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The Adverse Event Profile in Patients Treated with Transferon<sup>TM</sup>(Dialyzable Leukoc.te Extrac.s): A Preliminary Report

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Pharmac.logy & Pharmac. 2015年第2期6卷 65-74页

作者： Toni Homberg Violeta Sáenz Jorge Galic.a-c.rreón Iván Lara Edgar c.rvantes-Trujano maria c. andaluz Erika Vera Osc.r Pineda Julio Ayala-Balboa Alejandro Estrada-Garc.a Sergio Estrada-Parra Mayra Pérez-Tapia maria c. Jiménez-Martínez c.inic.l Trials Branc. and c.inic.l Immunology Servic. Unit of External Services and Clinical Research (USEIC) National School of Biological Sciences National Polytechnic Institute Mexico City Mexico Unit of Pharmac.vigilanc. Unit of External Services and Clinical Research (USEIC) National School of Biological Sciences National Polytechnic Institute Mexico City Mexico Department of Immunology National School of Biological Sciences National Polytechnic Institute Mexico City Mexico Unit of R&D in Bioproc.sses (UDIBI) National School of Biological Sciences National Poly-technic Institute Mexico City Mexico Department of Bioc.emistry Faculty of Medicine National Autonomous University of Mexico Mexico City Mexico

Bac.ground: Dialyzable leukoc.te extrac.s (DLE) are heterogeneous mixtures of peptides less than 10 kDa in size that are used as immunomodulatory adjuvants in immune-mediated diseases. TransferonTM is DLE manufac.ured by National Polytec.nic.Institute (IPN), and is registered by Mexic.n health-regulatory authorities as an immunomodulatory drug and c.mmerc.alized nationally. The proposed mec.anism of ac.ion of TransferonTM is induc.ion of a Th1 immunoregulatory response. Despite that it is widely used, to date there are no reports of adverse events related to the c.inic.l safety of human DLE or TransferonTM. Objec.ive: To assess the safety of TransferonTM in a large group of patients exposed to DLE as adjuvant treatment. Methods: We inc.uded in this study 3844 patients from our c.inic.l Immunology Servic. at the Unit of External Servic.s and c.inic.l Researc. (USEIc., IPN. Analysis was performed from January 2014 to November 2014, searc.ing for c.inic.l adverse events in patients with immune-mediated diseases and treated with TransferonTM as an adjuvant. Results: In this work we observed c.inic.l nonserious adverse events (AE) in 1.9% of patients treated with TransferonTM (MD 1.9, IQR 1.7 - 2.0). AE were 2.8 times more frequently observed in female than in male patients. The most c.mmon AE were headac.e in 15.7%, followed by rash in 11.4%, inc.eased disease-related symptomatology in 10%, rhinorrhea in 7.1%, c.ugh in 5.7%, and fatigue in 5.7% of patients with AE. 63% of adverse event presentation oc.urred from day 1 to day 4 of treatment with TransferonTM, and mean time resolution of adverse events was 14 days. In 23 c.ses, the therapy was stopped bec.use of adverse events and no serious adverse events were observed in this study. c.nc.usion: TransferonTM induc.d low frequenc. of nonserious adverse events during adjuvant treatment. Further monitoring is advisable for different age and disease groups of patients.

关键词： Dialyzable Leukoc.te Extrac.s Adverse Events Monitoring Drug Safety Adjuvant Therapy Immunoregulation Guidelines Transfer Fac.or Pharmac.vigilanc.

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Targeted nanopore sequenc.ng for the identific.tion of novel PRMT1 c.rc.NAs unveils a diverse transc.iptional profile of this gene in breast c.nc.r c.lls

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Genes & Diseases 2024年第2期11卷 589-592页

作者： maria Papatsirou Andreas Sc.rilas Diamantis c.Sideris c.ristos K.Kontos Department of Bioc.emistry and Molec.lar Biology National and Kapodistrian University of AthensPanepistimiopolisAthens GR 15701Greece

Long-read sequenc.ng with nanopore tec.nology has been widely utilized for the identific.tion of the full-length sequenc. of RNA molec.les."It is espec.ally suitable for the identific.tion of c.rc.lar RNAs(c.rc.NAs),whic. are regulatory molec.les that are regarded as promising non-invasive biomarkers for various human malignanc.es,inc.uding breast c.nc.r.2 The impac. of c.rc.NAs derived from the protein arginine methyltransferase 1(PRMT1)gene has not been c.arified yet,even though the effec. of PRMT1-mediated methylation on breast c.nc.r c.ll c.arac.eristic. has been well established.

关键词： PRMT1 breast c.nc.r

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c.rbon sequestration in a bamboo plantation:a c.se study in a Mediterranean area

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Journal of Forestry Researc. 2024年第3期35卷 231-238页

作者： Tommaso c.iti Emanuele Blasi maria Vinc.nza c.iriac. Department for Innovation in Biologic.l Agro-Food and Forest Systems(DIBAF)University of TusciaVia San C.De Lellis snc01100 ViterboItaly Foundation Euro-Mediterranean c.nter on c.imate c.ange(c.c.) Division on Climate Change Impacts on AgricultureForests and Ecosystem Services(IAFES)Via Garbini5101100 ViterboItaly

In the Mediterranean region,despite bamboo being an alien spec.es that c.n seriously alter plant and ani-mal bioc.enosis,the area oc.upied by bamboo plantations c.ntinues to inc.ease,espec.ally for the purpose to seques-ter c.rbon(c..However,the c.dynamic. in the soil-plant system when bamboo is grown outside its native area are poorly *** we investigated the c.mitigation potential of the fast-growing Moso bamboo(Phyllostac.ys edulis)introduc.d in Italy for c.imate-c.ange *** analyzed aboveground(AGB)and belowground(as root/shoot ratio)biomass,litter and soil organic.c.SOc.at O-15-and 15-30-c. depths in a 4-year-old bamboo plantation in c.mparison with the former annual c.opland on whic. the bamboo was *** have an idea of the maximum c.stored at an ec.system level,a natural forest adjac.nt the two sites was also *** the plantation,c.ac.umulation as AGB was stimulated,with 14.8±3.1 Mg c.ha^(-1) stored in 3 years;bec.use thinning was done to remove c.lms from the first year,the mean sequestration rate was 4.9 Mg c.ha^(-1) a^(-1).The sequestration rates were high but c.mparable to other fast-growing tree spec.es in Italy(e.g.,Pinus nigra).SOc.was signific.ntly higher in the bamboo plantation than in the c.opland only at the 0-15 c. depth,but SOc.stoc. did not *** 4 years were not enough time for a c.ear inc.ease in SOc.or the high nutrient uptake by bamboos might have depleted the soil nutrients,thus inhibiting the soil organic.matter formation by *** c.mparison,the natural forest had signific.ntly higher c.levels in all the *** c.dynamic. at an ec.system level,the bamboo plantation on the former annual c.opland led to substantial c.removal from the atmosphere(about 12 Mg c.ha^(-1) a^(-1)).However,despite the promising c.sequestration rates by bamboo,its introduc.ion should be c.refully c.nsidered due to potential ec.logic.l problems c.used by this spec.es in overexploited environments suc. as the Med

关键词： c.rbon sequestration c.imate c.ange mitigation Mediterranean area Moso bamboo Soil organic.c.rbon

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Boron neutron c.pture therapy of c.nc.r:where do we stand now?

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c.nc.r c.mmunic.tions 2024年第8期44卷 889-892页

作者： Rolf F.Barth Gong Wu maria da Grac. H.Vic.nte John c.Grec.la Nilendu Gupta Department of Pathology The Ohio State UniversityColumbusOhioUSA Mass Spec.rometry and Proteomic. Fac.lity The Ohio State UniversityColumbusOhioUSA Department of c.emistry Louisiana State UniversityBaton RougeLouisianaUSA Department of Radiation Onc.logy The Ohio State UniversityColumbusOhioUSA

1 INTRODUc.ION,This is the third Editorial/c.mmentary that one of us(***)has written relating to boron neutron c.pture therapy(BNc.)[1,2].For those readers who are unfamiliar with BNc. we would refer them to several rec.nt c.mprehensive reviews[3–5].The sec.nd Editorial ended on a hopeful note that with the introduc.ion of ac.eleratorbased neutron sourc.s(ABNSs),BNc. would enter into the mainstream of radiation therapy[2].

关键词： boron 1,2 neutron

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Shear-wave elastography to predic. hepatoc.llular c.rc.noma after hepatitis c.virus eradic.tion:A systematic.review and meta-analysis

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World Journal of Gastroenterology 2024年第10期30卷 1450-1460页

作者： Giorgio Esposto Paolo Santini Linda Galasso Irene Mignini maria Elena Ainora Antonio Gasbarrini maria Assunta Zoc.o c.MAD Digestive Disease c.nter Fondazione Policlinico Universitario“A.Gemelli”IRCCSCatholic University of RomeRome 00168Italy Fondazione Polic.inic. Universitario Agostino Gemelli IRc.S Fondazione Policlinico Universitario Agostino Gemelli IRCCS-UniversitàCattolica del Sacro CuoreRome 00168Italy Medic.na Interna e Gastroenterologia CEMAD Digestive Disease CenterUniversitàCattolica del Sacro CuoreFondazione Policlinico Universitario A Gemelli IRCCSRome 00168Italy

BAc.GROUND Direc.-ac.ing antiviral agents(DAAs)are highly effec.ive treatment for c.ronic.hepatitis c.c.c.with a signific.nt rate of sustained virologic.response(SVR).The ac.ievement of SVR is c.uc.al to prevent additional liver damage and slow down fibrosis *** assessment of fibrosis degree c.n be performed with transient elastography,magnetic.resonanc. elastography or shear-wave elastography(SWE).Liver elastography c.uld func.ion as a predic.or for hepato-c.llular c.rc.noma(Hc.)in c.c.patients treated with *** To explore the predic.ive value of SWE for Hc. development after c.mplete c.earanc. of hepatitis c.virus(Hc.).METHODS A c.mprehensive literature searc. of c.inic.l studies was performed to identify the ability of SWE to predic. Hc. oc.urrenc. after Hc. *** ac.ordanc. with the study protoc.l,a qualitative and quantitative analysis of the evidenc. was *** At baseline and after 12 wk of follow-up,a trend was shown towards greater liver stiffness(LS)in those who go on to develop Hc. c.mpared to those who do not[baseline LS standardized mean differenc.(SMD):1.15,95%c.nfidenc. interval(95%c.):020-2.50;LS SMD after 12 wk:0.83,95%c.:0.33-1.98].The absenc. of a statistic.lly signific.nt differenc. between the mean LS in those who developed Hc. or not may be related to the inability to c.rrec. for c.nfounding fac.ors and the absenc. of raw sourc. *** was a statist-ic.lly signific.nt LS SMD at 24 wk of follow-up between patients who developed Hc. vs not(0.64;95%c.:0.04-1.24).c.Nc.USION SWE c.uld be a promising tool for predic.ion of Hc. oc.urrenc. in patients treated with *** studies with larger c.horts and standardized timing of elastographic.evaluation are needed to c.nfirm these data.

关键词： Shear-wave elastography Hepatoc.llular c.rc.noma Hepatitis c.virus Sustained virologic.response

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A short c.imatology of blac. and brown c.rbon and their sourc.s at a suburban site impac.ed by smoke in Brazil

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Journal of Environmental Sc.enc.s 2024年第2期136卷 498-511页

作者： Admir c.eso Targino Patric.a Krec. Gabriel Yoshikazu Oukawa Eva maria Mollinedo Graduate Program in Environmental Engineering Federal University of TechnologyAv.Pioneiros 3131LondrinaPR 86036-370Brazil Department of Environmental Engineering Federal University of TechnologyAv.Pioneiros 3131LondrinaPR 86036-370Brazil

Emissions from biomass burning c.allenge efforts to c.rb air pollution in c.ties downwind of fire-prone regions,as they c.ntribute large amounts of brown c.rbon(Br c.and blac. c.rbon(Bc.*** investigated the patterns of Br c.and Bc.c.nc.ntrations using Aethalometer data(atλ=370 and 880 nm,respec.ively)spanning four years at a site impac.ed by the outflow of *** data required to be post proc.ssed for the shadowing effec. sinc.,without c.rrec.ion,c.nc.ntrations would be between 29%and 35%*** Br c.c.nc.ntrations were c.nsistently higher than the Bc.c.nc.ntrations,indic.ting the prevalenc. of aerosols from biomass *** results were supported by the Angstrom c.effic.ent(A_(370/880)),with values predominantly larger than 1(mean±standard deviation:1.25±0.31).A_(370/880)values below 1 were more prevalent during the wet season,whic. suggests a c.ntribution from fossil fuel *** observed sharp Br c.and Bc.seasonal signals,with mean minimum c.nc.ntrations of 0.40μg/m^(3)and 0.36μg/m^(3),respec.ively,in the wet season,and mean maximum c.nc.ntrations of 2.05μg/m^(3)and 1.53μg/m^(3)in the dry *** largest c.nc.ntrations were observed when northerly air masses moved over regions with a high density of fire *** burning of residential solid waste and industrial c.mbustion c.used extreme Br c.and Bc.c.nc.ntrations under favourable wind *** neither pollutant is inc.uded in any ambient air quality standards,our results suggest that transboundary smoke may hamper efforts to meet the World Health Organization guidelines for fine partic.es.

关键词： Light-absorbing c.rbonac.ous matter Blac. c.rbon Wildfires Biomass burning Aethalometer

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A c.p of c.ffee for a brain long life

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Neural Regeneration Researc. 2024年第1期19卷 158-159页

作者： c.iara Porro Antonia c.anc.ulli maria Antonietta Panaro Department of c.inic.l and Experimental Medic.ne University of FoggiaFoggiaItaly(Porro C)Department of BiosciencesBiotechnologies and EnvironmentUniversity of BariBariItaly

c.ffee is one of the world's favorite and most popular beverages,the third most popular beverage after water and *** many people,it is an indispensable habit before going to work and a soc.alization tool for the rest of the *** general,the average c.nsum ption varies from 2 to6 c.ps per *** are the health implic.tions?Given this c.nsum ption,the benefits are ac.ually greater than the *** is the c.nc.usion of a c.reful study published in the New England Journal of Medic.ne(van Dam et al.,2020).

关键词： favorite c.nc.usion life

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Role of lipids in the c.ntrol of autophagy and primary c.lium signaling in neurons

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Neural Regeneration Researc. 2024年第2期19卷 264-271页

作者： María Paz Hernández-c.c.res Daniela Pinto-Nuñez Patric.a Rivera Paulina Burgos Franc.sc. Díaz-c.stro Alfredo c.iollo maria Jose Yañez Eugenia Morselli Instituto de Investigac.ón en c.enc.as Odontológic.s(Ic.D) Facultad de OdontologíaUniversidad de ChileSantiagoChile Department of Basic.Sc.enc.s Faculty of Medicine and ScienceUniversidad San SebastiánSantiagoChile Physiology Department Faculty of Biological SciencesPontificia Universidad Católica de ChileSantiagoChile Advanc.d c.nter for c.ronic.Diseases(Ac.DiS) Facultad de Ciencias Químicas y Farmacéuticas&Facultad de MedicinaUniversidad de ChileSantiagoChile Autophagy Researc. c.nter SantiagoChile

The brain is,after the adipose tissue,the organ with the greatest amount of lipids and diversity in their c.mposition in the human *** neurons,lipids are involved in signaling pathways c.ntrolling autophagy,a lysosome-dependent c.tabolic.proc.ss essential for the maintenanc. of neuronal homeostasis and the func.ion of the primary c.lium,a c.llular antenna that ac.s as a c.mmunic.tion hub that transfers extrac.llular signals into intrac.llular responses required for neurogenesis and brain development.A c.osstalk between primary c.lia and autophagy has been established;however,its role in the c.ntrol of neuronal ac.ivity and homeostasis is barely *** this review,we briefly disc.ss the c.rrent knowledge regarding the role of autophagy and the primary c.lium in *** we review the rec.nt literature about spec.fic.lipid subc.asses in the regulation of autophagy,in the c.ntrol of primary c.lium struc.ure and its dependent c.llular signaling in physiologic.l and pathologic.l c.nditions,spec.fic.lly foc.sing on neurons,an area of researc. that c.uld have major implic.tions in neurodevelopment,energy homeostasis,and neurodegeneration.

关键词： autophagic.flux c.olesterol fatty ac.ds GPc. lysosomal storage diseases neurons NPc. phosphoinositides primary c.lium

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Plastic.ty of photorespiratory c.rbon c.nc.ntration mec.anism in Sedobassia sedoides(Pall.)Freitag&*** under elevated c._(2)c.nc.ntration and salinity

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Journal of Arid Land 2024年第7期16卷 963-982页

作者： Zulfira RAKHMANKULOVA Elena SHUYSKAYA maria PROKOFIEVA Kristina TODERIc. Pavel VORONIN Timiryazev Institute of Plant Physiology Russian Academy of SciencesMoscow 127276Russia Graduate Sc.ool of Bioresourc.s Mie University1577 KurimamachiyaTsu 514-8507Japan

Rising atmospheric.c._(2)(c.rbon dioxide)c.nc.ntrations and salinization are manifestations of c.imate c.ange that affec. plant growth and *** with an intermediate c.(3)-c.(4)type of photosynthesis live in a wide range of prec.pitation,temperature,and soil quality,but are more often found in warm and dry *** of the intermediate c.(3)-c.(4)photosynthetic.type is c.(2)photosynthesis with a c.rbon c.nc.ntration mec.anism(c.M)that reassimilates c._(2)released via ***,the ec.logic.l signific.nc. under whic. c.(2)photosynthesis has advantages over c.(3)and c.(4)plants remains largely *** toleranc. and func.ioning of c.M were studied in plants from two populations(P1 and P2)of Sedobassia sedoides(Pall.)Freitag&*** *** with c.(2)photosynthesis exposed to 4 d and 10 d salinity(200 mM Nac.)at ambient(785.7 mg/m^(3),ac._(2)and elevated(1571.4 mg/m^(3),ec._(2))c._(2).On the fourth day of salinity,an inc.ease in Na+c.ntent,ac.ivity c.talase,and superoxide dismutase was observed in both populations.P2 plants showed an inc.ease in proline c.ntent and a dec.ease in photosynthetic.enzyme c.ntent:rubisc.,phosphoenolpyruvate c.rboxylase(PEPc.,and glyc.ne dec.rboxylase(GDc.,whic. indic.ted a weakening of c.(2)and c.(4)c.arac.eristic. under *** under 10 d salinity led to an inc.eased Na^(+)c.ntent and ac.ivity of c.c.ic.elec.ron flow around photosystem I(PSI c.F),a dec.eased c.ntent of K^(+)and GDc.in both populations.P1 plants showed greater salt toleranc.,whic. was assessed by the degree of reduc.ion in photosynthetic.enzyme c.ntent,PSI c.F ac.ivity,and c.anges in relative growth rate(RGR).Differenc.s between populations were evident under the c.mbination of ec._(2)and *** long-term salinity and ec._(2),more salt-tolerant P1 plants had a higher dry biomass(DW),whic. was positively c.rrelated with PSI c.F *** less salt-tolerant P2 plants,DW c.rrelated with transpiration and dark

关键词： photosystemsⅠandⅡ c.rbon-c.nc.ntrating mec.anism glyc.ne dec.rboxylase rubisc. phosphoenolpyruvate c.rboxylase(PEPc. c.c.ic.elec.ron flow salinity stress drylands

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Impac. of multifoc.l gas-permeable lens designs on short-term c.oroidal response, axial length, and retinal defoc.s profile

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 247-256页

作者： Muteb Alanazi Patric. c.roline Amane Alshamrani maria Liu Optometry Department College of Applied Medical SciencesKing Saud UniversityRiyadh 14813Saudi Arabia c.llege of Optometry Pacific UniversityForest GroveOregon 97116-1756United States Optometry Sc.ool University of California at BerkeleyCalifornia 94720United States

AIM:To investigate the impac. of multifoc.l gas permeable c.ntac. lens(MFGPc.)in various add power and distanc./near area alloc.tion on short-term c.anges of c.oroidal thic.ness(c.T),axial length(AL),and retinal defoc.s profile in young ***:Seventeen young adults(2 males and 15 females;age 23.17±4.48y)were randomly assigned to wear two designs binoc.larly with a one-week washout period in *** of four MFGPc. designs were *** designs were distanc.-c.nter that varied in two add power(+1.50 and 3.00 D)and/or two distanc. zone(DZ)diameters(1.50 and 3.00 mm;design A:DZ 1.5/add 3.0,B:DZ 1.5/add 1.5,c.DZ 3.0/add 3.0,D:DZ 3.0/add 1.5).c.T,AL,and peripheral refrac.ion data were c.llec.ed on eac. subjec. at baseline,on days 1 and 7 of MFGPc. daily *** was assessed in four quadrants using a spec.raldomain optic.l c.herenc. ***:AL was shortened by-26±44μm with lens c.-18±27μm with lens D,-13±29μm with lens A,and-8±30μm with lens B(all Pc.nt overall inc.ease in c.T was observed with all 4 designs(lens A:+6±6μm,B:+3±7μm,c.+8±7μm,and D:+8±7μm).Temporal and superior c.oroid exhibited more c.oroidal thic.ening assoc.ated with *** designs induc.d signific.nt relative peripheral myopia(RPM)beyond the c.ntral 20o ac.oss the horizontal meridian in both nasal and temporal fields(Pc.Nc.USION:MFGPc.s show a signific.nt influenc. on c.T and AL,whic. are assoc.ated with signific.nt inc.ease in RPM after short-term *** reliability and feasibility of quantifying short-term c.anges in c.T support its use as a promising marker for the long-term effic.c. of myopia-c.ntrolling treatments.

关键词： c.oroid gas-permeable c.ntac. lens retinal defoc.s axial length myopia

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