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Occurrence and patterns of nutritional traits and polycyclic aromatic hydrocarbons(PAHs)in sea cucumber(Holothuria poli)tissues:benefits and risk for human health

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Food Quality and Safety 2022年第2期6卷 287-309页

作者： Francesca Biandolino Isabella Parlapiano Lucia Spada Antonella Di Leo maria calo Giovanni Fanelli Ermelinda Prato Santina Giandomenico CNR-IRSA National Research CouncilWater Research Institute--Via Roma 3TarantoItaly

Objectives:The paper evaluates the benefit and risk for human health associated with consumption of sea cucumber Holothuria poli(H.polil from Italian coasts(Central Mediterranean Sea).Materials and Methods:Body wall(BW),internal tunic(ITu),muscle bands(MBs),alimentary canal(AC),gonad(Gd),and respiratory tree(RT)of H.polii were analyzed for proximate composition.Moreover,amino acids(AAs),fatty acids(FAs)and polycyclic aromatic hydrocar bons(PAHs)were determined with high-performance liquid chromatography coupled with ultraviolet-visible spectroscopy(UPLC UV/Vis),gas chromatography-flame ionization detector(GC-FID)and gas chromatography mass spectrometry(GC-MS),respectively.Results:Differences in the contents of total amino acids(TAAs)occurred based on tissue and sex,with AC and MB of female and Gd of male showing higher contents(range 47.8-60.2 g/kg we weight(ww)).Glycine and glutamic acid were the most abundant.Polyunsaturated fatty acid(PUFA)was the major class of FAs and arachidonic acid and eicosapentenoic acid(EPA)were the predominant PUFA.n-3 PUFA showed higher content in Gd,AC,and RT,indicating higher quality.A favorable n-3/n-6 in the range of 1.04-1.67 was observed.PAHs showed values ranging from 23 to 207μg/kg ww with the highest levels in Gd and AC tissues and the lower in BW.Benzo[alpyrene,the most toxic compound,was detected in all tissues,of both sexes,at levels of 1.5-18μg/kg ww.Conclusion:All tissues of H.poli,although with differences among them,are valuable food and can contribute for a healthy diet.Excess cancer risk(CR)values for Gd and AC tissues were above the considerable CR threshold of one in 10000 established by the United States Environmental Protection Agency(USEPA)for high ingestion rate of this seafood.

关键词： Holothuria poli,nutitional quality polycyclic aromatic hydrocarbons risk assessment estimated weekly intake cancer risk

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Omega 3 and atrial fibrillation:Where are we?

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World Journal of Cardiology 2016年第2期8卷 114-119页

作者： Annamaria Martino Laura Pezzi Roberta Magnano Elisa Salustri maria Penco Leonardo calo' Division of Cardiology Policlinico Casilino Department of Cardiovascular RespiratoryNephrologic and Geriatrics SciencesUmberto I HospitalSapienza University Department of Cardiology University of l’Aquila

Anti-arrhythmic properties of n-3 polyunsaturated fatty acids, at least in part mediated by anti-oxidant, anti-inflammatory and anti-fibrotic power, have been widely proved. Effect of fish oil on atrial fibrillation, both in primary and in secondary prevention and after cardiac surgery, are controversial, mostly due to lack of homogeneity between studies but also due to individual variability in response to fatty acids administration. Inclusion of measurement of incorporation of fish oil into cell membranes, appears to be essential in future studies, to assess their antiarrhythmic effect.

关键词： N-3 polyunsaturated fatty acids Atrial fibrillation Upstream therapy Omega-3 index Cardiac surgery

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Thermodynamics of clayedrug complex dispersions: Isothermal titration calorimetry and high-performance liquid chromatography

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Journal of Pharmaceutical Analysis 2020年第1期10卷 78-85页

作者： Ana-maria Totea Juan Sabin Irina Dorin Karl Hemming Peter R.Laity Barbara R.Conway Laura Waters Kofi Asare-Addo School of Applied Sciences Department of PharmacyUniversity of HuddersfieldQueensgateHuddersfieldHD13DHUK AFFINImeter Edificio EmprendiaCampus VidaSantiago de CompostelaSpain Malvern Panalytical Ltd. MalvernUK School of Applied Sciences Department of ChemistryUniversity of HuddersfieldQueensgateHuddersfieldHD13DHUK Department of Materials Science and Engineering University of SheffieldSir Robert Hadfield BuildingMappin StreetSheffieldS13JDUK

An understanding of the thermodynamics of the complexation process utilized in sustaining drug release in clay matrices is of great importance.Several characterisation techniques as well as isothermal calorimetry were utilized in investigating the adsorption process of a model cationic drug(diltiazem hydrochloride,DIL)onto a pharmaceutical clay system(magnesium aluminium silicate,MAS).X-ray powder diffraction(XRPD),attenuated total reflectance Fourier transform infrared spectroscopy(ATRFTIR)and optical microscopy confirmed the successful formation of the DIL-MAS complexes.Drug quantification from the complexes demonstrated variable behaviour in the differing media used with DIL degrading to desacetyl diltiazem hydrochloride(DC-DIL)in the 2 M HCl media.Here also,the authors report for the first time two binding processes that occurred for DIL and MAS.A competitor binding model was thus proposed and the thermodynamics obtained suggested their binding processes to be enthalpy driven and entropically unfavourable.This information is of great importance for a formulator as care and consideration should be given with appropriate media selection as well as the nature of binding in complexes.

关键词： Clay-drug complex dispersions Magnesium aluminium silicate Diltiazem hydrochloride Isothermal titration calorimetry High performance liquid chromatography

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Comparison of partners-heart failure algorithm vs care alert in remote heart failure management

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World Journal of Cardiology 2015年第12期7卷 922-930页

作者： Leonardo calo’ Annamaria Martino Claudia Tota Alessandro Fagagnini Renzo Iulianella Marco Rebecchi Luigi Sciarra Giuseppe Giunta maria Grazia Romano Roberto Colaceci Antonio Ciccaglioni Fabrizio Ammirati Ermenegildo de Ruvo Division of Cardiology Policlinico Casilino Cardiovascular RespiratoryNephrologic and Geriatrics Sciences DepartmentUmberto I HospitalSapienza University of Rome Department of Cardiology G.B. Grassi Hospital

AIM: To compare the utility of the partners-heart failure(HF) algorithm with the care alert strategy for remote monitoring,in guiding clinical actions oriented to treat impending HF.METHODS: Consecutive cardiac resynchronizationdefibrillator recipients were followed with biweekly automatic transmissions. After every transmission,patients received a phone contact in order to check their health status,eventually followed by clinical actions,classified as "no-action","non-active" and "active". Active clinical actions were oriented to treat impending HF. The sensitivity,specificity,positive and negative predictive values and diagnostic accuracy of the partners-HF algorithm vs care alert in determining active clinical actions oriented to treat pre-HF status and to prevent an acute decompensation,were also calculated.RESULTS: The study population included 70 patients with moderate to advanced systolic HF and QRS duration longer than 120 ms. During a mean follow-up of 8 ± 2 mo,665 transmissions were collected. No deaths or HF hospitalizations occurred. The sensitivity and specificity of the partners-HF algorithm for active clinical actions oriented to treat impending HF were 96.9%(95%CI: 0.96-0.98) and 92.5%(95%CI: 0.90-0.94) respectively. The positive and negative predictive values were 84.6%(95%CI: 0.82-0.87) and 98.6%(95%CI: 0.98-0.99) respectively. The partners-HF algorithm had an accuracy of 93.8%(95%CI: 0.92-0.96) in determining active clinical actions. With regard to active clinical actions,care alert had a sensitivity and specificity of 11.05%(95%CI: 0.09-0.13) and 93.6% respectively(95%CI: 0.92-0.95). The positive predictive value was 42.3%(95%CI: 0.38-0.46); the negative predictive value was 71.1%(95%CI: 0.68-0.74). Care alert had an accuracy of 68.9%(95%CI: 0.65-0.72) in determining active clinical actions.CONCLUSION: The partners-HF algorithm proved higher accuracy and sensitivity than care alert in determining active clinical actions oriented to treat impending HF. Future studies in larger populations shoul

关键词： Heart failure Cardiac resynchronization therapy Defibrillators Remote monitoring

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