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Immune response against HBsAg vaccine

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World Journal of Gastroenterology 1998年第6期4卷 9-11页

作者： maria cristina Honorati and Andrea Facchini

ＨｅｐａｔｉｔｉｓＢｖｉｒｕｓ（ＨＢＶ）ｉｓａｈｅｐａｄｎａｖｉｒｕｓｗｈｉｃｈｃａｎｃａｕｓｅｓｙｓｔｅｍｉｃｉｎｆｅｃｔｉｏｎａｎｄｈｅｐａｔｏｃｅｌｕｌａｒｄａｍａｇｅｉｎｈｕｍａｎｓ．Ｉｎｆｅｃｔｉｏｎｉｓａ... 详细信息

ＨｅｐａｔｉｔｉｓＢｖｉｒｕｓ（ＨＢＶ）ｉｓａｈｅｐａｄｎａｖｉｒｕｓｗｈｉｃｈｃａｎｃａｕｓｅｓｙｓｔｅｍｉｃｉｎｆｅｃｔｉｏｎａｎｄｈｅｐａｔｏｃｅｌｕｌａｒｄａｍａｇｅｉｎｈｕｍａｎｓ．Ｉｎｆｅｃｔｉｏｎｉｓａｃｑｕｉｒｅｄｔｈｒｏｕｇｈｃｏｎ...

关键词： rHBsAg hepatitis B vaccines vaccination

Investigating local corrosion processes of magnesium alloys with scanning probe electrochemical techniques: A review

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Journal of Magnesium and Alloys 2022年第11期10卷 2997-3030页

作者： Mara cristina Lopes de Oliveira Rejane maria Pereira da Silva Ricardo M.Souto Renato Altobelli Antunes Federal University of ABC Center for EngineeringModeling and Applied Social SciencesAv.Dos Estados500109210-580Santo AndréSP Brazil Instituto de Pesquisas Energéticas e Nucleares IPEN/CNENAv.Prof.Lineu Prestes2242São PauloBrazil Institute of Material Science and Nanotechnology University of La LagunaP.O.Box 456La LagunaTenerife 38200Spain

The study of corrosion of magnesium and its alloys has emerged a hot topic in the applications of lightweight structural materials. The inherently high electrochemical activity of bare magnesium surfaces still lacks a convincing mechanism to describe the observed experimental characteristics, and it has prompted the development of various types of protective coatings with the aim of slowing metal dissolution. In recent years, new instruments and techniques have been developed to study with spatial resolution the local corrosion processes that occur in metallic materials in general, and for magnesium and its alloys in particular, both for bare surfaces and coated. Scanning microelectrochemical techniques, such as local electrochemical impedance spectroscopy(LEIS), scanning electrochemical microscopy(SECM), scanning vibrating electrode technique(SVET), scanning ion-selective electrode technique(SIET) and scanning Kelvin probe(SKP) can provide information about the local electrochemical activity of metallic surfaces. In the present work, the applications of these techniques in corrosion studies of magnesium and its alloys are reviewed. Assessment of corrosion mechanisms, barrier properties of conventional coatings and active corrosion behavior of self-healing coatings are examined. Limitations and future developments in this area are discussed.

关键词： Magnesium alloys LEIS SECM SVET SIET SKP

Hepatocellular carcinoma after direct-acting antiviral hepatitis C virus therapy:A debate near the end

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World Journal of Gastroenterology 2020年第43期26卷 6770-6781页

作者： cristina maria Muzica Carol Stanciu Laura Huiban Ana-maria Singeap Catalin Sfarti Sebastian Zenovia Camelia Cojocariu Anca Trifan Department of Gastroenterology Grigore T.Popa University of Medicine and PharmacySt.Spiridon Emergency HospitalIasi 700115Romania

Direct acting antivirals(DAAs)have revolutionized the treatment of hepatitis C virus(HCV)infection,achieving high rates(≥95%)of sustained virological response,with a good safety profile and high compliance ***,it had been expected that viral clearance will reduce morbidity and mortality rates,as well as the risk of hepatocellular carcinoma(HCC).However,since 2016,concerns have been raised over an unexpected high rate of HCC occurrence and recurrence after DAA therapy,which led to an avalanche of studies with contradictory *** aimed to review the most recent and relevant articles regarding the risk of HCC after DAA treatment and identify the associated risk factors.

关键词： Hepatocellular carcinoma Direct acting antivirals therapy Hepatitis C virus infection Sustained virological response Risk factors of hepatocellular carcinoma Review

Gastrointestinal manifestations in myotonic muscular dystrophy

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World Journal of Gastroenterology 2006年第12期12卷 1821-1828页

作者： Massimo Bellini Sonia Biagi cristina Stasi Francesco Costa maria Gloria Mumolo Angelo Ricchiuti Santino Marchi Gastroenterology Unit Department of Internal MedicineUniversity of PisaItaly

Myotonic dystrophy （MD） is characterized by myotonic phenomena and progressive muscular weakness. Involvement of the gastrointestinal tract is frequent and may occur at any level. The clinical manifestations have previously been attributed to motility disorders caused by smooth muscle damage, but histologic evidence of alterations has been scarce and conflicting. A neural factor has also been hypothesized. In the upper digestive tract, dysphagia, heartburn, regurgitation and dyspepsia are the most common complaints, while in the lower tract, abdominal pain, bloating and changes in bowel habits are often reported. Digestive symptoms may be the first sign of dystrophic disease and may precede the rnusculo-skeletal features. The impairment of gastrointestinal function may be sometimes so gradual that the patients adapt to it with little awareness of symptoms. In such cases routine endoscopic and ultrasonographic evaluations are not sufficient and targeted techniques （electrogastrography, manornetry, electromyography, functional ultrasonography, scintigraphy, etc.） are needed. There is a low correlation between the degree of skeletal muscle involvement and the presence and severity of gastrointestinal disturbances whereas a positive correlation with the duration of the skeletal muscle disease has been reported. The drugs recommended for treating the gastrointestinal complaints such as prokinetic, antidyspeptic drugs and laxatives, are mainly aimed at correcting the motility disorders. Gastrointestinal involvement in MD remains a complex and intriguing condition since many important problems are still unsolved. Further studies concentrating on genetic aspects, early diagnostic techniques and the development of new therapeutic strategies are needed to improve our management of the gastrointestinal manifestations of MD.

关键词： Myotonic dystrophy Digestive disorders Gastrointestinal symptoms

COVID-19 ocular findings in children: a case series

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World Journal of Pediatrics 2021年第3期17卷 329-334页

作者： Celia Fernandez Alcalde maria Granados Fernandez maria Nieves Moreno cristina Calvo Rey Iker Fakes Romero Susana Noval Martin Department of Ophthalmology Hospital Universitario La PazPaseo de la Castellana 26128046 Madrid28046 MadridMadridEspana Paediatric and Infectious Diseases Department Hospital Universitario La Paz and Fundacion IdipazMadridSpain Translational Research Network in Pediatric Infectious Diseases(RITIP) MadridSpain Microbiology and Parasitology Department Hospital Universitario La PazMadridSpain Universidad Autonoma de Madrid MadridSpain

Children account for 1%of cases of COVID-19 in most published series,with significantly reduced risk of developing severe forms of disease or death[1-3].Because most children present with mild forms of acute respiratory infections,interest has been focused initially on children with underly-ing/comorbid diseases and concentrated rare fatalities[1,4].

关键词： acute ocular respiratory

SmartFlare^(TM) is a reliable method for assessing mRNA expression in single neural stem cells

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World Journal of Stem Cells 2021年第12期13卷 1918-1927页

作者： Andrea Diana maria Dolores Setzu Zaal Kokaia Roxana Nat cristina Maxia Daniela Murtas Department of Biomedical Sciences University of CagliariMonserrato 09042CagliariItaly Laboratory of Stem Cells&Restorative Neurology Lund Stem Cell CenterLund UniversityLund SE-22184LundSweden Institute of Neuroscience Medical University of InnsbruckInnsbruck 6020Austria

BACKGROUND One of the most challenging tasks of modern biology concerns the real-time tracking and quantification of mRNA expression in living *** this matter,a novel platform called SmartFlare^(TM) has taken advantage of fluorophore-linked nanoconstructs for targeting RNA *** fluorescence emission does not account for the spatial mRNA distribution,NanoFlare technology has grown a range of theranostic applications starting from detecting biomarkers related to diseases,such as cancer,neurodegenerative pathologies or embryonic developmental *** To investigate the potential of SmartFlare^(TM) in determining time-dependent mRNA expression of prominin 1(CD133)and octamer-binding transcription factor 4(OCT4)in single living cells through *** Brain fragments from the striatum of aborted human fetuses aged 8 wk postconception were processed to obtain *** the in vitro differentiation,neurospheres were gently dissociated with Accutase *** cells were resuspended in a basic medium enriched with fetal bovine serum,plated on poly-L-lysine-coated glass coverslips,and grown in a lapse of time from 1 to 4 *** cell mRNA detection was performed using SmartFlare^(TM) probes(CD133,Oct4,Actin,and Scramble).All the samples were incubated at 37°C for 24 *** nuclear staining,Hoechst 33342 was ***^(TM) CD133-and OCT4-specific fluorescence signal was assessed using a semiquantitative visual approach,taking into account the fluorescence intensity and the number of labeled *** In agreement with previous PCR experiments,a unique expression trend was observed for CD133 and OCT4 genes until 7 d in vitro(DIV).Fluorescence resulted in a mixture of diffuse cytoplasmic and spotted-like pattern,also detectable in the contacting neural *** 15 to 30 DIV,only few cells showed a scattered fluorescent pattern,in line with the differentiation progression and coherent with mRNA downregulation of

关键词： mRNA detection SmartFlareTM NanoFlare Live staining Nanotechnology Neural stem cell genes

Effect of the addition of different sodium alginates on viscoelastic,structural features and hydrolysis kinetics of corn starch gels

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Food Bioscience 2022年第3期47卷 271-278页

作者： Leticia Montes maria Santamaria Raquel Garzon cristina M.Rosell Ramón Moreira Department of Chemical Engineering Universidade de Santiago de Compostelarúa Lope Gómez de Marzoas/n15782Santiago de CompostelaSpain Institute of Agrochemistry and Food Technology (IATA-CSIC).C/Agustin Escardino 746980PaternaSpain

Corn starch gels(1:4 w:w)were made with the addition(up to 2%w/w starch basis)of sodium alginates of different average molecular sizes and *** of the starchy gels were characterized to evaluate their *** were subjected to in vitro digestion to estimate the effect of alginates addition on glycemic *** alginates significantly decreased the value of the elastic modulus of *** coordination number obtained from complex modulus indicated that in general,less compact structures were obtained in the presence of *** results were confirmed by scanning electron micrographs,where significant differences in the structure of alginate-corn starch gels were observed,but molecular size of alginates was not *** rate decreased with the presence of alginates in corn starch gels by interactions of alginates with leached *** high alginate content,slower hydrolysis rates were determined when the most hygroscopic alginates were added.

关键词： Biopolymers In vitro digestion Average molecular weight Rheology Scanning electron microscopy(SEM)

Pain assessment and management in the newborn:A systematized review

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World Journal of Clinical Cases 2021年第21期9卷 5921-5931页

作者： maria Teresa Garcia-Rodriguez Sergio Bujan-Bravo Rocio Seijo-Bestilleiro cristina Gonzalez-Martin Research in Nursing and Health Care Institute of Biomedical Research of A Coruña(INIBIC)Complexo Hospitalario Universitario de A Coruña(CHUAC)SERGASAs Xubias 8415006 A Coruña Universidade da Coruña(UDC)A Coruña 15006Spain Health Sciences Complexo Hospitalario Universitario de A CoruñaA Coruña 15006Spain

BACKGROUND Neonatal pain has been underdiagnosed due to several false *** To determine the status of neonatal pain in newborns who are admitted to intensive care *** Different databases were *** reviews and research reports conducted in newborns that were written in English,Spanish,or Portuguese,published between 2010 and 2020,and having free access to the full text were selected.A total of 135 articles were found,and 18 articles were finally *** Newborns are exposed to numerous painful *** order to assess their pain levels,several scales have been used,although they are sometimes not correctly *** terms of pain management,the nursing team plays a very important role based mainly on both pharmacological and non-pharmacological *** Nursing staff members must be well trained in order to identify pain and to interpret the scales ***,they have an important role in performing non-pharmacological procedures for pain management.

关键词： Neonatal pain Intensive care unit Nursing Management Treatment Systematized review

Goal-directed therapy in intraoperative fluid and hemodynamic management

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The Journal of Biomedical Research 2013年第5期27卷 357-365页

作者： maria cristina Gutierrez Peter G.Moore Hong Liu Department of Anesthesiology and Pain Medicine University of California Davis Health System

Intraoperative fluid management is pivotal to the outcome and success of surgery, especially in high-risk proce- dures. Empirical formula and invasive static monitoring have been traditionally used to guide intraoperative fluid management and assess volume status. With the awareness of the potential complications of invasive procedures and the poor reliability of these methods as indicators of volume status, we present a case scenario of a patient who underwent major abdominal surgery as an example to discuss how the use of minimally invasive dynamic monitoring may guide intraoperative fluid therapy.

关键词： high-risk surgery hemodynamic fluid monitoring goal-directed therapy