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Effect of genetic factors on the association between coronary artery disease and PTPN22 polymorphism

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World Journal of Cardiology 2014年第6期6卷 376-380页

作者： Fulvia Gloria-Bottini Patrizia Saccucci maria banci Paolo Nardi Mattia Scognamiglio Antonio Pellegrino Egidio Bottini Luigi Chiariello Department of Biomedicine and Prevention School of MedicineUniversity of Rome Tor Vergata00133 RomeItaly Department of Cardiology Valmontone Hospital Department of Cardiac Surgery University of Rome Tor VergataSchool of Medicine

PTPN22 has been previously found associated with coronary artery disease(CAD). In the present note we have studied the effect of p53 codon 72,acid phosphatse locus 1(ACP1) and adenosine deaminase(ADA) genetic polymorphism on the strength of association between PTPN22 and CAD. We have studied 133 non diabetic subjects with CAD,122 non diabetic cardiovascular patients without CAD and 269 healthy blood donors. Informed written consent was obtained from all subjects and the study was approved by the Ethical Committee. A high significant association between PTPN22 and CAD is observed in carriers of *A allele of ACP1 with a higher proportion of *T allele carriers in non diabetic subjects with CAD as compared to controls and to non diabetic subjects with cardiovascular diseasewithout CAD. A similar pattern is observed in carriers of *Pro allele of p53 codon 72 with a higher proportion of *T allele carriers in non diabetic subjects with CAD as compared to other groups. A highly significant association between PTPN22 and CAD is observed in carriers of ADA2 *2 allele with higher proportion of *T allele carriers in non diabetic subjects with CAD as compared to other group. There is a high significant correlation between the number of factors that contributes to increase the strength of association between PTPN22 *T and CAD and the proportion of *T carriers in CAD. ACP1,p53 codon 72 and ADA are involved in immune reaction and give an important additive contribution to the strength of association between PTPN22 and CAD. This study stresses the importance of the simultaneous analysis of multiple genes functionally related to a specific disease: the approach may give important hints to understand multifactorial disorders.

关键词： Coronary artery disease PTPN22 Acid phosphatse locus 1 Adenosine deaminase 2 p53 codon 72

Experience of a Single Center in the Diagnosis and Classification of Cases of Left Ventricular Noncompaction

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International Journal of Clinical Medicine 2015年第4期6卷 235-248页

作者： Roberta Martinoli Patrizia Saccucci Federica Papetti Alessandro Dofcaci Stefano Piccirilli Ilaria Sansoni Francesca Ianniello Federica Ferrante maria banci Department of Biomedicine and Prevention University of Rome “Tor Vergata” Rome Italy Operating Unit of Cardiology Valmontone Hospital Rome Italy Department of Cardiology University of Rome “Tor Vergata” Rome Italy Department of Imaging Diagnostic University Campus Biomedical Rome Italy Operating Unit of Gynecology Valmontone Hospital Rome Italy Operating Unit of Neurology Valmontone Hospital Rome Italy

Objectives: To analyse the clinical profile of consecutive cases of Left Ventricular Non Compaction (LVNC) with particular interest in non-compacted segments valuation. Methods: There were 18,000 patients seen from 2007 to 2010, with a complete evaluation including family history and personal cardiac history, clinical examination and electrocardiography. Diagnosis was based on three published definitions. Results: The diagnosis of LVNC was placed in 1.4% of cases. Clinical and echo-cardiographic data for the 250 cases of LVNC are presented. Trabecular meshwork was observed predominantly at the apex (91.6%), in the lateral and inferior wall (40.4% and 38.0% respectively), and less frequently in the posterior and anterior wall (21.6% and 9.2% respectively). Conclusions: This study suggests that LVNC is a form of cardiomyopathy with higher prevalence and relatively better prognosis than previously reported.

关键词： Cardiomyopathy Endocardial Morphogenesis Isolated Left Ventricular Noncompaction Heart Failure Echocardiography

The association of adenosine deaminase with coronary artery disease: Effect of gender and diabetes

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Health 2013年第2期5卷 166-169页

作者： Fulvia Gloria-Bottini Krzysztof Safranow maria banci Agnieszka Binczak-Kuleta Patrizia Saccucci Andrzej Ciechanowicz Andrea Magrini Zdzislawa Kornacewicz-Jach Egidio Bottini Dariusz Chlubek Department of Biochemistry and Medical Chemistry Pomeranian Medical University Szczecin Poland Department of Biomedicine and Prevention School of Medicine University of Rome Tor Vergata Rome Italy Department of Cardiology Pomeranian Medical University Szczecin Poland Department of Cardiology Valmontone Hospital Valmontone Italy Department of Laboratory Diagnostics and Molecular Medicine Pomeranian Medical University Szczecin Poland

An association between ADA1 and Coronary Artery Disease (CAD) has been observed in Polish and in Italian populations but in Italian population the association was present in males only. In order to enlighten these differences we have carried out a collaborative study in the two populations. In Italy 215 subjects admitted to the Hospital for CAD, 275 subjects with Type 2 Diabetes (T2D) without CAD and 398 healthy new-borns were studied. In Poland 173 subjects with CAD and 200 healthy newborns were studied. Written informed consent was obtained from all subjects or from their mothers to participate to the study that was approved by the I.R.B. ADA1 polymorphism was determined by DNA analysis. Three way contingency table analysis was performed by a log linear model. The association between CAD and ADA1 is present in non diabetic male subjects only: OR = 0.195, p = 0.007 in the Italian population and OR = 0.163, p = 0.004 in the Polish population. The data suggest a significant role of immunological mechanisms in the pathogenesis of CAD without diabetes. Gender differences in immune diseases could explain the lack of association in females.

关键词： ADA CAD Gender Diabetes

Biodegradability of bioplastics in different aquatic environments:A systematic review

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Journal of Environmental Sciences 2024年第8期142卷 169-181页

作者： maria Cristina Lavagnolo Valentina Poli Anna maria Zampini Valentina Grossule Department of Civil Environmental and Architectural Engineering-Laboratory of Environmental EngineeringUniversity of PadovaLungargine Rovetta 8Padova 35100Italy

Bioplastics were first introduced as environmentally friendly materials,with properties similar to those of conventional plastics.A bioplastic is defined as biodegradable if it can be decomposed into carbon dioxide under aerobic degradation,or methane and CO_(2)under anaerobic conditions,inorganic compounds,and new cellular biomass,by the action of naturally occurring *** definition however does not provide any information on the environmental conditions,timescale and extent at which decomposition processes should *** regard to the aquatic environment,recognized standards have been established to assess the ability of plastics to undergo biodegradation;however,these standards fail to provide clear targets to be met to allow labelling of a bioplastic as ***,these standards grant the user an extensive leeway in the choice of process *** these reasons,the comparison of results deriving from different studies is *** authors analysed and discussed the degree of biodegradability of a series of biodegradable bioplastics in aquatic environments(both fresh and salt water)using the results obtained in the laboratory and from on-site testing in the context of different research *** Oxygen Demand(BOD),CO_(2)evolution,surface erosion and weight loss were the main parameters used by researchers to describe the percentage of *** results showed a large variability both in weight loss and BOD,even when evaluating the same type of *** confirms the need for a reference range of values to be established with regard to parameters applied in defining the biodegradability of bioplastics.

关键词： Biodegradation Bioplastic Plastic Natural environment Plastic waste

Carbon sequestration in a bamboo plantation:a case study in a Mediterranean area

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Journal of Forestry Research 2024年第3期35卷 231-238页

作者： Tommaso Chiti Emanuele Blasi maria Vincenza Chiriaco Department for Innovation in Biological Agro-Food and Forest Systems(DIBAF)University of TusciaVia San C.De Lellis snc01100 ViterboItaly Foundation Euro-Mediterranean Center on Climate Change(CMCC) Division on Climate Change Impacts on AgricultureForests and Ecosystem Services(IAFES)Via Garbini5101100 ViterboItaly

In the Mediterranean region,despite bamboo being an alien species that can seriously alter plant and ani-mal biocoenosis,the area occupied by bamboo plantations continues to increase,especially for the purpose to seques-ter carbon(C).However,the C dynamics in the soil-plant system when bamboo is grown outside its native area are poorly *** we investigated the C mitigation potential of the fast-growing Moso bamboo(Phyllostachys edulis)introduced in Italy for climate-change *** analyzed aboveground(AGB)and belowground(as root/shoot ratio)biomass,litter and soil organic C(SOC)at O-15-and 15-30-cm depths in a 4-year-old bamboo plantation in comparison with the former annual cropland on which the bamboo was *** have an idea of the maximum C stored at an ecosystem level,a natural forest adjacent the two sites was also *** the plantation,C accumulation as AGB was stimulated,with 14.8±3.1 Mg C ha^(-1) stored in 3 years;because thinning was done to remove culms from the first year,the mean sequestration rate was 4.9 Mg C ha^(-1) a^(-1).The sequestration rates were high but comparable to other fast-growing tree species in Italy(e.g.,Pinus nigra).SOC was significantly higher in the bamboo plantation than in the cropland only at the 0-15 cm depth,but SOC stock did not *** 4 years were not enough time for a clear increase in SOC,or the high nutrient uptake by bamboos might have depleted the soil nutrients,thus inhibiting the soil organic matter formation by *** comparison,the natural forest had significantly higher C levels in all the *** C dynamics at an ecosystem level,the bamboo plantation on the former annual cropland led to substantial C removal from the atmosphere(about 12 Mg C ha^(-1) a^(-1)).However,despite the promising C sequestration rates by bamboo,its introduction should be carefully considered due to potential ecological problems caused by this species in overexploited environments such as the Med

关键词： Carbon sequestration Climate change mitigation Mediterranean area Moso bamboo Soil organic carbon

Has the open surgical approach in colorectal cancer really become uncommon?

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1485-1492页

作者： maria Cariati Giuseppe Brisinda maria Michela Chiarello Department of Surgery Azienda Sanitaria Provinciale di CrotoneCrotone 88900Italy Abdominal and Endocrine Metabolic Medical and Surgical Sciences Fondazione Policlinico Universitario A Gemelli IRCCSRome 00168Italy Department of Surgery Azienda Sanitaria Provinciale di CosenzaCosenza 87100Italy

Colorectal cancer is the third most common cancer in the *** is man-datory to treat patients with colorectal *** colorectal cancer be treated in laparoscopy?Scientific literature has validated the oncological quality of laparo-scopic approach for the treatment of patients with colorectal *** non-inferiority trials with good remote control have answered positively to this long-debated *** as 1994,first publications demonstrated technical feasibility and compliance with oncological imperatives and,as far as short-term outcomes are concerned,there is no difference in terms of mortality and post-operative morbidity between open and minimally invasive surgical approaches,but only longer operating times at the beginning of the ***,from 2007 onwards,long-term results were published that demonstrated the ab-sence of a significant difference regarding overall survival,disease-free survival,quality of life,local and distant recurrence rates between open and minimally in-vasive *** this editorial,we aim to summarize the clinical and technical aspects which,even today,make the use of open surgery relevant and necessary in the treatment of patients with colorectal cancer.

关键词： Colorectal cancer Laparoscopy Laparoscopic colorectal resection Bowel obstruction Bowel perforation Advanced colorectal cancer

History of chronic gastritis:How our perceptions have changed

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World Journal of Gastroenterology 2024年第13期30卷 1851-1858页

作者： Dmitry Bordin maria Livzan Department of Pancreatic Biliary and Upper GI Tract DiseasesA.S.Loginov Moscow Clinical Scientific CenterMoscow 111123Russia Department of Propaedeutic of Internal Diseases and Gastroenterology Russian University of MedicineMoscow 127006Russia Department of Outpatient Therapy and Family Medicine Tver State Medical UniversityTver 170100Russia Department of Internal Medicine and Gastroenterology Omsk State Medical UniversityOmsk 644099Russia

Currently,the diagnostic strategy for chronic gastritis(CG)is aimed not just at fixing the presence of gastric mucosal inflammation,but also at gastric cancer(GC)risk stratification in a particular *** classification approach with the definition of the stage of gastritis determines the need,activities and frequency of dynamic monitoring of a ***,this attitude to the patient suffering from CG was far from *** present publication is a literature review describing the key milestones in the history of CG research,from the description of the first observations of inflammation of the gastric mucosa,assessment of gastritis as a predominantly functional disease,to the advent of endoscopy of the upper digestive tract and diagnostic gastric biopsy,assessment of the role of Helicobacter pylori infection in progression of inflammatory changes to atrophy,intestinal metaplasia,dysplasia and GC.

关键词： Chronic gastritis Intestinal metaplasia Dysplasia Gastric cancer Helicobacter pylori

Smoking, ACP1 and Infertility in Subjects with Varicocele

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Kinetic scale magnetic holes in the terrestrial magnetosheath:A review

Health（健康） 2019年第10期

作者： Anna Neri maria banci Adalgisa Pietropolli Fulvia Gloria-Bottini Andrea Magrini

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Science China Earth Sciences 2024年第9期67卷 2739-2771页

作者： Quanqi SHI Shutao YAO maria HAMRIN Ji LIU Shandong Provincial Key Laboratory of Optical Astronomy and Solar-Terrestrial Environment Institute of Space SciencesShandong UniversityWeihai 264209China Department of Physics UmeåUniversityUmeå90746Sweden Department of Physics University of AlbertaEdmonton T6K 2P6Canada

Magnetic holes at the ion-to-electron kinetic scale(KSMHs)are one of the extremely small intermittent structures generated in turbulent magnetized *** recent years,the explorations of KSMHs have made substantial strides,driven by the ultra-high-precision observational data gathered from the Magnetospheric Multiscale(MMS)*** review paper summarizes the up-to-date characteristics of the KSMHs observed in Earth’s turbulent magnetosheath,as well as their potential impacts on space *** review starts by introducing the fundamental properties of the KSMHs,including observational features,particle behaviors,scales,geometries,and distributions in terrestrial *** have discovered that KSMHs display a quasi-circular electron vortex-like structure attributed to electron diamagnetic *** electrons exhibit noticeable non-gyrotropy and undergo *** occurrence rate of KSMH in the Earth’s magnetosheath is significantly greater than in the solar wind and magnetotail,suggesting the turbulent magnetosheath is a primary source ***,KSMHs have also been generated in turbulence simulations and successfully reproduced by the kinetic equilibrium ***,KSMHs have demonstrated their ability to accelerate electrons by a novel non-adiabatic electron acceleration mechanism,serve as an additional avenue for energy dissipation during magnetic reconnection,and generate diverse wave phenomena,including whistler waves,electrostatic solitary waves,and electron cyclotron waves in space *** results highlight the magnetic hole’s impact such as wave-particle interaction,energy cascade/dissipation,and particle acceleration/heating in space *** end this paper by summarizing these discoveries,discussing the generation mechanism,similar structures,and observations in the Earth’s magnetotail and solar wind,and presenting a future extension perspective in this active field.

关键词： Magnetic hole Magnetic dip/cavity Electron vortex Magnetosheath Turbulence Coherent structure Mirror mode Kinetic scale Electron acceleration Whistler