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Study of risk factors for gastric cancer by populational databases analysis

World Journal of Gastroenterology 2013年第48期19卷 9383-9391页

作者： Fangio Ferrari marco antonio moura reis Master’s Program on Health and Environment University of the Region of Joinville-Univille Joinville Santa Catarina 89219-710 Brazil

AIM:To study the association between the incidence of gastric cancer and populational exposure to risk/protective factors through an analysis of international ***:Open-access global databases concerning the incidence of gastric cancer and its risk/protective factors were identified through an extensive search on the *** its distribution was neither normal nor symmetric,the cancer incidence of each country was categorized according to ranges of percentile *** association of each risk/protective factor with exposure was measured between the extreme ranges of the incidence of gastric cancer(under the 25th percentile and above the 75th percentile)by the use of the Mann-Whitney test,considering a significance level ***:A variable amount of data omission was observed among all of the factors under study.A weak or nonexistent correlation between the incidence of gastric cancer and the study variables was shown by a visual analysis of scatterplot *** contrast,an analysis of categorized incidence revealed that the countries with the highest human development index(HDI)values had the highest rates of obesity in males and the highest consumption of alcohol,tobacco,fruits,vegetables and meat,which were associated with higher incidences of gastric *** was no significant difference for the risk factors of obesity in females and fish ***:Higher HDI values,coupled with a higher prevalence of male obesity and a higher per capita consumption of alcohol,tobacco,fruits,vegetables and meat,are associated with a higher incidence of gastric cancer based on an analysis of populational global data.

关键词： Gastric cancer Risk factors Epidemiologic factors Environment Public health

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Uncovering the multifaceted roles played by neutrophils in allogeneic hematopoietic stem cell transplantation

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Cellular & Molecular Immunology 2021年第4期18卷 905-918页

作者： Cristina Tecchio marco antonio Cassatella Department of Medicine Section of Hem atology and Bone Marrow Transplant UnitUniversity of VeronaVeronaItaly Department of Medicine Section of General PathologyUniversity of VeronaVeronaItaly

Allogeneic hematopoietic stem cell transplantation(alloHSCT)is a life-saving procedure used for the treatment of selected hematological malignancies,inborn errors of metabolism,and bone marrow *** role of neutrophils in alloHSCT has been traditionally evaluated only in the context of their ability to act as a first line of defense against ***,recent evidence has highlighted neutrophils as key effectors of innate and adaptive immune responses through a wide array of newly discovered ***,neutrophils are emerging as highly versatile cells that are able to acquire different,often opposite,functional capacities depending on the microenvironment and their differentiation ***,we review the current knowledge on the multiple functions that neutrophils exhibit through the different stages of alloHSCT,from the hematopoietic stem cell(HSC)mobilization in the donor to the immunological reconstitution that occurs in the recipient following HSC *** also discuss the influence exerted on neutrophils by the immunosuppressive drugs delivered in the course of alloHSCT as part of graft-versushost disease(GVHD)***,the potential involvement of neutrophils in alloHSCT-related complications,such as transplant-associated thrombotic microangiopathy(TA-TMA),acute and chronic GVHD,and cytomegalovirus(CMV)reactivation,is also *** on the data reviewed herein,the role played by neutrophils in alloHSCT is far greater than a simple antimicrobial ***,much remains to be investigated in terms of the potential functions that neutrophils might exert during a highly complex procedure such as alloHSCT.

关键词： neutrophils allogeneic hematopoietic stem cell transplantation(alloHSCT) alloHSCT-associated complications lowdensity neutrophils(LDNs) normal-density neutrophils(NDNs)

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Influence of manufacturing process-induced geometrical defects on the energy absorption capacity of polymer lattice structures

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Defence Technology（防务技术） 2024年第5期35卷 47-59页

作者： Alexandre Riot Enrico Panettieri antonio Cosculluela marco Montemurro Universite de Bordeaux Arts et Metiers Institute of TechnologyCNRSINRABordeaux INPHESAM UniversiteI2M UMR 5295F-33405 TalenceFrance French Atomic Energy Commission Route des GargailsCedexF-33114Le BarpFrance

Modern additive manufacturing processes enable fabricating architected cellular materials of complex shape,which can be used for different *** them,lattice structures are increasingly used in applications requiring a compromise among lightness and suited mechanical properties,like improved energy absorption capacity and specific stiffness-to-weight and strength-to-weight ratios.A dedicated modeling strategy to assess the energy absorption capacity of lattice structures under uni-axial compression loading is presented in this *** numerical model is developed in a non-linear framework accounting for the strain rate effect on the mechanical responses of the lattice *** geometries,i.e.,cubic body centered cell,octet cell,rhombic-dodecahedron and truncated cuboctahedron 2+,are ***,the influence of the relative density of the representative volume element of each geometry,the strain-rate dependency of the bulk material and of the presence of the manufacturing process-induced geometrical imperfections on the energy absorption capacity of the lattice structure is *** main outcome of this study points out the importance of correctly integrating geometrical imperfections into the modeling strategy when shock absorption applications are aimed for.

关键词： Lattice structures Architected cellular materials Dynamic simulation Energy absorption Geometrical imperfection Additive manufacturing

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Biomarkers in colorectal cancer: Current clinical utility and future perspectives

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World Journal of Clinical Cases 2018年第15期6卷 869-881页

作者： marco Vacante antonio Maria Borzì Francesco Basile antonio Biondi Department of General Surgery and Medical-Surgical Specialties University of Catania

Colorectal cancer(CRC) is a major cause of cancer death worldwide. CRC has poor prognosis and there is a crucial need for new diagnostic and prognostic biomarkers to avoid CRC-related deaths. CRC can be considered a sporadic disease in most cases(75%-80%), but it has been suggested that crosstalk between gene mutations(i.e., mutations of BRAF, KRAS, and p53 as well as microsatellite instability) and epigenetic alterations(i.e., DNA methylation of Cp G island promoter regions) could play a pivotal role in cancer development. A number of studies have focused on molecular testing to guide targeted and conventional treatments for patients with CRC, sometimes with contrasting results. Some of the most useful innovations in the management of CRC include the possibility to detect the absence of KRAS, BRAF, NRAS and PIK3 CA gene mutations with the subsequent choice to administer targeted adjuvant therapy with anti-epidermal growth factor receptor antibodies. Moreover, CRC patients can benefit from tests for microsatellite instability and for the detection of loss of heterozygosity of chromosome 18 q that can be helpful in guiding therapeutic decisions as regards the administration of 5-FU. The aim of this review was to summarize the most recent evidence on the possible use of genetic or epigenetic biomarkers for diagnosis, prognosis and response to therapy in CRC patients.

关键词： Biomarkers Colorectal cancer Epigenetics Tumor markers DNA methylation

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Familial adenomatous polyposis and changes in the gut microbiota: New insights into colorectal cancer carcinogenesis

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World Journal of Gastrointestinal Oncology 2021年第6期13卷 495-508页

作者： antonio Biondi Francesco Basile marco Vacante Department of General Surgery and Medical-Surgical Specialties University of CataniaCatania 95123Italy Multidisciplinary Research Center for Rare Diseases University of CataniaCatania 95123Italy

Patients with familial adenomatous polyposis(FAP),an autosomal dominant hereditary colorectal cancer syndrome,have a lifetime risk of developing cancer of nearly 100%.Recent studies have pointed out that the gut microbiota could play a crucial role in the development of colorectal adenomas and the consequent progression to colorectal *** gut bacteria,such as Fusobacterium nucleatum,Escherichia coli,Clostridium difficile,Peptostreptococcus,and enterotoxigenic Bacteroides fragilis,could be implicated in colorectal carcinogenesis through different mechanisms,including the maintenance of a chronic inflammatory state,production of bioactive tumorigenic metabolites,and DNA *** using the adenomatous polyposis coliMin/+mouse model,which resembles FAP in most respects,have shown that specific changes in the intestinal microbial community could influence a multistep progression,the intestinal“adenoma-carcinoma sequence”,which involves mucosal barrier injury,low-grade inflammation,activation of the Wnt ***,modulation of gut microbiota might represent a novel therapeutic target for patients with *** of probiotics,prebiotics,antibiotics,and nonsteroidal anti-inflammatory drugs could potentially prevent the progression of the adenoma-carcinoma sequence in *** aim of this review was to summarize the best available knowledge on the role of gut microbiota in colorectal carcinogenesis in patients with FAP.

关键词： Familial adenomatous polyposis Microbiota Colorectal cancer Polyps Carcinogenesis Bacteria

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Performance evaluation of permissioned blockchains for financial applications: The ConsenSys Quorum case study

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Blockchain(Research and Applications) 2022年第1期3卷 1-12页

作者： marco Mazzoni antonio Corradi Vincenzo Di Nicola Conio Inc. c/o The Orrick Building405 Howard StreetSan FranciscoCA94105USA Department of Computer Science and Engineering University of BolognaViale Risorgimento 2BolognaItaly

Given the availability of several blockchain technologies in permissioned contexts,blockchain application designers have to cope with the increasing complexity of choosing which technology and consensus algorithm best fit a specific use ***,the lack of a standard framework allowing to assess the scalability of permissioned blockchain platforms and to compare performances and features of consensus algorithms makes the development of a sensible evaluation a costly and difficult time-consuming *** this article,we propose a practical scalability and applicability evaluation of the Quorum blockchain and its consensus *** we apply our evaluation workflow to a financial use case,we define a methodology that can be generalized to any permissioned blockchain *** leverage Hyperledger Caliper as a benchmarking tool,and Docker as a deployment tool,making our analysis easy to be repeated,cross-platform,and cost-effective.

关键词： Blockchain Consensus Benchmark Quorum Cryptocurrency

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Nonlinear Diffusion and Transient Osmosis

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Communications in Theoretical Physics 2011年第8期56卷 352-366页

作者： Akira Igarashi Lamberto Rondoni antonio Botrugno marco Pizzi Dipartimento di Matematica Politecnico di Torino INFN Sezione di Torino Kavli Institute for Theoretical Physics China CAS Eltek Group

We investigate both analytically and numerically the concentration dynamics of a solution in two containers connected by a narrow and short channel, in which diffusion obeys a porous medium equation. We also consider the variation of the pressure in the containers due to the flow of matter in the channel. In particular, we identify a phenomenon, which depends on the transport of matter across nano-porous membranes, which we call ＂transient osmosis＂. We find that nonlinear diffusion of the porous medium equation type allows numerous different osmotic-like phenomena, which are not present in the case of ordinary Fickian diffusion. Experimental results suggest one possible candidate for transiently osmotic processes.

关键词： anomalous transport porous medium equation osmotic pressure

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Non-coding RNAs and other determinants of neuroinflammation and endothelial dysfunction:regulation of gene expression in the acute phase of ischemic stroke and possible therapeutic applications

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Neural Regeneration Research 2021年第11期16卷 2154-2158页

作者： Mario Daidone marco Cataldi antonio Pinto Antonino Tuttolomondo Department of Health Promotion Maternal and Infant CareInternal Medicine and Medical Specialties“G.D’Alessandro”University of PalermoPiazza delle Cliniche n.2PalermoItaly

Ischemic stroke occurs under a variety of clinical conditions and has different pathogeneses,resulting in necrosis of brain *** pathogenesis is characterized by neuroinflammation and endothelial *** of the main processes triggered in the early stages of ischemic damage are the rapid activation of resident inflammatory cells(microglia,astrocytes and endothelial cells),inflammatory cytokines,and translocation of intercellular nuclear *** in stroke includes all the processes mentioned above,and it consists of either protective or detrimental effects concerning the“polarization”of these *** polarization comes out from the interaction of all the molecular pathways that regulate genome expression:the epigenetic *** recent years,new regulation mechanisms have been cleared,and these include non-coding RNAs,adenosine receptors,and the activity of mesenchymal stem/stromal cells and *** reviewed how long non-coding RNA and microRNA have emerged as an essential mediator of some neurological *** also clarified that their roles in cerebral ischemic injury may provide novel targets for the treatment of ischemic *** date,we do not have adequate tools to control pathophysiological processes associated with *** goal is to review the role of non-coding RNAs and innate immune cells(such as microglia and mesenchymal stem/stromal cells)and the possible therapeutic effects of their modulation in patients with acute ischemic stroke.A better understanding of the mechanisms that influence the“polarization”of the inflammatory response after the acute event seems to be the way to change the natural history of the disease.

关键词： acute phase cerebrovascular disease endothelial dysfunction epigenetics genetics neuroiflammation non-coding RNAs stroke

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Liver transplantation for intermediate hepatocellular carcinoma: An adaptive approach

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World Journal of Gastroenterology 2017年第18期23卷 3195-3204页

作者： marco Biolato Giuseppe Marrone Luca Miele antonio Gasbarrini antonio Grieco Liver Transplant Medicine Gastroenterological Area Gastroenterological and Endocrino Metabolical Sciences Department Fondazione Policlinico Universitario Gemelli Universita’ Cattolica del Sacro Cuore

Hepatocellular carcinoma is becoming an increasing indication for liver transplantation, but selection and allocation of patients are challenging because of organ shortages. Conventional Milan criteria are the reference for the selection of patients worldwide, but many expanded criteria, like University of California San Francisco criteria and up-to-7 criteria, have demonstrated that survival and recurrence results are lower than those for restricted indications. Correct staging is crucial and should include surrogate markers of biological aggressiveness(α-fetoprotein, response to loco-regional treatments). Successful down-staging can select between patients with tumor burden initially beyond transplantation criteria those with a more favorable biology, provided a 3-mo stability in meeting the transplantation criteria. Allocation rules are constantly adjusted to minimize the imbalance between the priorities of candidates with and without hepatocellular carcinoma, and take into account local donor rate and waitlist dynamics. Recently, Mazzaferro et al proposed a benefit-oriented "adaptive approach", in which the selection and allocation of patients are based on their response to non-transplantation treatments: low priority for transplantation in case of complete response, high priority in case of partial response or recurrence, and no listing in case of progression beyond transplantation criteria.

关键词： Milan criteria α-fetoprotein Down-staging Allocation Adaptive approach

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Archean-Ediacaran evolution of the Campos Gerais Domain-A reworked margin of the São Francisco paleocontinent(SE Brazil):Constraints from metamafic-ultramafic rocks

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Geoscience Frontiers 2022年第5期13卷 286-308页

作者： marco Aurélio Piacentini Pinheiro George L.Guice Joana reis Magalhães Geological Survey of Brazil–CPRM Av Brazil 1731Belo Horizonte 30140-002Brazil Department of Mineral Sciences National Museum of Natural HistorySmithsonian Institution10th Street and Constitution Avenue NWWashington D.C.20560USA

The Campos Gerais Domain(CGD)in southeastern Brazil is an approximately 180 km×35 km area of Archean–Proterozoic rocks located southwest of the São Francisco Craton(SFC).The Archean–Paleopro terozoic evolution of the CGD—alongside its potential correlation with the SFC or other cratonic blocks in the region-is currently *** present the results of systematic petrography,bulkrock geochemistry,mineral chemistry and geochronology for a suite of scarcely studied mafic–ultramafic rocks from the *** also provide a compilation of previously reported bulk-rock geochemical and spinel group mineral chemical data for mafic–ultramafic rocks throughout the CGD,and geochronological information for various lithotypes in the *** CGD records a protracted Mesoarchean to Statherian(3.1–1.7 Ga)crustal evolution,which we interpret to share a common history with the southern SFC and their related reworked segments,suggesting that it is a westward extension of this cratonic *** metavolcano-sedimentary rocks of the Fortaleza de Minas and Alpinópolis segments represent a Mesoarchean greenstone belt that is stratigraphically and chemically comparable to Archean greenstone belts worldwide,and that is broadly coeval with a local suite of tonalite-trondhjemite-grano diorite(TTG)gneisses and migmatites.U-Pb SHRIMP zircon data from a subalkaline metagabbro yielded a concordia age of ca.2.96 Ga,revealing a previously unrecognized phase of Archean magmatism in the CGD that can be chrono-correlated with metakomatiite and TTG generation elsewhere in the São Francisco *** data contradict a hypothesis whereby the metavolcano-sedimentary rocks of the Jacuí-Bom Jesus da Penha and Petúnia segments represent an ophiolite,as previously suggested,instead presenting features that point to formation in association with a continental *** with a U-Pb(SHRIMP)crystallization age of ca.2.13 Ga recorded by zircon grains from a metaultramafic rock,these data h

关键词： Komatiites São Francisco Craton Southern Brasília Orogen Archean geodynamics Rhyacian orogeny

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