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Calcium-sensitive protein MLC1 as a possible modulator of the astrocyte functional state

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Neural Regeneration Research 2025年第7期20卷 2008-2010页

作者： elena Ambrosini Angela Lanciotti maria Stefania Brignone Department of Neuroscience Istituto Superiore di SanitàRomeItaly

Astrocytes,the main population of glial cells in the central nervous system(CNS),exert essential tasks for the control of brain tissue homeostasis,supporting neuron and other glial cell activity from the developmental stage to adult *** maintain the optimal functionality of the brain,astroglial cells are particularly committed to reacting to every change in tissue homeostatic conditions,from mild modifications of the physiological environment,a process called astrocyte activation,to the more severe alterations occurring in pathological situations causing astrocyte reactivity or reactive astrogliosis(Escartin et al.,2021).During these reactive states,astrocytes mount an active,progressive response encompassing morphological,molecular,and interactional remodeling,leading to the acquisition of new functions and the loss of others,whose intensity,duration,and reversibility are dependent on the nature of the stimulus and regulated in a context-specific manner.

关键词： alterations modulator maintain

Recent developments in Boolean networks control

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Journal of Control and Decision 2016年第1期3卷 1-18页

作者： Ettore Fornasini maria elena Valcher Dipartimento di Ingegneria dell’Informazione Universitàdi PadovaPadovaItaly

The aim of this survey paper is to provide the state of the art of the research on control and optimal control of Boolean control networks,under the assumption that all the state variables are accessible and hence available for *** and sufficient conditions for stabilisability to a limit cycle or to an equilibrium point are ***,it is shown that when such conditions are satisfied,stabilisation can always be achieved by means of state *** results are obtained for the safe control problem that is investigated for the first time in this *** and infinite horizon optimal control are subsequently considered,and solution algorithms are provided,based on suitable adaptations of theRiccati difference and algebraic ***,an appropriate definition of the cost function allows to restate and to solve both stabilisation and safe control as infinite horizon optimal control problems.

关键词： Boolean control networks algebraic representation controllability stabilisation optimal control safe control

Hidden in plain sight:Morphological and phylogenetic evidence for Bouteloua arizonica,a species distinct from Bouteloua aristidoides(Poaceae,Chloridoideae)

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Plant Diversity 2021年第2期43卷 125-133页

作者： Luis Fernando Cuellar-Garrido maria elena Siqueiros-Delgado Herbario Luz maria Villarreal de Puga Del Instituto de Botanica(IBUG) Departamento de Botanica y ZoologíaCentro Universitario de Ciencias Biologicas y AgropecuariasUniversidad de GuadalajaraCamino Ing.Ramon Padilla Sanchez 2100CP 45200ZapopanJaliscoMexico Departamento de Biologia Centro de Ciencias BioasicasUniversidad Autonoma de AguascalientesAvenida Universidad 940CP 20131AguascalientesMexico

Two varieties of Bouteloua aristidoides have been recognized,the widespread *** and the more narrowly distributed *** two varieties differ in inflorescence form even more than that seen between many other closely related species of *** therefore asked whether these taxa might be better regarded as distinct species.A total of 93 vouchers were studied by using morphometry(principal components analysis and statistical tests),leaf micromorphology,ancestral state reconstruction,and/or molecular(ITS,trnC-rpoB and trnT-L-F)phylogenetic *** from the ITS tree,all results supported elevation of *** *** to the rank of species,thus the new combination Bouteloua arizonica(***)***&Columbus *** ***.,is *** and combined chloroplast-nuclear molecular trees depicted *** as monophyletic(even in sympatric populations with ***)and reveals phylogenetic structure within *** for which the presence of new undescribed varieties of ***(different from ***)is *** differs from *** in having fewer branches per inflorescence,a bigger branch with more spikelets,and a shorter branch *** electron microscopy revealed the presence of papillae on leaves of *** as a clear *** mature plants of *** from seeds in a greenhouse revealed a strong cleistogamous nature for this species for which gene flow in sympatric populations with *** seems unlikely.A taxonomic treatment and distribution map for identification of *** is provided.

关键词： Ancestral state reconstruction Bouteloua arizonica Cleistogamy Morphology Phylogeny Sympatry

Outpatient management of obscure gastrointestinal bleeding:A new perspective in high-risk patients

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World Journal of Gastroenterology 2024年第19期30卷 2502-2504页

作者： maria elena Riccioni Clelia Marmo Digestive Endoscopy Unit Fondazione Policlinico Universitario Agostino GemelliIRCCSUniversitàCattolica del Sacro CuoreLargo Agostino GemelliRome 00168Italy CEMAD Centro Malattie Dell’Apparato Digerente Fondazione Policlinico Universitario Agostino GemelliIRCCSUniversitàCattolica del Sacro CuoreLargo Agostino GemelliRome 00168Italy

Mid-gastrointestinal bleeding accounts for approximately 5%-10%of all gastrointestinal bleeding cases,and vascular lesions represent the most frequent *** rebleeding rate for these lesions is quite high(about 42%).We hereby recommend that scheduled outpatient management of these patients could reduce the risk of rebleeding episodes.

关键词： Gastrointestinal bleeding Small bowel bleeding Recurrent bleeding Rebleeding risk Rebleeding Outpatient management

Liposomes as immunological adjuvants and delivery systems in the development of tuberculosis vaccine:A review

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Asian Pacific Journal of Tropical Medicine 2022年第1期15卷 7-16页

作者： Nur Ellene Mat Luwi Suhana Ahmad Ahmad Suhaimi Nurfatihah Azlyna Asyikin Nordin maria elena Sarmiento Armando acosta Mohd Nor Norazmi Vuk Uskoković Rohimah Mohamud Ramlah Kadir Department of Immunology School of Medical SciencesUniversiti Sains Malaysia16150 Kubang KerianKelantanMalaysia School of Health Sciences Universiti Sains Malaysia16150 Kubang KerianKelantanMalaysia Department of Mechanical Engineering San Diego State UniversityCampanile Dr.5500San Diego 921982CAUSA TardigradeNano LLC IrvineCA 92604USA

Liposomes are phospholipid bilayer vesicles,which are biocompatible,biodegradable and nontoxic vehicles suitable for numerous drug and gene delivery *** this review,we discuss the prospect of using liposome technology in the development of a vaccine for *** remains an important health problem that requires the development of an effective vaccine,especially since the only approved vaccine for it continues to be the Bacille Calmette-Geurin(BCG)one developed 100 years *** review focuses on the different applications of liposomes toward achieving this *** liposomal formulations showing prospect in the research stage and in clinical trials are discussed.

关键词： Liposomes Tuberculosis vaccine Adjuvant Delivery system Tuberculosis

Selective intestinal decontamination for the prevention of early bacterial infections after liver transplantation

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World Journal of Gastroenterology 2016年第26期22卷 5950-5957页

作者： elena Resino Rafael San-Juan Jose maria Aguado Unit of Infectious Diseases 12 de Octubre University Hospital

Bacterial infection in the first month after liver transplantation is a frequent complication that poses a serious risk for liver transplant recipients as contributes substantially to increased length of hospitalization and hospital costs being a leading cause of death in this period. Most of these infections are caused by gramnegative bacilli, although gram-positive infections, especially Enterococcus sp. constitute an emerging infectious problem. This high rate of early postoperative infections after liver transplant has generated interest in exploring various prophylactic approaches to surmount this problem. One of these approaches is selective intestinal decontamination(SID). SID is a prophylactic strategy that consists of the administration of antimicrobials with limited anaerobicidal activity in order to reduce the burden of aerobic gram-negative bacteria and/or yeast in the intestinal tract and so prevent infections caused by these organisms. The majority of studies carried out to date have found SID to be effective in the reduction of gram-negative infection, but the effect on overall infection is limited due to a higher number of infection episodes by pathogenic enterococci and coagulase-negative staphylococci. However, difficulties in general extrapolation of the favorable results obtained in specific studies together with the potential risk of selection of multirresistant microorganisms has conditioned controversy about the routinely application of these strategies in liver transplant recipients.

关键词： Selective intestinal decontamination Liver transplant Infection Gram-negative bacterial infection Gram-positive bacterial infection Multirresistant

Dynamic contrast enhanced ultrasound in gastrointestinal diseases:A current trend or an indispensable tool?

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World Journal of Gastroenterology 2023年第25期29卷 4021-4035页

作者： Mattia Paratore Matteo Garcovich maria elena Ainora Laura Riccardi Antonio Gasbarrini maria Assunta Zocco Medicina Interna e Gastroenterologia CEMAD Digestive Disease CenterFondazione Policlinico Universitario A.Gemelli IRCCSRome 00168Italy Medicina Interna e Gastroenterologia CEMAD Digestive Disease CenterUniversità Cattolica del Sacro CuoreFondazione Policlinico Universitario A.Gemelli IRCCSRome 00168Italy

Contrast enhanced ultrasound(CEUS)has been widely implemented in clinical practice because of the enormous quantity of information it provides,along with its low cost,reproducibility,minimal invasiveness,and safety of the secondgeneration ultrasound contrast *** overcome the limitation of CEUS given by the subjective evaluation of the contrast enhancement behaviour,quantitative analysis of contrast kinetics with generation of time-intensity curves has been introduced in recent *** quantification of perfusion parameters[named as dynamic-CEUS(D-CEUS)]has several applications in gastrointestinal neoplastic and inflammatory ***,the limited availability of large studies and the heterogeneity of the technologies employed have precluded the standardisation of D-CEUS,which potentially represents a valuable tool for clinical practice in management of gastrointestinal *** this article,we reviewed the evidence exploring the application of D-CEUS in gastrointestinal diseases,with a special focus on liver,pancreas,and inflammatory bowel diseases.

关键词： Quantitative perfusion analysis Gastrointestinal diseases Time-intensity curve Multiparametric ultrasound

A comparative study of Epipactis atrorubens in two different forest communities of the Middle Urals, Russia

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Journal of Forestry Research 2020年第6期31卷 2111-2120页

作者： elena Filimonova Natalia Lukina Margarita Glazyrina Galina Borisova Tripti Adarsh Kumar maria Maleva Laboratory of Anthropogenic Dynamics of Ecosystems Ural Federal UniversityEkaterinburgRussia 620002 Department of Experimental Biology and Biotechnology Ural Federal UniversityEkaterinburgRussia 620002

The objective of this study was to compare ecophysiological and morphological parameters of a regionally endangered orchid species,Epipactis atrorubens(*** Bernh.)Bess.,growing in two forest communities(on serpentine and granite outcrops)of the Middle Urals,***,dominance,and phytocoenosis studies showed the colonization of a wide range of plant species on both *** physicochemical properties of the soil,chemical composition and morphological features of ***,growing under technogenic conditions(asbestos deposits),on serpentine outcrops and in the natural environment of the granite massif were studied for the first *** serpentine substrate differed from the granite one by its greater stoniness,circumneutral pH and lower contents of available nitrogen and *** high concentrations of magnesium were found in the serpentine soil,some 79 times higher than in the granite *** concentrations of nickel(94 times),chromium(59 times),cobalt(17 times),and iron(4 times)were found in the serpentine substrate,higher than in the granite *** differences between the sites for available metal contents and for root and shoot metal contents were significantly *** of most of the metals in the roots were higher than in the *** higher metal concentrations and lower nitrogen and phosphorus levels in serpentine soils,*** had a larger population and greater viability compared to those growing on *** on serpentine outcrops were characterized by the formation of a larger number of fruits,greater root lengths and thicker leaf blades,compared to plants on *** well-developed orchid mycorrhizae contributed to the survival of this species under unfavorable serpentine ***,serpentine outcrops formed due to the mining of asbestos could be a suitable substrate for the light-demanding *** due to its capacity to adapt to dry,rocky,nutrient-depleted soils a

关键词： Orchids Forest phytocoenosis Serpentine Granite Metal accumulation

Trends in tropospheric ozone concentrations and forest impact metrics in Europe over the time period 2000–2014

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Journal of Forestry Research 2021年第2期32卷 543-551页

作者： Chiara Proietti maria Francesca Fornasier Pierre Sicard Alessandro Anav elena Paoletti Alessandra De Marco Italian Institute for Environmental Protection and Research(ISPRA) via Brancati 4800144 RomeItaly ARGANS 260 route du Pin Montard06410 BiotFrance Italian National Agency for New Technologies Energy and the EnvironmentC.R.Casaccia00123 RomeItaly IRET-CNR Via Madonna del Piano 10Florence50019 Sesto FiorentinoItaly

In Europe,tropospheric ozone pollution appears as a major air quality issue,and ozone concentrations remain potentially harmful to *** this study we compared the trends of two ozone metrics widely used for forests protection in Europe,the AOT40(Accumulated Ozone over Threshold of 40 ppb)which only depends on surface air ozone concentrations,and the Phytotoxic Ozone Dose which is the accumulated ozone uptake through stomata over the growing season,and above a threshold Y of uptake(PODY).By using a chemistry transport model,we found that European-averaged ground-level ozone concentrations(−2%)and AOT40 metric(−26.5%)significantly declined from 2000 to 2014,due to successful control strategies to reduce the emission of ozone precursors in Europe since the early *** contrast,the stomatal ozone uptake by forests increased from 17.5 to 26.6 mmol O3 m^(−2)despite the reduction in ozone concentrations,leading to an increase of potential ozone damage on plants in *** a climate change context,a biologically-sound stomatal flux-based standard(PODY)as new European legislative standard is needed.

关键词： Tropospheric ozone AOT40 POD Trendm Mann-Kendall test