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第十五届国际药理学大会

作者： Mirossay Ladislav Oravkinova Irina Tokarcikova Katarina Jamborova Erika Sarissky marek Mojzis Jan Mirossay Andrej P.J.Safarik Univ. Fac. Med.Dept. Pharmacol.KosiceSlovak Republic. Pediatric Hospital Dept.Pediat.Oncol.KosiceSlovak Republic. P.J. Safarik Univ. Fac. Med.Dept.Pharmacol.KosiceSlovak Republic. P.J. Safarik Univ. Fac. Med.Dept.Pharmacol.KosiceSlovak Republic. P.J. Safarik Univ. Fac. Med.Dept.Pharmacol.KosiceSlovak Republic. P.J. Safarik Univ. Fac. Med.Dept.Pharmacol.KosiceSlovak Republic. P.J. Safarik Univ. Fac. Med.Dept.Pharmacol.KosiceSlovak Republic.

＜正＞ Objective: Cellular drug resistance measured at initial diagnosis is associated with an increased relapse risk and unfavorable clinical outcome in childhood ALL. In addition, the presence of adverse clinical prognostic factors such as age. and pro - B and T - lineage immunophenotype have been shown to be associated with cellular resistance to drugs in children with ALL. P - glycoprotein （Pgp）, the gene product of MDR1, confers multidrug resistance to a number of antineoplastic agents. A silent mutation in the exon 26 （C3435T） has been associated with altered expression and function of Pgp in tissues. Methods: MIT cytotoxicity assay, PCR alnalysis of C3435T polymorphism in MDR1 gene. Results: We compared the impact of C3435T polymorphism on in vitro chemosensitivity of leukemia cells to methylprednisolone. CC genotype carriers showed higher IC50 values in comparison with the carriers of CT or TT genotype. Statistical analysis Mann- Whitney U test showed P = 0.035. Conclusions: The group of patients with CC genotype seems to be more resistant to glucocorticoids, or at least methyprednisolone.

关键词： ALL MDR1 gene polymorphism glucocorticoid

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用遥感法获取地球信息

科学与社会 1985年第4期 17-25页

作者： Heinz Kautzleben Karl-Heinz marek 何永晋德意志民主共和国科学院地学与空间科学学部波茨坦地球物理中央研究所

有关地球、地球资源及其各种自然作用的信息处理正在发生根本性的变革.这类信息称为"地球信息",大多可用遥感方法获取.对信息的需求实际上正在导致产生新一代的遥感系统.

关键词：需求地球行星遥感系统遥感数据制图学遥感方法遥测方法

Attenuation of dextran sodium sulphate induced colitis in matrix metalloproteinase-9 deficient mice

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World Journal of Gastroenterology 2006年第40期12卷 6464-6472页

作者： Alfredo Santana Carlos Medina Maria Cristina Paz-Cabrera Federico Díaz-Gonzalez Esther Farré Antonio Salas marek W Radomski Enrique Quintero Gastroenterology Department and Research Unit Hospital Universitario de Canarias Tenerife Spain Reumathology Department Hospital Universitario de Canrias Tenerife Spain Pathology Department Hospital Mutua de Terrassa Barcelona Spain Institute of Molecular Medicine University of Texas Houston-Texas United States

AIM: To study whether matrix metalloproteinase-9 (MMP-9) is a key factor in epithelial damage in the dextran sodium sulphate (DSS) model of colitis in ***: MMP-9-deficient and wild-type (wt) mice were given 5% DSS in drinking water for 5 d followed by recovery up to 7 d. On d 5 and 12 after induction of colitis, gelatinases, MMP-2 and MMP-9, were measured in homogenates of colonic tissue by zymography and Western blot, whereas tissue inhibitor of metalloproteinases (TIMPs) were measured by reverse zymography. The gelatinolytic activity was also determined in supernatants of polymorphonuclear leukocytes (PMN) isolated from mice blood. Moreover, intestinal epithelial cells were stimulated with TNF-α to study whether these cells were able to produce MMPs. Finally, colonic mucosal lesions were measured by microscopic examination. RESULTS: On d 5 of colitis, the activity of MMP-9 was increased in homogenates of colonic tissues (0.24 ± 0.1 vs 21.3 ± 6.4, P < 0.05) and PMN from peripheral blood in wt (0.5 ± 0.1 vs 10.4 ± 0.7, P < 0.05), but not in MMP-9-deficient animals. The MMP-9 activity was also up-regulated by TNF-α in epithelial intestinal cells (2.5 ± 0.5 vs 14.7 ± 3.0, P < 0.05). Although colitis also led to increase of TIMP-1 activity, the MMP-9/TIMP-1 balance remained elevated. Finally, in the MMP-9-deficient colitic mice both the extent and severity of intestinal epithelialinjury were significantly attenuated when compared with wt mice. CONCLUSION: We conclude that DSS induced colitis is markedly attenuated in animals lacking MMP-9. This suggests that intestinal injury induced by DSS is modu-lated by MMP-9 and that inhibition of this gelatinase may reduce inflammation.

关键词：病理治疗临床肠炎

Planting Geometry Effects on the Growth and Yield of Dryland Cotton

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Agricultural Sciences 2018年第1期9卷 99-116页

作者： R. L. Baumhardt R. C. Schwartz G. W. marek J. M. Bell Soil and Water Management Research Conservation and Production Research Laboratory USDA-ARS Bushland TX USA Agronomy Texas A & M AgriLife Research and Extension Amarillo TX USA

The declining Ogallala Aquifer beneath the Southern High Plains may necessitate dryland crop production and cotton (Gossypium hirsutum L.) is a well-adapted and potentially profitable alternative crop. The limited growing season duration of the Texas Panhandle and southwestern Kansas, however, imposes significant production risk due to incomplete boll maturation. Emphasizing earlier boll production that is usually confined to sites on lower fruiting branches may reduce risk, but offsetting high planting densities are needed to maintain desirable lint yield. Our objectives were to quantify planting: 1) row width and 2) in-row spacing effects on growth, yield, and fiber quality of dryland cotton. Field tests of row widths from 0.25 to 0.76 m and plant densities with in-row spacing ranging from 0.075 to 0.15 m were conducted from 1999 to 2005 on a nearly level Pullman clay loam (fine, mixed, superactive, thermic Torrertic Paleustoll) managed in a wheat (Triticum aestivum L.), cotton, fallow (W-Ctn-F) rotation. To expand the basis of comparison, cotton growth and yields were simulated using GOSSYM and long-term (1958-2000) weather records from Bushland, TX, as input for all combinations of 0.38 or 0.76 m row widths and plant spacing of 0.075, 0.10 and 0.15 m. Experimental and computer simulated plant height and harvested boll number increased significantly with increased row spacing and, occasionally, in-row plant spacing. Modeled lint yield for 0.38 m rows decreased by approximately 50% compared with the 582 kg·ha-1 yield for conventional row spacing, which was practically duplicated by field observations in 2001 and 2004. Measured fiber quality occasionally improved with conventional row spacing over ultra-narrow rows, but was unaffected by plant spacing. Because narrow rows and frequent plant spacing did not improve lint yield or fiber quality of dryland cotton, we do not recommend this strategy to overcome a thermally limited growing season.

关键词： Dryland Crop Production Thermally Limited Growing Season Ultra-Narrow Row Spacing

Inter-observer variability in histopathological assessment of liver biopsies taken in a pediatric open label therapeutic program for chronic HBV infection treatment

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World Journal of Gastroenterology 2006年第11期12卷 1713-1717页

作者： marek Woynarowski Joanna Cielecka-Kuszyk Andrzej Ka■u■y(n|')ski Aleksandra Omulecka Maria Sobaniec-■otowska Julian Stolarczyk Wojciech Szczepa(n|')ski Department of Gastroenterology Hepatology and Immunology Children's Health Memorial InstituteWarsawPoland Department of Pathology Children's Health Memorial Institute WarsawPoland Department of Pathology Polish Mother Memorial Research Institute ■ód(z|')Poland Department of Pathology Medical University of ■ód(z|') Poland Department of Clinical Pathology Medical University of Bialystok Poland Department of Pathology Medical Academy of Gda(n|')sk Poland Department of Pathology Jagiellonian University Medical College KrakówPoland

瞄准：到我们的知识，在感染 HBV 的孩子的肝活体检视调查结果的内部观察员的可变性没迄今为止被学习。因此，我们试图比较不同病理学家对在在干扰素处理以前从孩子获得的肝活体检视分级和阶段的评价。方法：我们从 11 个医学中心收集了... 详细信息

瞄准：到我们的知识，在感染 HBV 的孩子的肝活体检视调查结果的内部观察员的可变性没迄今为止被学习。因此，我们试图比较不同病理学家对在在干扰素处理以前从孩子获得的肝活体检视分级和阶段的评价。方法：我们从 11 个医学中心收集了 920 活体检视。活体检视被 6 独立地考察估计了 Batts-Ludwig 的从学术中心的病理学家为分级和阶段得分。在观察员之中的令人满意的同意被定义为有一样的意见的至少 60% 观察员。在为一样的活体检视标本的最大、最小的分数之间的令人满意的分散被定义为 1 削尖的最大值。结果：为分级的令人满意的内部观察员的同意在 75.7% 活体检视在 51.6% 并且为阶段被获得。为分级分数的令人满意的分散在 72.7% 盒子中在 44.5% 并且为阶段被观察。结论：我们的学习表明那：(1 ) 病理学家们在他们对分级和肝活体检视的阶段的评价不同；(2 ) 为阶段的内部观察员的可变性为分级是比那低的；并且(3 ) 不管评价的内部观察员的可变性，有长期的 HBV 感染的孩子的多数对中等发炎温和、对中等纤维变性温和。

关键词：组织病理学肝组织检查儿科治疗方法慢性乙型肝炎

布尔诺Beatified Restituta教堂

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现代装饰 2021年第2期 86-91页

作者： marek Jan ?těpěn 范嘉苑捷克Atelier ?těpěn BoysPlayNice

建筑师marek Jan ?těpěn在过去的30年间,断断续续地对这座教堂调整着设计构思。在1968年的时候,关于建造这座教堂的想法在一次氛围轻松的谈话中被提出,50年之后,它终于被建造出来。这是一座为纪念修女Marie Restituta而建造的教堂,它...

建筑师marek Jan ?těpěn在过去的30年间,断断续续地对这座教堂调整着设计构思。在1968年的时候,关于建造这座教堂的想法在一次氛围轻松的谈话中被提出,50年之后,它终于被建造出来。这是一座为纪念修女Marie Restituta而建造的教堂,它距离其出生地仅约1英里。场地以矩形基座为布局,定义出神圣空间的范围。教堂位于住宅区中心,一处峡谷的山脚下。场地上坐落着三个建筑体量——教堂、高塔以及由Zdenek Bures设计的宗教中心。教堂采用了圆形的布局结构,象征着天堂与永恒(相反,方形象征着大地与短暂)。教堂的屋顶下方环绕着一圈彩色玻璃,反射出天空的景象。彩色圆环漂浮于Lesna地区的上空,如果从一种比喻性和先验性的层面上来说,就像是天堂漂浮在Lesna的上空。

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Flutamide-induced alterations in transcriptional profiling of neonatal porcine ovaries

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Journal of Animal Science and Biotechnology 2019年第3期10卷 618-632页

作者： Katarzyna Knapczyk-Stwora Anna Nynca Renata E.Ciereszko Lukasz Paukszto Jan P.Jastrzebski Elzbieta Czaja Patrycja Witek marek Koziorowski Maria Slomczynska Department of Endocrinology Institute of Zoology and Biomedical ResearchJagiellonian University in KrakowGronostajowa 9 Street30-387 KrakowPoland Laboratory of Molecular Diagnostics Faculty of Biology and BiotechnologyUniversity of Warmia and Mazury in OlsztynOlsztynPoland Department of Animal Anatomy and Physiology Faculty of Biology and BiotechnologyUniversity of Warmia and Mazury in OlsztynOlsztynPoland Department of Plant Physiology Genetics and BiotechnologyFaculty of Biology and BiotechnologyUniversity of Warmia and Mazury in OlsztynOlsztynPoland Department of Physiology and Reproduction of Animals University of RzeszowRzeszowPoland

Background: Androgens are involved in the regulation of ovarian development during fetal/neonatal *** chemicals displaying anti-androgenic activities may affect multiple signal transduction pathways by blocking endogenous androgen *** aim of the current study was to examine effects of the anti-androgen flutamide on the expression of coding transcripts and long non-coding RNAs(lncRNAs) in neonatal porcine *** employing RNA-Seq technology we aimed to extend our understanding of the role of androgens in neonatal folliculogenesis and examine the impact of the anti-androgen flutamide on ovarian ***: Piglets were subcutaneously injected with flutamide(50 mg/kg BW) or corn oil(controls) between postnatal days 1 and 10(n = 3/group).Ovaries were excised from the 11-day-old piglets and total cellular RNAs were isolated and ***: Flutamide-treated piglet ovaries showed 280 differentially expressed genes(DEGs;P-adjusted < 0.05 and log2 fold change ≥1.0) and 98 differentially expressed lncRNAs(DELs;P-adjusted < 0.05 and log2 FC ≥ 1.0).The DEGs were assigned to GO term,covering biological processes,molecular functions and cellular components,which linked the DEGs to functions associated with cellular transport,cell divisions and *** addition,STRING software demonstrated strongest interactions between genes related to cell *** between DEGs and DELs were also found,revealing that a majority of the genes targeted by the flutamide-affected lncRNAs were associated with intracellular transport and cell ***: Our results suggest that neonatal exposure of pigs to flutamide alters the expression of genes involved in ovarian cell proliferation,ovarian steroidogenesis and oocyte fertilization,which in turn may affect female reproduction in adult life.

关键词： Flutamide LncRNA Ovary Pig RNA-Seq Transcriptome

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Limited Knowledge of Safe Driving Practice among Drivers with Diabetes in Armenia: Association with Greater Risk of Motor Vehicle Accidents

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Journal of Diabetes Mellitus 2019年第1期9卷 14-23页

作者： Lilit Petrosyan Zhanna Ghazaryan Greta Muradyan Elena Aghajanova marek Brabece Denisa Janickova Zdarska Katarina Halciakova Jan Polak Brian MFrier Jan Broz N8 Policlinic Yerevan State Medical UniversityYerevanArmenia “SourbAstvatsamayr”Medical Centers YerevanArmenia Armenian-American Wellness Center YerevanArmenia Department of Endocrinology Yerevan State Medical University“Muratsan”University HospitalYerevanArmenia Institute of Computer Science The Czech Academy of SciencesPragueCzech Republic Czech Institute of Informatics Roboticsand CyberneticsCzech Technical University in PraguePragueCzech Republic Department of Internal Medicine Second Medical Faculty of Charles UniversityPragueCzech Republic Department for the Study of Obesity and Diabetes Third Medical Faculty of Charles UniversityPragueCzech Republic British Heart Foundation Centre for Cardiovascular Science The Queen’s Medical Research InstituteUniversity of EdinburghEdinburghUK

Aims: The aims of the study were to assess the degree of knowledge and adherence to the recommended safe practice for driving and the risk of road traffic accidents among people with diabetes mellitus in Armenia. Methods: A total of 628 respondents, including 200 drivers, out of 641 consecutive attendees at six diabetes clinics, participated in the survey. A modified British questionnaire on driving and diabetes was used to obtain the relevant data. The information from all 103 drivers treated with insulin and 73 taking sulfonylureas was reviewed. Results: The study revealed that of 176 insulin and sulfonylurea-treated drivers, 161 (91.5%) had never received any advice about safe driving practices. Among the drivers, 156 (88.6%) never measured their blood glucose before, or during driving. The survey revealed that 86 (51.2%) of 168 patients had a history of at least one motor vehicle accident within the previous 5 years. The average road traffic accident rate per person/year was 0.21. Conclusions: The study revealed a lack of knowledge among drivers with diabetes treated with insulin or sulfonylureas concerning recommended safe practices for driving. This was associated with significant hypoglycemia while driving and an elevated rate of road traffic accidents.

关键词： Driving Hypoglycemia Road Traffic Accident

Antiproliferative and antiangiogenic effects of selected chalcones.

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Antiproliferative and antiangiogenic effects of selected cha...

第十五届国际药理学大会

作者： Mojzisova Gabriela Mojzis Jan Rlatova Martina Voharova Viktoria Varinska Lenka Perjesi Pal Sarissky marek Mrossay Ladislav P.J.Safarik Univ. Fac. Med.Dept. Exp.MedKosiceSlovak Republic. P.J.Safarik Univ. Fac. Med.Dept.Pharmacol.KosiceSlovak Republic. P.J.Safarik Univ. Fac. Med.Dept.Pharmacol.KosiceSlovak Republic. P.J.Safarik Univ. Fac. Med.Dept.Pharmacol.KosiceSlovak Republic. P.J.Safarik Univ. Fac. Med.Dept.Pharmacol.KosiceSlovak Republic. Dept. Med. Chem. Med. SchoolUniv. PecsHungary. P.J.Safarik Univ. Fac. Med.Dept. Pharmacol.KosiceSlovak Republic. P.J.Safarik Univ. Fac. Med.Dept. Pharmacol.KosiceSlovak Republic.

＜正＞ Objective: In the present work,we tested four newly synthesized chalcones （Ch1 - Ch4） for their antiproliferative and antiangiogenic effects. Methods: MIT cytotoxicity assay,cell cycle analysis,apoptosis detection by flow cytometry or DNA fragmentation,endothelial cell migration （ECM）. inhibition of capillary tube formation （CTF） by human umbilical vein endothelial cells Results: We found the highest cytotoxic effect of *** of Jurkat and HeLa cells with Ch1 at 1 mmol/L for 72h caused 87 and 45% reduction in cell survival, resp. Furthermore, it caused initial G2/M arrest in both cell lines followed by an increase in the proapoptotic sub-G0/G1 fraction. Apoptosis was also confirmed by both *** chalcones tested only Ch1 possess significant antiangiogenic effect. It completely inhibited CTF in concentrations 10-7 - 10-8 mol/***. Ch1 in the same concentrations blocked also ECM. .Conclusions: The present study demonstrates antiproliferative and antiangiogenic properties of selected chalcones. Ch1 turned out to be the most effective agent of all.

关键词： chalcones - antiproliferative-antiangiogenic

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钢丝与钢丝绳的特殊试验法

金属制品 1980年第3期 52-56页

作者： marek.J.Bergander 贾希高

超声疲劳试验是给20毫米长的钢丝试样施加超声频率的震动。测量应力值和它的一些变化,用大约六分钟就相当于用几天确定的疲劳值。应用很广的线与线制品,其关健特性是它的耐疲劳。可惜,在这方面疲劳试验没有得到广泛应用。这主要是由于... 详细信息

超声疲劳试验是给20毫米长的钢丝试样施加超声频率的震动。测量应力值和它的一些变化,用大约六分钟就相当于用几天确定的疲劳值。应用很广的线与线制品,其关健特性是它的耐疲劳。可惜,在这方面疲劳试验没有得到广泛应用。这主要是由于费用高和花费时间长。对消除这些因素虽已进行了多年研究,但还

关键词：钢丝绳沃勒超声波电磁波弹性模数疲劳试验方法