检索结果-南通市图书馆

Candidate genes for male and female reproductive traits in Canchim beef cattle

Journal of Animal Science and Biotechnology 2018年第1期9卷 59-68页

作者： marcos Eli Buzanskas daniela do Amaral Grossi Ricardo Vieira Ventura Flavio Schramm Schenkel Tatiane Cristina Seleguim Chud Nedenia Bonvino Stafuzza Luciana Diniz Rola Sarah Laguna Conceio Meirelles Fabiana Barichello Mokry Maurício de Alvarenga Mudadu Roberto Hiroshi Higa marcos vinícius Gualberto Barbosa da silva Maurício Mello de Alencar Luciana Correia de Almeida Regitano danísio Prado Munari Departamento de Zootecnia Universidade Federal da Paraíba(UFPB)AreiaParailba 58397-000Brazil Fast Genetics SaskatoonSK S7K 2K6Canada Beef Improvement Opportunities(BIO) GuelphON N1K 1ESCanada Department of Animal and Poultry Science University of GuelphCentre for Genetic Improvement of Livestock(CGIL)GuelphON N1G 2W1Canada Departamento de Ciencias Exatas Faculdade de Ci6ncias Agrarias e VeterinariasUniversidade Estadual Paulista(Unesp)JaboticabalSao Paulo 14884 900Brazil Departamento de Zootecnia Nucleo de Pesquisa e Conservacao de CervMeosFaculdade de Ciencias Agrarias e VeterinariasUniversidade Estadual Paulista(Unesp)JaboticabalSao Paulo 14884 900Brazil Department of Animal Science Federal University/of Lavras(UFLA)LavrasMinas Gerais 37200 000Brazil Department of Genetics and Evolution Federa University of Sao Carlos(UFSCar)Sao CarlosSao Paulo 13565-905Brazil Embrapa Agricultural Informatics Campinas55o Paulo 13083 886Brazil Embrapa dairy Cattle Juiz de ForaMinas Gerais 36038 330Brazil Embrapa Southeast Livestock Sao CarlosSao Paulo 13560 970Brazil

Background： Beef cattle breeding programs in Brazil have placed greater emphasis on the genomic study of reproductive traits of males and females due to their economic importance. In this study, genome-wide associations were assessed for scrotal circumference at 210 d of age, scrotal circumference at 420 d of age, age at first calving, and age at second calving, in Canchim beef cattle. data quality control was conducted resulting in 672,778 SNPs and 392 ***： Associated SNPs were observed for scrotal circumference at 420 d of age（435 SNPs）, followed by scrotal circumference at 210 d of age（12 SNPs）, age at first calving（six SNPs）, and age at second calving（four SNPs）. We investigated whether significant SNPs were within genic or surrounding regions. Biological processes of genes were associated with immune system, multicellular organismal process, response to stimulus, apoptotic process, cellular component organization or biogenesis, biological adhesion, and ***： Few associations were observed for scrotal circumference at 210 d of age, age at first calving, and age at second calving, reinforcing their polygenic inheritance and the complexity of understanding the genetic architecture of reproductive traits. Finding many associations for scrotal circumference at 420 d of age in various regions of the Canchim genome also reveals the difficulty of targeting specific candidate genes that could act on fertility; nonetheless,the high linkage disequilibrium between loci herein estimated could aid to overcome this issue. Therefore, al relevant information about genomic regions influencing reproductive traits may contribute to target candidate genes for further investigation of causal mutations and aid in future genomic studies in Canchim cattle to improve the breeding program.

关键词： Animal breeding Composite breed Genome-wide association Genomic data Single nucleotide polymorphism

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cytokines and T Helper Cells in Diabetic Nephropathy Pathogenesis

引用

Journal of Diabetes Mellitus 2016年第4期6卷 230-246页

作者： Liliane silvano Araújo marcos vinícius da silva Crislaine Aparecida da silva Maria Luiza Reis Monteiro Lívia Helena de Morais Pereira Laura Penna Rocha Rosana Rosa Miranda Corrêa Marlene Antônia Reis Juliana Reis Machado General Pathology and Nephropathology Service Institute of Biological and Natural Sciences of Federal University of Triangulo Mineiro Uberaba Brazil Immunology Institute of Biological and Natural Sciences of Federal University of Triangulo Mineiro Uberaba Brazil General Pathology Institute of Tropical Pathology and Public Health of Federal University of Goiás Goiania Brazil

Diabetic Nephropathy (DN) is considered the main cause of end stage kidney disease around the world. However, its pathogenesis is not completely established. More than just a direct consequence of chronic glycemic changes, recent studies had suggested Diabetic Nephropathy could be considered an inflammatory disease. It has been shown that concentrations of pro-inflammatory cytokines, as IL-1, IL-6, IL-18, IL-33, IFN-γ and TNF-α actively participate in development and progression of DN, and thus, are involved in pathogenesis. Besides, changes in acquired immune response, especially the presence of cellular immune response profiles of pro-inflammatory and effector nature, mainly Th1 and Th17, as the imbalance between interaction of cytokines and T regulatory cells, foment the onset and progression of DN. Here we summarize the main evidences that support the critical role of the immune system in this condition. These new conceptual advances in DN understanding are essential for development of new the rapeutical strategies and prognostic factors, which could be protagonists or adjuvants to the current ones, leading ultimately to a better clinical management of DN patients.

关键词： Diabetic Nephropathy Cytokines Cellular Immunity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pathogenesis and clinical management of arboviral diseases

引用

World Journal of Virology 2025年第1期14卷 9-50页

作者： Victoria Cenci Dietrich Juan marcos Caram Costa Marina Maria Gomes Leite Oliveira Carlos Eduardo Oliveira Aguiar Luis Guilherme de Oliveira silva Marcel silva Luz Fabian Fellipe Bueno Lemos Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

Arboviral diseases are viral infections transmitted to humans through the bites of arthropods,such as mosquitoes,often causing a variety of pathologies associated with high levels of morbidity and *** the past decades,these infections have proven to be a significant challenge to health systems worldwide,particularly following the considerable geographic expansion of the dengue virus(DENV)and its most recent outbreak in Latin America as well as the difficult-tocontrol outbreaks of yellow fever virus(YFV),chikungunya virus(CHIKV),and Zika virus(ZIKV),leaving behind a substantial portion of the population with complications related to these ***,the world is experiencing a period of intense globalization,which,combined with global warming,directly contributes to wider dissemination of arbovirus vectors across the ***,all continents remain on high alert for potential new ***,this review aims to provide a comprehensive understanding of the pathogenesis of the four main arboviruses today(DENV,ZIKV,YFV,and CHIKV)discussing their viral characteristics,immune responses,and mechanisms of viral evasion,as well as important clinical aspects for patient *** includes associated symptoms,laboratory tests,treatments,existing or developing vaccines and the main associated complications,thus integrating a broad historical,scientific and clinical approach.

关键词： Arboviruses Arbovirus infections Dengue Zika virus Yellow fever Chikungunya virus Clinical diagnosis Pathogenesis Flavivirus Togaviridae infections

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Energy Efficiency in Social Interest Housing:NZEB Building Analysis for Southern Brazil

引用

Journal of Civil Engineering and Architecture 2021年第11期15卷 567-576页

作者： marcos vinícius de Lima Thaísa Leal da silva Lauro AndréRibeiro Postgraduation Program of Architecture and Urbanism School of Engineering and Applied SciencesIMEDRua Senador Pinheiro304Passo Fundo/RS 99070-220Brazil

This article aims to investigate the potential for energy savings and impact on greenhouse gas(GHG)generation of social housing in southern *** and energy analysis of two architectural projects was carried out,one of them being a social interest housing unit and an optimized version of this unit characterized as Nearly Zero Energy Building(NZEB).At the end of the study,a cost analysis was carried out taking into account the building construction and local electricity generation through the installation of a photovoltaic(PV)*** the methods,software SketchUp Make and EnergyPlus was used for computer simulation,after which the PV power generation system for both buildings was dimensioned using the PvSol ***,the percentage of adaptive comfort of ASHRAE 55 was calculated,as well as financial analysis for the building construction and PV modules *** is concluded that it is possible to reduce energy consumption of this social interest housing by 52%and the heating consumption by 72%with passive strategies and envelope *** in an efficient building results in a 29%increase in building costs and promotes savings of 39.5 tCO_(2)over the life of the *** study demonstrates the importance of making NZEB buildings economically viable.

关键词： Energy efficiency social interest housing NZEBs simulation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Economic Feasibility Evaluation of the Use of Wind Microgenerator in Multifamily Building in Southern Brazil

引用

Journal of Civil Engineering and Architecture 2022年第10期16卷 513-518页

作者： Lauro AndréRibeiro marcos vinícius de Lima Wilson Levy Braga da silva Neto Marília Marton Correia Thaísa Leal da silva Postgraduation Program of Architecture and Urbanism School of Engineering and Applied SciencesATITUS EducaçãoRua Senador Pinheiro304Passo Fundo/RS 99070-220Brazil Postgraduation Program in Smart and Sustainable Cities at Universidade Nove de Julho Rua Vergueiro235/249-LiberdadeSão Paulo/SP 01525-000Brazil

There is a growing worldwide interest in the potential of using existing buildings to generate their own energy as a way to alleviate problems related to the exhaustion of energy resources,environmental degradation and the constant increase in energy-related *** the distributed electricity generation solutions on the market today,wind energy can be a solution for many existing city buildings ***,the objective of this article is to investigate the economic viability of generating wind energy in a multifamily building located in Southern Brazil,(city of Passo Fundo),seeking to supply the condominium electric energy for the period of one year of consumption with a renewable *** this end,the energy demand of the condominium and the energy generation of the wind turbine were taken into account to calculate the economic viability of the *** results showed a positive NPV(net present value)demonstrating the economic feasibility of carrying out such an *** IRR(internal rate of return)was 15.22%and the return on investment(payback)occurs in 7.88 years.

关键词： Wind energy microgeneration renewable energy economic analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Diabetes and obesity:A debate on bariatric interventions and its implications

引用

World Journal of Diabetes 2024年第11期15卷 2157-2161页

作者： JoséC Tatmatsu-Rocha marcos R Lima da silva College of Medicine Postgraduate Program in Physiotherapy and FunctionalityDepartment of PhysiotherapyFederal University of Ceará-UFCFortaleza 60430-450CearáBrazil

In this editorial,we comment on an article by Tang et al published in the World Journal of *** and diabetes are two pathological situations that are intrinsically *** lifestyle changes nor pharmacological treatments have achieved diabetes *** this perspective,bariatric surgery has been widely used as an approach for weight loss in obese patients and as a strategy to promote metabolic *** main effects of bariatric surgery involve direct action in improving cardiovascular function and endothelial function and reducing insulin resistance,leading to diabetes remission in the short term following *** this context,it has been observed that hormones from the gastrointestinal tract and endothelium play a prominent role in this *** reversing endothelial dysfunction,it is possible to balance pro-inflammatory cytokine production,improving the availability of nitric oxide and inhibiting vascular oxidative ***,it can be considered an efficient anti-inflammatory strategy,alleviating interferon-gamma-mediated adipose tissue *** current challenge must be to unravel the pathophysiological mechanisms and potential targets for treating metabolic diseases.

关键词： Bariatric surgery Diabetes mellitus Oxidative stress Endothelial dysfunction Obesity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mortality Trends for Neglected Tropical Diseases in the State of Sergipe,Brazil,1980-2013

引用

Infectious Diseases of Poverty 2017年第1期6卷 173-180页

作者： marcos Antonio Costa de Albuquerque danielle Menezes Dias Lucas Teixeira Vieira Carlos Anselmo Lima Angela Maria da silva University Hospital Federal University of SergipeRua Claudio Batista s/nB.Santo AntonioAracajuSE 49060-108Brazil Post-doc Medicine Unit Federal University of SergipeRua Claudio Batista s/nB.Santo AntonioAracajuSE 49060-108Brazil

Background:Neglected Tropical Diseases are a set of communicable diseases that affect the population so low socioeconomic status,particularly 1.4 billion people who are living below the poverty *** study has investigated the magnitude and mortality time trends for these diseases in the state of Sergipe,Northeast Region of ***:We conducted an ecological study of time series,based on secondary data derived from the Mortality Information System of the Ministry of *** mortality rates(crude,age-standardized rates and proportional ratio)were calculated from the deaths due to Neglected Tropical Diseases in the state of Sergipe,from 1980 to *** time trends were obtained using the Joinpoint regression ***:Three hundred six thousand and eight hundred seventy-two deaths were certified in the state and Neglected Tropical Diseases were mentioned as the underlying cause in 1,203 certificates(0.39%).Mean number of deaths was 35.38 per year,and crude and age-standardized mortality rates were,respectively:2.16 per 100000 inhabitants(95%CI:1.45-2.87)and 2.87 per 100000 inhabitants(95%CI:1.93-3.82);the proportional mortality ratio was 0.41%(95%CI:0.27-0.54).In that period,Schistosomiasis caused 654 deaths(54.36%),followed by Chagas disease,with 211(17.54%),and by Leishmaniases,with 142(11.80%)*** other diseases totalized 196 deaths(16.30%).There were increasing mortality trends for Neglected Tropical Diseases,Schistosomiasis and Chagas disease in the last 15 years,according to the age-standardized rates,and stability of the mortality trends for ***:The Neglected Tropical Diseases show increasing trends and are a real public health problem in the state of Sergipe,since they are responsible for significant mortality *** following diseases call attention for showing greater number of deaths in the period of study:Schistosomiasis,Chagas disease and *** finally suggest that public managers take appropri

关键词： Mortality Neglected tropical diseases Trends Joinpoint

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Physicochemical and Sensory Characterization of Banana and Aracá-Boi Jam

引用

Food and Nutrition Sciences 2014年第8期5卷 733-741页

作者： Eliseth de Souza Viana Jaciene Lopes de Jesus Ronielli Cardoso Reis marcos vinícius silva de Andrade Celio Kersul do Sacramento Brazilian Agricultural Research Corporation EMBRAPANational Cassava&Fruits Research CenterCruz das AlmasBrazil Federal University of Reconcavo Baiano Cruz das AlmasBrazil State University of Santa Cruz IlhéusBrazil

This study evaluated the physicochemical and sensory properties of mixed jam elaborated with banana and ara?á-boi. Four banana extract (BE) and ara?á-boi (AB) jams were prepared using the following proportions: F1 (70% BE:30% AB), F2 (60% BE:40% AB), F3 (40% BE:60% AB) and F4 (30% BE:70% AB). The jams were analyzed for physicochemical and sensory properties. The sensory acceptance test was performed by 50 panelists who were asked to indicate how much they liked/ disliked the jams based on the following attributes: color, aroma, flavor and texture. The formulations that contained more BE (F1 and F2) showed a lower titratable acidity (TA), higher ratio (SS/TA) and higher total sugar. A global analysis of the internal preference mapping verified that formulations F1 and F2 were preferred for flavor and had good acceptance levels for the other evaluated attributes, which indicated that the consumers favored jams with lower concentrations of AB and higher concentrations of BE. The formulation F1 was considered the most accepted for all attributes evaluated and showed high purchase intent (68%), and was therefore appropriate for industrialization and consumption.

关键词： Musa spp. Eugenia stipitata Acceptance Preference Mapping Fruits Processing

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dietary xylanase and live yeast supplementation influence intestinal bacterial populations and growth performance of piglets fed a sorghum-based diet

引用

Animal Nutrition 2020年第4期6卷 457-466页

作者： Gemma González-Ortiz Marco A.Callegari Pete Wilcock Diego Melo-Duran Michael R.Bedford Hilário R.V.Oliveira marcos A.A.da silva Carlos R.Pierozan Caio A.da silva AB Vista MarlboroughWiltshireSN84ANUnited Kingdom AKEI Animal Research Fartura18870000Brazil Servei de Nutricio i Benestar Animal(SNiBA) Department de Ciencia Animal i dels AlimentsUniversitat Autonoma de Barcelona(UAB)08193Spain Universidade Estadual Norte do Parana Bandeirantes86360000Brazil Universidade Estadual de Londrina Londrina86051990Brazil

This study was to evaluate the effect of xylanase supplementation and the addition of live yeast,Saccharomyces cerevisiae,on growth performance and intestinal microbiota in *** hundred and eighty commercial crossbred 23-d-old piglets(PIC 417)were sorted by initial BW and allocated to 3 treatments:control(CTR)diet,CTR diet supplemented with xylanase at 16,000 birch xylan units/kg(XYL)and XYL diet supplemented with live yeast(2 x 1010 CFU/g)at 1 kg/t(XYL+LY).Each treatment had 10 replicates,with 6 animals each.A sorghum-based diet and water were available ad libitum for 42 d of the *** daily gain(ADG)and average daily feed intake(ADFI)were measured from 0 to 42 d(23-to 65-d-old)and feed conversion ratio(FCR)*** the end of the study,bacterial identification through 16 S rRNA(V3 to V4)sequencing of the ileal and caecal digesta from one piglet per replicate was *** treatment effects were observed on *** offered the live yeast in addition to the xylanase had increased ADG compared with those supplemented with xylanase alone(XYL+LY ***;P=0.655).FCR was improved with XYL and XYL+LY compared with CTR(P=0.018).Clostridiaceae counts in the ileum tended to reduce by 10%with XYL and 14%with XYL+LY compared to CTR(P=0.07).XYL and XYL+LY increased the counts of Lactobacillaceae in the caecum compared with CTR(P<0.0001).Dietary supplementation of live yeast combined with xylanase improved growth performance and microbial balance of piglets during the nursery phase.

关键词： Sorghum Nursery piglet Xylanase Live yeast Growth performance Microbiota

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Chemical and microbiological characterization of tinctures and microcapsules loaded with Brazilian red propolis extract

引用

Journal of Pharmaceutical Analysis 2017年第5期7卷 280-287页

作者： Erika Tayse da Cruz Almeida Maria Cristina Delgado da silva José marcos dos Santos Oliveira Regianne Umeko Kamiya Rodolfo Elleson dos Santos Arruda danilo Abreu Vieira Valdemir da Costa silva Pierre Barnabé Escodro Irinaldo Diniz Basílio-Júnior Ticiano Gomes do Nascimento Laboratório de Controle de Qualidade e Análise de Fármacos Medicamentos e AlimentosCurso de FarmáciaEscola de Enfermagem e FarmáciaUniversidade Federal de AlagoasCampus A.C.SimõesBR 104 Norte-Km 97MaceióAL.CEP:57072-970Brazil Laboratório de Controle de Qualidade Microbiológico de Alimentos Faculdade de NutriçãoUniversidade Federal de AlagoasCampus A.C.SimõesBR 104 Norte/Km 97MaceióAL.CEP:57072-970Brazil

The aim of this study was to characterize tinctures and microcapsules loaded with an ethanol extract of red propolis through chemical, physicochemical and microbiological assays in order to establish quality control tools for nutraceutical preparations of red propolis. The markers(isoflavonoids, chalcones, pterocarpans,flavones, phenolic acids, terpenes and guttiferones) present in the tinctures A and B were identified and confirmed using LC/ESI/FTMS/Orbitrap. Four compositions(A, B, C and D) were prepared to contain B tincture of the red propolis with some pharmaceutical excipients and submitted to two drying processes, i. ***-drying and freeze-drying to obtain microcapsules loaded with the red propolis extract. The tinctures and microcapsules of the red propolis were submitted to the total flavonoid content and antioxidant activity *** antibacterial activity and minimum inhibitory concentration(MIC) were tested using Staphylococcus aureus ATCC 25293 and Pseudomonas aeruginosa ATCC 27853 strains. The tinctures and microcapsules presented high flavonoid quantities from 20.50 to 40.79 mg/100 mg of the microcapsules. The antioxidant activity and IC50 were determined for the tinctures A and B(IC50: 6.95 μg/m L and 7.48 μg/m L), the spray-dried microcapsules(IC50: 8.89–15.63 μg/m L) and the freeze-dried microcapsules(IC50: 11.83–23.36 μg/m L). The tinctures and microcapsules were proved to be bioactive against gram-positive and gram-negative bacteria with inhibition halos superior to 10 mm at concentration of 200 μg/m L and MIC values of 135.87–271.74 μg/m L using gram-positive strain and 271.74–543.48 μg/m L using gram-negative strain. The tinctures and microcapsules of the red propolis have a potential application for nutraceutical products.

关键词： Red propolis Tinctures Microcapsules Isoflavonoids LC/ESI/FTMS/Orbitrap Antioxidant activity Antibacterial activity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：