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Association of the level of heteroplasmy of the 15059G>A mutation in the MT-CYB mitochondrial gene with essential hypertension

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World Journal of Cardiology 2013年第5期5卷 132-140页

作者： Igor A Sobenin Dimitry A Chistiakov margarita a sazonova Maria M Ivanova Yuri V Bobryshev Alexander N Orekhov Anton Y Postnov Russian Cardiology Research and Production Complex 121552 Moscow Russia Institute of General Pathology and Pathophysiology Russian Academy of Medical Sciences 125315 Moscow Russia Department of Medical Nanobiotechnology Pirogov Russian State Medical University 119992 Moscow Russia Institute for Atherosclerosis Research Skolkovo Innovative Centre 143025 Moscow Russia Faculty of Medicine School of Medical Sciences University of New South Wales Sydney NSW 2052 Australia

AIM: To examine whether the heteroplasmy level for 15059G>A mutation in the mitochondrial genome might be associated with essential hypertension. METHODS: This cross-sectional study involved 196 unrelated participants randomly selected from general population (90 males and 106 females) who underwent a regular medical check-up at the Institute for Ath-erosclerosis Research (Moscow, Russia). One hundred and twenty of them (61%) had essential hypertension, and 76 (39%) were apparently healthy normotensive persons. The level of heteroplasmy for 15059G>A mutation occurring in the coding region of cytochrome b gene (MT-CYB) of mtDNA isolated from the blood leukocytes, was quantified using DNA pyrosequencing method. RESULTS: The 15059G>A heteroplasmy level ranged between 4% and 83%, with a median level of 31%. Between the upper and lower quartiles of 15059G>A heteroplasmy distribution, significant differences were observed for patients’ age, systolic blood pressure, and triglyceride levels. 15059G>A heteroplasmy correlated both with age (r = 0.331, P A heteroplasmy, and hypertension independently explains more 5% variability. The 15059G>A heteroplasmy exceeding 31% was found to be significantly associated with a higher risk of essential hypertension (odds ratio 2.76; P (Fisher) 0.019]. The study participants with high 15059G>A heteroplasmy level were found to have significantly higher age (P A heteroplasmy level. These observations suggested a positive correlation between the level of 15059G>A heteroplasmy and essential hypertension. CONCLUSION: This study provides the evidence of association of mtDNA 15059G>A mutation heteroplasmy with essential hypertension.

关键词： Essential hypertension Heteroplasmy Mi-tochondrial DNA 15059G>A mutation

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Sheared peridotite xenolith from the *** kimberlite pipe,Arkhangelsk Diamond Province,Russia:Texture,composition,and origin

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Geoscience Frontiers 2017年第4期8卷 653-669页

作者： Alexey Vladimirovich Kargin Lyudmila Vyacheslavovna sazonova Anna Andreevna Nosova Vladimir Anatolievich Pervov Elena Vladimirovna Minevrina Vladimir Anatolievich Khvostikov Zhanna Petrovna Burmii Institute of Geology of Ore Deposits PetrographyMineralogyand GeochemistryRussian Academy of Sciences(IGEM RAS) Lomonosov Moscow State University Departamento de Geologia.Sociedade Mineira de Catoca Institute of Technological Problems of Microelectronics and Ultrapure Materials Russian Academy of Sciences

The petrography and mineral composition of a mantle-derived garnet peridotite xenolith from the *** kimberlite pipe（Arkhangelsk Diamond Province,Russia） was *** on petrographic characteristics,the peridotite xenolith reflects a sheared *** sheared peridotite experienced a complex evolution with formation of three main mineral assemblages：（1） a relict harzburgite assemblage consist of olivine and orthopyroxene porphyroclasts and cores of garnet grains（Gar1） with sinusoidal rare earth elements（REE） chondrite C1 normalized patterns;（2） a neoblastic olivine and orthopyroxene assemblage;（3） the last assemblage associated with the formation of clinopyroxene and garnet marginal zones（Gar2）.Major and trace element compositions of olivine,orthopyroxene,clinopyroxene and garnet indicate that both the neoblast and clinopyroxene-Gar2 mineral assemblages were in equilibrium with a high Fe-Ti carbonate-silicate metasomatic *** nature of the metasomatic agent was estimated based on high field strength elements（HFSE） composition of olivine neoblasts,the garnet-clinopyroxene equilibrium condition and calculated by REE-composition of Gar2 and *** these evidences indicate that the agent was a high temperature carbonate-silicate melt that is geochemically linked to the formation of the protokimberlite melt.

关键词： Sheared peridotite Mantle metasomatism Kimberlite Olivine Garnet Clinopyroxene

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Phlogopite in mantle xenoliths and kimberlite from the Grib pipe,Arkhangelsk province,Russia:Evidence for multi-stage mantle metasomatism and origin of phlogopite in kimberlite

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Geoscience Frontiers 2019年第5期10卷 1941-1959页

作者： A.V. Kargin L.V. sazonova A.A. Nosova N.M. Lebedeva Yu.A. Kostitsyn E.V. Kovalchuk V.V. Tretyachenko Ya.S. Tikhomirova Institute of Geology of Ore Deposits PetrographyMineralogyand GeochemistryRussian Academy of Sciences (IGEM RAS)MoscowRussia Lomonosov Moscow State University MoscowRussia Vernadsky Institute of Geochemistry and Analytical Chemistry of Russian Academy of Sciences MoscowRussia AC ALROSA Research Geological Prospecting Enterprise ArkhangelskRussia

We present petrography and mineral chemistry for both phlogopite,from mantle-derived xenoliths (garnet peridotite,eclogite and clinopyroxene-phlogopite rocks) and for megacryst,macrocryst and groundmass flakes from the Grib kimberlite in the Arkhangelsk diamond province of Russia to provide new insights into multi-stage metasomatism in the subcratonic lithospheric mantle (SCLM) and the origin of phlogopite in *** on the analysed xenoliths,phlogopite is characterized by several *** first generation (Phl1) occurs as coarse,discrete grains within garnet peridotite and eclogite xenoliths and as a rock-forming mineral within clinopyroxene-phlogopite *** second phlogopite generation (Phl2) occurs as rims and outer zones that surround the Phl1 grains and as fine flakes within kimberlite-related veinlets filled with carbonate,serpentine,chlorite and *** garnet peridotite xenoliths,phlogopite occurs as overgrowths surrounding garnet porphyroblasts,within which phlogopite is associated with Cr-spinel and minor *** eclogite xenoliths,phlogopite occasionally associates with carbonate bearing veinlet ***,from the kimberlite,occurs as megacrysts,macrocrysts,microcrysts and fine flakes in the groundmass and matrix of kimberlitic *** phlogopite grains within the kimberlite are characterised by signs of deformation and form partly fragmented grains,which indicates that they are the disintegrated fragments of previously larger ***1,within the garnet peridotite and clinopyroxeneephlogopitexenoliths,is characterised bylow Ti and Cr contents (TiO292) typical of primary peridotite phlogopite in mantle peridotite xenoliths from global kimberlite *** formed during SCLM metasomatism that led to a transformation from garnet peridotite to clinopyroxene-phlogopite rocks and the crystallisation of phlogopite and high-Cr clinopyroxene megacrysts before the

关键词： Mantle metasomatism Kimberlite Phlogopite Mantle xenoliths Megacrysts

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The comparison of intravenous and lymphotropic routes of <sup>99m</sup>Tc ciprofloxacin in experimental pulmonary suppuration

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Health 2011年第11期3卷 663-667页

作者： Yuriy Lishmanov Svetlana sazonova Yevgeny Sokolovich Vladimir Chernov 不详

Intravenously injected “99mTc-ciprofloxacin” is rapidly accumulated and washed from the septic focus. Lymphotropic injections provide targeted and long-lasting effect of antibiotics. After injection into the interspinous ligament the drug slowly enters the inflammation area (by-passing the urinary organs and liver), where it is maximally accumulated only after 24 h, which allows to reduce the number of injections and the total dose of the antibiotic.

关键词： Pulmonary Suppuration Lymphotropic Route 99mTc Ciprofloxacin

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利用泥炭和腐泥作为动物饲料的新的长远方向

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腐植酸 1994年第1期 42-46页

作者： T.N.sazonova A.V.Poenikov V.A.Petrunina 王曾辉

泥炭和腐泥是动物饲料的补充原料,它们含有许多常量及微量元素、生理活性物质和维生素。为了供给动物更完备的营养,开发了利用泥炭、腐泥、生物活性物质和脂肪添加剂制成块状或粒状饲料的技术,报告中提出了这种设备的设计。

关键词：饲料泥炭腐泥

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硫磺改性硅酸锌和硅酸铝及以其为基础的建筑用材料生产工艺研发

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天然气工业 2024年第11期44卷 192-196页

作者：涅列京·丹·阿伊什科夫·亚·加罗曼诺夫·康·弗科洛什金·叶·亚萨宗诺娃·伊·亚尤苏波娃·阿·安阿赫梅托娃·列·阿巴拉耶娃·利·巴俄罗斯天然气科学研究院有限责任公司俄罗斯天然气工业股份公司喀山国立研究型技术大学俄罗斯

高含硫油气田开发面临剧毒硫化氢的安全处理及所形成的硫资源化利用的双重科学挑战。随着石油天然气生产行业不断发展,其加工过程中副产的硫磺越来越多,硫磺产品除用于制硫酸、化肥和橡胶添加剂等主流用途外,开发新的硫磺相关产品或材... 详细信息

高含硫油气田开发面临剧毒硫化氢的安全处理及所形成的硫资源化利用的双重科学挑战。随着石油天然气生产行业不断发展,其加工过程中副产的硫磺越来越多,硫磺产品除用于制硫酸、化肥和橡胶添加剂等主流用途外,开发新的硫磺相关产品或材料显得尤为重要。为此,聚焦于高含硫油气田开发中硫化氢的处理及硫的有效利用问题,提出了通过硫磺改性金属硅酸盐生产新型建筑材料的创新思路,并进行了硫磺改性金属硅酸盐的实验室研究和分析,提出了相关材料可能的应用领域。研究结果表明:①用氯化锌和氯化铝对无定形二氧化硅进行改性,有助于增加无定形二氧化硅表面活性中心数量;②物理化学和量子化学计算表明,金属氯化物与无定形二氧化硅中的氧和硅发生了化学反应;③在生产硫磺改性金属硅酸盐的工艺中应用金属(Zn、Al)氯化物作为亲电活化剂,所制得的材料指标优良,满足建筑行业要求。结论认为,研究成果不仅解决了含硫废弃物处理难题,还开辟了用硫磺改性金属硅酸盐生产新型建筑材料的新途径,产品具有广阔的应用前景,具有重要的生态意义和经济价值。

关键词：硫化氢硫含硫材料氯化铝氯化锌金属硅酸盐

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