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Possible viral agents to consider in the differential diagnosis of blepharoconjunctivitis

World Journal of Virology 2024年第4期13卷 120-134页

作者： Mutali Musa Babatunde Ismail Bale Ayuba Suleman Gladness Aluyi-Osa Ekele Chukwuyem FabianaD’Esposito Caterina Gagliano Antonio Longo Andrea Russo marco Zeppieri Department of Optometry University of BeninBenin 300283Nigeria Department of Ophthalmology Africa Eye Laser Centre LtdBenin 300105Nigeria Department of Ophthalmology Centre for Sight Africa LtdNkpor 434212Nigeria Imperial College Ophthalmic Research Group Unit Imperial CollegeLondon NW15QHUnited Kingdom GENOFTA srl Via A.Balsamo93Naples 80065Italy Department of Medicine and Surgery University of Enna"Kore"Catania 94100Italy Eye Clinic Catania University San Marco HospitalCatania 95121Italy Department of Ophthalmology University Hospital of CataniaCatania 95123Italy Department of Ophthalmology University Hospital of UdineUdine 33100Italy

BACKGROUND Blepharoconjunctivitis poses a diagnostic challenge due to its diverse etiology,including viral *** can be acute or chronic,selflimiting,or needing medical *** To review possible viral agents crucial for accurate differential diagnosis in cases of *** The PubMed database was searched for records relating to viral *** search string generated was“("virally"[All Fields]OR"virals"[All Fields]OR"virology"[MeSH Terms]OR"virology"[All Fields]OR"viral"[All Fields])AND"Blepharoconjunctivitis"[All Fields]".RESULTS A total of 24 publications were generated from the search *** lists from each relevant article were also searched for more information and included in this *** etiologies such as adenovirus,herpes simplex virus(HSV),varicella-zoster virus(VZV),and Epstein-Barr virus(EBV)are frequently *** infections manifest with follicular conjunctivitis and preauricular lymphadenopathy,often presenting as epidemic *** and VZV infections can result in herpetic keratitis and may exhibit characteristic dendritic corneal ***,although less common,can cause unilateral or bilateral follicular conjunctivitis,particularly in immunocompromised *** potential viral agents,such as enteroviruses and molluscum contagiosum virus,should also be considered,especially in pediatric *** Prompt recognition of these viral etiologies is essential for appropriate management and prevention of ***,a thorough understanding of the clinical presentation,epidemiology,and diagnostic modalities is crucial for accurate identification and management of viral blepharoconjunctivitis.

关键词： Viral Blepharoconjunctivitis Herpes simplex virus Varicella-Zoster Epstein-Barr

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C19MC miRNA-520G induces SP100 antiviral gene transcription and inhibits melanin production in skin cutaneous melanoma

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Genes & Diseases 2024年第1期11卷 60-63页

作者： Goodwin G.Jinesh Marian T.Smallin Nino Mtchedlidze Isha Godwin marco Napoli Nicole Hackel Manali S.Phadke Avani A.Deshpande Xiaobo Li John H.Lockhart Jaden R.Baldwin Suehelay Acevedo-Acevedo Yifeng Gao Michelle A.Reiser Keiran S.M.Smalley Elsa R.Flores Andrew S.Brohl Department of Molecular Oncology H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA Molecular Medicine Program H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA Saveetha Medical College ChennaiTamil Nadu 602105India Tumor Biology Department H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA Sarcoma Department H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA

SP100 is an antiviral protein that restricts the productive stage of human papillomavirus(HPV)and multiple other viruses,and viruses in turn block sUMO-1-mediated stabilization of SP100 and promotes its degradation(Table S1).Interferon(IFN)signaling could still produce more SP100 through transcription to counteract viruses.1 Viruses also disable the transcriptional up-regulation of SP100 to achieve persistent infection in hosts.

关键词： SP100 melanoma stabilization

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σ-Phase in Lean Duplex Stainless Steel Sheets

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Acta Metallurgica Sinica(English Letters) 2015年第3期28卷 331-337页

作者： marco Breda Massimo Pellizzari marco Frigo Industrial Engineering Department(DII) University of PadovaVia Marzolo 9Int.435131 PaduaItaly Industrial Engineering Department(DII) University of TrentoVia Mesiano 7738123 TrentoItaly Outokumpu S.p.A. Piazza Piccapietra 916121 GenoaItaly

The precipitation kinetics of secondary phases in two austeno-ferritic lean duplex stainless steels（lean DSS）were examined after aging the materials at 800 ℃.Owing to the instability of ferrite,all DSS are known to be sensitive to solid-state phase transformations in the critical temperature range 600-1,000 ℃ and different secondary phases may form,depending on composition and *** performed thermodynamic simulations revealed the proneness to the precipitation of such phases also have been done in lean DSS,but only information on the equilibrium microstructures were ***,the materials were aged at various times,in order to verify the simulations and determine the precipitation *** occurred structural modifications were observed and quantified by scanning electron microscope and X-ray diffraction measurements,determining phase type,composition and volumetric *** 800 ℃,grade 2101 was found to be only affected by Cr_2N nitrides precipitation,whereas a significant amount of σ-phase was found to form in LDX 2404 for treatment longer than 1 h,almost totally replacing ferrite after 50 *** to now,the intermetallic σ-phase has been observed only in the high alloyed DSS,and the unexpected precipitation in grade 2404 highlighted that the increased content of molybdenum in this steel might be considered as determinant for the formation.

关键词： Lean duplex stainless steels Isothermal heat treatments σ-Phase Chromium nitrides Precipitation kinetics

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Elastic period of vibration calculated experimentally in buildings hosting permanent GPS stations

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Earthquake Engineering and Engineering Vibration 2018年第3期17卷 607-625页

作者： marco Gatti Department of Engineering University of Ferrara

During the earthquake in Emilia（Italy） of 2012,ca.30 permanent GPS stations were in operation within a radius of about 100 km from the epicenter,each equipped with an antenna rigidly fixed to the host building and sampling the GPS signal at a high rate（〉 1 Hz）.From the recording of the GPS measurements,the instantaneous displacements s（t） in the NorthSouth and East-West directions of the phase centers of the single GPS antennas at each permanent station during the most important seismic sequences were calculated in kinematic ***,for each of the two displacements considered as two distinct external forces,the elastic response spectra of the building were determined and from them the two periods of vibration T along two orthogonal directions coinciding with the walls of the building were *** experimentally obtained periods of vibration were compared with those inferable from the technical *** this way,a sufficiently large sample was obtained per building type,geometry（square,rectangular,regular or irregular planimetry）,height（from a minimum of 4 to a maximum of 20 m） and materials（masonry,reinforced concrete,etc.）.From the computational point of view,the study confirmed that GPS is an emerging tool for monitoring dynamic displacements and the experimentally estimated value of T is always lower than the one estimated with the formulae reported in the *** limitations of the study lie in the impossibility to choose a priori the geometry and/or structural type of the building hosting the GPS station.

关键词： permanent GPS stations Emilia-Romagna Italy earthquake period vibrations dynamic structure

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大陆俯冲界面之上大规模硅富集流体的地球物理学证据

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中国科学：地球科学 2024年第9期54卷 2848-2863页

作者：毛元彤赵亮 marco G.MALUSÀ Stefano SOLARINO Silvia PONDRELLI 孙宝璐 Coralie AUBERT Simone SALIMBENI Elena EVA Stéphane GUILLOT 中国科学院地质与地球物理研究所岩石圈演化与环境演变全国重点实验室北京100029 中国科学院大学地球与行星科学学院北京100049 Department of Earth and Environmental Sciences University of Milano-BicoccaMilan 20126Italy Istituto Nazionale di Geofisica e Vulcanologia Osservatorio Nazionale TerremotiGenova 16145Italy Istituto Nazionale di Geofisica e Vulcanologia Sezione di BolognaBologna 40127Italy UniversitéGrenoble Alpes UniversitéSavoie Mont BlancCNRSIRDUGEISTerreGrenoble 38000France

俯冲带中的流体可能对俯冲过程产生重要影响.然而,关于大陆俯冲期间流体规模及其作用的地球物理约束仍然有限.西阿尔卑斯造山带是全球保存最完好的大陆俯冲带之一,为认识大陆俯冲过程中流体作用的影响提供了重要的参考.本文综合多种地... 详细信息

俯冲带中的流体可能对俯冲过程产生重要影响.然而,关于大陆俯冲期间流体规模及其作用的地球物理约束仍然有限.西阿尔卑斯造山带是全球保存最完好的大陆俯冲带之一,为认识大陆俯冲过程中流体作用的影响提供了重要的参考.本文综合多种地球物理方法分析了西阿尔卑斯造山带地区的V_(P)/V_(S)比值,发现在俯冲区的上盘侧存在高V_(P)/V_(S)(>1.9)带,与部分蛇纹岩化的上覆地幔楔位置一致;而在下盘侧存在异常低的V_(P)/V_(S)(<1.7)带,异常深度浅于30km.本文认为,观测到的低V_(P)/V_(S)比值异常是由地壳内广泛分布的富硅岩脉导致,指示了在俯冲时期大陆俯冲界面之上可能存在的富硅流体流动.本文的结果暗示俯冲时期的流体流动可能降低了俯冲界面的有效应力,从而促进了大陆俯冲.

关键词：西阿尔卑斯造山带地壳精细结构接收函数 V_(P)/V_(S)波速比硅富集

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Impact of dental and orofacial trauma on oral health-related quality of life in adults:A systematic review

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Chinese Journal of Traumatology 2024年第5期27卷 249-253页

作者： Santosh Kumar Verma Awanindra Kumar Jha Om Prakash Subia Ekram Chandmani Tigga Mohammad Kashif Noorani Vini Mehta Aida Meto Agron Meto Luca Fiorillo marco Cicciù Department of Periodontology&Oral Implantology Dental CollegeRajendra Institute of Medical SciencesRanchi834009JharkhandIndia Department of Orthodontic and Dentofacial Orthopedic Dental CollegeRajendra Institute of Medical SciencesRanchi834009JharkhandIndia Department of Oral and Maxillofacial Surgery Dental College Rajendra Institute of Medical SciencesRanchi834009JharkhandIndia Prosthodontics and Crown and Bridge and Oral Implantology 800001PatnaIndia Department of Public Health Dentistry Dr.D.Y.Patil Dental College and HospitalDr.D.Y.Patil VidyapeethPimpriPune411018MaharashtraIndia Department of Dentistry Faculty of Dental SciencesUniversity of Aldent1007TiranaAlbania Department of Biomedical and Dental Sciences Morphological and Functional ImagesUniversity of Messina98100MessinaItaly Multidisciplinary Department of Medical-Surgical and Dental Specialties Second University of Naples80100NaplesItaly Department of Surgery and Surgical Specialties University of Catania95100CataniaItaly

Purpose:Dental and orofacial trauma among the adult population constitutes a major public health *** impact is not just physical but also *** analyse the impacts of dental and orofacial trauma on oral health-related quality of life(OHRQoL)in adults and determine whether the 2 variables are closely ***:This is a systematic *** terms“dental trauma”,“orofacial trauma”,“oral health”,“oral health related impact life”,“OHRQoL”,“positive and negative affect scale”,“quality of life”,“facial injuries”,“adults”,and“young adults”were researched in the databases of PubMed,ScienceDirect,Scopus and Google Scholar for associated studies up to December 30,2022.A comprehensive search was designed and the articles were independently screened for eligibility by 2 *** included studies’author,year of publication,the country where the study was conducted,population demographics(number and age),an instrument used for assessing OHRQoL and the relevant result were recorded and *** quality of the evidence was assessed using Joanna Briggs Institute checklist for observational ***:Out of 482 unique records,3 articles were included for data *** studies were *** studies did not mention confounding *** scales were used for dental and orofacial trauma and *** has a directly proportional relationship with orofacial *** with orofacial trauma have a significant impact on this value with a prevalence of 88.4%.Conclusion:The highest impact on OHRQoL was seen immediately after the diagnosis of an orofacial *** impact increases with the severity of the ***,to promote overall dental and general health,health education initiatives should include information on the causes,prevention,and requirement for prompt responses by the populace in seeking dental intervention.

关键词： Dental trauma Oral health Oral health-related quality of life Orofacial trauma

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Small Cell Neuroendocrine Carcinoma of the Vulva: Case Report and Literature Review

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Open Journal of Obstetrics and Gynecology 2024年第2期14卷 295-300页

作者： Gabriela Françóes Rostirolla Alessandra Guerra Maria Carolina Rey Alt Luiza Tesser Dalla Libera Maria Eduarda Appel Binda Márcia Appel Fernando De marco dos Santos Department of Obstetrics and Gynecology Caxias do Sul University Caxias do Sul Brazil Department of Pathology UNIVATES Lajeado RS Medical Student Caxias do Sul University Caxias do Sul Brazil Department of Obstetric and Gynecology Federal University of Rio Grande do Sul Porto Alegre Brazil Department of Oncology Surgeon Caxias do Sul University Caxias do Sul Brazil

Background: Neuroendocrine neoplasms are those that develop from a neuroendocrine cell. They most commonly affect the lungs, gastrointestinal tract, and pancreas, being rare conditions in the female genital tract. When present, these neoplasms often manifest with nonspecific signs and symptoms such as pain, itching, swelling, single-focus lesions, bleeding, and enlargement of inguinal lymph nodes, in addition to the presence of progressively enlarging vulvar nodules. Consequently, the diagnostic investigation involves histopathological examination and confirmation through immunohistochemistry. Objective: To present a comprehensive understanding of this rarely studied pathology. The primary objective is to provide valuable insights that could aid in the future development of universally applicable treatment guidelines. Case Presentation: A 57-year-old female, with no prior comorbidities, menopause at 36, who presented with a left vulvar nodule accompanied by intense pain and swelling, later diagnosed with small cell neuroendocrine carcinoma in the vulva. Conclusion: This case report highlights the importance of enhancing our knowledge regarding small cell neuroendocrine carcinoma in the vulva, given its scarcity in medical literature. The information presented here underscores the need for standardized diagnostic and treatment approaches, paving the way for future consensus on managing this uncommon but challenging neoplasm.

关键词： Vulvar Neoplasms Carcinoma Small Cell Carcinoma Neuroendocrine Genital Neoplasms Female Vulvar Diseases

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Correlation between Intestinal Health and Coccidiosis Prevalence in Broilers during Different Seasons of the Year in Brazil from 2012 to 2018

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Food and Nutrition Sciences 2024年第3期15卷 179-198页

作者： Fabio Luis Gazoni Gabriela Miotto Galli Marcel Manente Boiago Lenita Moura Stefani Aline Zampar marco A. Juárez-Estrada Guillermo Tellez-Isaias Aleksandro S. da Silva Animal Health and Reproduction Veterinary Medicine Graduate Program Federal University of Santa Maria (UFSM) Santa Maria Brazil Animal Science Graduate Program Federal University of Rio Grande do Sul (UFRGS) Porto Alegre Brazil Animal Science Graduate Program Santa Catarina State University (UDESC) Chapecó Brazil Departamento de Medicina y Zootecnia de Aves Facultad de Medicina Veterinaria y Zootecnia Universidad Nacional Autonoma de Mexico Ciudad Universitaria Ciudad de Mexico Mexico Department of Poultry Science Division of Agriculture University of Arkansas Fayetteville AR USA

Coccidiosis is a disease caused by intracellular protozoan parasites, specifically belonging to the genus Eimeria. These parasites target the gastrointestinal tract in different types of hosts, causing sores in the intestinal lining. The presence of these lesions reduces the animal’s ability to digest and absorb nutrients, significantly impacting their overall performance. The current study aimed to explore the potential correlation between seasonal variations and the incidence of Eimeria spp-induced lesions in broiler chickens’ gastrointestinal tracts in Brazil from 2012 to 2018. A total of 8,607 broiler chickens, aged 14 to 42 days, were sampled from 103 poultry integrated companies in Brazil to conduct intestinal health examinations. The sampling process involved selecting 3 to 6 chickens from each poultry house for examination. The assessment included various abnormalities such as shedding of intestinal cells and excessive fluid and mucus presence, thickening and tension of the intestines, food movement, roughened mucosal surface resembling a Turkish towel in the small intestine, tissue death, duodenal inflammation, intestinal inflammation, gizzard erosion, presence of worms and bedding material, and ingestion of mealworms. During the seasons, winter exhibited the highest average occurrence of Eimeria maxima microorganisms at 52.83%, with E. acervulina following closely at 26.42% in second place. In spring, E. maxima had an occurrence of 11.31%, while in fall, E. tenella had the lowest occurrence at 6.74%. When analyzing the seasonal occurrence of Eimeria, it was observed that E. maxima micro was more common during winter compared to summer (P = 0.0491). However, no discernible variation was observed in the occurrence of the remaining species across different seasons. Research findings suggest that subclinical coccidiosis is most prevalent during the winter season in Brazil. Likewise, clinical disease caused by E. acervulina is also prevalent during this time. I

关键词： Eimeria Epidemiology Intestinal Pathology Broiler Chickens Brazil

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Ubiquitination and PARylation cross-talk about immunity

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Molecular Plant 2021年第12期14卷 1976-1978页

作者： marco Trujillo Faculty of Biology Cell BiologyⅡUniversity of Freiburg79104 FreiburgGermany

Post-translational modifications(PTMs)allow organisms to quickly respond and acclimate to environmental *** attachment of ubiquitin and its different polymeric forms,act as signals that modulate most aspects of cellular *** is of key importance to maintain protein homeostasis during the immune response by coordinating the major degradation path-ways,namely proteasomal and vacuolar in plants(Trujillo,2021).Poly(ADP-ribosyl)ation(PARylation),has also been linked to various stress responses and shows many commonalities to ubiquitination(Rissel and Peiter,2019).Yao et al.(2021)have now uncovered a link between these two PTMs.

关键词： maintain translational polymeric

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Activity-dependent remodeling of genome architecture in engram cells facilitates memory formation and recall

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Neural Regeneration Research 2022年第5期17卷 991-993页

作者： Asaf marco Neuro-Epigenetics Laboratory the Robert H.Smith Faculty of FoodEnvironment and Agriculturethe Hebrew University of JerusalemRehovol CampusIsrael

The formation and preservation of longterm memories critically depend upon coordinated activity of neuronal circuits,intracellular signaling cascades and synaptic remodeling(Josselyn et al.,2015).These essential proce... 详细信息

关键词： remodeling ngram

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