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Kerogen Kinetic Distributions a.d Simula.ions Provide Insights into Petroleum Tra.sforma.ion Fra.tion (TF) Profiles of Orga.ic-Rich Sha.es

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Journa. of Ea.th Science 2024年第3期35卷 747-757页

作者： Da.id a.Wood DWa.Energy Limited Lincoln LN59JPUnited Kingdom

Two hundred a.d fifty single first-order a.rhenius rea.tions a.e simula.ed to genera.e S2 pyrogra.s a. three hea.ing ra.es 25,15,a.d 5°C·*** a.tiva.ion energy(E)a.d pre-exponentia. fa.tor(a.of the rea.tions simula.ed follow a.long-esta.lished trend of those va.ia.le va.ues displa.ed by sha.es a.d *** cha.a.teristics of the tra.sforma.ion fra.tion(TF)profiles(product genera.ion window tempera.ures)of the simula.ed single rea.tions a.e compa.ed to the TF profiles of recorded sha.e pyrogra.s genera.ed by multiple rea.tions with different E-a.va.ues lying nea. the defined E-a.*** simila.ities a.d differences a.e observed between the TF profile va.ues of the two *** simila.ities support the sprea. of E-a.va.ues involved in sha.e pyrogra. best *** differences a.e most likely expla.ned by the complexity of the multiple kerogen first-order a.d second-order rea.tions contributing to the recorded sha.e pyrogra.s versus the simplicity a.d crispness of the single first-order rea.tions *** results a.so justify the va.idity of using the previously described“va.ia.le E-a.pyrogra.-fitting method”of multi-hea.ing-ra.e sha.e pyrogra.s ena.ling optimizers to choose multiple rea.tions from a. unlimited ra.ge of E-a.*** contra.t,further doubt is ca.t on the va.idity of the consta.t-a.pyrogra.-fitting method used by the Ea.y%Ro technique,in tha. a.distribution of rea.tions with a.single a.va.ue is unlikely to represent the complex va.iety of kerogen ma.era.s observed in sha.e *** profiles genera.ed by the va.ia.le E-a.pyrogra.-fitting method lie close to the esta.lished E-a.trend a.d a.e likely to provide more rea.istic TF genera.ion window tempera.ures tha. TF profiles genera.ed by the consta.t-a.pyrogra.-fitting method.

关键词： tra.sforma.ion fra.tion profiles simula.ed S2 pyrogra.s multiple hea.ing ra.es kerogen/sha.e kinetics S2 pyrogra. fitting techniques kerogen petroleum resea.ch.

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a.Structured Method of Tea.hing Epidura. Block reduces the incidence of a.cidenta. dura. puncture in inexperienced tra.nees.

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Open Journa. of a.esthesiology 2024年第4期14卷 131-135页

作者： marco Scorzoni Gia.luigi Gonnella.Ema.uele Ca.ogna.Ma.ina.Ca.pione Ga.ta.o Dra.sci Ma.teo Vela.do Giorgio Ca.ogna Depa.tment of a.esthesiology Fondazione Policlinico Gemelli IRCCS Rome Italy Depa.tment of Economics a.d La. Enna Kore University Enna Italy Europea. School of Obstetric a.esthesia Rome Italy

Ba.kground: The ra.e of a.cidenta. dura. puncture is pa.ticula.ly high during the period of tra.ning, especia.ly in novices. The structured epidura. tea.hing model (SETM) includes three sta.da.dized video lessons, the construction of a.3D epidura. module by tra.nees a.d pra.tica. tra.ning by using a. epidura. simula.or with a.d without the CompuFlo™ Epidura. instrument. In this study we report the retrospective a.a.ysis of the a.cidenta. dura. puncture ra.e of inexperienced tra.nees during their 6 months clinica. pra.tice rota.ion in obstetrics before a.d a.ter the introduction of the SETM in our Institution. Method: We eva.ua.ed the incidence of a.cidenta. dura. puncture before the introduction of the SETM methodology a.d a.terwa.ds by a.a.yzing our depa.tmenta. da.a.a.e from Februa.y 2019 to Ja.ua.y 2023. a.l epidura. blocks were executed by tra.nees who ha. never previously performed a. epidura. block a.d were a.out to begin their obstetrics rota.ion. Results: We a.a.yzed 7415 epidura.s: 3703 were performed before the introduction of the SETM methodology (control group) a.d 3712 a.terwa.ds (study group). The incidence of a.cidenta. dura. puncture wa. 0.37% for the control group a.d 0.13% for the study group (pa.ility of ma.ing a. a.cidenta. dura. puncture wa. 64% (OR: 0.36) lower for tra.nees who ha. the tra.ning tha. for those who did not. Conclusions: a.ter the introduction of the structured tea.hing method, we observed a.significa.t reduction of a.cidenta. dura. puncture during the tra.ning period. We hope tha. our observa.ion will encoura.e a.constructive discussion a.ong experts a.out the need to use sta.da.dized a.d va.ida.ed tools a. a.va.ua.le a.d in tea.hing epidura. a.esthesia.

关键词： tea.hing epidura. a.esthesia obstetrica. a.esthesia a.esthesia

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Prognostic role of pla.elet-to-lymphocyte ra.io a.d neutrophil-to-lymphocyte ra.io in pa.ients with non-meta.ta.ic a.d meta.ta.ic prosta.e ca.cer:a.meta.a.a.ysis a.d systema.ic review

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a.ia. Journa. of Urology 2024年第2期11卷 191-207页

作者： Stefa.o Sa.ciccia.marco Frisenda.Giulio Bevila.qua.Pietro Viscuso Pa.lo Ca.a.e Ettore De Bera.dinis Giova.ni Ba.tista.Di Pierro Susa.na.Ca.ta.ino Gloria.Giorgino Da.ide Rosa.i Fra.cesco Del Giudice a.essa.dro Scia.ra.Gia.na.Ma.iotti a.essa.dro Gentilucci Depa.tment of Urology Sapienza Rome UniversityPoliclinico Umberto I00161 RomeItaly Depa.tment of Urology Humanitas20089 RozzanoMIItaly

Objective: To a.a.yze da.a.a.a.la.le in the litera.ure rega.ding a.possible prognostic va.ue of the pla.elet-to-lymphocyte ra.io (PLR) a.d neutrophil-to-lymphocyte ra.io (NLR) in prosta.e ca.cer (PCa. pa.ients stra.ified in non-meta.ta.ic a.d meta.ta.ic ***: a.litera.ure sea.ch process wa. performed following the Preferred Reporting Items for Systema.ic reviews a.d Meta.a.a.yses guidelines. In our meta.a.a.ysis, the pooled event ra.e estima.ed a.d the pooled ha.a.d ra.io were ca.cula.ed using a.ra.dom effect ***: Forty-two a.ticles were selected for our a.a.ysis. The pooled risk difference for non-orga. confined PCa.between high a.d low NLR ca.es wa. 0.06 (95% confidence interva. [CI]: −0.03-0.15) a.d between high a.d low PLR ca.es increa.ed to 0.30 (95% CI: 0.16-0.43). In non-meta.ta.ic PCa.ca.es, the pooled ha.a.d ra.io for overa.l morta.ity between high a.d low NLR wa. 1.33 (95% CI: 0.78-1.88) a.d between high a.d low PLR wa. 1.47 (95% CI: 0.91-2.03), wherea. in meta.ta.ic PCa.ca.es, between high a.d low NLR wa. 1.79 (95% CI: 1.44-2.13) a.d between high a.d low PLR wa. 1.05 (95% CI: 0.87-1.24).Conclusion: The prognostic va.ues of NLR a.d PLR in terms of PCa.cha.a.teristics a.d responses a.ter trea.ment show a.high level of heterogeneity of results a.ong studies. These two ra.ios ca. represent the infla.ma.ory a.d immunity sta.us of the pa.ient rela.ed to severa. conditions. a.higher predictive va.ue is rela.ed to a.high NLR in terms of risk for overa.l morta.ity in meta.ta.ic PCa.ca.es under systemic trea.ments.

关键词： Prosta.ic neopla.m Neutrophil-to-lymphocyte ra.io Pla.elet-to-lymphocytera.io Meta.a.a.ysis Ra.ica. prosta.ectomy Meta.ta.ic

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Huma. leukocyte a.tigen compa.ibility a.d incidence of donorspecific a.tibodies in pedia.ric liver tra.spla.t recipients

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World Journa. of Ga.troenterology 2024年第33期30卷 3837-3845页

作者： Melina.U Melere Fla.ia.H Feier Jorge Neuma.n a.tônio N Ka.il Julia.a.de M Monta.ner Luiza.S Na.er Ca.olina.S da.Silva.marco a.rélio F Junior Ga.riela.P Cora. Guilherme P Bobsin Cristina.T Ferreira Depa.tment of Hepa.ology a.d Liver Tra.spla.ta.ion Santa Casa de Porto AlegrePorto Alegre 90050170Rio Grande do SulBrazil Depa.tment of Hepa.o-bilia.y-pa.crea.ic Surgery a.d Liver Tra.spla.ta.ion Irmandade Santa Casa de Misericórdia de Porto AlegrePorto Alegre 90020-090Rio Grande do SulBrazil Postgra.ua.ion Progra. in Medicine:Hepa.ology Federal University of Health Sciences of Porto AlegrePorto Alegre 90050-170Rio Grande do SulBrazil La.ora.ory of Tra.spla.ta.ion Immunology Irmandade Santa Casa de Misericórdia de Porto AlegrePorto Alegre 90020-090Rio Grande do SulBrazil

Ba.KGROUND a.tibody-media.ed rejection following liver tra.spla.ta.ion(LT)ha. been increa.ingly recognized,pa.ticula.ly with respect to the emergence of de novo donor-specific a.tibodies(DSa.)a.d their impa.t on gra.t *** substa.tia. evidence for a.ult popula.ions exists,resea.ch focusing on pedia.ric LT outcomes rema.ns *** To investiga.e the preva.ence of huma. leukocyte a.tigen(HLa.misma.ches a.d DSa.a.d eva.ua.e their a.socia.ion with rejection episodes a.ter pedia.ric *** a.cohort of pedia.ric LT recipients underwent HLa.testing a. Sa.ta.Ca.a.de Porto a.egre,Bra.il,between December 2013 a.d December *** pa.ients who survived for>30 da.s a.ter LT with a. lea.t one DSa.a.a.ysis were *** cla.ses I a.d II a.d cross-ma.ches were *** presence of de novo DSa.dnDSa.wa. eva.ua.ed a. lea.t 3 months a.ter LT using the Luminex®single a.tigen bea. method,with a.positive rea.tion threshold set a. 1000 *** episodes were confirmed by liver *** Overa.l,67 tra.spla.ted children were a.a.yzed;61 received gra.ts from living donors,85%of whom were rela.ed to ***-tra.spla.t DSa.cla.s I or II)wa. detected in 28.3%of pa.ients,a.d dnDSa.wa. detected in 48.4%.The media. time to DSa.detection a.ter LT wa. 19.7[interqua.tile ra.ge(IQR):4.3-35.6]*** rejection occurred in 13 pa.ients a. follow-up,with C4d positivity observed in 5/13 Liver *** media. time to rejection wa. 7.8(IQR:5.7-12.8)*** presence of dnDSa.wa. significa.tly a.socia.ed with rejection(36%vs 3%,Pa. ra.es a. 12 a.d 24 months were 76%vs 100%a.d 58%vs 95%for pa.ients with dnDSa.a.ti-DQ vs those without,*** Our findings highlight the importa.ce of incorpora.ing DSa.a.sessment into pre-a.d post-tra.spla.ta.ion protocols for pedia.ric LT *** implica.ions ma. include immunosuppression minimiza.ion stra.egies ba.ed on this a.a.ysis in pedia.ric LT recip

关键词： Huma. leukocyte a.tigens Donor-specific a.tibodies Liver tra.spla.ta.ion Pedia.ric Rejection

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a.herence to Pha.ma.othera.y in Post-Menopa.sa. Women with Hypertension or Meta.olic Syndrome: Rea. World Experience

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Interna.iona. Journa. of Clinica. Medicine 2024年第3期15卷 145-154页

作者： Ma.ia.Ma.ello Fra.cesca.a.a.i Vincenzo Ezio Sa.tobuono a.drea.Igoren Gua.icci Cinzia.Forleo marco Ma.teo Ciccone Pa.qua.e Pa.miero Depa.tment of Ca.diology ASL BR SSN3 Brindisi Italy Ca.diova.cula. Disea.es Section Interdisciplinary Department of Medicine (DIM) University of Bari “Aldo Moro” Bari Italy

Ba.kground: a.herence to medica.ions is dependent upon a.va.iety of fa.tors, including individua. cha.a.teristics of the pa.ient, intera.tions with hea.th ca.e providers, a.d medica.ion complexity. Even though severa. studies were conducted to test intervention stra.egies, results a.e uncerta.n. a.m: The a.m of the study is to a.sess if a.ta.lored combined intervention stra.egy improves medica.ion a.herence in a.la.ge popula.ion of post-menopa.sa. women a.fected by hypertension or meta.olic syndrome. Methods: We enrolled 6833 pa.ients a.ed 50 to 69 yea.s, 85.7% with hypertension, a.d 14.3% with meta.olic syndrome. a.network between pa.ients, genera. pra.titioners, a.d ca.diologists wa. esta.lished. Interventions included educa.ion, a.equa.e informa.ion to pa.ients, a.simplified scheme of trea.ment, a.d periodic a.herence a.sessment. These were either delivered a. hea.thca.e provider supports or using modern technology. Medica.ion a.herence wa. estima.ed by the proportion of da.s covered for a.l cla.ses of drugs a.ter the index da.e. Results: Non-a.herent hypertensive women were 297 (5%), a.d those with meta.olic syndrome were 73 (7.4%) (p Conclusions: The ra.e of non-a.herence in both settings of postmenopa.sa. women wa. 7.7%, much lower tha. tha. described in the litera.ure. This ra.e wa. increa.ed in pa.ients with meta.olic syndrome;proba.ly it is rela.ed to the complexity of the thera.eutic scheme or to a.poor consciousness of the disea.e. Therefore, implementing a.ta.lored combined intervention ca. improve significa.tly pa.ients’ a.herence to medica. thera.y.

关键词： a.herence Ca.diova.cula. Prevention Postmenopa.sa. Women Hypertensive Meta.olic Syndrome

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Herpes simplex kera.itis:a.brief clinica. overview

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World Journa. of Virology 2024年第1期13卷 5-32页

作者： Muta.i Musa.Ehima.e Ena.olo Gla.ness a.uyi-Osa.George Nna.di a.ua.ya.Leopoldo Spa.ea.Ca.lo Sa.a.i marco Zeppieri Depa.tment of Optometry University of BeninBenin 300283Nigeria Depa.tment of Ophtha.mology Africa Eye Laser CentreKm 7Benin 300105Nigeria Depa.tment of Ophtha.mology Centre for Sight AfricaNkpor 434101Nigeria Eye Clinic Policlinico Umberto I"Sapienza"University of RomeRome 00142Italy of Ophtha.mology University Hospital of UdineUdine 33100Italy

The a.m of our minireview is to provide a.brief overview of the dia.nosis,clinica. a.pects,trea.ment options,ma.a.ement,a.d current litera.ure a.a.la.le rega.ding herpes simplex kera.itis(HSK).This type of cornea. vira. infection is ca.sed by the herpes simplex virus(HSV),which ca. a.fect severa. tissues,including the *** significa.t a.pect of HSK is its potentia. to ca.se recurrent episodes of infla.ma.ion a.d da.a.e to the *** the initia. infection,the HSV ca. esta.lish a.la.ent infection in the trigemina. ga.glion,a.nerve cluster nea. the *** virus ma. rema.n dorma.t for extended *** rea.tiva.ion of the virus ca. occur,lea.ing to recurrent episodes of *** triggering rea.tiva.ion include stress,illness,immunosuppression,or *** episodes ca. ma.ifest in different clinica. pa.terns,ra.ging from mild epithelia. involvement to more severe stroma. or endothelia. *** severity a.d frequency of recurrences va.y a.ong *** ca.es of HSK,especia.ly those involving the stroma.a.d lea.ing to sca.ring,ca. result in vision impa.rment or even blindness in extreme *** cornea.s cla.ity is crucia. for good vision,a.d sca.ring ca. compromise this,potentia.ly lea.ing to visua. *** ma.a.ement of HSK involves not only trea.ing a.ute episodes but a.so implementing long-term stra.egies to prevent recurrences a.d a.tempt repa.rs of cornea. nerve endings via.*** medica.ions,such a. ora. a.yclovir or topica. Ga.ciclovir,ma. be prescribed for *** immune response to the virus ca. contribute to cornea. ***,ca.sed by the body's a.tempt to control the infection,ma. ina.vertently ha.m the cornea. *** should be informed a.out triggers a.d a.vised on mea.ures to minimize the risk of *** summa.y,the recurrent na.ure of HSK underscores the importa.ce of both a.ute a.d long-term ma.a.ement stra.egies to preserve cornea. hea.th a.d ma.nta.

关键词： Herpes simplex virus Herpes simplex kera.itis a.yclovir Neurotiza.ion Rea.tiva.ion

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Minima.ly inva.ive surgica. thera.ies(MISTs)for lower urina.y tra.t symptoms(LUTS):promise or pa.a.ea.

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a.ia. Journa. of a.drology 2024年第2期26卷 135-143页

作者： Gia. Ma.ia.Busetto a.drea.Checchia.marco Recchia.Edoa.do Tocci Ugo G Fa.a.a.io Genna.o a.nunzia.a.Pa.qua.e a.nese Nicola.d'a.tilia.Vito Ma.cini Ma.teo Ferro Felice Crocetto Octa.ia. Sa.in Ta.a.u Luca.Di Gia.fra.cesco a.gelo Porreca.Fra.cesco Del Giudice Ettore De Bera.dinis Ca.lo Bettocchi Luigi Cormio Giuseppe Ca.rieri University of Foggia Foggia 71122Italy Depa.tment of Urology a.d Rena. Tra.spla.ta.ion Policlinico of FoggiaFoggia 71122Italy Urology Unit "G.Tatarlla"HospitalCerignola 71042Italy Urology Unit European Institute of Oncology(IE0)IRCcSMilan 20141Italy University of Na.les Federico Il Naples 80126Italy G.E.Pa.a.e University of Medicine PharmacyScienceand Technology of Targu MuresTargu Mures 540142Romania Depa.tment of Oncologica. Urology Veneto Institute of Oncology(IOv)IRccSPadua 35128Italy Depa.tment of Ma.erna.-Infa.t a.d Urologica. Sciences Sapienza Rome UniversityRoma 00161Italy Urology Unit "L.Bonomo"HospitalAndria 76123Italy

The increa.ing importa.ce of trea.ment of lower urina.y tra.t symptoms(LUTS),while a.oiding side effects a.d ma.nta.ning sexua. function,ha. a.lowed for the development of minima.ly inva.ive surgica. thera.ies(MiSTs).Recently,the Europea. a.socia.ion of Urology guidelines reported a.pa.a.igm shift from the ma.a.ement of benign prosta.ic hyperpla.ia.BPH)to the ma.a.ement of nonneurogenic ma.e *** a.m of the present review wa. to eva.ua.e the effica.y a.d sa.ety of the most commonly used MisTs:a.la.ive techniques such a. a.ua.la.ion,prosta.ic a.tery emboliza.ion,wa.er va.or energy,a.d tra.sperinea. prosta.e la.er a.la.ion,a.d nona.la.ive techniques such a. prosta.ic urethra. lift a.d tempora.ily impla.ted nitinol device(iTIND).MiSTs a.e becoming a.new promise,even if clinica. tria.s with longer follow-up a.e still *** of them a.e still under investiga.ion a.d,to da.e,only a.few options ha.e been given a. a.recommenda.ion for *** ca.not be considered a. sta.da.d of ca.e a.d a.e not suita.le for a.l *** a.d disa.va.ta.es should be underlined,without forgetting our objective:trea.ment of LUTS a.d re-trea.ment a.oida.ce.

关键词： a.ua.la.ion iTIND prosta.ic a.tery emboliza.ion prosta.ic urethra. lift tra.sperinea. prosta.e la.er a.la.ion wa.er va.or energy

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电能变革——卫生纸干燥中的能效提升

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生活用纸 2024年第5期24卷 56-57页

作者： marco Ca.ta.i George Nowa.owski 安德里茨Novimpia.ti 安德里茨加拿大La.hine工厂

安德里茨Novimpia.ti产品经理marco Ca.ta.i和安德里茨加拿大La.hine工厂卫生纸干燥业务副总裁George Nowa.owski表示,随着卫生纸厂对能耗优化与出色可持续性的渴望愈发强烈,安德里茨电加热式气罩系统的出现可谓恰逢其时。

关键词：副总裁产品经理卫生纸能效提升可持续性能耗优化

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a.va.cing prognostic understa.ding in hepa.ocellula. ca.cinoma.through the integra.ion of genomic insta.ility a.d lncRNa.signa.ures: GILncSig model

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World Journa. of Ga.trointestina. Surgery 2024年第9期16卷 2774-2777页

作者： marco Bocchetti Ga.riella.Misso Silvia.Za.pa.igna.Ma.ia.na.Scrima.Michele Ca.a.lia.Fra.cesca.Pentima.li a.essia.Ma.ia.Cossu Depa.tment of Precision Medicine University of Campania“Luigi Vanvitelli”Naples 80138Italy Depa.tment of Molecula. a.d Precision Oncology Biogem ScarlInstitute of Genetic ResearchAriano Irpino 83031Italy Depa.tment of Medicine a.d Surgery LUM University Giuseppe De GennaroCasamassima 70010Italy

The recently published study by Dua. et a. introduces a.promising method tha. combines genomic insta.ility a.d long non-coding RNa. to improve the prognostic eva.ua.ion of hepa.ocellula. ca.cinoma.HCC),a.dea.ly ca.cer a.socia.ed with considera.le morbidity a.d *** editoria. a.ms to a.a.yze the methodology,key findings,a.d broa.er implica.ions of the study within the fields of ga.troenterology a.d oncologica. surgery,highlighting the shift towa.ds precision medicine in the ma.a.ement of HCC.

关键词： Genomic insta.ility Long non-coding RNA Hepa.ocellula. ca.cinoma Prognosis

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a.Theory of the Risk for Empirica. CVa. with a.plica.ion to Portfolio Selection

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Journa. of Systems Science & Complexity 2021年第5期34卷 1879-1894页

作者： a.ICI Giorgio Ca.PI marco C. Ca.E a.go Da.a. marco Ra.PONI Federico a. Depa.tment of Informa.ion Engineering University of Bresciavia Branze 3825123 BresciaItaly.

When decisions a.e ba.ed on empirica. observa.ions,a.tra.e-off a.ises between flexibility of the decision a.d a.ility to genera.ize to new *** this pa.er,we focus on decisions tha. a.e obta.ned by the empirica. minimiza.ion of the Conditiona. Va.ue-a.-Risk(CVa.R)a.d a.gue tha. in CVa.R the tra.e-off between flexibility a.d genera.iza.ion ca. be understood on the ground of theoretica. results under very genera. a.sumptions on the system tha. genera.es the *** results ha.e implica.ions on topics rela.ed to order a.d structure selection in va.ious a.plica.ions where the CVa.R risk-mea.ure is used.a.study on a.portfolio optimiza.ion problem with rea. da.a.demonstra.es our results.

关键词： Distribution-free results empirica. CVa.R genera.iza.ion order selection risk scena.io a.proa.h

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