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Journal of Energy and Power Engineering 2018年第8期12卷 395-401页

作者： Celia Regina Nugoli Estevam Denis Henrique Garcia Bonafé Amanda Aguiar dos Santos Giuliano Pierre Estevam Antonio marcos Cossi Department of Analysis and Development of Systems Faculty of Technology of the State of Sao PauloFATEC AracatubaAracatuba 16045-800Brazil Department of Mathematics State University of Sao Paulo Julio de Mesquita FilhoIlha Solteira 15385-800Brazil

The economic development and disorderly population growth,coupled with the modern society’s lifestyle,are complex processes that share a common denominator:the availability of an adequate and reliable supply of *** alternative is sustainable development through alternative sources of energy,such as solar energy,wind energy and *** both the international and domestic markets,biomass is considered one of the main alternatives for the diversification of the energy matrix and the consequent reduction of dependence on fossil *** objective of this work is to develop a linear programming model that helps in the decision making as to the feasibility of the implantation of biodigesters for the production of biogas in rural properties destined for *** order to solve the proposed model,the classic simplex method was implemented,in the Java programming language with the aim of obtaining results that can be used to support decision making.

关键词： Renewable energy biogas bioenergy

Are There Schizophrenia Genetic Markers and Mutations? A Systematic Review and Meta-Analyses

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Health 2017年第5期9卷 811-838页

作者： Maria Auxiliadora Brasil Sampaio Cardoso Tárcia Januário do Nascimento Gabriel Pereira Bernardo Lorena Pereira Bernardo Maria Mirelle Ferreira Leite Barbosa Pedro Januário Nascimento Neto Danilo Ferreira de Sousa Antonio Gilvan Teixeira Júnior marcos Antonio Pereira de Lima Marcial Moreno Moreira David de Sousa Gregório Lídia Coelho do Nascimento Santos Modesto Leite Rolim Neto Postgraduate Program in Health Science FMABC Santo André Brazil Faculty of Medicine Estacio (FMJ) Juazeiro do Norte Brazil Federal University of Cariri (UFCA) Faculty of Medicine Barbalha Brazil Science without Borders fellow at University of Liverpool Liverpool UK

Background: Schizophrenia is a severe psychiatric disorder with a complex genetic factor determining its disease onset. Nevertheless, it is not clear in this mental disorder. Objective: To conduct a systematic review of articles regarding the genetic markers and mutations in schizophrenia. Methods: A systematic review of articles on genetic markers and mutations in schizophrenia, published from January 1, 2011, to September 7, 2015, on SCOPUS database was carried out. Search terms were “Genetic markers”, “Mutation”, and “Schizophrenia”. Results: Of the 527 retrieved studies, 31 met the eligibility criteria. Genetic polymorphism, Immune-associated genes, TCF4 and ZNF804A association with microRNA, Neuregulin gene, Chromosome 13q32 and 11p15.4, genes involved in glutamatergic via schizophrenia and brain structure, appeared to be associated with the origin of schizophrenia. Conclusion: Some studies show genes involved in several pathways leading to the disease pathogenesis such as that one related with the dopaminergic and immune system, or rare alleles. Some genes present no involvement in the etiology of this mental disorder. These findings clarify the genetic complexity of schizophrenia and affirm that together, the genes have an overall effect greater than the sum of the individual effect of each gene.

关键词： Schizophrenia Genetic Markers Mutations Systematic Review

Characterization of Clinical and Environmental Isolates of <i>Cryptococcus neoformans</i>/<i>Cryptococcus gattii</i>Complex Maintained in Yeast Culture Collection in São Paulo, Brazil

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Open Journal of Epidemiology 2018年第2期8卷 76-92页

作者： Pedro Henrique Magalhã es Cardoso Bosco Christiano Maciel da Silva Jairo Ivo dos Santos Rennan Luiz Oliveira dos Santos Diniz Pereira Leite Jú nior marcos Ereno Auler Luciana da Silva Ruiz Eriques Gonç alves da Silva Dé bora Moreira Carina Domaneschi Francisco de Assis Baroni Marcia de Souza Carvalho Melhem Marilena dos Anjos Martins Claudete Rodrigues Paula Faculty of Veterinary Medicine and Zootechny-FMVZ-USP University of S&#227 o Paulo (USP) S&#227 o Paulo Brazil Faculty of Medicine/FMUSP University of S&#227 o Paulo (USP) S&#227 o Paulo Brazil Federal University of Santa Catarina (UFSC) Florian&oacute polis Brazil Faculty of Dentistry University of S&#227 o Paulo (FOUSP) S&#227 o Paulo Brazil Faculty of Medicine Federal University of Mato Grosso (UFMT) Cuiab&aacute Brazil Faculty of Pharmacy University of the Western Center of Paran&aacute (UNICENTRO) Guarapuava Brazil Institute Adolfo Lutz (IAL) Bauru Brazil Federal Rural University of Rio de Janeiro (UFRRJ) Serop&eacute dica Brazil Institute Adolfo Lutz (IAL) S&#227 o Paulo Brazil

Objective: As isolates of Cryptococcus are frequently kept collection stocks in institutions, sometimes without proper characterization, we sought to determine the genotype profiles, protease and phospholipase activities “in vitro” and the susceptibility testing for azoles and amphotericin B. Methodology: 84 isolates from several regions of Brazil (40 samples from clinical origin and 44 isolates from environmental origin) were maintained at the microorganism’s bank of the Biomedical Science Institute (ICB-USP) of the São Paulo University, in São Paulo, Brazil. This isolates was submitted fungal strains determination, DNA extraction and purification, determination of genotype by URA5 gene RFLP of CGB-positive isolates, protease and phospholipase activity and susceptibility to antifungals. Results: Of six CGB positive isolates tested by RFLP-PCR, only four presented a genomic profile consistent C. gattii species (VGII), while two other were C. neoformans (VNI and VNIII), indicating the existence of canavanine-resistante C. neoformans isolates in the culture collections. The clinical isolates secreted higher levels of phospholipase and environmental isolates but no differences were observed for the protease levels. Almost all isolates were sensible to azoles and amphotericin B. Conclusion: We point out in this research the existence of C. neoformans strains resistant to canavanine and intrinsic characteristic of C. gatti. These results demonstrate the importance to perform a detailed characterization of isolates kept in culture collections.

关键词： Cryptococcus Complex Genotyping Protease Phospholipase Etest Culture Collection

Analysis of PTEN Methylation Pattern by Pyrosequencing in Renal Cell Carcinoma

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Dissolution of FeNb in liquid steel and best practices to increase niobium recovery during ladle refining

Journal of Cancer Therapy（癌症治疗） 2020年第12期

作者： Eurico Cleto Ribeiro de Campos marcos Gonçalves Adriano Júnior Marcus Rivabem Winheski Renan Martins Ademar Lopes

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Baosteel Technical Research 2010年第S1期4卷 19-页

作者： Edmundo Burgos CRUZ Daniel Pallos FRIDMAN Marcelo C CARBONI Rogerio Contato GUIMARAES marcos A Stuart NOGUEIRA Ferdinando Luiz CAVALLANTE CBMM Araxa MGBrasil CBMM Sao Paulo SPBrasil Sao Paulo Polytechnic School Brasil

This paper presents a microstructural characterization of standard ferroniobium(FeNb) and a study of its dissolution in *** dissolution trials at different temperatures were carried out in a laboratory induction *** microstructure at the interface between solid FeNb and frozen steel was analyzed and compared with the original FeNb *** results allowed clarifying both the FeNb dissolution mechanism and its incorporation kinetics at steelmaking *** results from the dissolution of standard FeNb in liquid steel proved that the dissolution rates of FeNb particles were higher than those reported in the pertinent literature,where models assume that FeNb dissolves only by the diffusion of solid particles due to its high melting temperatures(over 1 600℃).Most recent FeNb phase diagrams and DTA analyses have shown that standard FeNb begins to melt down below 1 600℃.The experimental evidences in this work have led to the adoption of a new description of the dissolution mechanism whereby standard FeNb dissolves predominantly by the melting of its eutectic zones at 1500℃to 1510℃and,later on,by the melting of the primary laths between 1530℃and 1575℃,i.e.,below the steelmaking temperatures of around 1 600℃.Based on these results and on previous melting-shop experience,this paper recommends the best practices for the addition of FeNb during the microalloyed steels secondary refining phase.

关键词： FeNb ferroniobium dissolution microalloyed steel steelmaking

Robot-Assisted Nephrotomy as a Nephron-Sparing Approach for Completely Intraparenchymal Renal Tumors

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Maternal mental disorders in pregnancy and the puerperium and risks to infant health

Open Journal of Urology（泌尿学期刊） 2023年第10期

作者： marcos Dall’Oglio Matheus Miranda Paiva Fabrício Golono Kaminagakura José Augusto Farias da Silva Júnior JorgeOcké

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World Journal of Clinical Pediatrics 2012年第4期1卷 20-23页

作者： Priscila Krauss Pereira Lúcia Abelha Lima Letícia Fortes Legay Jacqueline Fernandes de Cintra Santos Giovanni marcos Lovisi Institute of Public Health Studies Federal University of Rio de JaneiroRio de JaneiroCEP 21944-970RJBrazil

Prenatal and postnatal period presents the highest prevalence of mental disorders in women's lives and depression is the most frequent one,affecting approximately one in every five *** aggravating factor here is that during this period psychiatric symptoms affect not only women's health and well-being but may also interfere in the infant's intra and extra-uterine *** the causes of the relationship between maternal mental disorders and possible risks to a child's health and development remain unknown,it is suspected that these risks may be related to the use of psychotropic drugs during pregnancy,to substance abuse and the mother's ***,after delivery,maternal mental disorders may also impair the ties of affection(bonding) with the newborn and the ma-ternal capacity of caring in the post-partum period thus increasing the risk for infant infection and malnutrition,impaired child growth that is expressed in low weight and height for age,and even behavioral problems and vulnerability to presenting mental disorders in *** speaking,research on this theme can be divided into the type of mental disorder analyzed: studies that research minor mental disorders during pregnancy such as depression and anxiety find an association between these maternal disorders and obstetric complications such as prematurity and low birth weight,whereas studies that evaluate severe maternal mental disorders such as schizophrenia and bipolar disorder have found not only an association with general obstetric complications as well as with congenital malformations and perinatal ***,the success of infant growth care programs also depends on the mother's mental well *** findings have led to the need for new public policies in the field of maternal-infant care geared toward the population of ***,more research is necessary so as to confirm the association between all factors with greater scientific rigor.

关键词： Maternal welfare Mental disorders Pregnancy Puerperium Infant health

Ergonovine stress echocardiography: Recent experience and safety in our centre

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World Journal of Cardiology 2010年第12期2卷 437-442页

作者： Alejandro Cortell Pedro marcos-Alberca Carlos Almería JoséL Rodrigo Leopoldo Pérez-Isla Carlos Macaya JoséLuis Zamorano University Clinic San Carlos Cardiovascular InstituteProfesor Martín Lagos Street

AIM:To study recent experience and safety of ergonovine stress echocardiography in our ***:In this study we collected the clinical variables of patients referred since 2002 for ergonovine stress echocardiography,in addition to indications,the results of this test,complications,blood pressure and heart rate values during the test and the number and results of tests requested before this ***:We performed 40 tests in 38 patients,2 tests were carried out to verify therapy *** prevalence of classic cardiovascular risk factors was low and the most frequent indication was chest pain (57.5%).Coronary angiography was performed in 32 patients,and showed normal coronary arteries in 27 patients and non-significant stenosis in 5 *** 16 patients,coronary angiography was carried out after a positive or inconclusive ischemia *** 6 patients had a normal stress test(5 exercise electrocardiography tests and 1 nuclear imaging test).Of the 40 ergonovine stress echocardiography tests,6 were positive(4 in the right coronary artery territory and 2 in the circumflex coronary artery territory),all of them by echocardiographic criteria,and by electrocardiographic criteria in only 3(50%).The presence of non-significant coronary artery stenosis was more frequent in patients with positive ergonovine stress echocardiography(50%vs 6%,P =0.038),and were related to ischemic *** the maximum stress stage,there was a higher systolic(130.26±19.17 mmHg vs 136.58±27.27 mmHg,95%CI:-12.77 to 0.14 mmHg,P=0.055)and diastolic blood pressure(77.89±13.49 mmHg vs 83.95± 15.73 mmHg,95%CI:-10.41 to-1.69 mmHg,P=0.008) than at the baseline stage,and the same was registered with heart rate(73±10.96 beats/minvs 79.79± 11.72 beats/min,95%CI:-9.46 to-4.11 beats/min,P <0.01).Nevertheless,there were only 2 hypertensive reactions during the last stage,which did not force a premature end to the test,without sustained tachy or bradyarrhythmias,and the technique was

关键词： Coronary angiography Ergonovine Myocardial ischaemia Stress echocardiography Vasospasm

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巴西的现代化道路(1808~1930)

世界近现代史研究 2022年第1期 83-93,324,325页

作者：〔巴西〕马科斯·科尔代罗·皮雷斯安玮晨(译) 巴西圣保罗州立大学哲学与科学学院政治经济学系南开大学世界近现代史研究中心和拉美研究中心

1822年巴西帝国建立,但殖民时期的经济和社会结构并没有被破坏。由于新兴咖啡资产阶级和军人不断扩张政治权力,以及奴隶制废除消除了帝国的社会基础,巴西帝国衰亡了。1889年巴西共和国建立后,也没有进行结构性改革,经济依然依赖初级产... 详细信息

1822年巴西帝国建立,但殖民时期的经济和社会结构并没有被破坏。由于新兴咖啡资产阶级和军人不断扩张政治权力,以及奴隶制废除消除了帝国的社会基础,巴西帝国衰亡了。1889年巴西共和国建立后,也没有进行结构性改革,经济依然依赖初级产品出口。咖啡经济带动了巴西工业化的不断发展,第一次世界大战后,工业资产阶级、城市中产阶级和工人阶级的政治影响力不断增强,他们渴望分享权力,但这些新兴社会阶级并没有被寡头政治所接纳,使得政治秩序愈发紧张。在1929年经济危机的冲击下,巴西寡头集团内部分裂了,其经济基础也被摧毁了,从而引发了1930年革命,初级产品出口也被进口替代工业化取代了。

关键词：巴西咖啡工业化社会结构政治结构

Climate Justice Dimensions:Approaching Loss and Damage and Adaptation towards a Just City

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Journal of Geographical Research 2023年第4期6卷 26-44页

作者： Pedro Henrique Campello Torres Gabriel Pires de Araújo marcos Tavares de Arruda Filho Isabela Carmo Cavaco Beatriz Dunder Institute of Energy and Environment University of São PauloSão Paulo05508-900Brazil

The escalating occurrence of severe climatic events over the past decade,with a projection for further intensification due to the climate emergency,underscores the critical role of urban and regional planning in climate action towards just *** and regions are both significant contributors to CO_(2)emissions and are vulnerable to the adverse impacts of climate *** paper contends that urban and regional planning must undergo a paradigm shift to address this *** justice,encompassing dimensions of inequality and environmental equity,is a pivotal dialogue in these *** a comprehensive review,this study contributes to the evolving landscape of climate justice planning and policy,offering insights that could resonate across the Global South and *** an illustrative case,the authors delve into Brazil’s climate challenges,discussing adaptation planning and post-disaster response,and emphasizing the need for localized and community-driven *** article delves into the interplay between Loss and Damage,adaptation,and just cities,with a focus on the Global *** authors scrutinize the emerging discourse on Loss and Damage,its associations with climate impacts,and the quest for a just and equitable *** work advances the understanding of the distinction between adaptation and Loss and Damage actions,highlighting the significance of a dedicated fund for addressing Loss and Damage in vulnerable countries.

关键词： Climate justice Loss and Damage Global South Just adaptation Brazil