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Influence of the rainfall in the content of nutrients in litter in agroforestry systems managed with burning and without burning in Amazon

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Agricultural Sciences 2013年第11期4卷 26-36页

作者： Rosecélia Moreira Da Silva Castro maria de lourdes pinheiro ruivo Jorge Luiz Piccinin Eraldo Ferreira Rodrigues Brazilian Company of Agricultural Research Statistical Department Belém Brasil Emilio Goeldi Pará Museum Coordination of Earth Sciences and Ecology Belém Brasil Federal University of Rural Amazonia Institute Sciences Agricultural Belém Brasil

This study evaluated the nutrient content of the litter, testing different treatments with burning and no burning, of the vegetation, to identify which one provides better efficiency in operation and production of nutrients in different seasonal conditions. The study area is located on the property of the family farmer, initially selected by a diagnosis socioeconomic, community Benjamin Constant, in northeastern Para. Litter was collected during two periods: dry season (November) and rainy (March) in 2009. For the collection of litter samples, we used collectors measuring (0.25 × 0.25 m2), which were placed directly on the soil surface. The collected material was stored in paper bags and taken to the laboratory for Chemical Analysis of the Brazilian Agricultural Research Corporation (EMBRAPA), which was determined by analyses of macronutrients (N, P, K, Ca, Mg, Na) and micronutrients (Fe, Cu, Mn, Zn). The highest concentrations of macronutrients were found in N for agroforestry systems with and without burning in two seasons (wet and dry). All macronutrients showed influence of seasonality, which was verified by the wide variation in nutritional behavior. The decreasing concentration of nutrients was presented N > Ca > Mg > Na > K > P in agroforestry system with burning, with maximum values of all nutrients in the rainy season, and N, P, K, Ca, Na in higher concentrations in agroforestry system without burning, and showed only the Mg peak in agroforestry system with burning. The behavior of the concentration of nutrients was opposite to that observed one, for all elements analyzed showed a reduction in the concentrations of nutrients in the dry season. The decreasing concentration of nutrients was presented Fe > Mn > Zn > Cu.

关键词： Forest Management Ecosystem Seasonality Litterfall

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designing Artemisinins with Antimalarial Potential, Combining Molecular Electrostatic Potential, Ligand-Heme Interaction and Multivariate Models

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Computational Chemistry 2023年第1期11卷 1-23页

作者： Josué de Jesus Oliveira Araújo Ricardo Morais de Miranda Jeferson Stiver Oliveira de Castro Antonio Florêncio de Figueiredo Ana Cecília Barbosa pinheiro Sílvia Simone dos Santos Morais Marcos Antonio Barros dos Santos Andréia de lourdes Ribeiro pinheiro Andréia de lourdes Ribeiro pinheiro Fábio dos Santos Gil Heriberto Rodrigues Bitencourt Gustavo Nery Ramos Alves José Ciríaco pinheiro Laboratório de Química Teórica e Computacional Universidade Federal do Pará Belém PA Brasil Instituto Federal de Educaç &atilde o Ciência e Tecnologia do Pará Belém PA Brasil Universidade do Estado do Amapá Macapá AP Brasil Fundaç &atilde o Santa Casa de Misericórdia do Pará Belém PA Brasil Universidade do Estado do Pará Barcarena PA Brasil departamento de Biologia Universidade do Estado do Maranh&atilde o S&atilde o Luís MA Brasil Laboratório de Síntese Organica Universidade Federal do Pará Belém PA Brasil

Artemisinins tested against W-2 strains of malaria falciparum are investigated with molecular electrostatic potential (MEP), in an attempt to identify key features of the compounds that are necessary for their activities, as well as to investigate likely interactions with the receptor in a biological process and to use that information to propose new molecules. In order to discover the best geometry involving the ligand-receptor complexes (heme) studied and help in the proposition of the new derivatives, molecular simulations of interactions between the most negative charged region around the peroxide and heme locates (the ones around the Fe2+ ion) were carried out. In addition, PCA (principal components analysis), HCA (hierarchical cluster analysis), SDA (stepwise discriminant analysis), and KNN (K-nearest neighbor) multivariate models were employed to investigate which descriptors are responsible for the classification between the higher and lower antimalarial activity of the compounds, and also this information was used to propose new potentially active molecules. The information accumulated in studies of MEP, molecular docking, and multivariate analysis supported the proposal of new structures with potential antimalarial activities. The multivariate models constructed were applied to the new structures and indicated numbers 19 and 20 as the most prominent for syntheses and biological assays.

关键词： Artemisinins Antimalarial Potential Molecular Electrostatic Potential Ligand-Heme Interaction Multivariate Models

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Real-world treatment patterns and disease control over one year in patients with inflammatory bowel disease in Brazil

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World Journal of Gastroenterology 2021年第23期27卷 3396-3412页

作者： Ligia Yukie Sassaki Sender J Miszputen Roberto Luiz Kaiser Junior Wilson R Catapani Mauro Bafutto António S Scotton Cyrla Zaltman Julio pinheiro Baima Hagata S Ramos Mikaell Alexandre Gouvea Faria Carolina D Gonçalves Isabella Miranda Guimaraes Cristina Flores Heda M B S Amarante Rodrigo Bremer Nones JoséMiguel Luz Parente Murilo Moura Lima Júlio maria Chebli maria de lourdes Abreu Ferrari Julia F Campos maria G P Sanna Odery Ramos Rogério Serafim Parra Jose J R da Rocha Omar Feres Marley R Feitosa Rosana Fusaro Caratin Juliana Tosta Senra Genoile Oliveira Santana department of Internal Medicine Botucatu Medical School at Sao Paulo State University(UNESP)Botucatu 18618-687São PauloBrazil department of Gastroenterology Escola Paulista de MedicinaSao PauloSão Paulo 18618-687São PauloBrazil department of Proctology Kaiser Day HospitalSão Jose do Rio Preto 15015-110São PauloBrazil department of Gastroenterology Faculdade de Medicina do ABCSanto Andre 09060-870São PauloBrazil department of Gastroenterology Faculdade de MedicinaGoiania 74535-170GoiásBrazil department of Gastroenterology CMIP Centro Mineiro de PesquisaJuiz de Fora 36010-570Minas GeraisBrazil department of Internal Medicine Federal University of Rio de JaneiroRio de Janeiro 21941-913Rio de JaneiroBrazil department of Gastroenterology Escola Paulista de MedicinaSão Paulo 04023-900São PauloBrazil Hospital de Clínicas de Porto Alegre Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Hospital de Clinicas da Universidade Federal do Paraná Hospital de Clinicas da Universidade Federal do ParanáCuritiba ParanáParanáBrazil Gastroenterology department Hospital Nossa Senhora das GraçasCuritiba 80810-040ParanáBrazil department of General Medicine Universidade Federal do PiauíTeresina 64049-550PiauíBrazil Gastroenterology Hospital Universitario da Universidade Federal do PiauiTeresina 64049-550PiauíBrazil department of Medicine University Hospital of Federal University of Juiz de ForaJuiz de ForaJuiz de Fora 36036-247Minas GeraisBrazil department of Clinical Medicine Universidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Hospital de Clinicas da Universidade Federal do Paraná Hospital de Clinicas da Universidade Federal do ParanáCuritiba 80060-900ParanáBrazil department of Surgery and Anatomy Ribeirao Preto Medical SchoolUniversity of Sao PauloRibeirão Preto 14048-900São PauloBrazil Scientific Affairs Takeda Pharmaceuticals BrazilSao Paulo 04709-011Brazil Clinical Research Takeda PharmaceuticalsSão Paulo 04709-011Sã

BACKGROUND Crohn’s disease(CD)and ulcerative colitis(UC)are inflammatory bowel diseases(IBDs)with a remission-relapsing presentation and symptomatic exacerbations that have detrimental impacts on patient quality of life and are associated with a high cost burden,especially in patients with moderate-to-severe *** Real-world Data of Moderate-to-Severe Inflammatory Bowel Disease in Brazil(RISE BR)study was a noninterventional study designed to evaluate disease control,treatment patterns,disease burden and health-related quality of life in patients with moderate-to-severe active *** report findings from the prospective follow-up phase of the RISE BR study in patients with active UC or *** To describe the 12-mo disease evolution and treatment patterns among patients with active moderate-to-severe IBD in *** This was a prospective,noninterventional study of adult patients with active Crohn’s disease(CD:Harvey-Bradshaw Index≥8,CD Activity Index≥220),inadequate CD control(i.e.,calprotectin>200μg/g or colonoscopy previous results),or active ulcerative colitis(UC:Partial Mayo score≥5).Enrollment occurred in 14 centers from October 2016 to February *** proportion of active IBD patients after 9-12 mo of follow-up,Kaplan-Meier estimates of the time to mild or no activity and a summary of treatment initiation,discontinuation and dose changes were *** The study included 118 CD and 36 UC patients,with mean±SD ages of 43.3±12.6 and 44.9±16.5 years,*** most frequent drug classes at index were biologics for CD(62.7%)and 5-aminosalicylate derivates for UC patients(91.7%).During follow-up,65.3%of CD and 86.1%of UC patients initiated a new treatment at least ***/dose changes occurred in 68.1%of CD patients[median 2.0(IQR:2-5)]and 94.3%of UC patients[median 4.0(IQR:3-7)].On average,CD and UC patients had 4.4±2.6 and 5.0±3.3 outpatient visits,*** median time to first mild or no activity was 319(IQR:239-3

关键词： Crohn’s disease Ulcerative colitis Inflammatory bowel diseases Prospective study

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