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Evaluation of the Antidiabetic Activity and Toxicological Properties of Hippocratea Velutina (Afzel.)

Clinical Complementary Medicine and Pharmacology 2023年第2期3卷 50-56页

作者： Farouk A.Oladoja Emmanuel SIrokosu marcus D.Ayoola Oyinloye O.Elijah Murtala A.Akanji Ogunleye T.Beatrice Odewo A.Samuel Department of Pharmacology and Toxicology Faculty of PharmacyOlabisi Onabanjo UniversityAgo-Iwoye 121102Ogun-State.Nigeria Department of Pharmacology and Therapeutics Faculty of Basic Medical ScienceOlabisi Onabanjo University.Ago-Iwoye 121102Ogun-State.Nigeria Department of Pharmacognosy Faculty of PharmacyObafemi Awolowo University Ile-Ife 220282Osun-State.Nigeria Forest Research Institute of Nigeria Ibadan 200221Oyo-State.Nigeria

Background:Hippocratea velutina(HV)is a novel plant folklorically used for lowering blood glucose,hence a potential source of new antidiabetic ***:The study evaluated the anti-diabetic potentials of the methanol extract of Hippocratea velutina leaf and its toxicity profile in mice and ***:Acute and subacute toxicity tests of the plant extract were carried out by using a modified OECD *** antidiabetic activity in streptozotocin-induced diabetic rats at 50,150,and 300 mg/kg for 28 days was assayed,while glibenclamide(5 mg/kg)and distilled water were the positive and negative controls,*** examination of vital organs was also carried ***:Preliminary phytochemical screening of the leaf extract showed the presence of tannins,flavonoids,saponins,alkaloids,terpenoids,deoxy-sugars,and anthraquinones in *** extract had LD 50 greater than 2000 mg/kg in *** had no toxic effects on the haematological and biochemical components from blood samples collected but caused significant blood glucose level reduction in normal rats at 150 and 300 mg/*** streptozotocin-induced diabetic rats,the extract elicited a non-dose-dependent antidiabetic effect on day seven at all the tested doses,significantly higher than glibenclamide(10 mg/kg).However,on days 14,21,and 28,the extract activity at all the tested doses and glibenclamide were *** extract did not affect the liver,brain,kidney,and pancreas histology at 200 mg/kg but caused slight and severe effects on these organs at 400 and 800 mg/kg,***:The study concluded that Hippocratea velutina possessed antihyperglycaemic activity and was non-toxic at low doses but could have deleterious effects to the liver and kidney at high concentrations.

关键词： Hippocratea Velutina Diabetes mellitus Haematological and biochemical parameters

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动物与当代建筑和设计

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世界建筑 2018年第7期 10-22页

作者：珍妮弗·沃尔琪马库斯·欧文斯徐知兰(译) 范路(校) 加州大学伯克利分校环境设计学院不详

动物和设计有什么关系?设计师是如何看待、关怀和使用动物的?我们在文中分析了一系列以动物为主要特征的设计项目,定义了人与动物研究(HAS)领域和设计研究领域之间的交叉地带,并探讨了动物或动物性在设计中的广义社会价值。首先,我们回... 详细信息

动物和设计有什么关系?设计师是如何看待、关怀和使用动物的?我们在文中分析了一系列以动物为主要特征的设计项目,定义了人与动物研究(HAS)领域和设计研究领域之间的交叉地带,并探讨了动物或动物性在设计中的广义社会价值。首先,我们回顾了涉及这两个领域之间交叠范畴的文献。其次,我们探讨了对若干著名设计博客网站上的动物设计项目进行雪球式调查的结果。我们认为设计师特别关注的动物种类、动物设计类型标准化进程,以及在设计圈内广为传播的设计项目,都揭示了设计师的若干文化盲点和偏见。最后,文章提出了动物设计策略如何凸显与通过调动认知、行为和渴望作为技术实践实现功能目的相关的广义社会转型过程。文章认为设计研究作为跨审美领域和技术实践领域的综合,不仅对人类和动物的关系具有见解独到的洞察,对技艺和技术的研究也同样如此。而本文提出这个观点则是为了帮助设计研究领域建立更宏大的框架,同时也有助于人类与非人类动物之间形成更宽泛的关系。

关键词：人类与动物研究设计研究科技研究网络文化建筑学

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1999～2006年急性冠脉综合征患者死亡及心力衰竭发生率降低

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美国医学会杂志（中文版） 2007年第6期26卷 323-330页

作者： keith A. A. Fox Philippe Gabriel Steg kim A. Eagle Shaun G. Goodman Frederick A. Anderson Christopher B. Granger marcus D. Flather Andrzej Budaj Ann Quill Joel M. Gore 康俊萍（译）马长生（校） Cardiovascular Research Division of Medical and Radiological Sciences The University of Edinburgh Edinburgh Scotland Hospital Bichat Paris France University of Michigan Health System Ann Arbor Canadian Heart Research Centre and Terrence Donnelly Heart Centre Division of Cardiology St Michael＇s Hospital University of Toronto Toronto Ontario University of Massachusetts Medical School Worcester Royal Brompton ＆ Harefield NHS Trust London England Postgraduate Medical School Grochowski Hospital Warsaw Poland Duke University Medical Center Durham NC 不详

背景：有关药物和介入治疗对ST段抬高型和非ST段抬高型急性冠脉综合征（non—ST-segment elevation acute coronary syndrome，NSTE ACS）患者的作用，随机试验已经提供了足够的证据，但是是否已经转化为相应的临床变化还不清楚。目的... 详细信息

背景：有关药物和介入治疗对ST段抬高型和非ST段抬高型急性冠脉综合征（non—ST-segment elevation acute coronary syndrome，NSTE ACS）患者的作用，随机试验已经提供了足够的证据，但是是否已经转化为相应的临床变化还不清楚。目的：确定ST段抬高型心肌梗死（ST-segment elevation myocardial infarction，STEMI）和NSTE ACS患者的院内治疗改变是否伴随临床结果的改善。设计、地点及患者：全球急性冠脉事件注册研究（Global Registry of Acute Coronary Events，GRACE）是一项多国家队列研究。自1999年7月1日至2006年12月31日，该研究共入选并随访了来自14个国家、113家医院的44372例ACS患者。主要观测指标：当前循证药物和介入治疗应用的趋势及患者预后（死亡、充血性心力衰竭、肺水肿、心源性休克、卒中和心肌梗死）。结果：随着研究时间的进展，相关药物的应用增加（β-受体阻滞剂、他汀类药物、血管紧张素转换酶抑制剂、行或未行经皮冠状动脉介入治疗[percutaneous coronary intervention，PCI]患者应用噻氯毗啶、糖蛋白Ⅱb／Ⅲa抑制剂和低分子肝素；P〈0．001）。STEMI患者药物再灌注治疗下降了22个百分点（95％可信区间[confidence interval，CI]，-27～-17），而直接PCI增加了37个百分点（95％CI，33—41）。在NSTEMI患者中，PCI的比例显著升高了18个百分点（95％CI，15～20）。充血性心力衰竭和肺水肿在STEMI患者中降低了9个百分点（95％CI，-12～-6），在NSTEACS患者中降低了6．9个百分点（95％CI，-8．4～-4．7）。STEMI患者的院内死亡率降低了18个百分点（95％CI，-5．3～-1．9），心源性休克降低了24个百分点（95％CI，-4．3～-0．5）。校正了危险评分后，NSTEACS患者的院内死亡率降低了0．7个百分点（95％CI，-1．7～0．3）；STEMI患者6个月随访时卒中发生率降低了0．8个百分点（95％CI，-1．7～0．1），心肌梗死发生率降低了2．8个百分点（95％CI，-6．4～0．9）。NSTEACS患者6个月死亡率降低了1．6个百分点（95％CI，-3．0～-0．1），卒中发生率降低了0．7个百分点（95％CI，-1．4～0．1）。结论：在本项多国家观察性研究中，ACS患者治疗的改善与6个月新发心力衰竭、死亡率、卒中和心肌梗死发生率显著降低相关。

关键词：充血性心力衰竭急性冠脉综合征院内死亡率发生率经皮冠状动脉介入治疗血管紧张素转换酶抑制剂糖蛋白Ⅱb/Ⅲa抑制剂非ST段抬高型

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Early Hepatic Encephalopathy after a Transjugular Intrahepatic Portosystemic Shunt Procedure: Case Report

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Open Journal of Gastroenterology 2021年第6期11卷 81-88页

作者： Miriam Viviane Baron Gabriela Di Lorenzo Garcia Scherer Michele Paula dos Santos Andres Felipe Mantilla Santamaria Cristine Brandenburg Isabel Cristina Reinheimer marcus Vinicius de Mello Pinto Aline Ronis Sampaio Alexandre Gomes Sancho Alexandre Gomes Sancho Esteban Fortuny Pacheco Felice Picariello Danielle de Mello Florentino Joice Nedel Ott Carolina Gonçalves Pinheiro Nathália ken Pereira Iketani Sonia Carvalho Patrícia Froes Meyer Bartira Ercília Pinheiro da Costa Postgraduate Program in Medicine and Health Sciences of the Pontifical Catholic University of Rio Grande do Sul (PUC/RS) Porto Alegre Rio Grande do Sul Brazil School of Medicine of the Pontifical Catholic University of Rio Grande do Sul (PUC/RS) Porto Alegre Rio Grande do Sul Brazil Industrial University of Santander (UIS) Bucaramanga Colombia University of Vale do Acaraú (IDJ/UVA) Ceará Brazil Celulare Institute Rio de Janeiro Brazil Unigranrio Rio de Janeiro Brazil Universidad Finis Terrae Santiago Chile Università degli Studi di Napoli Federico II Napoli Italy Uniredentor University Rio de Janeiro Brazil Postgraduate Program in Health Sciences of the Faculty of Medicine of ABC (FABC) S&#227o Paulo Brazil Hospital Beneficiente Portuguesa of Belém Pará Brazil Rigshospital Copenhagen East K&#248benhavn Denmark Centro Universitário do Rio Grande do Norte Natal Brazil

Patients with decompensated hepatic cirrhosis may present systemic alterations and dysfunction of multiple organs. Ascites, portal hypertension, esophageal varices, and hepatic encephalopathy are common complications arising from cirrhosis. The aim of this paper is to report a case of a patient with liver cirrhosis and the complications of a transjugular intrahepatic portosystemic shunt. Male, elderly, and ex-alcoholic, diagnosed with liver cirrhosis, ascites, and esophageal varices. He underwent transjugular intrahepatic portosystemic shunt due to portal hypertension and returned to the hospital after 24 hours with agitation and mental confusion. He had a bowel movement stop, neurological worsening, loss of renal function, hepatic hydrothorax, hepatic encephalopathy, hypernatremia, hypocalcemia, and hypophosphatemia. He underwent a new procedure to occlude the transjugular intrahepatic portosystemic shunt, showing improvement of the mental status and ascites. However, continued with decompensation and hydro-electrolytic disorders. He evolved with worsening of the ventilatory pattern, and neurological and renal function, with a fatal outcome. Esophageal varices due to portal hypertension can be corrected with the transjugular intrahepatic portosystemic shunt. However, complications such as hypernatremia, hepatic hydrothorax, and hepatic encephalopathy may occur. Therefore, there is a need for reintervention to shunt or reduce its caliber. Thus, for patients with advanced age and decompensated cirrhosis, the potential risks and benefits of this procedure should be carefully evaluated due to the risk of complications and death.

关键词： Ascites Hypernatremia Portasystemic Shunt Transjugular Intrahepatic Hepatic Encephalopathy

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爱情三十六计

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歌海 2005年第6期 47-47页

作者：胡如虹 Savan koteeha Andew marcus Franpton Wayne Wikins

关键词：三十六计爱情飞歌南宁国际民歌艺术节晚会文化品牌现代性民族性艺术性博览会

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运动时间及强度对不好运动超重女性减肥的影响随机试验

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美国医学会杂志（中文版） 2004年第2期23卷 100-100页

作者： JohnM.Jakicic BessH.marcus karaI.Gallaghen 顾佳

背景:运动时间较长、强度较大也许有助于长期减肥.目的:比较不同的运动时间及强度对12个月后体重降低和心肺适应能力的影响.研究设计、地点及参试者:在一项大学体重控制计划中,201例不好运动的女性(平均[SD]年龄,37.0[5.7]岁;平均[SD]... 详细信息

背景:运动时间较长、强度较大也许有助于长期减肥.目的:比较不同的运动时间及强度对12个月后体重降低和心肺适应能力的影响.研究设计、地点及参试者:在一项大学体重控制计划中,201例不好运动的女性(平均[SD]年龄,37.0[5.7]岁;平均[SD]体重指数,32.6[4.2])参与了这项始于2000年1月止于2001年12月的随机试验.

关键词：超重女性减肥运动疗法心肺适应能力

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Non-Hodgkin’s Lymphoma Associated with Metastatic Lung Cancer: Case Report

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Advances in Lung Cancer 2021年第3期10卷 40-47页

作者： Miriam Viviane Baron Gabriela Di Lorenzo Garcia Scherer Célia Regina Martins korzenieski Julia Braga da Silveira Carolina Boeira Soares Carina Marangoni marcus Vinicius de Mello Pinto Aline Ronis Sampaio Alexandre Gomes Sancho Esteban Fortuny Pacheco Felice Picariello Joice Nedel Ott Isabel Cristina Reinheimer Carolina Gonçalves Pinheiro Nathália ken Pereira Iketani Cristine Brandenburg Danielle de Mello Florentino Patrícia Froes Meyer Bartira Ercília Pinheiro da Costa Postgraduate Program in Medicine and Health Sciences of the Pontifical Catholic University of Rio Grande do Sul (PUC/RS) Porto Alegre Brazil School of Medicine of the Pontifical Catholic University of Rio Grande do Sul (PUC/RS) Porto Alegre Brazil School of Health and Life Sciences of the Pontifical Catholic University of Rio Grande do Sul (PUC/RS) Porto Alegre Brazil Celulare Institute Rio de Janeiro Brazil Unigranrio Rio de Janeiro Brazil Universidad Finis Terrae Santiago Chile Università degli Studi di Napoli Federico II Napoli Italy Postgraduate Program in Health Sciences of the Faculty of Medicine of ABC (FMABC) S&#227 o Paulo Brazil Hospital Beneficiente Portuguesa of Belém Pará Brazil Federal University of Ceará (UFC) Fortaleza Brazil Uniredentor University Rio de Janeiro Brazil Centro Universitário do Rio Grande do Norte Natal RN Brazil

Lymphomas are neoplastic transformations that affect lymphoid cells. Diffuse large B-cell non-Hodgkin’s lymphoma has a high degree of cell proliferation, accounting for 30% of all lymphomas. Lung cancer is the leading cause of death worldwide and the recommended treatment is chemotherapy. Among the main complications resulting from non-Hodgkin’s lymphoma, lung cancer and chemotherapy used in their treatment, we can mention sepsis, acute kidney injury and febrile neutropenia. Febrile neutropenia can occur by suppressing the production of neutrophils. Sepsis, a widespread infection, is the main cause of acute kidney injury, which can also be caused by hydroelectrolytic complications or by nephrotoxicity. This is a report of a smoking patient with metastatic lung cancer who sought care due to progressive dysphagia, cough with chest pain, fever, and lower airways critical obstruction due to mediastinal lymphadenopathy, being diagnosed with diffuse large B-cell non-Hodgkin’s lymphoma. The patient evolved to death because of a significant worsening of the ventilatory pattern of multifactorial cause, mainly due to sepsis, acute kidney injury, and febrile neutropenia. The patient had mostly classic characteristics of her comorbidities, however, the overlapping of interrelated comorbidities led to the outcome of death. What is unusual about the present case report is that the patient’s characteristics, such as age, sex, and ethnicity, are opposite to those described as risk factors for diffuse large B-cell non-Hodgkin’s lymphoma.

关键词： Acute kidney Injury Febrile Neutropenia Sepsis Chemotherapy

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Prehospital system delay in patients with ST-segment elevation myocardial infarction in Singapore

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World Journal of Emergency Medicine 2015年第4期6卷 277-282页

作者： Andrew Fu Wah Ho Pin Pin Pek Stephanie Fook-Chong Ting Hway Wong Yih Yng Ng Aaron Sung Lung Wong marcus Eng Hock Ong Singhealth Emergency Medicine Residency Program Singapore Health Services Department of Emergency Medicine Singapore General Hospital Division of Research Singapore General Hospital Department of General Surgery Singapore General Hospital Medical Department Singapore Civil Defence Force Department of Cardiology National Heart Centre

BACkGROUND: Timely reperfusion in ST-segment elevation myocardial infarction(STEMI)improves outcomes. System delay is that between first medical contact and reperfusion therapy,comprising prehospital and hospital components. This study aimed to characterize prehospital system delay in ***: A retrospective chart review was performed for 462 consecutive STEMI patients presenting to a tertiary hospital from December 2006 to April 2008. Patients with cardiac arrest secondarily presented were excluded. For those who received emergency medical services(EMS),ambulance records were reviewed. Time intervals in the hospital were collected prospectively. The patients were divided into two equal groups of high/low prehospital system delay using visual binning ***: Of 462 patients, 76 received EMS and 52 of the 76 patients were analyzed. The median system delay was 125.5 minutes and the median prehospital system delay was 33.5minutes(interquartile range [IQR]=27.0, 42.0). Delay between call-received-by-ambulance and ambulance-dispatched was 2.48 minutes(IQR=1.47, 16.55); between ambulance-dispatch and arrival-at-patient-location was 8.07 minutes(IQR=1.30, 22.13); between arrival-at- and departurefrom-patient-location was 13.12 minutes(IQR=3.12, 32.2); and between leaving-patient-location to ED-registration was 9.90 minutes(IQR=1.62, 32.92). Comparing patients with prehospital system delay of less than 35.5 minutes versus more showed that the median delay between ambulancedispatch and arrival-at-patient-location was shorter(5.75 vs. 9.37 minutes, P<0.01). The median delay between arrival-at-patient-location and leaving-patient-location was also shorter(10.78 vs.14.37 minutes, P<0.01).CONCLUSION: Prehospital system delay in our patients was suboptimal. This is the first attempt at characterizing prehospital system delay in Singapore and forms the basis for improving efficiency of STEMI care.

关键词： Myocardial infarction Emergency medical services Delay First medical contact Door to balloon

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癌症筛查之未来

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上海预防医学 2017年第3期29卷 245-247页

作者： Cheryll C.Thomas Thomas B.Richards marcus Plescia Faye L.Wong Rachel Ballard Theodore R.Levin Bruce N.Calonge Otis W.Brawley John Iskander 徐海燕(翻译) 陆仁敏(审校) 蔡颖(审校) Division of Cancer Prevention and Control National Center for Chronic Disease Prevention and Health PromotionCDC National Cancer Institute The Permanente Medical Group Inc.and Kaiser Permanente Medical CenterWalnut Creek and AntiochCalifornia The Colorado Trust American Cancer Society Office of the Associate Director for Science CDC 不详

1引言癌症已成为美国的第二大致死病因,52%的人死于肺癌、支气管癌、女性乳腺癌、宫颈癌、结直肠癌、口腔及咽喉癌、前列腺癌和皮肤癌（黑色素瘤）。19世纪30年代,包括宫颈癌在内的子宫癌,位居美国女性癌症死亡第一位。50年代,随着巴氏... 详细信息

1引言癌症已成为美国的第二大致死病因,52%的人死于肺癌、支气管癌、女性乳腺癌、宫颈癌、结直肠癌、口腔及咽喉癌、前列腺癌和皮肤癌（黑色素瘤）。19世纪30年代,包括宫颈癌在内的子宫癌,位居美国女性癌症死亡第一位。50年代,随着巴氏涂片技术（Pap test）的应用,可以在细胞水平检测宫颈的变化,宫颈癌死亡率显著降低,这是第一个癌症筛查检测技术。此后,已有多种影像学检查（例如乳腺癌钼靶X线、内窥镜检查和计算机体层扫描）和实验室检测方法（粪便隐血试验）用于癌症筛检。

关键词：筛查方法女性乳腺癌巴氏涂片癌死亡率结直肠癌致死病因钼靶黑色素瘤计算机体层扫描粪便隐血试验

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Oligomeric and fibrillar species of β-amyloid(Aβ42) both impair mitochondrial function in P301L tau transgenic mice

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世界最新医学信息文摘 2016年第4期 8-8页

作者： Anne Eckert Susanne Hauptmann Isabel Scherping Jessica Meinhardt Virginie Rhein Stefan Drse Ulrich Brandt marcus Fndrich Walter E.Müller Jiirgen Gtz

We recently provided evidence for a mitochondrial dysfunction in P301L tau transgenic mice,a strain modeling the tau pathology of Alzheimer's disease(AD)and frontotemporal dementia(FTD).In addition to tau aggregates,the AD brain is further characterized by Aβpeptide-containing *** we addressed the role of Aβ,this indicated a synergistic action of tau and Aβpathology on the *** the present study,we compared the toxicity of different Aβ42 conformations in light of recent studies suggesting that oligomeric rather than fibrillar Aβmight be the actual toxic ***,both oligomeric and fibrillar,but not disaggregated(mainly monomeric)Aβ42 caused a decreased mitochondrial membrane potential in cortical brain cells obtained from FTD P301L tau transgenic *** was not observed with cerebellar preparations indicating selective vulnerability of cortical ***,we found reductions in state 3 respiration,the respiratory control ratio,and uncoupled respiration when incubating P301L tau mitochondria either with oligomeric or fibrillar preparations of Aβ***,we found that aging specifically increased the sensitivity of mitochondria to oligomeric Aβ42 damage indicating that oligomeric and fibrillar Aβ42 are both toxic,but exert different degrees of toxicity.

关键词： Alzheimer’s disease Amyloid aggregates Amyloid β-peptide Amyloid toxicity Fibrils Frontotemporal dementia Globulomer Mitochondria Oligomer Protein aggregation Respiration Tau Transgenic mice

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