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Celiac disease markers in patients with liver diseases: A single center large scale screening study

World Journal of Gastroenterology 2012年第43期18卷 6255-6262页

作者： Pavel Drastich Eva Honsová Alena Lodererová marcela jaresová Aneta Pekáriková Iva Hoffmanová Ludmila Tuková Helena Tlaskalová-Hogenová Julius piák Daniel Sánchez Department of Hepatogastroenterology Institute for Clinical and Experimental Medicine 14021 Prague Czech Republic Department of Clinical and Transplant Pathology Institute for Clinical and Experimental Medicine 14021 Prague Czech Republic Department of Immunology Institute for Clinical and Experimental Medicine 14021 Prague Czech Republic Department of Immunology Institute of Microbiology Academy of Sciences of the Czech Republic 14220 Prague Czech Republic 2nd Department of Internal Medicine 3rd Faculty of Medicine Charles University 10034 Prague Czech Republic

AIM:To study the coincidence of celiac disease, we tested its serological markers in patients with various liver ***:Large-scale screening of serum antibodies against tissue transglutaminase (tTG), and deamidated gliadin using enzyme-linked immunosorbent assay and serum antibodies against endomysium using immunohistochemistry, in patients with various liver diseases (n = 962) and patients who underwent liver transplantation (OLTx, n = 523) was performed. The expression of tTG in liver tissue samples of patients simultaneously suffering from celiac disease and from various liver diseases using immunohistochemistry was carried out. The final diagnosis of celiac disease was confirmed by histological analysis of small-intestinal biopsy. RESULTS:We found that 29 of 962 patients (3%) with liver diseases and 5 of 523 patients (0.8%) who underwent OLTx were seropositive for IgA and IgG anti-tTG antibodies. However, celiac disease was biopsy-diagnosed in 16 patients:4 with autoimmune hepatitis type Ⅰ, 3 with Wilson's disease, 3 with celiac hepatitis, 2 with primary sclerosing cholangitis, 1 with primary biliary cirrhosis, 1 with Budd-Chiari syndrome, 1 with toxic hepatitis, and 1 with non-alcoholic steatohepatitis. Unexpectedly, the highest prevalence of celiac disease was found in patients with Wilson's disease (9.7%), with which it is only rarely associated. On the other hand, no OLTx patients were diagnosed with celiac disease in our study. A pilot study of the expression of tTG in liver tissue using immunohistochemistry documented the overexpression of this molecule in endothelial cells and periportal hepatocytes of patients simultaneously suffering from celiac disease and toxic hepatitis, primary sclerosing cholangitis or autoimmune hepatitis type Ⅰ. CONCLUSION:We suggest that screening for celiac disease may be beneficial not only in patients with associated liver diseases, but also in patients with Wilson's disease.

关键词： Tissue transglutaminase Anti-tissue transglutaminase antibodies Autoimmune liver diseases Wilson's disease Celiac disease Liver transplantation

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