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World Journal of Gastroenterology 2015年第5期21卷 1614-1620页

作者： Márcia Soares-Mota Tianny A Silva Luanda M Gomes marco as pinto Laura MC Mendon?a Maria Lúcia F Farias Tiago Nunes Andrea Ramalho Cyrla Zaltman Instituto de Nutricao Josué de Castro Federal University of Rio de JaneiroRio de Janeiro 21941-913Brazil Departamento de Clínica Médica Hospital Universitário Clementino Fraga FilhoFederal University of Rio de JaneiroRio de Janeiro 21941-901Brazil Nutrition and Immunology Chair ZIEL Research Center for Nutrition and Food SciencesTechnical University of MünchenFreising-Weihenstephan80333 MünchenGermany

AIM:To assess the vitamin A status of patients with Crohn's disease(CD) by evaluating serum retinol levels and the relative dose response(RDR) test(liver retinol stores).METHODS:Vitamin A nutritional status was measured by serum retinol obtained by high performance liquid chromatography and the RDR test for evaluation of the hepatic *** composition was performed by densitometry by dual-energy X-ray *** A dietary intake was assessed from a semiquantitative food frequency ***:This study included 38 CD patients and 33 *** serum retinol concentrations were detected in 29% of CD patients vs 15% in controls(P < 0.005).The RDR test was positive in 37% of CD patients vs 12% in controls,which indicated inadequate hepatic vitamin A stores(P < 0.005).Individuals with hypovitaminosis A had lower BMI and body fat compared with those without this *** was no association between vitamin A deficiency and its dietary intake,ileal location,presence of disease activity and prior bowel ***:Patients with CD have higher prevalence of vitamin A deficiency,as assessed by two independent methods.

关键词： Crohn's disease Vitamin A Serum retinol Relative dose response test Body composition

Non-coding RNAs and other determinants of neuroinflammation and endothelial dysfunction:regulation of gene expression in the acute phase of ischemic stroke and possible therapeutic applications

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Neural Regeneration Research 2021年第11期16卷 2154-2158页

作者： Mario Daidone marco Cataldi Antonio pinto Antonino Tuttolomondo Department of Health Promotion Maternal and Infant CareInternal Medicine and Medical Specialties“G.D’Alessandro”University of PalermoPiazza delle Cliniche n.2PalermoItaly

Ischemic stroke occurs under a variety of clinical conditions and has different pathogeneses,resulting in necrosis of brain *** pathogenesis is characterized by neuroinflammation and endothelial *** of the main processes triggered in the early stages of ischemic damage are the rapid activation of resident inflammatory cells(microglia,astrocytes and endothelial cells),inflammatory cytokines,and translocation of intercellular nuclear *** in stroke includes all the processes mentioned above,and it consists of either protective or detrimental effects concerning the“polarization”of these *** polarization comes out from the interaction of all the molecular pathways that regulate genome expression:the epigenetic *** recent years,new regulation mechanisms have been cleared,and these include non-coding RNAs,adenosine receptors,and the activity of mesenchymal stem/stromal cells and *** reviewed how long non-coding RNA and microRNA have emerged as an essential mediator of some neurological *** also clarified that their roles in cerebral ischemic injury may provide novel targets for the treatment of ischemic *** date,we do not have adequate tools to control pathophysiological processes associated with *** goal is to review the role of non-coding RNAs and innate immune cells(such as microglia and mesenchymal stem/stromal cells)and the possible therapeutic effects of their modulation in patients with acute ischemic stroke.A better understanding of the mechanisms that influence the“polarization”of the inflammatory response after the acute event seems to be the way to change the natural history of the disease.

关键词： acute phase cerebrovascular disease endothelial dysfunction epigenetics genetics neuroiflammation non-coding RNAs stroke

Role of autophagy in cholangiocarcinoma:Pathophysiology and implications for therapy

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World Journal of Clinical Cases 2021年第22期9卷 6234-6243页

作者： Elisabetta Ninfole Claudio pinto Antonio Benedetti marco Marzioni Luca Maroni Department of Gastroenterology and Hepatology UniversitàPolitecnica delle MarcheAncona 60126Italy Department of Gastroenterology UniversitàPolitecnica delle MarcheAncona 60126Italy

Cholangiocarcinoma(CCA)is a malignant tumour of the biliary system that originates from the neoplastic transformation of *** is characterized by late diagnosis and poor outcome,with surgery considered as the last option for *** is a physiological lysosomal degradation process,essential for cellular homeostasis and ubiquitous in all eukaryotic *** studies have reported a potential involvement of autophagy in cancer,but it remains unclear whether activation of this process represents a survival mechanism of cancer *** the present review,we examine the autophagic process and summarize the current knowledge about the involvement of autophagy in the progression of *** link between autophagy and chemoresistance and the use of autophagic markers in diagnosis are also considered in *** evidence shows that the combination of autophagy modulators(activators or inhibitors)with conventional chemotherapeutic agents offers a possible treatment option against signalling pathways that are hyperactivated or altered in *** vitro evidence suggests that combination of chemotherapy agents,such as cisplatin,under activation or inhibition of autophagic processes,in two different CCA cell lines,may improve chemosensitivity and reduce cell survival,respectively.A deeper understanding of these pathways,in both cancer and non-cancer cells,could unveil possible therapeutic targets to treat CCA patients.

关键词： Cholangiocarcinoma Cholangiocytes Autophagy Apoptosis Chemoresistance Autophagolysosome

Impact of jejunostomy during esophagectomy for cancer on health related quality of life

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Chinese Journal of Cancer Research 2014年第6期26卷 678-684页

作者： marco Scarpa Francesco Cavallin Giulia Noaro Eleonora pinto Rita Alfieri Matteo Cagol Carlo Castoro Surgical Oncology Unit Veneto Institute of Oncology (IOV-IRCCS) Padua 35128 Italy

Background： The aim of this study was to evaluate the impact of jejunostomy during esophagectomy for cancer on postoperative health-related quality of life（HRQL）.Methods： We evaluate all consecutive patients who underwent esophagectomy for cancer at the surgical oncology unit of the Veneto Institute of Oncology（IOV-IRCCS） between January 2008 and March 2014. The primary outcome was HRQL, which was assessed using nine scales of EORTC C30 and OES18 questionnaires. General linear models were estimated to evaluate mean score difference（MD） of each selected scale in patients with and without jejunostomy, adjusting for clinically relevant confounders. The secondary outcomes were morbidity, hospital stay, postoperative weight loss and postoperative albumin impairment. Results： Jejunostomy was performed in 40 on 109 patients（41.3%） who participated in quality of life investigation. A clinically and statistically significantly worse eating at admission（P=0.009） became not clinically significant at 3 months after surgery（MD =9.1）. Jejunostomy was associated to clinically and statistically significantly poorer emotional function（EF） at 3 months after surgery（MD =-15.6; P=0.04）. Hospital stay was longer in jejunostomy group（median, 20 vs. 17 days, P=0.02）.Conclusions： In our series patients who had a jejunostomy during esophagectomy had been selected for their risk for postoperative complication. However, their postoperative outcome was actually similar compared to those without jejunostomy. Nevertheless, jejunostomy was associated to clinically and statistically significantly poorer EF at 3 months after surgery. Therefore, patient candidate to esophagectomy and feeding jejunostomy should receive additional psychological support.

关键词： Health-related quality of life(HRQL) jejunostomy esophagectomy esophageal cancer

Impact of age-related comorbidity on results of colorectal cancer surgery

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World Journal of Gastroenterology 2009年第45期15卷 5706-5711页

作者： Corrado Pedrazzani Guido Cerullo Giovanni De marco Daniele Marrelli Alessandro Neri Alfonso De Stefano Enrico pinto Franco Roviello Department of Human Pathology and Oncology Unit of Surgical OncologyUniversity of Siena 53100 SienaItaly

AIM: To analyze the correlation between preexisting comorbidity and other clinicopathological features, short-term surgical outcome and long-term survival in elderly patients with colorectal cancer (CRC). METHODS: According to age, 403 patients operated on for CRC in our department were divided into group A (< 70 years old) and group B (≥ 70 years old) and analyzed statistically. RESULTS: Rectal localization prevailed in group A (31.6% vs 19.7%, P = 0.027), whereas the percentage of R0 resections was 77% in the two groups. Comorbidity rate was 46.2% and 69.1% for group A and B, respectively (P < 0.001), with a huge difference as regards cardiovascular diseases. Overall, postoperative morbidity was 16.9% and 20.8% in group A and B, respectively (P = 0.367), whereas mortality was limited to group B (4.5%, P = 0.001). In both groups, patients who suffered from postoperative complications had a higher overall comorbidity rate, with preexisting cardiovascular diseases prevailing in group B (P = 0.003). Overall 5-year survival rate was significantly betterfor group A (75.2% vs 55%, P = 0.006), whereas no signif icant difference was observed considering disease-specif ic survival (76.3% vs 76.9%, P = 0.674). CONCLUSION: In spite of an increase in postoperative mortality and a lower overall long-term survival for patients aged ≥ 70 years old, it should be considered that, even in the elderly group, a signif icant number of patients is alive 5 years after CRC resection.

关键词： Colorectal cancer Elderly Post-operative complications Co-morbidity Aged

Puff Models for Simulation of Fugitive Hazardous Emissions in Atmosphere

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Journal of Environmental Protection 2011年第2期2卷 154-161页

作者： Ledina Lentz Pereira Camila pinto da Costa marco Tullio Vilhena Tiziano Tirabassi University of the South End of Santa Catarina (UNESC) Federal University of Pelotas (UFPel) Federal University of Rio Grande do Sul (UFRGS)

A puff model for the dispersion of material from fugitive hazardous emissions is presented. For vertical diffusion the model is based on general techniques for solving time dependent advection-diffusion equation: the ADMM (Advection Diffusion Multilayer Method) and GILTT (Generalized Integral Laplace Transform Technique) techniques. Both approaches accept wind and eddy diffusion coefficients with any restriction in their height functions. Comparisons between values predicted by the models against experimental ground-level concentrations (from Copenhagen data set) are shown. The preliminary results confirm the applicability of the approaches proposed and are promising for future work.

关键词： Hazardous Emissions Advection-Diffusion Equation Analytical Solutions Air Pollution Modeling Puff Models

Comparison between Non-Gaussian Puff Model and a Model Based on a Time-Dependent Solution of Advection-Diffusion Equation

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Journal of Environmental Protection 2010年第2期1卷 172-178页

作者： Tiziano Tirabassi Davidson M. Moreira marco Tullio Vilhena Camila pinto da Costa 不详

A comparison between a non-Gaussian puff model and an advanced time-dependent model to simulate the pollutant dispersion in the Planetary Boundary Layer is presented. The puff model is based on a general technique for solving the K-equation, using the truncated Gram-Charlier expansion (type A) of the concentration field and finite set equations for the corresponding moments. The other model (named ADMM: Analytical Dispersion Multilayers Model) is an semi- analytical solution to the time-dependent two-dimensional advection-diffusion equation based on a discretization of the PBL in N sub-layers;in each sub-layers the advection-diffusion equation is solved by the Laplace transform technique, considering an average value for eddy diffusivity and the wind speed. A preliminary performance evaluation is shown in the case of continuous emission from an elevated source in a variable boundary layer. Both models were able to correctly reproduce the concentration field measured and so to be used as operative air pollution models.

关键词： Advection-Diffusion Equation Air Pollution Modeling Analytical Solution Puff Models

Simultaneous Measurements of Rainfall Intensity, Low Energy Neutrons and Gamma Radiation in Sao Jose Dos Campos, SP, Brazil

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Journal of Environmental Science and Engineering(B) 2013年第11期2卷 643-647页

作者： Marcelo Pego Gomes Inacio Malmonge Martin Mauro Angelo Alves Bogos Nubar Sismanoglu marco Antonio S. Ferro marcos pinto Flavio Antonio IAE (Institute of Aeronautics and Space) Sao Josedos Campos 1222 6900 Brazil Physics Department ITA (the Technological Institute of Aeronautics) Sao Jose dos Campos 1222 8900 Brazil

The article aims to study the possible correlation between the presence and intensity of rainfall X- and T-radiation and low energy neutrons at one specific location in S[io Jos6 dos Campos, SP, Brazil. Monitoring of these parameters was carried out from end February to half of June 2013 just in Physics Department of ITA （Technological Institute of Aeronautics）. By correlating the data of measurements of intensity of X and ）,-radiations with the rainfall it has been found that this meteorological parameter had a significant influence on the background of these radiation profile. A possible reason for this fact is associated with the presence of radon gas in the environment that is dragged to the surface during the occurrences of local rainfall. In relation neutrons, it was possible to note that the rainfall has small influence on this parameter measures.

关键词： X- and y-radiation low energy neutron rainfalls experimental measurements.

Acute appendicitis: What is the gold standard of treatment?

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World Journal of Gastroenterology 2013年第47期19卷 8799-8807页

作者： Cesare Ruffolo Alain Fiorot Giulia Pagura Michele Antoniutti marco Massani Ezio Caratozzolo Luca Bonariol Francesco Calia di pinto Nicolò Bassi Ⅱ Deparment of Surgery (Ⅳ Unit) Regional Hospital "Ca’ Foncello"31100 TrevisoItaly

McBurney’s procedure represented the gold-standard for acute appendicitis until 1981,but nowadays the number of laparoscopic appendectomies has progressively increased since it has been demonstrated to be a safe procedure,with excellent cosmetic results and it also allows a shorter hospitalization,a quicker and less painful postoperative *** aim of this editorial was to perform a review of the literature in order to address controversial issues in the treatment of acute appendicitis.

关键词： Acute appendicitis Surgery Laparoscopy

Use of Extra-Narrow-Diameter Implants in Reduced Alveolar Ridge:A Case Report

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Journal of Biomaterials and Nanobiotechnology 2020年第2期11卷 101-109页

作者： Camila Ferreira Mattos marco Antonio Alencar De Carvalho Jorge Jose De Carvalho Paulo Goncalo pinto Dos Santos Jorge Luis Da Silva Pires Igor Da Silva Brum Department of Implantology Faculty of DentistryState University of Rio de JaneiroRio de JaneiroBrazil Department of Biology Faculty of DentistryState University of Rio de JaneiroRio de JaneiroBrazil

Background: Narrow-diameter implants (3.0 - 3.5 mm range) have been introduced for the replacement of teeth with insufficient bone structure and/or limited mesiodistal or interimplant spaces, and appear to offer clinical results similar to those obtained with implants of greater diameter. Studies using extra-narrow-diameter implants (2.8 mm) are scarce. Case Presentation: A 59-year-old male patient received two extra-narrow-diameter implants, 2.8 × 11 mm in the region between elements 11 and 14. Together, two 3.5 × 8.5 mm SYSTHEX®platform 4.1 implants were installed in the region of elements 15 and 16 to provide greater stability in the occlusion. Of four previous implants on the maxillary left side, one in the region between the elements 23 and 24 that was located in a very apical position and vestibularized was removed. The provisional was already installed on the elements 11, 21, and 22 with the metal cores already prepared and with the Globteck®implants in the region of the elements 23, 24, and 27. The functional and esthetic results were satisfactory. Conclusions: Insertion of extra-narrow-diameter implants of 2.8 mm in the maxillary anterior region is a reliable option in a patient with absence of elements 12 and 13, restoring masticatory function and aesthetics in the upper arch.

关键词： Dental Implants Narrow-Diameter Maxilla Bone Density