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Destabilization of HIF-1a by Diabetes, Oxidative Stress, Obesity and Other Related Disorders

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Journal of Diabetes Mellitus 2023年第2期13卷 142-162页

作者： Angelos Karavasilis Petros Karkalousos maria Trapali Christina Fountzoula George Albert Karikas Department of Biomedical Sciences School of Health and Care Sciences University of West Attica Athens Greece

One of the most fundamental molecular processes in response to hypoxia is the activation and stabilization of a transcriptional factor called hypoxia induced factor 1a (HIF-1a), which is responsible for the regulation of many downstream effector genes. Multiple key biological pathways such as proliferation, energy metabolism, invasion, and metastasis are governed by these genes. This article discusses the role of hypoxia-inducible factor 1a (HIF-1a) in metabolic and pathological processes, particularly in adipose tissue, oxidative stress, inflammation, diabetes and cancer. HIF1A is a basic helix-loophelix PAS domain containing protein, and is considered as the master transcriptional regulator of cellular and developmental response to hypoxia. HIF-1a regulates the expression of genes involved in angiogenesis, glucose metabolism, inflammation and oxidative stress. In obesity, adipose tissue hypoxia leads to increased expression of HIF-1a, which can lead to chronic inflammation and adipose tissue dysfunction. Another field that HIF-1a is also involved in cancer pathogenesis pathways, such as proliferation, invasion, angiogenesis, and metastasis, and is considered a potential therapeutic target for metabolic/genetic diseases and cancer. Direct and indirect HIF-1 inhibitors have been identified, but only a few have entered clinical trials due to their multiple side effects.

关键词： HIF-1a Diabetes Oxidative Stress Obesity Cancer Angiogenesis Mitochondria

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美食传说,有味还有道

初中生 2024年第18期 4-13页

作者： Paul Yee Wenxi garcia 不详

主题语境:人与社会——民间传说,饮食文化。一位加拿大华商儿童文学作家创作的《中国神话盛宴》(Chinese Fairy Tale Feasts)一书中,讲述了20多个跟中国美食有关的民间传说。拉面、虾仁鲜饺、米饭,这些我们习以为常的食物背后,原来还有... 详细信息

主题语境:人与社会——民间传说,饮食文化。一位加拿大华商儿童文学作家创作的《中国神话盛宴》(Chinese Fairy Tale Feasts)一书中,讲述了20多个跟中国美食有关的民间传说。拉面、虾仁鲜饺、米饭,这些我们习以为常的食物背后,原来还有一些听起来不可思议的故事。事实上,神奇的事情往往发生在最虔诚、最善良的人身上。

关键词：饮食文化儿童文学作家民间传说美食拉面虾仁米饭

The Phenomenon of Oncology Nurses’ Tendency to Change Duties in Greek Public Hospitals: A Study of Its Causes and Suggestions

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Open Journal of Nursing 2021年第7期11卷 578-590页

作者： Charalampos Platis Nantia Papadopoulou maria-Elisavet Psomiadi Paraskevi Theofilou Petros Galanis Greek D.R.G. Institute SA Athens Greece General Anti-Cancer Hospital Agios Savvas Athens Greece Ministry of Health Athens Greece National and Kapodistrian University of Athens Athens Greece

Background: The concept of job satisfaction is of great importance regarding its impact on employees’ productivity and efficiency. Especially for oncology nurses has become apparent over the past decades that job satisfaction is a determinant factor not only for the quality of services they provide but also of their tendency to change duties and resign from workplace. While this phenomenon is vastly described by the literature, no survey that investigates nursing personnel’s tendency to resign from workplace has been conducted in Greece. Objectives: To investigate oncology nurses’ job satisfaction while examining the causes of their dissatisfaction in regard to their tendency to change duties, either by departing from the oncology field or by resigning. Material and Method: Using a structured questionnaire, a survey was conducted in four hospitals in the region of Attica that fall within the Greek National Health System, ESY. The research sample comprised 278 oncology nurses, men and women, with varied work experience. The data were analyzed using the SPSS software, applying descriptive statistics, inferential statistics, and Principal Component Analysis. Results: Our findings concerning participants’ job satisfaction were mainly positive. Most of the oncology nurses partaking in the study expressed their willingness to remain in their current workplace, as their placements enable them to diffuse in their tasks the knowledge and experience previously acquired. Conclusion: As oncology nurses’ job satisfaction influences their overall performance and dedication in their profession, parameters as working conditions, equal distribution of the workload, independent decision making and seniors’ management recognition of their work, need to be considered as primarily fields of improvement. With this being the first study in Greece that investigates oncology nurses’ job satisfaction in rela

关键词： Job Satisfaction Oncology Nurses Burnout Syndrome Resigning from Workplace

Serum Lipids and Lipokines as Prognostic/Diagnostic Biomarkers in Common Cancers

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Journal of Diabetes Mellitus 2022年第2期12卷 122-140页

作者： Nikolaos Dogkas maria Τrapali Christine Fountzoula Georgios Albert Karikas Petros Karkalousos Biochemistry Laboratory General Anticancer Hospital of Piraeus “METAXA” Piraeus Greece Department of Biomedical Sciences School of Health and Care Sciences University of West Attica Athens Greece

Total cholesterol (CHOL) levels have been shown in many studies, to be higher in people with several types of cancer. Similar results are observed for both triglycerides (TG) and low-density cholesterol (LDL), as opposed to high-density cholesterol (HDL). Chemotherapy seems to reduce CHOL and LDL, leading to a reduction. Furthermore, the recurrence of high levels of CHOL, TG and LDL, as well as low levels of HDL, after receiving treatment, or when patients appear to have been cured, are signs of a possible recurrence of the disease. Lipoprotein α (Lpa), occurs at higher levels in patients than in healthy people, whereas lipokines resistin and bisfatin, “hormonal” products of adipose tissue exhibited high levels in cancer cases, compared to control groups.

关键词： Cancer Total Cholesterol Triglycerides HDL LDL Resistin Visfatin

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超声波检查在眼科的应用

国外医学.眼科学分册 1980年第6期 1-12页

作者：朱宣和 garcia C 中国医学科学院首都医院眼科德克萨斯州大学医学院

超声波检查是利用高频率声波的回声进行检查,自1956年首次应用于眼科,现已成为眼及眼眶疾病的重要诊断方法。这种检查方法简单易行,并对病人无损害。可显示眼球及眼眶内组织的横断面,区别几种组织的特点。故当屈光间质不清或病变位于视... 详细信息

超声波检查是利用高频率声波的回声进行检查,自1956年首次应用于眼科,现已成为眼及眼眶疾病的重要诊断方法。这种检查方法简单易行,并对病人无损害。可显示眼球及眼眶内组织的横断面,区别几种组织的特点。故当屈光间质不清或病变位于视线不可见的地方,超声波检查显得尤为重要。此外,超声波可精确地测量某些组织的厚度或距离。

关键词：超声波检查回声眶壁反射声眶脂体眶脂肪肿物视神经疾病视神经炎视网膜脱离眼科

Long term clinical and dermoscopic follow-up of a child with a Spitz nevus

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Open Journal of Pediatrics 2012年第3期2卷 253-256页

作者： Massimiliano Scalvenzi maria Grazia Francia Franco Palmisano Claudia Costa Department of Dermatology University of Naples Federico II Naples Italy

Background: Spitz nevus is uncommon, benign melanocytic neoplasm that may show some clinical, dermoscopical and histological features of melanoma. It occurs often in childhood, but may appear also in early adulthood. Rare congenital cases have been reported in literature. It is frequently located on the face and the lower extremities, but in some cases may appears on the trunk. Methods: We report a case of a 9-years-old girl presented to our Dermatology Unit because of the presence of a pigmented lesion on her right leg, 4 mm in diameter, which was clinically and dermoscopically diagnosed as Spitz nevus. We described the clinical and dermoscopic features that we observed every six months, over 11 years follow-up period. Objective: Our observation show that the globular, the starburst, the homogeneous patterns and diffuse brown colour with diffuse hypopigmented areas may be the different expression that correspond to possible evolutionary phases of pigmented Spitz nevus.

关键词： Spitz Nevus Evolution Dermoscopy

穿越被疫情封锁的2700公里,一头大象回归自由

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中国慈善家 2022年第5期 66-77页

作者：龚怡洁 SOFIA lopez MANAN(摄影) 不详

2020年5月,阿根廷北部,一支车队悄然驶来,划开原野上沉寂的空气。这个西班牙语国家,充满着从阳光、探戈、啤酒和交谈里涌出的热浪,如今却因为新冠疫情,被迫凝滞了下来。这个车队犹如不速之客,他们获准从停滞的城市社区中逃逸,完成一段长... 详细信息

2020年5月,阿根廷北部,一支车队悄然驶来,划开原野上沉寂的空气。这个西班牙语国家,充满着从阳光、探戈、啤酒和交谈里涌出的热浪,如今却因为新冠疫情,被迫凝滞了下来。这个车队犹如不速之客,他们获准从停滞的城市社区中逃逸,完成一段长达5天5夜的跨境旅程。旅程锚定的目的地,是距阿根廷首都布宜诺斯艾利斯2700公里的巴西马托格罗索州沙帕达一杜斯吉马朗伊斯。

关键词：西班牙语阿根廷回归自由车队不速之客

Effects of Pumping Height and Repeated Pumping in Atlantic Salmon Salmo salar

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Natural Resources 2016年第6期7卷 377-383页

作者： Åsa maria Espmark Kjell Ø. Midling Jonatan Nilsson Odd-Børre Humborstad Nofima AS Sunndals&oslash ra Norway Nofima AS Troms&oslash Norway Institute of Marine Research Bergen Norway

The aim of this study was to evaluate the effects of pumping height and repeated pumping on the generalized stress response and gross injuries in harvest sized Atlantic salmon. Fish pumped from a net pen at either high (5.2 m) or low (3.6 m) pumping heights showed an elevated, but not severe physiological stress response (pH, pCO2, lactate, potassium, haematocrit, and sodium) compared to fish netted (not pumped), while effects of different pumping heights were overall not demonstrated. Repeated pumping (either 3 or 6 times) also caused an increase in stress response (pH, pCO2, pO2, lactate, potassium and sodium) compared to control fish, and a positive dose-response relationship was found for lactate. No fish died as a result of pumping, nor were injuries observed that could exclusively be attributed to pumping. In conclusion, although elevated from the control groups, the stress response following increasing pumping height and repeated pumping as conducted in these experiments were not indicative of causing severe stress or injuries.

关键词： Handling Pumping Height Repeated Pumping Atlantic Salmon Stress Welfare

形式迷情 Pavillon de Costes餐厅

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室内设计与装修 2009年第10期 30-35页

作者： Jacques garcia 朱旻麒

作为法国的顶级餐厅品牌，Pavilion是Costes兄弟在国内的经营的第一家餐饮店。在巴黎，Costes兄弟几乎是家喻户哓，他们的名下有许多家酒店、咖啡馆及私人会所，但它们无一例外地都位于巴黎市内。就像位于蓬皮杜艺术中心的Cafe Beaubour... 详细信息

作为法国的顶级餐厅品牌，Pavilion是Costes兄弟在国内的经营的第一家餐饮店。在巴黎，Costes兄弟几乎是家喻户哓，他们的名下有许多家酒店、咖啡馆及私人会所，但它们无一例外地都位于巴黎市内。就像位于蓬皮杜艺术中心的Cafe Beaubourg一样，

关键词：餐厅艺术中心巴黎市餐饮店咖啡馆酒店