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Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?

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World Journal of Gastroenterology 2010年第29期16卷 3704-3708页

作者： Rosilene G badiani Vitória becker Renata M Perez Carla AL Matos Lara b.lemos Valéria P Lanzoni Luis Eduardo C Andrade Alessandra Dellavance Antonio Eduardo b Silva Maria Lucia G Ferraz Division of Gastroenterology Federal University of Sao Paulo04023-900Sao PauloBrazil Department of Internal Medicine Federal University of Rio de Janeiro21941-913Rio de JaneiroBrazil Department of Pathology Immunology Group Fleury Medicine and Health 不详

AIM:To evaluate the overlap of autoimmune hepatitis in hepatitis C virus(HCV)-infected patients with intense interface ***:Among 1759 patients with hepatitis C submitted to liver biopsy,92(5.2%) presented intense interface *** patients were evaluated regarding the presence of antinuclear antibody(ANA),anti-smooth muscle antibody(SMA) and anti-liver/kidney microsomal antibody(LKM-1),levels of γ-globulin and histological findings related to autoimmune hepatitis(plasma cell infiltrate and presence of rosettes).RESULTS:Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies(ANA=12%,SMA=5%,LKM-1=0%) and the median γ-globulin level was within the normal *** histological findings of autoimmune disease were observed in only two cases(2%).After applying the score for diagnosis of autoimmune hepatitis,only one patient was classified with a definitive diagnosis of autoimmune *** overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this *** presence of intense interface hepatitis was associated with more advanced age,both at the time of infection and at the time of the biopsy,and higher prevalence of blood transfusion and alcohol ***:Although possible,overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis,an unusual presentation which seems to be related to other host variables.

关键词： Hepatitis C Liver biopsy Antinuclear antibody Autoimmune hepatitis Interface hepatitis

Nutrition and exercise can attenuate inflammatory and psychobiological changes in hypoxia?

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Asian Pacific Journal of Tropical biomedicine 2017年第1期7卷 86-90页

作者： Aline Venticinque Caris Wanessa Ysis Valdir de Aquino lemos Ricardo bottura Ronaldo Vagner Thomatieli dos Santos Department of Psychobiology Federal University of Sao Paulo(UNIFESP)SantosBrazil Department of bioscience Federal University of Sao Paulo(UNIFESP)SantosBrazil

Exposure to hypoxia causes damage in several physiological systems, whose tissues are dependent on the O2 supply. Recently, there has been growing attention on the immunosuppressive and inflammatory potential of the hypoxia, including stimulation, nuclear factor kappa b pathway in macrophages and Th2 response from lymphocytes. These changes may result in transient immunosuppression and happen at the same time to worsening of cognition and other psychobiological aspects. Furthermore, exercise and nutrition, especially glutamine supplementation may provide important role, not pharmacological partially reversing the effects of hypoxia. In fact, recent studies show that moderate exercise can improve cognition in people exposed to hypoxia while the exercise associated with glutamine supplementation can reverse the increase in inflammatory markers and the Th1/Th2 balance. This review aims to bring the light of the discussion about nonpharmacological ways to prevent the effects of hypoxia on the connection between the immune system and the central nervous system.

关键词： Physical exercise High altitude Inflammation Cognition Glutamine

Role of non-Helicobacter pylori gastric Helicobacters in helicobacter pylori-negative gastric mucosa-associated lymphoid tissue lymphoma

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世界胃肠病学杂志:英文版 2023年第32期29卷 4851-4859页

作者： Fabian Fellipe bueno lemos Marcel Silva Luz Samuel Luca Rocha Pinheiro Kádima Nayara Teixeira Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029094Brazil Campus Toledo Universidade Federal do ParanáToledo 85919899Brazil

Marginal zone lymphomas rank as the third most prevalent form of non-Hodgkin b-cell lymphoma,trailing behind diffuse large b-cell lymphoma and follicular *** mucosa-associated lymphoid tissue lymphoma(GML)is a low-grade b-cell neoplasia frequently correlated with Helicobacter pylori(***)-induced chronic *** the other hand,a specific subset of individuals diagnosed with GML does not exhibit *** *** contrast to its ***-positive counterpart,it was previously believed that ***-negative GML was less likely to respond to antimicrobial *** this,surprisingly,increasing evidence supports that a considerable proportion of patients with ***-negative GML show complete histopathological remission after bacterial eradication ***,the precise mechanisms underlying this treatment responsiveness are not yet fully *** recent years,there has been growing interest in investigating the role of *** gastric helicobacters(NHPHs)in the pathogenesis of ***-negative ***,additional research is required to establish the causal relationship between NHPHs and *** this minireview,we examined the current understanding and proposed prospects on the involvement of NHPHs in ***-negative GML,as well as their potential response to bacterial eradication therapy.

关键词： Lymphoma b cell Marginal zone Gastric mucosa-associated lymphoid tissue lymphoma Helicobacter pylori Non-Helicobacter pylori gastric helicobacters Helicobacter heilmannii Helicobacter suis

Identification of victims of the collapse of a mine tailing dam in brumadinho

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Forensic Sciences Research 2022年第4期7卷 580-589页

作者： Ricardo Moreira Araújo Yara Vieira lemos Erlon Dias do Nascimento Anna Helena Silva Paraizo Alberto Julius Alves Wainstein Ana Paula Drummond-Lage Faculty of Medical Sciences of Minas Gerais Belo HorizonteBrazil Instituto Médico Legal AndréRoquette Belo HorizonteBrazil Corpo de bombeiros Militar de Minas Gerais Juiz de ForaBrazil

The collapse of the b1 Dam of VALESAmining company in brumadinho,Minas Gerais,brazil was the largest humanitarian disaster and occupational accident in the country’s history,and it posed challenges regarding the management and identification of multiple *** evaluated the impact of the iron ore tailings on the victims’*** examined the scientific identification of the victims and the dynamics of the disaster over the 1st year after it *** also determined the socio-demographic profiles of the *** this retrospective,cross-sectional study,we investigated the expert reports of the victims’biological remains from 25 January 2019 to 25 January *** analysed the socio-demographic data,identification methods,identification status,identification time,and necroscopic *** the study period,259 of 270 victims were identified,and 603 biological materials were analysed;among them,86.2%were body parts and 13.8%were whole *** the total cases registered that year,476(78.9%)were submitted during the first 10 weeks after the *** ridge analysis accounted for 67.9%of primary identifications and DNAanalysis did so for 91.6%of re-identification *** dismemberment was 3.4 times greater among mine workers than among community *** males accounted for the greatest number of victims(Pber of fatalities and greater dismemberment among employees than with community residents underlines the occupational dangers in the mining industry and clarifies the dynamics of the *** the initial weeks after the dam collapsed,friction ridge analysis was the most appropriate method for ***,DNAanalysis became the most-used technique for identification and re-identification owing to the great volume of body parts and decomposed biological ***

关键词： Disasters victim identification tailings mining legal medicine developing countries man-made disasters traumatic amputation

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基于有损信道的触觉媒体通信多路径调度

基于有损信道的触觉媒体通信多路径调度

作者： lemos Marisa Da Costa 电子科技大学

学位级别：硕士

最近发布的第五代（5G）新无线电（NR）特别关注超可靠低延迟通信（URLLC）和增强移动宽带（e Mbb）服务。URLLC服务需要1ms的低延迟和99.999%的高可靠性,而e Mbb服务需要高数据率。URLLC服务专注于触觉媒体,而e Mbb服务专注于视频。在5... 详细信息

最近发布的第五代（5G）新无线电（NR）特别关注超可靠低延迟通信（URLLC）和增强移动宽带（e Mbb）服务。URLLC服务需要1ms的低延迟和99.999%的高可靠性,而e Mbb服务需要高数据率。URLLC服务专注于触觉媒体,而e Mbb服务专注于视频。在5G NR服务中,除了视频外,还可以提供触觉媒体支持。在触觉媒体中出现的主要网络条件问题是降低体验质量（Qo E）的包丢失、延迟和抖动。然而,在实时应用中,触觉媒体流量需要实现高可靠性、低延迟和最小开销。本文重点研究了针对触觉媒体的多路径调度机制。多路径调度在URLLC服务中提供了很高的期望,以满足触觉媒体的可靠性和延迟（即端到端（E2E）延迟）的要求。本文研究了一种基于双连通性（DC）与数据包重复（PD）算法的多路径调度方案,将相同的包同时通过多个链路（或路径）传输,以满足触觉媒体的性能需求。论文主要工作和贡献如下:首先,研究了触觉媒体通信问题。触觉媒体通信面临的关键问题或挑战是要求高可靠性,最大包丢失概率为0.001%以及不超过1ms的端到端低延迟。此外,原则、网络架构、压缩、协议、定性特征、要求、网络条件问题、体验质量和服务质量方法被认为是触觉媒体通信的关键使能因素。其次,研究了多路径调度机制。给出了问题的求解公式、考虑的多路径模型、调度和信道算法。所提多路径机制的新颖之处在于,它可以通过网络中的不同路径传递压缩的触感媒体帧,如内部（I）、帧间（P）和双向（b）帧。最后,在Matlab中针对多业务流量（具有视频的触觉媒体）异构网络场景实现了所考虑的方法。仿真结果表明,在单连通的典型设置下,可靠性提高了57%,端到端延迟降低了23%,协议开销降低了20%。

关键词： URLLC 触觉媒体多路径调度算法数据包重复双连通性

Estimating the Selfing and Migration of Luehea divaricata Populations based on Genetic Structure Data, Using the EASYPOP Program

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Journal of Environmental Science and Engineering(b) 2018年第3期7卷 117-122页

作者： Caetano Miguel lemos Serrote Rosalina Armando Tamele Luciana Samuel Nhantumbo Lia Rejane Silveira Reiniger Departamento de Silvicultura e Maneio Florestal Faculdade de Ciências Agrárias Universidade Lúrio Unango 3302 Mozambique Departamento de Fitotecnia Universidade Federal de Santa Maria Santa Maria RS 97105-900 Brazil

Genetic structure data of five populations of the Luehea divaricata Mart. ＆ Zucc., forest tree species under development in the Atlantic Forest biome, obtained by microsatellite DNA markers, were used in simulations to study their reproductive and ecological pattern. Different selfing and migration rates were tested, using the observed and expected heterozygosity of 0.55 and 0.67, respectively, obtained through the use of microsatellite markers. Closest values were obtained with the use of selfing rates of 0.3 and migration of 0.2. These results suggest the presence of some self-incompatibility system between these species, which reduces, but does not prevent the self-fertilization. The migration rate contributes to a low genetic differentiation between the populations, making the reproductive mode, responsible for the inbreeding observed in the same populations. Authors suggest continuous monitoring of the genetic variability as a guarantee for the persistence of these populations. The study focus on the importance of using computer simulations to investigate ecologic, reproductive and genetic patterns for forestry populations, thus enabling the application of suitable measures for conservation.

关键词： Computational simulations conservation biology inbreeding heterozygosity

Prevalence of celiac disease in an urban area of brazil with predominantly European ancestry

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World Journal of Gastroenterology 2006年第40期12卷 6546-6550页

作者： Maria Angélica G Pereira Carmen L Ortiz-Agostinho Iêda Nishitokukado Maria N Sato Adérson OMC Damio Marília L Alencar Clarice P Abrantes-lemos Eduardo LR Canado Thales de brito Sérgio O Ioshii Sandra bM Valarini Aytan M Sipahi Department of Gastroenterology Medical Investigation Laboratories (LIM 07) University of So Paulo School of Medicine So Paulo SP Brazil Medical Investigation Laboratories (LIM 56) University of So Paulo School of Medicine So Paulo SP Brazil Institute of Tropical Medicine (LIM 06) University of So Paulo School of Medicine So Paulo SP Brazil Department of Histopathology Federal University of Paraná Brazil Department of Internal Medicine Catholic University of Paraná Brazil

AIM： To determine the prevalence of celiac disease in a group of volunteer blood donors at a blood bank in the city of Curitiba, brazil through detection of the serum marker immunoglobulin A （IgA） antitransglutaminase antibody. METHODS： blood samples collected from 2086 healthy subjects at the Paraná State Center for Hematology and Hemotherapy in Curitiba were submitted to ELISA testing for the IgA antitransglutaminase antibody. Positive samples received IgA antiendomysium antibody test through indirect immunofluorescence using human umbilical cord as substrate. Subsequently, patients who were positive on both tests underwent small bowel （distal duodenum） biopsy. RESULTS： Six subjects, four males and two females, tested positive for the two serum markers. Five of the six were submitted to intestinal biopsy （one declined the procedure）. biopsy results revealed changes in the distal duodenum mucosa （three classified as Marsh mb lesions and two as Marsh Ⅱ lesions）. Most donors diagnosed having celiac disease presented multiple symptoms （gastrointestinal tract complaints）. One donor reported having a family history of celiac disease （in a niece）. CONCLUSION： Among apparently healthy blood donors,the prevalence of biopsy-confirmed celiac disease was approximately 1：417, similar to that seen in European countries.

关键词： Celiac disease Epidemiology Malabsorption Prevalence Small bowel disease

Physiological and biochemical Responses of Wheat Subjected to Water Deficit Stress at Different Phenological Stages of Development

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Journal of Agricultural Science and Technology(b) 2011年第8期1卷 1116-1124页

作者： J. M. lemos E. C. G. Vendruscolo I. Schuster M. F. dos Santos Campus Palotina Universidade Federal do Parana Palotina Parana CEP 85.950-000 Brazil COODETEC-Cooperativa Central de Pesquisa Agrlcola Cascavel Parana CEP 85.813-450 Brazil

Proline has been proposed to be an osmoprotector and scavenger of reactive oxygen species in plants subjected to water deficit. The aim of this work was to study the effects of drought on each wheat phenological stage （tillering, booting, heading, flowering and grain-filling） using stress parameters such as the relative water content （RWC）, membrane stability index （MSI）, lipid peroxidation through malondialdehyde levels （MDA） and determination of proline content （PRO）. The brazilian commercial elite cultivar Triticum aestivum cv. CD 200126 was submitted to eight days of water deficit stress at each stage. The perception of stress was low at tillering and high at the final stages of growth, as verified by the reduction in the MSI and RWC. However, an increase in the MDA was clearly observed. We observed a high proline accumulation when stress was applied, although it was not sufficient to prevent damages. These results indicate that the relevant stages to evaluate the effect of water shortage during wheat plant development are booting, heading and flowering.

关键词： Drought phenological cycle proline stress parameters Triticum aestivum L.

Effectiveness of Helicobacter pylori eradication in the treatment of early-stage gastric mucosa-associated lymphoid tissue lymphoma:An up-to-date meta-analysis

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World Journal of Gastroenterology 2023年第14期29卷 2202-2221页

作者： Fabian Fellipe bueno lemos Caroline Tianeze de Castro Mariana Santos Calmon Marcel Silva Luz Samuel Luca Rocha Pinheiro Clara Faria Souza Mendes dos Santos Gabriel Lima Correa Santos Hanna Santos Marques Henrique Affonso Delgado Kádima Nayara Teixeira Cláudio Lima Souza Márcio Vasconcelos Oliveira Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029094BahiaBrazil Instituto de Saúde Coletiva Universidade Federal da BahiaSalvador 40110040BahiaBrazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45029094BahiaBrazil Campus Toledo Universidade Federal do ParanáToledo 85919899ParanáBrazil

bACKGROUND Gastric mucosa-associated lymphoid tissue(MALT)lymphoma(GML)is usually a low-grade b-cell neoplasia strongly associated with Helicobacter pylori(***)-induced chronic *** practice guidelines currently recommend *** eradication as the preferred initial treatment for early-stage *** determine the practical effect of bacterial eradication as the sole initial therapy for early-stage GML,an updated analysis and review of available evidence is *** To perform a meta-analysis to assess the rate of complete remission(CR)of ***-positive early-stage GML following bacterial *** We performed independent,computer-assisted literature searches using the PubMed/MEDLINE,Embase,and Cochrane Central databases through September *** and retrospective observational studies evaluating the CR of early-stage GML following bacterial eradication in ***-positive *** risk of bias was assessed using Joanna briggs Institute(JbI)Critical Appraisal *** pooled estimate of the complete histopathological remission rate and respective confidence intervals(95%CI)were calculated following the random-effects *** and inconsistency were assessed using Cochran’s Q test and I2 statistic,and heterogeneity was defined as P50%,*** and meta-regression analyses were conducted to explore potential sources of *** The titles and abstracts of 1576 studies were screened;96 articles were retrieved and selected for full-text ***,61 studies were included in the proportional meta-analysis(P-MA).Forty-six were prospective and fifteen were retrospective uncontrolled,single-arm,observational *** overall risk of bias was low to moderate in all but a single report,with an average critical appraisal score across all studies of 79.02%.A total of 2936 ***-positive early-stage GML patients,in whom *** was successfully eradicated,were incl

关键词： Lymphoma b-cell Marginal zone Gastric mucosa-associated lymphoid tissue lymphoma Stomach lymphoma Helicobacter pylori Therapeutics Eradication therapy