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Journal of Materials Science and Chemical Engineering 2013年第7期1卷 13-23页

作者： Vitor César Dumont Rafael Menezes Silva Luiz Edmundo Almeida-Júnior Juan Pedro Bretas Roa Adriana maria botelho maria Helena Santos Department of Dentistry Federal University of Vales do Jequitinhonha and Mucuri Diamantina Brazil Department of Dentistry Federal University of Vales do Jequitinhonha and Mucuri Diamantina Brazil Advanced Biomaterial Center-BioMat UFVJM Diamantina Brazil Department of Dentistry Federal University of Vales do Jequitinhonha and Mucuri Diamantina Brazil Advanced Biomaterial Center-BioMat UFVJM Diamantina Brazil Institute of Science and Technology UFVJM Diamantina Brazil

The study modifies an adhesive system with hydroxyapatite nanoparticles as load, characterizing it and evaluate the effectiveness of its bond to dental structure. The middle thirds of healthy premolar tooth crowns were obtained, and each crown was sectioned vertically, resulting in two sections. The sections were divided into ten groups (n = 15), in which resin composite restorations were simulated: (G1E and G1D) conventional adhesive system (SAC);(G2E and G2D) SAC modified with HAP;(G3E and G3D) Primer modified with HAP;(G4E and G4D) monocomponent adhesive system;(G5E and G5D) self-etching adhesive system. The specimens were submitted to the microshear test and characterization technique. There was statistically significant difference (Kruskal-Wallis) between the groups (p 0.01). G3 presented the highest bond strength to enamel (64.40 MPa, ±7.36) and dentin (39.59 MPa, ±21.46). The majority of specimens were found adhesive fractures. Bond strength to enamel and dentin of the primer modified with HAP of SAC showed higher values.

关键词： Nanostructures Composites Mechanical Properties Fracture

Auriculotherapy in primary health care: A large-scale educational experience in Brazil

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Journal of Integrative Medicine 2019年第4期17卷 302-309页

作者： Charles Dalcanale Tesser Ari Ojeda Ocampo More Melissa Costa Santos Emiliana Domingues Cunha da Silva Fatima Terezinha Pelachini Farias Lucio Jose botelho Department of Public Health Federal University of Santa Catarina Floriandpolis Santa Catarina 88036-800 Brazil Post-graduate Program in Public Health Federal University of Santa Catarina Florianopolis Santa Catarina 88036-800 Brazil Integrative Medicine and Acupuncture Service University Hospital Federal University of Santa Catarina Floriandpolis Santa Catarina 88036-800 Brazil Floriandpolis Municipality Health Office Florianopolis Santa Catarina 88036-800 Brazil

Auriculotherapy consists of physical stimuli applied to the outer ear and is commonly associated with traditional Chinese medicine (TCM). The authors present and discuss the development of a course that offers a semi-on-site auriculotherapy course for Brazilian primary health care (PHC) professionals. The course was funded by the Brazilian Ministry of Health and developed at the Federal University of Santa Catarina in 2015 by a team of experts in auriculotherapy. It consisted of 75 h of distance learning (five sequential modules) and 5 h of on-site learning. The modules included the following items:(1) introduction to integrative practices;(2) ear reflexology;(3) introduction to TCM;(4) biomedical view of auriculotherapy;and (5) auriculotherapy in PHC. The teaching material in eluded a workbook for each module, 14 video lectures and an interactive ear(on line resource) to study location and application to the main auricular points. The on-site lectures follow a structured script of ear palpation techniques, auricular seed insertion practice and clinical case discussions, under the supervision of trained instructors. The course was offered in 2016 and 2017 and on-site lectures took place in 25 cities, covering all Brazilian regions, in coordination with municipal or state boards of health. A total of 4273 health professionals concluded the training and their evaluation of the course was highly positive. The Brazilian experience of large-scale training shows the potential to disseminate auriculotherapy in the context of PHC, given that its practice is fast, easy to learn, safe, effective for different health problems and well accepted by the patients.

关键词： Auriculotherapy Traditional Chinese medicine Primary health care Health education Distance learning

Electromagnetic Characterization of Recyclable Polymer Nanofibers Based on PSU/Carbonyl Iron

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Journal of Renewable Materials 2019年第3期7卷 279-287页

作者： Daniel Consoli Silveira Tiago Teixeira da Silva Braga Daniel Molina Gil Newton Adriano dos Santos Gomes Lilia Müller Guerrini Edson Cocchieri botelho Department of Materials and Technology Sao Paulo State University(UNESP)School of EngineeringGuaratinguetá/SP-Brazil Electronic Warfare Laboratory Technological Institute of Aeronautics(ITA)Sao Josédos Campos/SP-Brazil Institute of Science and Technology Federal University of Sao Paulo(UNIFESP)Sao Josédos Campos/SP-Brazil

This study investigated and defined the optimal processing parameters for the electrospinning of polysulfone polymer solutions with N,*** of parameters such as solute concentration,electrical voltage,and working distance were correlated with the quality of the obtained nanofibers using morphological characterization via scanning electron microscopy(SEM).Carbonyl iron additive was dispersed in the polymer solutions,using ultrasonic tip,and the material processed via electrospinning with aforementioned parameters *** with the property of interaction with electromagnetic waves were *** dispersion of different concentrations of the additive and electromagnetic characterizations in the X-band of microwaves(8.2 and 12.4 GHz),using vector network analyzer(VNA)and rectangular waveguide,allowed the identification of the materials electromagnetic *** parameters allowed the calculation of reflected and transmitted energy by the material.

关键词： Carbonyl iron electromagnetic characterization electrospinning nanofibers polysulfone

Ileal intussusception due to a parasite egg: A case report

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World Journal of Gastroenterology 2014年第36期20卷 13191-13194页

作者： José Pedro Pinto Agostinho Cordeiro Ana Margarida Ferreira Conceio Antunes Patrícia botelho Ana Joo Rodrigues Pedro Leo Department of General Surgery Hospital of Braga 2242 Apartado Portugal Servi?o de Anatomia Patológica Hospital de Braga 2242 Apartado Portugal Life and Health Sciences Research Institute (ICVS) School of Health Sciences University of Minho Braga 2242 Apartado Portugal ICVS/3B’s-PT Government Associate Laboratory Braga/Guimar?es 2242 Apartado Portugal

Ileal intussusception is the invagination of the small intestine within itself and accounts for 1% of cases of acute obstruction. However, physicians do not initially consider intussusception as a possible diagnosis of obstruction due to its rarity in adults. Herein, we report the case of a 22-year-old male who was admitted to the Emergency Department with continuous abdominal pain. Ultrasonography and computed tomography revealed an ileal intussusception. The patient underwent surgical removal of the segment of the small bowel. Unexpectedly, pathology revealed that the invagination occurred due to a parasite egg, with features suggestive of Schistosoma species. Schistosomiasis, although considered a parasitic disease in tropical countries, is not absent from Europe and though it is highly improbable, it may be responsible for cases of intussusception in adults.

关键词： Ileal intussusception Parasite egg Bowel obstruction Schistosoma Abdominal pain

Salmonella infection after anterior cruciate ligament reconstruction:A case report

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World Journal of Orthopedics 2021年第4期12卷 246-253页

作者： Thomas Neri Margaux Dehon Elisabeth botelho-Nevers Celine Cazorla Sven Putnis Remi Philippot Frederic Farizon Bertrand Boyer Department of Orthopaedic Surgery University Hospital Centre of Saint-EtienneSaint-Etienne 42000France EA 7424-Inter-University Laboratory of Human Movement Science University Lyon-University Jean Monnet Saint EtienneSaint Etienne 42000France Infectious Diseases Department University Hospital of Saint-EtienneSaint-Etienne 42000France Avon Orthopaedic Centre Southmead HospitalBristolBS105NBUnited Kingdom

BACKGROUND Infections after anterior cruciate ligament reconstruction(ACLR)are *** cases of Salmonella infection have been described to our *** SUMMARY We describe a rare case of Salmonella infection in a 23-year-old patient following an *** patient presented with subacute septic arthritis,26 d after a hamstring autograft *** pathogen,Salmonella enterica typhimurium was isolated by bacteriological sampling of the first arthroscopic *** arthroscopic lavages were required,with intravenous antibiotic therapy for two weeks with cefotaxime and ciprofloxacin,followed by oral antibiotics with amoxicillin and ciprofloxacin for a total duration of three *** approach treated the infection but two years after the septic arthritis,faced with ongoing knee instability due to graft damage,a revision ACLR with a bone-tendon-bone graft was *** the last follow-up,full range of knee motion had been achieved and sports activities *** Infection after ACLR is rare and requires an early diagnosis and management in order to treat the infection and prevent arthritis-related joint cartilage destruction and damage to the graft.

关键词： Knee Anterior cruciate ligament Infection Salmonella Case report

Structural effects induced by dialysis-based purification of carbon nanomaterials

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Nano Materials Science 2024年第4期6卷 475-483页

作者： A.D.Veloso A.M.Ferraria A.M.botelho do Rego A.S.Viana A.J.S.Fernandes A.J.Fielding R.A.Videira M.C.Oliveira CQ-VR and Chemistry Department University of Tras-os-Montes e Alto Douro5000-801Vila RealPortugal BSIRG iBB-Institute for Bioengineering and BiosciencesDepartment of Chemical Engineeringand Associate Laboratory i4HB-Institute for Health and BioeconomyInstituto Superior TecnicoUniversidade de Lisboa1049-001LisbonPortugal Centro de Química Estrutural Institute of Molecular SciencesDepartamento de Química e BioquímicaFaculdade de Ci^enciasUniversidade de LisboaCampo Grande1749-016LisboaPortugal I3N and Physics Department University of AveiroCampus de Santiago3810-193AveiroPortugal Faculty of Science Pharmacy and Biomolecular SchoolLiverpool John Moores UniversityUnited Kingdom REQUIMTE/LAQV Laboratorio de FarmacognosiaDepartamento de QuímicaFaculdade de FarmaciaUniversidade do Porto4050-313PortoPortugal

Dialysis plays a crucial role in the purification of nanomaterials but its impact on the structural properties of carbon nanomaterials was never ***,a carbon-based nanomaterial generated electrochemically in potassium phosphate buffer,was characterized before and after dialysis against pure *** is shown that dialysis affects the size of the carbon domains,structural organization,surface functionalization,oxidation degree of carbon,and grade of ***,dialysis drives the nanomaterial organization from discrete roundish carbon domains,with sizes ranging from 70 to 160 nm,towards linear stacking structures of small nanoparticles(<15 nm).In parallel,alcohol and ether(epoxide)surface groups evolve into more oxidized carbon groups(e.g.,ketone and ester groups).Investigation of the as-prepared nanomaterial by electron paramagnetic resonance(EPR)revealed a resonance signal consistent with carbon-oxygen centred ***,this study brings to light the selective affinity of the carbon nanomaterial under study to capture Na^(+)ions,a property greatly enhanced by the dialysis process,and its high ability to trap oxygen,particularly before *** findings open new perspectives for the application of carbon-based nanomaterials and raise awareness of the importance of structural changes that can occur during the purification of carbon-based nanomaterials.

关键词： Nanocarbon Surface functionalization NMR XPS Hydrophilic carbon Paramagnetic

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粘结桥中使用非刚性连接体修复2个缺失后牙

北京大学学报（医学版） 2010年第5期42卷 575-577页

作者：谭京姜慧王新知 Michael G.botelho 北京大学口腔医学院.口腔医院修复科北京100081 北京友谊医院口腔科 Prince Philip Dental Hospital University of Hong Kong

目的:探讨在粘结桥中加入非刚性连接体用来修复2个缺失后牙。方法:在临床上选择缺失2个后牙且对颌为真牙的病例。共20例,男性9例,女性11例,平均年龄45.6岁,上颌12例,下颌8例。修复体中双尖牙的固位体与栓体连接,栓道与桥体连接,通过栓... 详细信息

目的:探讨在粘结桥中加入非刚性连接体用来修复2个缺失后牙。方法:在临床上选择缺失2个后牙且对颌为真牙的病例。共20例,男性9例,女性11例,平均年龄45.6岁,上颌12例,下颌8例。修复体中双尖牙的固位体与栓体连接,栓道与桥体连接,通过栓体与栓道将两部分连接在一起。修复体试戴后使用树脂粘接剂PANAVIAF粘结。结果:20例修复体平均使用时间为28.8个月,最长使用时间为42个月。20例病例中只有1例远中固位体发生脱落。经过表面处理后重新粘接,使用良好。所有基牙没有发现有继发龋和牙龈炎。结论:使用非刚性连接体,允许修复体在受到载荷时产生一定的自由动度,降低了金属固位体与树脂粘接面的应力,从而减少了脱粘接的发生。此种方法扩大了粘接桥的适应证,可以取得较好的临床治疗效果。

关键词：非刚性连接体牙应力分析牙修复体

Effect of Protein Adsorption onto the Dissolution of Silicon-Substituted Hydroxyapatite

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Journal of Encapsulation and Adsorption Sciences 2011年第4期1卷 72-79页

作者： Claudia Manuela botelho Roger Brooks Masanobu Kanitakahara Chikara Ohtsuki Serena Best maria Ascensao Lopers Neil Rushton William Bonfield JoséDomingos Santos Institute for Biotechnology and Bioengineering Centre of Biological EngineeringUniversidade do MinhoCampus de GualtarBragaPortugal Graduate School of Materials Science Nara Institute of Science and TechnologyTakayamaIkomaNaraJapan Orthopaedic Research Unit Addenbrooke’s HospitalCambridgeUK Department of Materials Science and Metallurgy University of CambridgeCambridgeUK Tohoku University Graduate School of Environmental StudiesAramakiAobaAoba-kuSendaiJapan Nagoya University Department of Crystalline Materials ScienceGraduate School of EngineeringFuro-choChikusa-kuNagoyaJapan CEMUC Faculty of EngineeringDepartment of Metallurgical and Materials EngineeringUniversity of PortoPortoPortugal

Several authors have shown the beneficial role to incorporate silicon into hydroxyapatite lattice, although, the mechanism behind the enhanced bioactivity of this Si-hydroxyapatite (Si-HA) is poorly understood. The incorporation of Si into the HA lattice alters the surface charge of HA, leading to more negative values. Due to the importance of the surface properties on the interaction between biomaterials, physiological fluids, and the host tissue, it is important to further characterize the surface of Si-HA by determining its surface energy and wettability. Our results showed that the incorporation of Si increased the hydrophilicity of HA, leading to a higher interfacial tension. Another important property for osteointegration is the formation of an apatite layer. The dissolution of Si-HA in the presence of serum-free simulated body fluid (SBF) started at early time points and using atomic force microscopy (AFM) it was possible to observe the dissolution at the grain boundaries and grains, therefore an apatite layer was formed in a short period of time. As the dissolution-precipitation process is much more complex in vivo, we tried to mimic the initial stages of the in vivo reaction by incubating the Si-HA in serum-SBF. It was shown that the dissolution kinetics in serum-SBF was slower when compared to the dissolution in serum free-SBF. At the same time point, no significant dissolution features were observed or apatite layer was visualized. The phase imaging AFM indicated the presence of a layer on top of these materials that could be a proteinaceous layer, as XPS analysis detected an increase on the concentration of nitrogen on the surface of the samples incubated in the presence of proteins.

关键词： Biomaterials Silicon Surface Properties Proteins Dissolution

Efflux Pumps Modulation in Colorectal Adenocarcinoma Cell Lines: The Role of Nuclear Medicine

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Journal of Cancer Therapy 2011年第3期2卷 408-417页

作者： Joao Casalta-Lopes Ana Margarida Abrantes Mafalda Laranjo Joana Rio Ana Cristina Goncalves Barbara Oliveiros Ana Bela Sarmento-Ribeiro maria Filomena botelho Biophysics Unit IBILIFaculty of MedicineUniversity of CoimbraCoimbraPortugal Centre of Investigation on Cancer Envi-ronmentGenetics and OncobiologyFaculty of MedicineUniversity of CoimbraCoimbraPortugal Institute of Nuclear Sciences Applied to Health University of CoimbraCoimbraPortugal Applied Molecular Biology Unit Faculty of MedicineUniversity of CoimbraCoimbraPortugal.

Introduction: Multidrug resistance (MDR) is one of the major problems of chemotherapy. Overexpression of efflux pumps, such as P-glycoprotein (Pgp), multiple resistance-related protein 1 (MRP-1) and lung resistance protein (LRP) can lead to MDR. Verapamil and L-buthionine-sulfoximine (BSO) are two modulators of these proteins. This study aims to compare 99mTc-Sestamibi transport kinetics in human colorectal adenocarcinoma cell lines, in the presence and absence of the MDR modulators verapamil and BSO. Material and Methods: MDR proteins expression was evaluated in sensitive (WiDr) and resistant (LS1034) human colorectal adenocarcinoma cell lines. Intracellular and plasma membrane Pgp and MRP1, and LRP expression was analyzed by flow-cytometry and western blot. Cellular transport kinetics was assessed using 99mTc-Sestamibi. MDR modulation was evaluated though retention studies in resistant cells after incubation with the modulators. Results: Pgp expression was significantly higher (p≤0.001) in resistant cells. These results were confirmed by western blot analysis. 99mTc-Sestamibi uptake and retention percentage were significantly higher (p99mTc-Sestamibi, there were differences among the MDR modulators used (p99mTc-Sestamibi could indicate MDR phenotype in colorectal adenocarcinoma cells. As the modulators used showed a reversion of the retention profile only for the first minutes, their administration should occur immediately before the administration of cytotoxic drugs.

关键词： Multidrug Resistance P-Glycoprotein Multidrug Resistance-Associated Protein 1 Major Vault Protein

Collaborative Intelligence in Smart Cities: A Systematic Review

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Social Networking 2018年第3期7卷 181-195页

作者： Viviani Kwecko Silvia S. da C. botelho Federal Institute of Science and Technology Education of Rio Grande do Sul—IFRS Rio Grande Brazil Federal University of Rio Grande—FURG Rio Grande Brazil

The objective of this research is to present a systematic analysis, in which we seek to identify the concepts of intelligent city, with the intention of recognizing the nature of this intelligence before the participation of the population. Therefore, the research associates concepts as smart cities, citizen participation and social web, identifying publications between 2012 and the first quarter of 2018 and questioning what the intelligent city is and how this concept is able to (re)organize the learning processes of the territory from the informal dynamics of the contemporary city. The qualitative analysis of the documents revealed an innumerable of definitions and related terms: smart, intelligent, ubiquitous, digital, knowledge, sustainable, crowd sourcing, innovative;structured in three types of approaches: technological focus, focus on human resources and focus on citizen-related governance from the following domains: media convergence, public and regulatory information policies, infrastructure management, real-time data mining and extraction, geographic information system, crowd computing, smart cities education, and social monitoring and control. In spite of the access to a great amount of data, we verify that the concept of intelligent city is referenced by a significant number of researches, but, in smaller number, works that present models of construction of a collective intelligence for the city. From this perspective, we identified the need to recognize technological education interventions for communication between individuals and the city. Because we believe that only through the implementation and management of techno-educommunication ecosystems will be able to promote a culture of participation.

关键词： Territorial Learning Non-Formal Education Technological Artifacts Informal Dynamics Citizen Participation