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Analysis of 12 variants in the development of gastric and colorectal cancers

World Journal of Gastroenterology 2017年第48期23卷 8533-8543页

作者： Giovanna C Cavalcante marcos at amador Andre M Ribeiro dos Santos Darlen C Carvalho Roberta B Andrade Esdras EB Pereira Marianne R Fernandes Danielle F Costa Ney PC Santos Paulo P Assumpcao Andrea Ribeiro dos Santos Sidney Santos Laboratório de Genética Humana e Médica Universidade Federal do Pará Núcleo de Pesquisas em Oncologia Universidade Federal do Pará

AIM To evaluate the relation between 12 polymorphisms and the development of gastric cancer(GC) and colorectal cancer(CRC).METHODS In this study,we included 125 individuals with GC diagnosis,66 individuals with CRC diagnosis and 475 cancer-free individuals. All participants resided in the North region of Brazil and authorized the use of their samples. The 12 polymorphisms(in CASP8,CYP2 E1,CYP19 A1,IL1 A,IL4,MDM2,NFKB1,PAR1,TP53,TYMS,UGT1 A1 and XRCC1 genes) were genotyped in a single PCR for each individual,followed by fragment analysis. To avoid misinterpretation due to population substructure,we applied a previously developed set of 61 ancestryinformative markers that can also be genotyped by multiplex PCR. The statistical analyses were performed in Structure v.2.3.4,R environment and SPSS *** After statistical analyses with the control of confounding factors,such as genetic ancestry,three markers(rs79071878 in IL4,rs3730485 in MDM2 and rs28362491 in NFKB1) were positively associated with the development of GC. One of these markers(rs28362491) and the marker in the UGT1 A1 gene(rs8175347) were positively associated with the development of CRC. Therefore,we investigated whether the joint presence of the deleterious alleles of each marker could affect the development of cancer and we obtained positive results in all analyses. Carriers of the combination of alleles RP1 + DEL(rs79071878 and rs28361491,respectively) are at 10-times greater risk of developing GC than carriers of other combinations. Similarly,carriers of the combination of DEL + RARE(rs283628 and rs8175347) are at about 12-times greater risk of developing CRC than carriers of other *** These findings are important for the comprehension of gastric and CRC development,particularly in highly admixed populations,such as the Brazilian population.

关键词： Inflammatory processes Immune response Genomic and cellular stability Gastric cancer Colorectal cancer Amazon

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Exhaust Ventilation through a Solar Chimney： A Response to High Hermeticity in Welfare Housing

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Journal of Civil Engineering and Architecture 2015年第7期9卷 767-774页

作者： marcos Eduardo Gonzalez-Trevizo Adolfo Gomez-amador Anibal Luna-Leon Carlos Escobar-Del POZO Carlos Javier Esparza Lopez Facultad de Arquitectura (Faculty of Architecture) Universidad Michoacana de San Nicoldls de Hidalgo (Michoacan Universityof Saint Nicholas of Hidalgo) Morelia MN 58030 Mexico Facultad de Arquitectura y DiseFzo (Faculty of Architecture and Design) Universidad de Colima (University of Colima) ColimaCL 28400 Mexico Facultad de Arquitectura y Diseho (Faculty of Architecture and Design) Universidad Aut6noma de Baja California (BajaCalifornia Autonomous University) Mexieali BC 21280 Mexico Facultad de Ingenieria Mecnica y Elctrica (Faculty of Mechanical and Electrical Engineering) Universidad de ColimaColima CL 28400 Mexico

This research reports on potentiality in the solar chimney as an exhaust ventilation device through a hypothetical statement that convenient weather conditions exist on sub-humid warm climate to enhance the performance ofa SC （solar chimney）, in order to increase ventilation to dissipate metabolic heat from inhabitants of airtight buildings. The methodology used in this research integrates the use of simplified mathematical models that predict in a semi-empirical way a potential volume flow through estimation of kinetic power generation, by natural circulation and stack effect in a typical covered-plate air solar collector. The study was carried out during the warm month of April, an important warm season for Colima, where the prevailing wind is about 6.8 m/s, the average temperature of maximums and minimums oscillates between 15.4℃and 34.4 ℃ with average relative humidity of 65% according to national weather service. A scale model of the SC was installed on environmental chambers. The results showed that this device is capable of generating ventilation conditions around light breeze parameters near between 0.6 m/s and 1.5 m/s width, a better performance at day in 45% approximately than the night values, making ventilation rates up 0.24 ACH （air changes per hour） as average air change rate.

关键词： Exhaust ventilation solar chimney air solar collector welfare housing.

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