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Use of a combination strategy to improve neuroprotection and neuroregeneration in a rat model of acute spinal cord injury

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Neural Regeneration Research 2019年第6期14卷 1060-1068页

作者： Elisa García Roxana Rodríguez-Barrera Vinnitsa Buzoianu-Anguiano Adrian Flores-Romero Emanuel Malagón-Axotla marco guerrero-godinez Estefanía De la Cruz-Castillo Laura Castillo-Carvajal Monserrat Rivas-Gonzalez Paola Santiago-Tovar Ivis Morales Cesar Borlongan Antonio Ibarra Centro de Investigación en Ciencias de la Salud (CICSA) Facultad de Ciencias de la SaludUniversidad Anáhuac México Campus Norte Centro de Investigación del Proyecto CAMINA A.C. Unidad de Investigación Médica en Enfermedades Neurologicas Hospital Especialidades CMN Siglo XXI Unidad de Rehabilitación Osteoarticular.Instituto Nacional de Rehabilitación. Luis Guillermo Ibarra Ibarra Center of Excellence for Aging and Brain Repair Department of Neurosurgery and Brain RepairUniversity of South Florida Morsani College of Medicine

Spinal cord injury is a very common pathological event that has devastating functional consequences in patients. In recent years, several research groups are trying to find an effective therapy that could be applied in clinical practice. In this study, we analyzed the combination of different strategies as a potential therapy for spinal cord injury. Immunization with neural derived peptides(INDP), inhibition of glial scar formation(dipyridyl: DPY), as well as the use of biocompatible matrix(fibrin glue: FG) impregnated with bone marrow mesenchymal stem cells(MSCs) were combined and then its beneficial effects were evaluated in the induction of neuroprotection and neuroregeneration after acute SCI. Sprague-Dawley female rats were subjected to a moderate spinal cord injury and then randomly allocated into five groups: 1) phosphate buffered saline; 2) DPY; 3) INDP + DPY; 4) DPY+ FG; 5) INDP + DPY + FG + MSCs. In all rats, intervention was performed 72 hours after spinal cord injury. Locomotor and sensibility recovery was assessed in all rats. At 60 days after treatment, histological examinations of the spinal cord(hematoxylin-eosin and Bielschowsky staining) were performed. Our results showed that the combination therapy(DPY+ INDP + FG+ MSCs) was the best strategy to promote motor and sensibility recovery. In addition, significant increases in tissue preservation and axonal density were observed in the combination therapy group. Findings from this study suggest that the combination theapy(DPY+ INDP + FG + MSCs) exhibits potential effects on the protection and regeneration of neural tissue after acute spinal cord injury. All procedures were approved by the Animal Bioethics and Welfare Committee(approval No. 178544; CSNBTBIBAJ 090812960)on August 15, 2016.

关键词： fibrin glue mesenchymal stem cells glial scar protective autoimmunity neural derived peptides neural regeneration

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Role of copper chelating agents: between old applications and new perspectives in neuroscience

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Neural Regeneration Research 2025年第3期20卷 751-762页

作者： Rosalba Leuci Leonardo Brunetti Vincenzo Tufarelli marco Cerini marco Paparella Nikola Puvača Luca Piemontese Department of Pharmacy-Pharmaceutical Science University of Bari Aldo MoroBariItaly Department of Precision and Regenerative Medicine and Jonian Area(DiMePRe-J) Section of Veterinary Science and Animal ProductionUniversity of Bari Aldo MoroBariItaly Department of Engineering Management in Biotechnology Faculty of Economics and Engineering Management in Novi SadUniversity Business Academy in Novi SadNovi SadSerbia

The role of copper element has been an increasingly relevant topic in recent years in the fields of human and animal health, for both the study of new drugs and innovative food and feed supplements. This metal plays an important role in the central nervous system, where it is associated with glutamatergic signaling, and it is widely involved in inflammatory processes. Thus, diseases involving copper(Ⅱ) dyshomeostasis often have neurological symptoms, as exemplified by Alzheimer's and other diseases(such as Parkinson's and Wilson's diseases). Moreover, imbalanced copper ion concentrations have also been associated with diabetes and certain types of cancer, including glioma. In this paper, we propose a comprehensive overview of recent results that show the importance of these metal ions in several pathologies, mainly Alzheimer's disease, through the lens of the development and use of copper chelators as research compounds and potential therapeutics if included in multi-target hybrid drugs. Seeing how copper homeostasis is important for the well-being of animals as well as humans, we shortly describe the state of the art regarding the effects of copper and its chelators in agriculture, livestock rearing, and aquaculture, as ingredients for the formulation of feed supplements as well as to prevent the effects of pollution on animal productions.

关键词： agriculture Alzheimer's disease chelators copper feed supplements multi-target

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From mice to humans:a need for comparable results in mammalian neuroplasticity

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Neural Regeneration Research 2025年第2期20卷 464-466页

作者： marco Ghibaudi Enrica Boda Luca Bonfanti Neuroscience Institute Cavalieri Ottolenghi OrbassanoItaly Department of Veterinary Sciences University of TurinTurinItaly Department of Neuroscience Rita Levi-Montalcini University of TurinTurinItaly

Brain plasticity-A universal tool with many variations:The study of brain plasticity has been gaining interest since almost a century and has now reached a huge amount of information(>80,000 results in PubMed).Overall,different types of plasticity,including stem cell-driven genesis of new neurons(adult neurogenesis),cells in arrested maturation(dormant neurons),neuro-glial and synaptic plasticity,can coexist and contribute to grant plastic changes in the brain,from a cellular to system level(Benedetti and Couillard-Despres,2022;Bonfanti et al.,2023).

关键词： plasticity al. arrest

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Novel Methodologies for Preventing Crack Propagation in Steel Gas Pipelines Considering the Temperature Effect

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Structural Durability & Health Monitoring 2025年第1期19卷 1-23页

作者： Nurlan Zhangabay Ulzhan Ibraimova marco Bonopera Ulanbator Suleimenov Konstantin Avramov Maryna Chernobryvko Aigerim Yessengali Department of Architecture and Urban Planning Mukhtar Auezov South Kazakhstan UniversityShymkent160012Kazakhstan Department of Industrial Civil and Road Construction Mukhtar Auezov South Kazakhstan UniversityShymkent160012Kazakhstan Mechanics Sound&Vibration LaboratoryDepartment of Civil EngineeringCollege of EngineeringNational Taiwan UniversityTaipei10617Taiwan Department of Reability&Dynamic Strength A.Pidhornyi Institute of Mechanical Engineering Problems of National Academy of Sciences of UkraineKharkiv61046Ukraine

Using the software ANSYS-19.2/Explicit Dynamics,this study performedﬁnite-element modeling of the large-diameter steel pipeline cross-section for the Beineu-Bozoy-Shymkent gas pipeline with a non-through straight crack,strengthened by steel wire *** effects of the thread tensile force of the steel winding in the form of single rings at the crack edges and the wires with different winding diameters and pitches were also *** results showed that the strengthening was preferably executed at a minimum value of the thread tensile force,which was 6.4%more effective than that at its maximum *** analysis of the inﬂuence of the winding dia-meters showed that the equivalent stresses increased by 32%from the beginning of the crack growth until the wire *** increment in winding diameter decelerated the disclosure of the edge crack and reduced its length by 8.2%.The analysis of the inﬂuence of the winding pitch showed that decreasing the distance between the winding turns also led to a 33.6%reduction in the length of the straight crack and a 7.9%reduction in the maximum stres-ses on the strengthened pipeline *** analysis of the temperature effect on the pipeline material,within a range from-40℃ to+50℃,resulted in a crack length change of up to 5.8%.As the temperature dropped,the crack length *** such a temperature range,the maximum stresses were observed along the cen-tral area of the crack,which were equal to 413 MPa at+50℃ and 440 MPa at-40℃.The results also showed that the presence of the steel winding in the pipeline signiﬁcantly reduced the length of crack propagation up to 8.4 times,depending on the temperature effect and design parameters of *** work integrated the existing methods for crack localization along steel gas pipelines.

关键词： Crack propagation ﬁnite-element internal pressure prestressing steel gas pipeline temperature effect

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Contingency Reserve Evaluation for Fast Frequency Response of Multiple Battery Energy Storage Systems in a Large-scale Power Grid

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CSEE Journal of Power and Energy Systems 2023年第3期9卷 873-883页

作者： Indira Alcaide-godinez Feifei Bai Tapan Kumar Saha Rizah Memisevic School of Information Technology and Electrical Engineering the University of QueenslandBrisbaneQLD 4072Australia School of Information Technology and Electrical Engineering the University of Queensland(UQ)BrisbaneQLD 4072 School of Engineering and Built Environment Griffith UniversityGold CoastQLD 4222Australia EPEC Group BrisbaneQLD 4014Australia

Recently,the fast frequency response(FFR)service by large-scale battery energy storage systems(BESSs)has been successfully proved to arrest the frequency excursion during an unexpected power ***,adequate frequency response relies on proper evaluation of the contingency reserve of *** BESS FFR reserve is commonly managed under fixed contracts,ignoring various response characteristics of different BESSs and their coexisting *** paper proposes a new methodology based on dynamic grid response and various BESS response characteristics to optimise the FFR reserves and prevent the frequency from breaching the under-frequency load shedding(UFLS)*** superiority of the proposed method is demonstrated to manage three large-scale BESSs operating simultaneously in an Australian power grid under high renewable penetration ***,the proposed method can identify remaining battery power and energy reserve to be safely utilised for other grid services(e.g.,energy arbitrage).The results can provide valuable insights for integrating FFR into conventional ancillary services and techno-effective management of multiple BESSs.

关键词： Fast frequency response(FFR) fast frequency contingency reserve multiple large-scale battery energy storage system(BESS) synthetic inertia requirement under-frequency load shedding(UFLS)

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Effect of Cambering on the Aerodynamic Performance of Heaving Airfoils

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Journal of Bionic Engineering 2009年第4期6卷 398-404,406-407页

作者： Joel E.guerrero Postdoctoral Research Fellow Department of CivilEnvironmental and Architectural EngineeringUniversity of GenoaVia Montallegro 1Genoa16145Italy

In the present work,a parametric numerical study is conducted in order to assess the effect of airfoil cambering on the aerodynamic performance of rigid heaving *** incompressible Navier-Stokes equations are solved in their velocity-pressure formulation using a second-order accurate in space and time finite-difference *** tackle the problem of moving boundaries,the governing equations are solved on overlapping structured *** numerical simulations are performed at a Reynolds number of Re=1100 and at different values of Strouhal number and reduced *** results obtained show that the airfoil cambering geometric parameter has a strong influence on the average lift coefficient,while it has a smaller impact on the average thrust coefficient and propulsive efficiency of heaving airfoils.

关键词： heaving airfoils structured overlapping grids incompressible Navier-Stokes equations airfoil cambering

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Bed-roughness investigation for a 2-D model calibration:the San Martin case study at Lower Parana

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International Journal of Sediment Research 2013年第4期28卷 458-469页

作者： Massimo guerrero Alberto LAMBERTI Laboratory of Hydraulic Engineering University of Bologna Environmental and Materials Engineering Department University of Bologna

This paper illustrates how the acoustic Doppler current profiler(ADCP) and single-beam echo-sounder(SBI:S)recordings can be used for the calibration of existing software to assist in generalizing the morphodynamie processes in large rivers at key sites such as bifurcations and *** of the MIKH21C numerical model by the Danish Hydraulic Institute at the 25-km-long reach of Lower Parana near Rosario(Argentina) is *** reach includes two downstream confluences and two *** model simulates a 2-1) depth-averaged How velocity and the related sediment fluxes to predict the bifurcation morphodynamics that affects the Parana *** investigate the river channel bathymetry,roughness,flow discharge allocation at bifurcations,suspended sediment concentration and grain size distributions,several instruments were *** instruments included two ADCPs by Teledyne RDI working at frequencies of 600 and 1,200 kHz,a Sontek ADCP working at a frequency of 1,000 kHz and a *** method to assess suspended sediment concentration and grain size distributions has been previously *** paper focuses primarily on investigating dune morphology(by means of SBES depth measurements) and friction velocity(by means of ADCP profiling) to determine the river channel ***2-D model results agree with observed values of bed-roughness,flow velocity and suspended sediment concentration distributions at the investigated sections,known data of water slope and total load of bed sediment are in good agreement with model results.

关键词： 2-D model calibration ADCP Bed-roughness Parana River

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Recent Advances to Understand Morphology Stability of Organic Photovoltaics

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Nano-Micro Letters 2017年第1期9卷 39-54页

作者： Antonio guerrero Germà Garcia-Belmonte Institute of Advanced Materials(INAM) Universitat Jaume I12006 Castello´Spain

Organic photovoltaic devices are on the verge of commercialization with power conversion efficiencies exceeding 10 % in laboratory cells and above 8.5 % in modules. However, one of the main limitations hindering their mass scale production is the debatable inferior stability of organic photovoltaic devices in comparison to other *** donor/acceptor morphology of the active layer is required to provide carrier separation and transport to the electrodes. Unfortunately, the beneficial morphology for device performance is usually a kinetically frozen state which has not reached thermodynamic equilibrium. During the last 5 years, special efforts have been dedicated to isolate the effects related to morphology changes taking place within the active layer and compare to those affecting the interfaces with the external electrodes. The current review discusses some of the factors affecting the donor/acceptor morphology evolution as one of the major intrinsic degradation pathways. Special attention is paid to factors in the nano- and microscale *** example, phase segregation of the polymer and fullerene domains due to Ostwald ripening is a major factor in the microscale domain and is affected by the presence of additives, glass transition temperature of the polymers or use of crosslinkers in the active layer. Alternatively, the role of vertical segregation profile toward the external electrodes is key for device operation, being a clear case of nanoscale morphology evolution. For example, donor and acceptor molecules actually present at the external interfaces will determine the leakage current of the device, energy-level alignment, and interfacial recombination processes. Different techniques have been developed over the last few years to understand its relationship with the device efficiency. Of special interest are those techniques which enable in situ analysis being nondestructive as they can be used to study accelerated degradation experiments and

关键词： Organic photovoltaics Intrinsic degradation Morphology Thermal degradation Interface

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Measurement of vibration frequencies of ties in masonry arches by means of a robotic total station

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Earthquake Engineering and Engineering Vibration 2022年第2期21卷 489-500页

作者： marco Gatti Dipartimento di Ingegneria University of Ferraravia Saragat 144123 FerraraItaly

Measurement of the vibration frequencies of eight ties set in masonry arches of a church by means of a robotic total station is *** instrument made continuous recordings(up to ten per second)of the three-dimensional positions of a reflector situated at 1/2 or 1/4 of the length of the tie during vertical oscillation induced by an impulsive *** recording slips,vibration amplitudes(and their accuracy),hourly diagram and experimental spectra of vibrations,and the corresponding frequencies were *** results were verified by comparing them with the vibration frequencies and indirectly the tension and fixed support constraint calculated from accelerometric *** study provides interesting information on the accuracies of the reflector′s three-dimensional coordinates,but highlighted certain limits in the application of robotized total stations for measuring vibration frequencies of ties in masonry arches.

关键词： RTS frequency vibrations ties arches

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Abc-frame complex-coefficient filter and controller based current harmonic elimination strategy for three-phase grid connected inverter

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Journal of Modern Power Systems and Clean Energy 2016年第1期4卷 87-93页

作者： Xiaoqiang GUO Josep M.guerrero Department of Electrical Engineering Yanshan UniversityQinhuangdao 066004China Department of Energy Technology Aalborg University9220 AalborgDenmark

Current quality is one of the most important issues for operating three-phase grid-connected inverter in distributed generation systems. In practice, the grid current quality is degraded in case of non-ideal utility voltage. A new control strategy is proposed for the three-phase gridconnected inverter. Different from the traditional method,our proposal utilizes the unique abc-frame complex-coefficient filter and controller to achieve the balanced, sinusoidal grid current. The main feature of the proposed method is simple and easy to implement without any frame transformation. The theoretical analysis and experimental test are presented. The experimental results verify the effectiveness of the proposed control strategy.

关键词： Grid-connected inverter Current control Complex-coefficient filter Complex-coefficient controller

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