检索结果-南通市图书馆

Blood concentration of aminothiols in children with relapse of nephrotic syndrome

世界儿科杂志:英文版 2016年第3期12卷 353-359页

作者： marcin tkaczyk Monika Miklaszewska Jolanta Lukamowicz Wojciech Fendler Division of Nephrology Polish Mother's Memorial Hospital Research Institute of lodz281/289 Rzgowska st.93-338lodzPoland Department of Pediatric Nephrology Collegium Medicum of Jagiellonian UniversityWielicka 26530-663 KrakowPoland Center of Medical Diagnostics Polish Mother's Memorial Hospital Research Institute of lodzPoland281/289 Rzgowska st.93-338 lodzPoland Medical University of lodz al.Kosciuszki 4lodzPoland

Background:The role of idiopathic nephrotic syndrome(INS)in the pathogenesis of atherosclerosis in childhood has not been clearly ***,antioxidative defense in INS is thought to be *** study aimed to assess the changes of plasma concentration of selected aminothiols in the blood of children with INS at various stages of the ***:This cross-sectional study was conducted in 125 children aged 2-18 *** children were divided into 4 groups:group A,early relapse(n=37);group B,early remission for 4-6 weeks from the onset(n=37);group C,late steroid-free remission(n=31);and group D,long-term remission for 2-5 years(n=20).Control group(E)consisted of 30 age-and gender-matched healthy *** study protocol comprised an analysis of plasma concentrations of glutathione,homocysteine,cysteine and cysteinylglycine by high-performance liquid *** of protein-bound and free aminothiols were *** injury was assessed by thrombomodulin,PAI-1 concentration,and von Willebrand factor ***:The children with INS had unbalanced aminothiol metabolism only in relapse and early remission,that shifted towards increased oxidative *** of cyclosporine A caused a significant increase in homocysteine and cysteine *** in aminothiol metabolism were significantly related to endothelial ***:The fi ndings of this study may be helpful in elucidating the pathogenesis of premature atherosclerosis in patients with INS refractory to the treatment or in the case of frequent relapse.

关键词： aminothiols children cyclosporine A homocysteine nephrotic syndrome

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：