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Neonatal neuroimaging after repair of congenital diaphragmatic hernia and long-term neurodevelopmental outcome

World Journal of Pediatric Surgery 2019年第3期2卷 2-8页

作者： Julia Kate Gunn-Charlton Alice C Burnett Stephanie malarbi margaret m moran Esther A Hutchinson Susan Greaves Rod W Hunt Newborn Intensive Care The Royal Children’s HospitalMelbourneVictoriaAustralia Neonatal Research Group Murdoch Children’s Research InstituteMelbourneVictoriaAustralia Department of Paediatrics The University of MelbourneMelbourneVictoriaAustralia Victorian Infant Brain Studies(VIBeS)Group Murdoch Children's Research InstituteMelbourneVictoriaAustralia Department of Occupational Therapy The Royal Children’s HospitalMelbourneVictoriaAustralia

Objective Previous outcome reports of congenital diaphragmatic hernia(CDH)have described neuroimaging anomalies and neurodevelopmental ***,the link between imaging and outcome has not been *** aimed to determine whether routine postoperative neonatal neuroimaging in infants with CDH detects later neurodevelopmental *** In a prospective cohort study within a clinical service in The Royal Children’s Hospital Newborn Intensive *** ultrasound was performed in 81 children and mRI in 57 children who subsequently underwent neurodevelopmental follow-up after surgery for *** scans were analyzed using a scoring system designed to identify injury,maturation and volume *** assessment occurred at 2 years(48)and neurocognitive assessment at 5 years(26)and/or 8 years(27).Brain imaging scores corrected for gestational age at scan time were correlated with outcome measures,adjusting for known clinical *** Clinically significant findings were identified on mRI of 16(28%)*** scores were in the normal range for all domains assessed at each *** impairment was seen in 23%at 2 years and verbal intellectual impairment in 25%at 8 *** cognitive scores were lower in 2-year-old children with white matter injury on mRI(p=0.03).mean motor scores were lower in 2-year-old children with brain immaturity(p=0.01).Associations between mRI and 5-year and 8-year assessments were no longer significant when adjusting for known clinical *** Neuroimaging abnormalities were associated with worse neurodevelopment at 2 years,but not with later neurocognitive outcomes,after accounting for clinical risk factors.

关键词： hernia routine maturity

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Associations between health-related fitness and patient-reported symptoms in newly diagnosed breast cancer patients

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Journal of Sport and Health Science 2024年第6期13卷 851-862页

作者： Ki-Yong An Fernanda Z.Arthuso myriam Filion Spencer J.Allen Stephanie m.Ntoukas Gordon J.Bell Jessica mcNeil Qinggang Wang margaret L.mcNeely Jeff K.Vallance Lin Yang S.Nicole Culos-Reed Leanne Dickau John R.mackey Christine m.Friedenreich Kerry S.Courneya Faculty of Kinesiology Sportand RecreationCollege of Health SciencesUniversity of AlbertaEdmonton T6G 2H9Canada Department of Kinesiology School of Health and Human SciencesUniversity of North Carolina at GreensboroGreensboroNC 27412USA Department of Cancer Epidemiology and Prevention Research Cancer Care AlbertaAlberta Health ServicesCalgary T2S 3C3Canada Faculty of Rehabilitation medicine University of AlbertaEdmonton T6G 2H9Canada Faculty of Health Disciplines Athabasca UniversityAthabasca T9S 3A3Canada Department of Oncology Cumming School of MedicineUniversity of CalgaryCalgary T2N 4N1Canada Faculty of Kinesiology University of CalgaryCalgary T2N 1N4Canada Faculty of medicine and Dentistry University of AlbertaEdmonton T6G 2H9Canada

Background:Newly diagnosed breast cancer patients experience symptoms that may affect their quality of life,treatment outcomes,and *** and managing breast cancer-related symptoms soon after diagnosis is *** purpose of this study was to investigate the associations between health-related fitness(HRF)and patient-reported symptoms in newly diagnosed breast cancer ***:This study utilized baseline data from the Alberta moving Beyond Breast Cancer Cohort Study that were collected within 90 days of *** measures included peak cardiopulmonary fitness(peak volume of oxygen consumption(VO_(2peak))),maximal muscular strength and endurance,flexibility,and body *** measures included depression,sleep quality,and *** multivariable logistic regression was performed for ***:Of 1458 participants,51.5%reported poor sleep quality,26.5%reported significant fatigue,and 10.4%reported moderate *** multivariable-adjusted models,lower relative VO_(2peak)was independently associated with a greater likelihood of all symptom measures,including moderate depression(pmptom(pmultiple symptoms(pmonstrated threshold associations with all symptom measures such that all 3 lower quartiles exhibited similar elevated risk compared to the highest *** strength of the threshold associations varied by the symptom measure with odds ratios ranging from-1.5 for poor sleep quality to-3.0 for moderate depression and multiple ***,lower relative upper body muscular endurance was also independently associated with fatigue in a dose-response manner(p=0.001),and higher body weight was independently associated with poor sleep quality in an inverted U pattern(p=0.021).Conclusion:Relative VO_(2peak)appears to be a critical HRF component associated with multiple patient-reported symptoms in newly diag

关键词： Breast cancer Fatigue Depression Sleep quality Cardiorespiratory fitness

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Defining Soil and Water Assessment Tool(SWAT)hydrologic responseunits(HRUs)by field boundaries

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International Journal of Agricultural and Biological Engineering 2015年第3期8卷 69-80页

作者： margaret m.Kalcic Indrajeet Chaubey Jane Frankenberger Graham Sustainability Institute University of MichiganAnn ArborMI 48104USA Department of Earth Atmosphericand Planetary SciencesPurdue UniversityWest LafayetteIN 47907USA Department of Agricultural and Biological Engineeri ng Purdue UniversityWest LafayetteIN 47907USA

The Soil and Water Assessment Tool(SWAT)is widely used to relate farm management practices to their impacts on surface waters at the watershed scale,yet its smallest spatial unit is not generally defined by physically meaningful *** hydrologic response unit(HRU)is the smallest spatial unit of the model,and the standard HRU definition approach lumps all similar land uses,soils,and slopes within a subbasin based upon user-defined *** standard method provides an efficient way to discretize large watersheds where simulation at the field scale may not be computationally *** relatively smaller watersheds,however,defining HRUs to specific spatial locations bounded by property lines or field borders would often be advantageous,yet this is not currently possible within the ArcSWAT *** this study,a simple approach is demonstrated that defines HRUs by field boundaries through addition of uniquely named soils to the SWAT user soil database and creation of a field boundary layer with majority land use and soil *** of nitrogen,phosphorus,and sediment losses were compared in a case study watershed where SWAT was set up using both the standard HRU definition and field boundary ***-scale results were reasonable and similar for both methods,but aggregating fields by majority soil type masked extremely high soil erosion predicted for a few *** from field-based HRU delineation may be quite different from the standard approach due to choosing a majority soil type in each farm *** approach is flexible such that any land use and soil data prepared for SWAT can be used and any shapefile boundary can divide HRUs.

关键词： watershed modeling Soil and Water Assessment Tool(SWAT) hydrologic response units field boundaries common land units landuse management

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Epidemiology of age-related macular degeneration (AmD): associations with cardiovascular disease phenotypes and lipid factors

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Eye and Vision 2016年第1期3卷 263-282页

作者： Katie L.Pennington margaret m.DeAngelis Department of Ophthalmology John A.Moran Eye CenterUniversity of UtahSalt Lake CityUTUSA

Age-related macular degeneration(AmD)is the leading cause of irreversible blindness in adults over 50 years ***,epidemiological,and molecular studies are beginning to unravel the intricate mechanisms underlying this complex disease,which implicate the lipid-cholesterol pathway in the pathophysiology of disease development and *** of the genetic and environmental risk factors associated with AmD are also associated with other complex degenerative diseases of advanced age,including cardiovascular disease(CVD).In this review,we present epidemiological findings associating AmD with a variety of lipid pathway genes,cardiovascular phenotypes,and relevant environmental *** a number of studies showing significant associations between AmD and these lipid/cardiovascular factors,results have been mixed and as such the relationships among these factors and AmD remain *** is imperative that researchers not only tease out the various contributions of such factors to AmD development but also the connections between AmD and CVD to develop optimal precision medical care for aging adults.

关键词： Atherosclerosis Hypertension Retina Statins Stroke Cholesterol Obesity BmI Antioxidants Genetic association

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Designing the new generation of intelligent biocompatible carriers for protein and peptide delivery

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Acta Pharmaceutica Sinica B 2018年第2期8卷 147-164页

作者： Angela m.Wagner margaret P.Gran Nicholas A.Peppas mcKetta Department of Chemical Engineering The University of Texas at Austin Institute for Biomaterials Drug Delivery and Regenerative Medicine The University of Texas at Austin Department of Biomedical Engineering The University of Texas at Austin Department of Pediatrics Dell Medical School The University of Texas at Austin Department of Surgery and Perioperative Care Dell Medical School The University of Texas at Austin Division of Pharmaceutics College of Pharmacy The University of Texas at Austin

Therapeutic proteins and peptides have revolutionized treatment for a number of diseases, and the expected increase in macromolecule-based therapies brings a new set of challenges for the pharmaceutics field. Due to their poor stability, large molecular weight, and poor transport properties,therapeutic proteins and peptides are predominantly limited to parenteral administration. The short serum half-lives typically require frequent injections to maintain an effective dose, and patient compliance is a growing issue as therapeutic protein treatments become more widely available. A number of studies have underscored the relationship of subcutaneous injections with patient non-adherence, estimating that over half of insulin-dependent adults intentionally skip injections. The development of oral formulations has the potential to address some issues associated with non-adherence including the interference with daily activities, embarrassment, and injection pain. Oral delivery can also help to eliminate the adverse effects and scar tissue buildup associated with repeated injections. However, there are several major challenges associated with oral delivery of proteins and peptides, such as the instability in the gastrointestinal(GI)tract, low permeability, and a narrow absorption window in the intestine. This review provides a detailed overview of the oral delivery route and associated challenges. Recent advances in formulation and drugdelivery technologies to enhance bioavailability are discussed, including the co-administration of compounds to alter conditions in the GI tract, the modification of the macromolecule physicochemical properties, and the use of improved targeted and controlled release carriers.

关键词： Oral delivery Hydrogels Protein delivery Peptide delivery Carbohydrates mucoadhesion

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Perspectives in nutrition / Gordon m. Wardlaw, margaret W. Kessel. 5th ed.

Perspectives in nutrition / Gordon M. Wardlaw, Margaret W. K...

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2002年

作者： Gordon m. Wardlaw margaret W. Kessel.

来源：畅想之星图书光盘版（南... 评论

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Optimal allocation of watershed management cost among different water users

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Ecological Economy 2006年第3期2卷 245-250页

作者： Wang Zanxin margaret m. Calderon Department of Business Administration Jiangsu Polytechnic University Changzhou 213164 P. R. China Institute of Renewable Natural Resources University of the Philippines Los Banos the Philippines

The issue of water scarcity highlights the importance of watershed management. A sound watershed manage- ment should make all water users share the incurred cost. This study analyzes the optimal allocation of watershed management cost among different water users. As a consumable, water should be allocated to different users the amounts in which their marginal utilities (mUs) or marginal products (mPs) of water are equal. The value of mUs or mPs equals the water price that the watershed manager charges. When water is simultaneously used as consumable and non- consumable, the watershed manager produces the quantity of water in which the sum of mUs and/or mPs for the two types of uses equals the marginal cost of water production. Each water user should share the portion of watershed management cost in the percentage that his mU or mP accounts for the sum of mUs and/or mPs. Thus, the price of consumable water does not equal the marginal cost of water production even if there is no public good.

关键词： Consumable Non-consumable Optimal allocation Watershed management cost

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Feasibility of sustaining the upland conversion program by establishing a domestic carbon market

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Forestry Studies in China 2008年第4期10卷 205-211页

作者： WANG Zan-xin margaret m. CALDERON School of Development Studies Yunnan University Kunming 650091 E R. China College of Forestry and Natural Resources University of the Philippines Los Banos Laguna 4031 Philippines

To sustain the upland conversion program （UCP） in China after the government compensation expires, we suggest an establishment of a domestic carbon market where forest carbon from the UCP can be traded. Taking southwest China＇s Yunnan Province as an example, we explored the feasibility of switching the UCP to a carbon offset project. The breakeven carbon price which is equivalent to the opportunity cost of agricultural cultivation was estimated and then compared with the carbon price in the international market. We found that it is feasible to change the UCP to a carbon offset project if the duration is longer than 10 years at a discount rate of 7%, and if the recent bid price （147.2 Yuan.t-1） for Chinese carbon offset project prevails. The feasibility is better for converted land with lower productivity when the project duration is given. For a given site index, the feasibility is lower as pro- ject length is reduced. The results of sensitivity analysis show that the feasibility will be enhanced as the discount rate increases; however, the changes in the price of agricultural products and the amount of sequestered carbon have insignificant effects on the choice of sites and project duration.

关键词： upland conversion program carbon sequestration domestic carbon market

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LOX upregulates FAK phosphorylation to promote metastasis in osteosarcoma

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Genes & Diseases 2023年第1期10卷 254-266页

作者： Xiang Chen margaret Clement mJohn Hicks Poonam Sarkar mWaleed Gaber Tsz-Kwong man Department of Pediatrics Baylor College of MedicineOne Baylor PlazaHoustonTX 77030USA Department of Pathology Baylor College of MedicineOne Baylor PlazaHoustonTX 77030USA Dan L.Duncan Comprehensive Cancer Center 7200 Cambridge StreetHoustonTX 77054USA Texas Children's Cancer and Hematology Centers 1102 Bates StHoustonTX 77030USA

Osteosarcoma is a malignant bone tumor that commonly occurs in the pediatric *** the use of chemotherapy and surgery,metastasis remains to be the leading cause of death in patients with *** have previously reported that cytoplasmic mislocalization of p27 is associated with a poor outcome in *** this study,we further show that lysyl oxidase(LOx)expression was associated with p27 *** is an enigmatic molecule that acts as a tumor suppressor or a metastatic promoter;however,its role in osteosarcoma is still ***,we performed both in vitro and in vivo analyses to dissect the role of Lox in *** result of our survival analysis indicated that Lox expression significantly correlated with a poor outcome in osteosarcoma with or without controlling for the initial metastasis status(Pmoted osteosarcoma cell proliferation,migration,and invasiveness in vitro and produced a higher number of mice with pulmonary metastases in an orthotopic xenograft mouse ***,phospho-FAK was increased in osteosarcoma cells with high LOX *** results further showed that FAK inhibition significantly reduced tumor cell proliferation and migration in vitro as well as LoX-mediated metastasis in ***,our findings suggest that there is a novel link between p27 mislocalization and LOX *** plays a pivotal role in osteosarcoma metastasis by upregulating FAK *** inhibition may constitute a promising therapeutic strategy to reduce the development of metastasis in osteosarcoma with Lox overexpression.

关键词： Focal adhesion kinase Lysyl oxidase metastasis Osteosarcoma

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Beyond direct neighbourhood effects: higher-order interactions improve modelling and predicting tree survival and growth

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National Science Review 2021年第5期8卷 38-47页

作者： Yuanzhi Li margaret m.mayfield Bin Wang Junli Xiao Kamil Kral David Janik Jan Holik Chengjin Chu Department of Ecology State Key Laboratory of BiocontrolSchool of Life SciencesSun Yat-sen University Guangxi Key Laboratory of Plant Conservation and Restoration Ecology in Karst Terrain Guangxi Institute of BotanyGuangxi Zhuang Autonomous Region and Chinese Academy of Sciences Department of Silviculture Faculty of Forestry and Wood TechnologyMendel University in Brno School of Biological Sciences The University of Queensland Department of Forest Ecology Silva Tarouca Research Institute

It is known that biotic interactions are the key to species coexistence and maintenance of species *** studies focus overwhelmingly on pairwise interactions between organisms, ignoring complex higher-order interactions(HOIs). In this study, we present a novel method of calculating individual-level HOIs for trees, and use this method to test the importance of size-and distance-dependent individual-level HOIs to tree performance in a 25-ha temperate forest dynamic plot. We found that full HOI-inclusive models improved our ability to model and predict the survival and growth of trees, providing empirical evidence that HOIs strongly influence tree performance in this temperate forest. Specifically, assessed HOIs mitigate the competitive direct effects of neighbours on survival and growth of focal trees. Our study lays a foundation for future investigations of the prevalence and relative importance of HOIs in global forests and their impact on species diversity.

关键词： pairwise interactions indirect interactions density-dependent size- and distance-dependent Zofin Forest Dynamic Plot

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