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effects of radiation and chemotherapy on adipose stem cells: Implications for use in fat grafting in cancer patients

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World Journal of Stem Cells 2021年第8期13卷 1084-1093页

作者： Rebecca Platoff Miguel A Villalobos Ashleigh Rapp Hagaman Yuan Liu Martha Matthews Michael e DiSanto Jeffrey P Carpenter Ping Zhang Department of Surgery Cooper University Health CareCamdenNJ 08103United States Department of Surgery Cooper Medical School of Rowan UniversityCamdenNJ 08103United States Department of Biomedical Sciences Cooper Medical School of Rowan UniversityCamdenNJ 08103United States

Autologous fat transplantation is a versatile tool in reconstructive ***-derived stem cells(ASCs)increase survival of fat grafts and thus are increasingly used for breast reconstruction in breast cancer ***,radiation and/or chemotherapy have been proposed to inhibit soft tissue regeneration in wound healing thus suggesting alteration in stem cell ***,elucidating effects of radiation and chemotherapy on ASCs is critical if one desires to enhance the survival of fat grafts in *** review outlines our work evaluating the function and recoverability of ASCs from radiation or chemotherapy patients,focusing specifically on their availability as a source of autologous stem cells for fat grafting and breast reconstruction in cancer *** though evidence suggests radiation and chemotherapy negatively influence ASCs at the cellular level,the efficiency of the isolation and differentiation capacity did not appear influenced in patients after receiving chemotherapy treatment,although fat from radiated patients exhibited significantly altered ASC differentiation into endothelial-like ***,the in vitro growth rates of patient’s ASCs do not differ significantly before or after *** together,these studies suggest ASCs as an important new tool for grafting and reconstruction even when radiation and chemotherapy treatment are involved.

关键词： Fat grafting Breast reconstruction Stem cells Breast cancer Radiation Chemotherapy

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Cardiorespiratory fitness,white blood cell count,and mortality in men and women

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Journal of Sport and Health Science 2022年第5期11卷 605-612页

作者： Stephen W.Farrell David Leonard Kerem Shuval Laura F.DeFina Carolyn e.Barlow Andjelka Pavlovic William L.Haskell Research Division The Cooper InstituteDallasTX 75230USA Department of Medicine Stanford UniversityPalo AltoCA 94305USA

Background:We examined the associations of cardiorespiratory fitness(CRF) and white blood cell count(WBC) with mortality ***: A total of 52,056 apparently healthy adults completed a comprehensive health examination,including a maximal treadmill test and blood chemistry *** was categorized as high,moderate,or low by age and sex;WBC was categorized as sex-specific ***:During 17.8± 9.5 years(mean± SD) of follow-up,a total of 4088 deaths *** regressed jointly,significantly decreased allcause mortality across CRF categories was observed within each quartile of WBC in *** WBC Quartile 1,all-cause mortality hazard ratios(HRs) with a 95% confidence interval(95%CI) were 1.0(referent),1.29(95%CI:1.06-1.57),and 2.03(95%CI:1.42-2.92) for high,moderate,and low CRF categories,respectively(p for trend ends were observed in the remaining 3 *** the exception of cardiovascular disease(CVD) mortality within Quartile 1(p for trend=0.743),there were also similar trends across CRF categories within WBC quartiles in men for both CVD and cancer mortality(p for trend en,there were no significant trends across CRF categories for mortality outcomes within Quartiles ***,we observed significantly decreased all-cause mortality across CRF categories within WBC Quartile 4(HR=1.05(95%CI:0.76-1.44),HR=1.63(95%CI:1.20-2.21),and HR=1.87(95%CI:1.29-2.69) for high,moderate,and low CRF,respectively(p for trend=0.002)).Similar trends in women were observed for CVD and cancer mortality within WBC Quartile 4 ***:There are strong joint associations between CRF,WBC,and all-cause,CVD,and cancer mortality in men;these associations are less consistent in women.

关键词： Complete blood count epidemiology Inflammation Physical fitness

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A SYNDROMe OF SeVeRe HYPOGLYCeMIA AND ACIDOSIS IN YOUNG IMMUNOSUPPReSSeD DIABeTIC MONKeYS - ASSOCIATION WITH SePSIS

A SYNDROME OF SEVERE HYPOGLYCEMIA AND ACIDOSIS IN YOUNG IMMU...

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2012中国器官移植大会

作者： Dirk J.van der Windt eefje M.Dons Gabriel J. echeverri Noriko Murase Rita Bottino Martin Wijkstrom Robert Wagner David K.C.cooper Thomas e.Starzl Transplantation Institute Department of SurgeryUniversity of Pittsburgh Medical CenterPittsburghPAUSA Division of Immunogenetics Department of PediatricsChildren's Hospital of PittsburghPittsburghPAUSA

Large animals treated with immunosuppressive drug regimens for preclinical experiments of transplantation have increased risks of infection,as do individuals with *** we report our experience with severe sepsis in two young cynomolgus monkeys that were subjected to diabetes induction +/- islet *** both monkeys,infection was associated with a syndrome of profound hypoglycemia accompanied by severe *** the discussion of these cases we include information on five immunosuppressed pigs that also experienced severe hypoglycemic episodes after diabetes induction and islet

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对爱尔兰西北部多尼戈尔郡大西洋岸沙丘系统制定综合参与性管理策略

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AMBIO－人类环境杂志 2000年第3期29卷 143-149页

作者： James Power John McKenna Michael J.MacLeod Andrew J.G.cooper Gerard Convie 沈德富阿尔斯特大学利物浦约翰穆尔斯大学多尼戈尔郡议会

爱尔兰海岸带的发展计划和资源管理,传统上是按照自上而下的部门型式进行的,民众参与或行政力量协作的机会是很有限的。在这些途径行不通的情况下,"海岸带综合管理(ICZM)"往往作为一种适宜的政策反应而提出来。本文作者论证,若首先在小... 详细信息

爱尔兰海岸带的发展计划和资源管理,传统上是按照自上而下的部门型式进行的,民众参与或行政力量协作的机会是很有限的。在这些途径行不通的情况下,"海岸带综合管理(ICZM)"往往作为一种适宜的政策反应而提出来。本文作者论证,若首先在小规模上引用"海岸带综合管理",它就可以成为更可持续的管理。为了在早期阶段产生可示范的效益,拟定好地方一级的行动计划大概更可能形成对海岸带综合管理的长期支持。在基线数据缺乏和对海岸过程了解很差的地方,这点是特别重要的。利用多尼戈尔郡的7个沙滩和沙丘系统作为示范场地,这种途径对提供有科学依据的、当地赞成的管理计划的潜力经受了一系列海岸问题的检验,如渐进的海岸线侵蚀、生境丧失、旅游业发展、互相冲突的娱乐活动和交通管理等问题。这些场地的每一个进展,都部分地依赖于现有各个社区组织的协作和行动。从最好的实例看,已经建立了一个利用许多海岸带综合管理中心原则(如范围广泛的民众参与、符合自然过程的操作)的地方团体。在以当地问题、实际问题实际解决和相对少数的有关利益方为重点的条件下,对管理计划所涉及的大多数问题和策略已经达成一致。这些计划将于2000年初开始执行。

关键词：爱尔兰海岸带综合管理沙丘沙滩

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Identification of new genetic risk factors for prostate cancer

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Asian Journal of Andrology 2009年第1期11卷 49-55页

作者： Michelle Guy Zsofia Kote-Jarai Graham G. Giles Ali Amin Al Olama Sarah K. Jugurnauth Shani Mulholland Daniel A. Leongamomlert Stephen M. edwards Jonathan Morrison Helen I. Field Melissa C. Southey Gianluca Severi Jenny L. Donovan Freddie C. Hamdy David R Dearnaley Kenneth R. Muir Charmaine Smith Melisa Bagnato Audrey T. Ardern-Jones Amanda L. Hall Lynne T. O＇Brien Beatrice N. Gehr-Swain Rosemary A. Wilkinson Angela Cox Sarah Lewis Paul M. Brown Sameer G. Jhavar Malgorzata Tymrakiewicz Artitaya Lophatananon Sarah L. Bryant The UK Genetic Prostate Cancer Study Collaborators British Association of Urological Surgeons＇ Section of Oncology and The UK ProtecT Study Collaborators Alan Horwich Robert A. Huddart Vincent S. Khoo Christopher C. Parker Christopher J. Woodhouse Alan Thompson Tim Christmas Chris Ogden Cyril Fisher Charles Jameson Colin S. cooper Dallas R. english John L. Hopper David e. Neal Douglas e easton Rosalind A. eeles Section of Cancer Genetics The Institute of Cancer Research Sutton Surrey SM2 5NG UK Cancer epidemiology Centre The Cancer Council Victoria Carlton VIC 3053 Australia Centre for Molecular Environmental Genetic and Analytic Epidemiology The University of Melbourne Carlton VIC 3053 Australia Cancer Research UK Genetic epidemiology Unit University of Cambridge Strangeways Laboratory Worts Causeway Cambridge CB1 8RN UK Department of Oncology University of Cambridge Strangeways Laboratory Worts Causeway Cambridge CB1 8RN UK Genetic epidemiology Laboratory Department of Pathology The University of Melbourne Parkville VIC 3052 Australia Department of Social Medicine University of Bristol Bristol BS8 2PR UK Academic Urology Unit University of Sheffield Sheffield SIO 2JF UK The Royal Marsden NHS Foundation Trust Sutton Surrey SM2 5PT and London SW3 6JJ UK University of Nottingham Medical School Queens Medical Centre Nottingham NG7 2UH UK Institute for Cancer Studies University of Sheffield Sheffield SIO 2RX UK Surgical Oncology （Uro-Oncology S4） Departments of Oncology and Surgery University of Cambridge Addenbrooke＇s Hospital Cambridge CB2 2QQ UK A full list of authors is provided in the Supplementary Note online Ka Shing Centre Cambridge CB2 ORE UK Cancer Research UK Cambridge Research Institute Li Ka Shing Centre Cambridge CB2 ORE UK.

There is evidence that a substantial part of genetic predisposition to prostate cancer （PCa） may be due to lower penetrance genes which are found by genome-wide association studies. We have recently conducted such a study and seven new regions of the genome linked to PCa risk have been identified. Three of these loci contain candidate susceptibility genes： MSMB, LMTK2 and KLK2/3. The MSMB and KLK2/3 genes may be useful for PCa screening, and the LMTK2 gene might provide a potential therapeutic target. Together with results from other groups, there are now 23 germline genetic variants which have been reported. These results have the potential to be developed into a genetic test. However, we consider that marketing of tests to the public is premature, as PCa risk can not be evaluated fully at this stage and the appropriate screening protocols need to be developed. Follow-up validation studies, as well as studies to explore the psychological implications of genetic profile testing, will be vital prior to roll out into healthcare.

关键词： prostate cancer genetics susceptibility loci SNPs relative risks

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脑卒中后90 d药物依从性的种族差异

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中华高血压杂志 2019年第6期27卷 599-599页

作者： Lank RJ Lisabeth LD Levine DA Zahuranec DB Kerber KA Shafie-Khorassani F Case e Zuniga BG cooper GM Brown DL Morgenstern LB 刘青(译) 叶鹏(摘、审校) 不详

研究者在一项基于人群的研究中评估了脑卒中后3个月服药依从性的种族差异,初步探索墨西哥裔美国人较非西班牙裔白人脑卒中复发风险增加的原因。方法:对2008-2015年监测脑卒中的德克萨斯州科珀斯克里斯蒂项目中的缺血性脑卒中病例在脑卒... 详细信息

研究者在一项基于人群的研究中评估了脑卒中后3个月服药依从性的种族差异,初步探索墨西哥裔美国人较非西班牙裔白人脑卒中复发风险增加的原因。方法:对2008-2015年监测脑卒中的德克萨斯州科珀斯克里斯蒂项目中的缺血性脑卒中病例在脑卒中后进行了3个月的前瞻性研究,以评估药物依从性。分析了5种类别的药物:他汀类、抗血小板类、抗凝剂、抗高血压药和抗抑郁药。药物依从定义为对于每个药物类别,患者报告在1周内从未漏服过。使用χ^2检验或Kruskal-Wallis非参数检验对人口统计学、风险因素和药物依从性进行种族比较。

关键词：药物依从性脑卒中后种族差异缺血性脑卒中服药依从性抗高血压药人口统计学非参数检验

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采用β受体阻滞剂和噻嗪类利尿剂作为高血压单药治疗和联合治疗时,血浆肾素活性对血压反应的预测

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中华高血压杂志 2010年第12期18卷 1198-1198页

作者： Turner ST Schwartz GL Chapman AB Beitelshees AL Gums JG cooper-DeHoff RM Boerwinkle e Johnson JA Bailey KR 黄晓斌

年龄和种族类别或肾素水平已被推荐作为使用8受体阻滞剂或噻嗪类利尿剂进行单药治疗预测血压反应的指标。然而使用B受体阻滞剂或噻嗪类利尿剂与其他抗高血压药物进行联合治疗，上述特征，或其他特征指标的预测作用还不明确。

关键词：噻嗪类利尿剂 β受体阻滞剂血浆肾素活性抗高血压药物预测作用联合治疗单药治疗血压反应

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Phase 3 trial of first generation protease inhibitor therapy for hepatitis C virus/human immunodeficiency virus coinfection

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World Journal of Hepatology 2017年第4期9卷 217-223页

作者： Kenneth e Sherman Minhee Kang Richard Sterling Triin Umbleja Kristen Marks Jennifer J Kiser Beverly Alston-Smith Wayne Greaves Adeel A Butt 无 Division of Digestive Diseases University of Cincinnati College of Medicine harvard T.h. Chan School of Public health Department of Gastroenterology Virginia Commonwealth University Division of Infectious Disease Weill Cornell Medical School University of Colorado School of Pharmacy NIAID-Division of AIDS Merck and Co Inc. University of Pittsburgh School of Medicine hamad healthcare Quality Institute the ACTG 5294 BIRTH Study Team

AIMTo evaluate efficacy/safety of hepatitis C virus (HCV) protease inhibitor boceprevir with pegylated interferon (PeG-IFN) alfa and weight-based ribavirin (RBV) in a phase 3 trial. MeTHODSA prospective, multicenter, phase 3, open-label, single-arm study of PeG-IFN alfa, weight-based RBV, and boceprevir, with a PeG-IFN/RBV lead-in phase was performed. The HCV/human immunodeficiency virus coinfected study population included treatment naïve (TN) and treatment experienced (Te) patients. Treatment duration ranged from 28 to 48 wk dependent upon response-guided criteria. All patients had HCV Genotype 1 with a viral load > 10000 IU/mL. Compensated cirrhosis was allowed. Sample size was determined to establish superiority to historical (PeG-IFN plus RBV) rates in sustained viral response (SVR). ReSULTSA total of 257 enrolled participants were analyzed (135 TN and 122 Te). In the TN group, 81.5% were male and 54.1% were black. In the Te group, 76.2% were male and 47.5% were white. Overall SVR12 rates (HCV RNA P = 0.002). Among the TN, SVR12 was 42.1% among whites and 27.4% among blacks (P = 0.09). CONCLUSIONThe trial met its hypothesis of improved SVR compared to historical controls but overall SVR rates were low. All-oral HCV treatments will mitigate these difficulties.

关键词： Human immunodeficiency virus Hepatitis C virus Boceprevir Pegylated interferon alfa Ribavirin

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Rapid, continuous projection multi-photon 3D printing enabled by spatiotemporal focusing of femtosecond pulses

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Light(Science & Applications) 2021年第10期10卷 1987-1997页

作者： Paul Somers Zihao Liang Jason e.Johnson Bryan W.Boudouris Liang Pan Xianfan Xu School of Mechanical engineering and Birck Nanotechnology Center Purdue UniversityWest LafayetteINUSA Charles D.Davidson School of Chemical engineering Purdue UniversityWest LafayetteINUSA Department of Chemistry Purdue UniversityWest LafayetteINUSA

There is demand for scaling up 3D printing throughput,especially for the multi-photon 3D printing process that provides sub-micrometer structuring capabilities required in diverse *** this work,high-speed projection multiphoton printing is combined with spatiotemporal focusing for fabrication of 3D structures in a rapid,layer-by-layer,and continuous *** focusing confines printing to thin layers,thereby achieving print thicknesses on the micron and sub-micron *** projection of dynamically varying patterns with no pause between patterns,a continuous fabrication process is established.A numerical model for computing spatiotemporal focusing and imaging is also presented which is verified by optical imaging and printing *** 3D structures with smooth features are fabricated,with millimeter scale printing realized at a rate above 10−3 mm3 s−*** method is further scalable,indicating its potential to make fabrications of 3D structures with micro/nanoscale features in a practical time scale a reality.

关键词： projection continuous thereby

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应用2017年美国心脏病学会/美国心脏协会血压指南预防潜在的心血管病事件

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中华高血压杂志 2018年第12期26卷 1104-1104页

作者： Bress AP Colantonio LD cooper R Kramer H Booth JN Odden MC Bibbins-Domingo K Shimbo D Whelton PK Levitan eB Howard G Bellows BK Kleindorfer D Safford MM Muntner P Andrew e 刘青叶鹏

该研究在美国高血压成人患者比较血压达到2017年美国心脏病学会/美国心脏协会(American College of Cardiology/American Heart Association,ACC/AHA)指南推荐的血压目标与(1)当前血压水平,(2)达到2003年高血压预防、检测、评估和治疗... 详细信息

该研究在美国高血压成人患者比较血压达到2017年美国心脏病学会/美国心脏协会(American College of Cardiology/American Heart Association,ACC/AHA)指南推荐的血压目标与(1)当前血压水平,(2)达到2003年高血压预防、检测、评估和治疗全国联合委员会(the joint national committee on prevention,detection,evaluatioyl and treatment of highblood pressure,JNC)第七次报告(JNC7)目标;以及(3)达到2014年JNC第8次报告(JNCS)血压目标时可预防的心血管事件数和治疗相关严重不良事件的发生次数。

关键词：美国心脏病学会美国心脏协会高血压心血管病事件预防指南 prevention 心血管事件

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