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Investigation of possible relationship between atopic dermatitis and salivary biomarkers,stress,and sleep disorders

World Journal of Clinical Cases 2023年第17期11卷 3958-3966页

作者： Juliany Estefan Dennis de Carvalho Ferreira Fernanda Sampaio Cavalcante Kátia Regina Netto dos Santos marcia ribeiro Dermatologia Pediátrica Universidade Federal do Rio de JaneiroRio de Janeiro 21941630Brazil Faculdade de Enfermagem Departamento de Fundamentos de EnfermagemUniversidade do Estado do Rio de JaneiroRio de Janeiro 20551030Brazil Departamento de Clínica Médica Instituto de Ciências MédicasUniversidade Federal do Rio de JaneiroCampus MacaéRio de Janeiro 27930-560Brazil Departamento de Microbiologia Médica Instituto de Microbiologia Paulo de GóesUniversidade Federal do Rio de JaneiroRio de Janeiro 21941630Brazil Genética médica Instituto de Puericultura e Pediatria Martagão Gesteira/Universidade Federal do Rio de JaneiroRio de Janeiro 21941630Brazil

Atopic dermatitis(AD)is a chronic,relapsing,multifactorial inflammatory disease with genetic,environmental,and immunological *** quality of life and sleep of patients and their families are affected by AD,which triggers stress,described as one of the factors that worsens *** biomarkers such as cortisol,alpha-amylase,chromogranin A,and melatonin have been associated with stress and sleep ***,the evaluation of stress and sleep disorders using salivary biomarkers in AD patients is *** review aims to describe the possible relationship between atopic dermatitis and stress,sleep disorders,and salivary biomarkers,seeking to contribute to better understanding and clinical management of *** descriptive study is characterized as a narrative literature review.A literature search was conducted of studies published in English and Portuguese between January 2012 and October 2022 that are available in electronic media from various databases,such as Scientific Electronic Library Online,Latin American and Caribbean Literature on Health Sciences,and *** is associated with different degrees of impact on the lives of individuals who present with the *** stress may induce changes in saliva composition and worsen AD;at the same time,the severity of the disease may be associated with emotional *** studies are needed to assess and correlate AD severity,stress,and sleep disturbances with salivary biomarkers in order to better understand this association.

关键词： Atopic dermatitis Sleep Psychological stress Chromogranin A Melatonin Cortisol

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A Proof-of-Concept Assessment of the Safety and Efficacy of Intralesional Diclofenac in the Treatment of Cutaneous Neurofibromas

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International Journal of Clinical Medicine 2015年第12期6卷 975-983页

作者： Mauro Geller Aguinaldo Bonalumi Filho Lisa Oliveira Allan ERubenstein Luiz Guilherme Darrigo Jr David Azulay Allan Bernacchi marcia Goncalves ribeiro Karin Soares Goncalves Cunha Immunology Department Fundacao Educacional Serra dos Orgaos(UNIFESO)TeresopolisBrazil Clinical Immunology Instituto de Pos-Graduacao Medica Carlos Chagas(IPGMCC)Rio de JaneiroBrazil Medical Genetics Service IPPMG-Universidade Federal Rio de JaneiroRio de JaneiroBrazil Hospital Naval Marcilio Dias Rio de JaneiroBrazil Sociedade Evangelica Beneficiente de Curitiba Outpatient Unit CuritibaBrazil NYU Langone Medical Center New YorkNYUSA Bone Marrow Transplant Unit Hospital das Clinicas da Faculdade de Medicina de Ribeirao PretoUniversidade de Sao Paulo(USP)Ribeirao PretoBrazil Pontifica Universidade Catolica do Rio de Janeiro(PUC-RJ) Rio de JaneiroRJBrazil Plastic Surgery Post-Graduation PUC-RJRio de JaneiroBrazil 1 Universidade Federal Fluminense(UFF) Rio de JaneiroBrazil

The objectives of this study were to assess the safety and efficacy of intralesionally administered diclofenac in the treatment of cutaneous neurofibromas in patients with NF1. This was a proof-of-concept, prospective, safety and efficacy study of the effect of intralesionally administered diclofenac 25 mg/ml given once a week to 3 target cutaneous neurofibromas for 4 consecutive weeks. Overall, there was no significant change in neurofibroma size. During the study, some treated lesions developed signs of necrosis and fell off after a few weeks, but none of the control neurofibromas fell off. There were no significant changes in patient’s vital signs. A few adverse events occurred, mostly at the injection sites. During the study, some neurofibromas developed necrosis after the diclofenac injections and eventually detached from the patient. Overall, diclofenac was well tolerated, suggesting minimal systemic exposure, which required confirmation and further studies, including bioavailability analysis.

关键词： Neurofibromatosis Type 1 Cutaneous Neurofibromas Diclofenac Sodium

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HLA antigens in individuals with down syndrome and alopecia areata

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World Journal of Clinical Cases 2014年第10期2卷 541-545页

作者： Juliany L Estefan Juliana C Oliveira Eliane D Abad Simone B Saintive Luis Cristóvao MS Porto marcia ribeiro Pediatric Dermatology Service Martagao Gesteira Pediatric Institute Federal University of Rio de JaneiroRio de Janeiro RJ 21941-901 Brazil Medical Genetics Service Martagao Gesteira Pediatric Institute Federal University of Rio de Janeiro Rio de Janeiro RJ 21941-901 Brazil Histocompatibility and Cryopreservation-HLA Laboratory State University of Rio de Janeiro Policlínica Piquet Carneiro/UERJ Rio de JaneiroRJ 21941-901 Brazil

AIM: To describe human leukocyte antigen(HLA) alleles in individuals with Down syndrome and alopecia areata. METHODS: A cross-sectional study was conducted, which evaluated 109 individuals. Ten with down syndrome(DS) and alopecia areata(AA), ten with DS without AA and ten with AA without DS, and their fami-lies. The individuals were matched by gender and age. The following data were computed: gender, age, ethnic group, karyotype, clinical presentation and family history of alopecia areata. Descriptive analysis: measures of central tendency and frequency distribution. Inferential analysis: Fisher's exact test to compare categorical data between the three groups and Kruskal-Wallis ANOVA test for numerical ***: Seventy per cent of evaluated individuals in the DS and AA group were male; presented mean age of 18.6(SD ± 7.2) years and 70% were Caucasian. We observed involvement of the scalp, with a single lesion in 10% and multiple in 90% of subjects. It was observed that there is no significant difference in the frequency distributions of the alleles HLA loci A, B, C, DRB1 and DQB1 of subjects studied. However, according to Fisher's exact test, there is a trend(P = 0.089) of DS group to present higher proportions of HLA-A 36 and HLA-B 15 than the AA group and AA and DS ***: There was a tendency for the DS group, to present proportion of HLA-A 36 and HLA-B 15 higher than the AA group and group of individuals with AA and DS. However, there was no significant difference in the frequency distribution of the alleles.

关键词： Down syndrome Alopecia areata Human leukocyte antigen antigens Immunology Genetic

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Clinical Assessment of the Use of Propinox Hydrochloride and Scopolamine Hydrochloride in the Treatment of Abdominal Colic: A Retrospective, Comparative Study

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International Journal of Clinical Medicine 2016年第7期7卷 474-480页

作者： Helio Rzetelna Carlos Frederico Porto Alegre Rosa Mario Kirzner Lucas Pereira Jorge de Medeiros Camila Melo marcia Gonçalves ribeiro Lisa Oliveira José Galvão Alves Mauro Geller Gastroenterology Department Universidade Federal do Rio de Janeiro (UFRJ) Rio de Janeiro Brazil Clinical Medicine Department Centro Universitário Volta Redonda (UNIFOA) Volta Redonda Brazil Clinical Medicine and Gastroenterology Department Universidade Estácio de Sá (UNESA) Rio de Janeiro Brazil Clinical Medicine Department Escola de Medicina Souza Marques Rio de Janeiro Brazil 5Inflammatory Bowel Diseases Outpatient Unit-18 ª enfermaria da Santa Casa da Misericórdia do Rio de Janeiro Rio de Janeiro Brazil Federação Brasileira de Gastroenterologia S&atildeo Paulo Brazil Grupo de Estudos de Doenças Inflamatórias Intestinais Rio de Janeiro Brazil UNESA Rio de Janeiro Brazil Gastroenterology Post-Graduation Program-PUC-Rio Rio de Janeiro Brazil Neurology Post-Graduation Program Universidade Federal do Estado do Rio de Janeiro (UERJ) Rio de Janeiro Brazil Pharmacology Department—UFRJ Rio de Janeiro Brazil Medical Genetics Service IPPMG-Universidade Federal Rio de Janeiro Rio de Janeiro Brazil Immunology Department Teresópolis Medical School (UNIFESO) Teresópolis Brazil Clinical Immunology Instituto de Pós-Gradua&ccedil&atildeo Médica Carlos Chagas (IPGMCC) Rio de Janeiro Brazil

Objectives: The purpose of this study was to evaluate and compare the use of propinox hydrochloride and scopolamine hydrochloride in patients presenting abdominal colic (abdominal pain), in terms of treatment efficacy and tolerability. Material & Methods: This was an analytical, retrospective, comparative study based on hospital records of outpatients treated at Serviço de Clínica Médica do Hospital das Clínicas Costantino Otaviano (HCTCO) and at Santa Casa de Misericórdia do Rio de Janeiro, from 1988-1998. Subjects were divided into two groups: patients from Group 1 were treated with propinox hydrochloride, while patients from Group 2 were treated with scopolamine hydrochloride. Statistical analysis was performed using GraphPad Prism version 5.0. For comparison of categorical variables, we used the chi-squared or Fisher’s test, while continuous variables were analyzed using ANOVA or the Student’s T test. Results: A total of 1042 subjects were included, of which 525 were allocated to Group 1 and 517 to Group 2. Mean treatment duration was 9.166 days (±4.208) in Group 1 and 8.795 days (±5.052) in Group 2, with no statistically significant difference in treatment duration between the two groups (p = 0.198). All subjects in Group 1 were treated with propinox 10 mg (2 coated tablets, three times per day) while all subjects in Group 2 were treated with scopolamine hydrochloride 10 mg (2 coated tablets, three times per day). There were no statistically significant between-group differences in weight, BMI, heart rate, and respiratory rate at pre- and post-treatment;with the exception of higher post-treatment systolic blood pressure in Group 1, blood pressure measures also remained homogenous. Adverse events were reported among both treatment groups with no significant between-group difference in incidence (p = 0566). At pretreatment, pain intensity was more severe in Group 1 (p = 0.0257), while at post-treatment, there was no statistically significant difference betw

关键词： Abdominal Colic Propinox Hydrochloride Scopolamine Hydrochloride

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Fecal calprotectin and endoscopic scores: The cornerstones in clinical practice for evaluating mucosal healing in inflammatory bowel disease

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World Journal of Gastroenterology 2024年第24期30卷 3022-3035页

作者： marcia Henriques de Magalhães Costa Ligia Yukie Sassaki Júlio Maria Fonseca Chebli Department of Clinical Medicine Fluminense Federal UniversityRio de Janeiro 24210-200Brazil Department of Internal Medicine Medical SchoolSão Paulo State University(Unesp)Botucatu 18618-686São PauloBrazil Division of Gastroenterology Department of MedicineUniversity Hospital of The Federal University of Juiz de ForaUniversity of Juiz de Fora School of MedicineJuiz de Fora 36036-247Minas GeraisBrazil

Managing inflammatory bowel disease(IBD)is becoming increasingly complex and personalized,considering the advent of new advanced therapies with distinct mechanisms of *** mucosal healing(MH)is a pivotal therapeutic goal in IBD management and can prevent IBD progression and reduce flares,hospitalization,surgery,intestinal damage,and colorectal *** proactive disease and therapy assessment is essential to achieve better control of intestinal inflammation,even if subclinical,to alter the natural course of *** monitoring of fecal calprotectin(FC)levels and interval endoscopic evaluations are cornerstones for evaluating response/remission to advanced therapies targeting IBD,assessing MH,and detecting subclinical ***,we comment on the article by Ishida et al Moreover,this editorial aimed to review the role of FC and endoscopic scores in predicting MH in patients with ***,we intend to present some evidence on the role of these markers in future targets,such as histological and transmural *** prospective multicenter studies with a stricter MH criterion,standardized endoscopic and histopathological analyses,and virtual chromoscopy,potentially including artificial intelligence and other biomarkers,are desired.

关键词： Fecal calprotectin Endoscopic scores Mucosal healing Histological healing Ulcerative colitis Inflammatory bowel diseases

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Clinical Assessment of Treatment Outcomes Following Borago officinalis Extract Therapy in Patients Presenting with Cyclical Mastalgia

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International Journal of Clinical Medicine 2015年第6期6卷 363-371页

作者： Carlos Romualdo Barboza Gama Ricardo Lasmar Gustavo Falcao Gama Lisa Oliveira Erika Cesar de Oliveira Naliato marcia Goncalves ribeiro Flavia de Paoli Adenilson de Souza da Fonseca Camila Sirieiro Abreu Mauro Geller Alessandra Santos Teresopolis Medical School—UNIFESO Rio de JaneiroBrazil Universidade Federal Fluminense—UFF Rio de JaneiroBrazil Universidade Federal de Juiz de Fora—UFJF Juiz de ForaBrazil Universidade Federal do Rio de Janeiro—UFRJ Rio de JaneiroBrazil Instituto de Pós-Graduacao Medica Carlos Chagas Rio de JaneiroBrazil

In order to evaluate the safety and efficacy of Borago officinalis (900 mg borage oil capsules) in the treatment of patients presenting with cyclic mastalgia, 91 subjects were included in the study. Efficacy assessments were performed based on data obtained prior to the start of treatment (Pretreatment), and after each menstrual cycle (Assessment 2—following 45 days of treatment;and Assessment 3—at the end of the 90-day treatment period). Primary efficacy measures considered the results of the Mastalgia Questionnaire, including a 100 mm visual analog pain scale assessing mean, most intense mastalgia severity, and impact on work, sleep, and sexual activity. Safety and tolerability measures included any changes in vital signs and physical exam in relation to pretreatment, any changes in clinical laboratory exams in relation to pretreatment, and the occurrence of adverse events after the first dose of study medication. The VAS scores of the mean mastalgia and most severe mastalgia both showed statistically significant

关键词： Cyclic Mastalgia Borago officinalis Borage Oil

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AI新时代面向文化遗产活化利用的智慧数据生成路径探析

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中国图书馆学报 2024年第2期50卷 4-29页

作者：范炜曾蕾四川大学公共管理学院信息资源管理系美国肯特州立大学信息学院

生成式人工智能引爆AI新时代，新技术不断涌现并快速迭代更新，AI技术应用呈现出百花齐放、百家争鸣的繁荣发展局面。借助AI发展东风，智慧数据的生成进入了高效、深化、多模态集成的新阶段，提升了数据驱动的文化遗产活化利用创新手段... 详细信息

生成式人工智能引爆AI新时代，新技术不断涌现并快速迭代更新，AI技术应用呈现出百花齐放、百家争鸣的繁荣发展局面。借助AI发展东风，智慧数据的生成进入了高效、深化、多模态集成的新阶段，提升了数据驱动的文化遗产活化利用创新手段和创新形式的丰富度与可行性。本文旨在探索面向文化遗产活化利用的智慧数据生成路径。首先，从AI技术视角，对文化遗产智慧数据的内涵与价值进行回顾并知新；其次，系统分析从多元异构数据资源中生成智慧数据的典型做法；再次，以羌年为例，探讨非遗活态文化的智慧数据生成思路。最后，总结归纳AI赋能文化遗产智慧数据生成路径的四点参考策略：(1)抓住AI赋能机遇，补齐数据基础设施短板，加强数据资源体系建设；(2)尽快开展馆藏数据资源的“大语言模型+知识库”结合工作，实现智能分析与计算增强；(3)鼓励更广泛的文化遗产数据开放与共享，支持活化利用的创新应用；(4)确保可信的智慧数据。图3。表1。参考文献68。

关键词：人工智能文化遗产活化利用智慧数据生成路径

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Comparison between Care Strategies for Patients with Osteoarthritis of the Hands Based on the Use of Joint Protection, Assistive Technology and Exercises

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Open Journal of Orthopedics 2024年第7期14卷 295-311页

作者： Daniele dos Santos Scarcella Talita Dias da Silva Victoria Yanara Hernandes da Silva Maria Cândida de Miranda Luzo Selma Lancman marcia Uchoa de Rezende Carlos Bandeira de Mello Monteiro Instituto de Ortopedia e Traumatologia Hospital das Clnicas HCFMUSP Faculdade de Medicina Universidade de So Paulo So Paulo Brazil Programa de Ps-Graduao em Cincias da Reabilitao Faculdade de Medicina Universidade de So Paulo So Paulo Brazil Escola de Artes Cincias e Humanidades Universidade de So Paulo So Paulo Brazil

Background: Osteoarthritis (OA) is a disabling disease that can affect 6% to 12% of the adult population and more than a third of people over 65 years of age. Purpose: To assess whether a group of people with hand osteoarthritis (hOA) who received different types of treatment improved their function after two years of follow-up. Method: The entire sample (n = 97) underwent three follow-up assessments regarding anthropometric parameters of the upper limbs and ability to perform functional activities. Subsequently, the sample was divided into two groups for the intervention periods, called the First Period (n = 73) and the Second Period (n = 24);the First Period kept the same protocol with orientations, and the Second Period went to an intervention with orientation strength exercises and use of orthosis. Findings: In the separate analysis of the three questions of the DASH pain module, no differences were found between the assessment moments for groups of guidelines, treatment, or symptoms. Significant effects were observed for F(2, 162) = 3.5, p = 0.033, η2 = 0.04, and interaction for moments and intervention F(2, 162) = 4.3, p = 0.016, η2 = 0.05. Implications: It can be concluded that only guidance treatment does not benefit patients with hand osteoarthritis. In contrast, guidance, exercise, and orthosis treatment can significantly improve the disease.

关键词： Hand Osteoarthritis Hand Deformities Occupational Therapy

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Climate Intervention: Possible Impacts on Global Security and Resilience

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Engineering 2016年第1期2卷 50-51页

作者： marcia McNutt Science Journals

Climate change is no longer a future possibility： There is already ample evidence that conditions are changing. Sea level is rising at increasing rates [1 ], storms are becoming more intense [2], and communities that have depended on meltwater runoff from snow- pack are running short of water during the dry seasont. As difficult as it might be for a human population of more than seven billion to adapt to these changing conditions, potentially more worrisome is the destabilizing effects of refugees from drought, floods, and rising seas. For example, a multiyear drought in the Middle East has been implicated as a contributing factor in the current civil war in Syria [3 ].

关键词：气候变化海平面上升弹性安全中东地区叙利亚融水干旱

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Floor dust erosion during early stages of coal dust explosion development

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International Journal of Mining Science and Technology 2019年第6期29卷 825-830页

作者： marcia L.Harris Michael J.Sapko Center for Disease Control and Prevention (CDC) National Institute for Occupational Safety and Health (NIOSH) Pittsburgh Mining Research Division (PMRD)

An ignition of methane and air can generate enough air flow to raise mixtures of combustible coal and rock *** expanding high temperature combustion products ignite the suspended dust mixture and will continue to propagate following the available combustible fuel *** the concentration of the dispersed rock dust is sufficient,the flame will stop ***-scale explosion tests were conducted within the National Institute for Occupational Safety and Health(NIOSH)Lake Lynn Experimental Mine(LLEM)to measure the dynamic pressure history and the post-explosion dust scour *** aim of this effort is to provide quantitative data on depth of dust removal during the early stages of explosion development and its relationship to the depth of floor dust collected for assessing the incombustible content most likely to participate in the combustion *** experimental work on dust removal on is not only important for coal mine safety but also for industrial dust explosions.

关键词： Underground Coal dust Explosion Dust sampling

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