there are long term sequels of immunochemotherapies on the progression of liver disease.

关键词： Marginal zone lymphoma Diffuse large B cell lymphoma Hepatitis C virus Non-Hodgkin’s lymphomas Hepatotoxicity Chemotherapy Immunochemotherapy Prognosis Rituximab

Hypoxia inducible factor-1αaccumulation in steatotic liver preservation:Role of nitric oxide

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World Journal of Gastroenterology 2010年第28期16卷 3499-3509页

作者： Mohamed Amine Zaouali Ismail Ben Mosbah eleonora Boncompagni Hassen Ben Abdennebi maria Teresa Mitjavila Ramon Bartrons Isabel Freitas Antoni Rimola Joan Roselló-Catafau Experimental Hepatic Ischemia Reperfusion Unit Institut of Biomedical Research of BarcelonaSpanish National Research Council08036BarcelonaSpain Liver Transplantation and Graft Viability Unit August Pi i Sunyer Biomedical Research Institut08036Barcelona Spain Animal Biology Department Pavia University27100PaviaItaly Laboratory of Human Physiology Faculty of PharmacyUniversity of Monastir5000Monastir Tunisia Department of Physiology Faculty of BiologyUniversity of Barcelona08028BarcelonaSpain Physiological Sciences Department Bellvitge CampusInstitut of Biomedical Research of Bellvitge-Barcelona University08907BarcelonaSpain

AIM:To examine the relevance of hypoxia inducible factor(HIF-1)and nitric oxide(NO)on the preservation of fatty liver against cold ischemia-reperfusion injury(IRI). METHODS:We used an isolated perfused rat liver model and we evaluated HIF-1αin steatotic and non-steatotic livers preserved for 24 h at 4℃in University of Wisconsin and IGL-1 solutions,and then subjected to 2 h of normothermic *** normoxic reperfusion,liver enzymes,bile production,bromosulfophthalein clearance,as well as HIF-1αand NO[endothelial NO synthase(eNOS)activity and nitrites/nitrates]were also *** factors associated with the higher susceptibility of steatotic livers to IRI,such as mitochondrial damage and vascular resistance were evaluated. RESULTS:A significant increase in HIF-1αwas found in steatotic and non-steatotic livers preserved in IGL-1 after cold *** preserved in IGL-1 showed a significant attenuation of liver injury and improvement in liver function *** benefits were enhanced by the addition of trimetazidine(an antiischemic drug),which induces NO and eNOS activation, to IGL-1 *** normoxic reperfusion,the presence of NO favors HIF-1αaccumulation,promoting also the activation of other cytoprotective genes,such as hemeoxygenase-1. CONCLUSION:We found evidence for the role of the HIF-1α/NO system in fatty liver preservation,especially when IGL-1 solution is used.

关键词： Fatty liver Tissue preservation Hypoxia inducible factor-1α IGL-1 Nitric oxide Trimetazidine