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Diet switch and omega-3 hydroxy-fatty acids display differential hepatoprotective effects in an obesity/nonalcoholic fatty liver disease model in mice

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World Journal of Gastroenterology 2018年第4期24卷 461-474页

作者： Roberto Rodriguez-Echevarria Jose Macias-Barragan marcela Parra-Vargas Judith Rebeca Davila-Rodriguez Eduardo Amezcua-Galvez Juan Armendariz-Borunda Institute for Molecular Biology and Gene Therapy-CUCS Department of Molecular Biology and GenomicsUniversity of GuadalajaraGuadalajara 44340Mexico Department of Health Sciences-CUValles University of GuadalajaraGuadalajara 46600Mexico Hospital Civil de Guadalajara Guadalajara 46600Mexico

AIM To study the effect of 18-hydroxy-eicosapentaenoic acid(18-HEPE) and 17-hydroxy-docosahexaenoic acid(17-HDHA) in a murine model of obesity/nonalcoholic fatty liver *** C57 BL/6 mice were fed with standard chow diet(CD) or high-fat, fructose-enriched diet(HFD) for 16 wk. Then, three groups were treated for 14 d with either, diet switch(HFD for CD), 18-HEPE, or 17-HDHA. Weightand fasting glucose were recorded on a weekly basis. Insulin tolerance test was performed at the end of treatment. Histological analysis(HE and Masson's trichrome stain) and determination of serum insulin, glucagon, glucagon-like peptide 1(GLP-1), glucose-dependent insulinotropic polypeptide, adiponectin and resistin were carried out as well as liver proteins by western *** Mice treated with hydroxy-fatty acids 18-HEPE and 17-HDHA displayed no weight loss or improved insulin sensitivity. However, these mice groups showed a significant amelioration on serum GLP-1, adiponectin and resistin levels. Also, a significant reduction on inflammatory infiltrate was observed at both portal and lobular zones. Furthermore, up-regulation of PPARα/γ protein levels was observed in liver tissue and it was associated with decreased levels of NF-κB also determined by western blot analysis. On the other hand, diet switch regimen resulted in a marked improvement in most parameters including: weight loss, increased insulin sensitivity, decreased steatosis, restored levels of insulin, glucagon, leptin, adiponectin and resistin. However, no significant changes were observed regarding inflammatory infiltrate in this last *** 18-HEPE and 17-HDHA differentially exert hepatoprotective effects through up-regulation of nuclear receptors PPARα/γ and amelioration of serum adipokines profile.

关键词： Nonalcoholic fatty liver disease Polyunsaturated fatty acids 18-hydroxy-eicosapentaenoic acid 17-hydroxy-docosahexaenoic acid Obesity

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Study of Diffusion through the Skin of Coated L-Ascorbic Acid by Fluid Bed Technology

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Journal of Encapsulation and Adsorption Sciences 2017年第2期7卷 75-82页

作者： Ferrándiz marcela Capablanca Lucía Biotechnology Research Group Textile Research Institute (AITEX) Alcoy Spain

Coating protects substances such as L-ascorbic acid from natural processes like oxidation. In this study, L-ascorbic acid was coated by fluid bed technology. A pH-dependent polymer was used as a coating material in order to release L-ascorbic acid (dissolution above pH 5.5) under conditions closest to the skin’s natural condition. Different techniques were used to determine the coating (SEM and size distribution) and to evaluate the percentage of coated L-ascorbic acid and its diffusion through the skin.

关键词： pH Dependent Polymer L-Acid Ascorbic Diffusion Fluid Bed

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Solar Wind Interaction with Jupiter’s Magnetosphere

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Advances in Aerospace Science and Technology 2023年第3期8卷 34-54页

作者： Jenny marcela Rodríguez-Gómez NASA Goddard Space Flight Center Greenbelt USA Physics Department The Catholic University of America Washington DC USA

This paper studies the effects of the solar wind on Jupiter’s magnetosphere. The solar wind parameters are characterized using the Michigan Solar Wind Model (mSWiM) solar wind data propagated to Jupiter from 1997 to 2016. This analysis covers almost solar cycles 23 and 24. Interplanetary fast shocks: Forward shocks (FS), Reverse shocks (RS), and solar wind dynamic pressure were obtained and analyzed during the apparent opposition periods. The fast forward (FS) shocks were predominant during this period. Generally, the solar wind dynamic pressure from FS and RS shocks follows the solar cycles 23 and 24.

关键词： Solar Wind Interplanetary Fast Shocks Magnetospheres

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Effects of Conservation Tillage on Total and Aggregated Soil Organic Carbon in the Andes

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Open Journal of Soil Science 2013年第8期3卷 361-373页

作者： marcela Quintero Nicholas B. Comerford Decision and Policy Analysis Research Area International Center for Tropical Agriculture (CIAT) Cali Colombia University of Florida North Florida Research and Education Center University of Florida (UF) Quincy USA University of Florida North Florida Research and Education Center University of Florida (UF) Quincy USA

Many Andisols of the Andes have been disturbed by traditional potato-based rotation agriculture disrupting soil structure, water retention capacity and organic matter content. This study was undertaken to investigate the contribution of conservation farming technology or reduced tillage in potato-based rotations in the Colombian Andes in order to rehabilitate total and aggregated soil organic C in disturbed organic matter-rich Andisols. Soils were sampled from farms with 7-year of reduced tillage and farms with conventional farming practices. Ultrasound energy was applied to samples to disrupt aggregation and total soil C was determined in order to investigate the amount of carbon held inside the aggregates of different soil size classes. Results indicated that reduced tillage in potato-based crop rotations increased the soil C concentration and average C content in the whole profile (≈117 cm depth) by 50 and 33% (1636 t C ha?1 vs. 1224 t C ha?1), respectively, as compared to conventional farming practices. Carbon content increased 177% in the subsoil (A2 horizon, 78 -117 cm depth, from 215 to 596 t?ha?1), although most of the soil C was in the A1 horizon (between 0 -78 cm average thickness, 1097 t?ha?1). These increases show that reduced tillage enhances C stores in Andisols which are already high in organic matter. In addition, C in aggregates represented more than 80% of the total organic matter and it was positively affected by conservation practices. The C increase was preferential in the smaller macroaggregates (

关键词： Conservation Tillage Soil Organic Carbon Soil Aggregates Andes Potato

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Blood pressure and stature in Helicobacter pylori positive and negative persons

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World Journal of Gastroenterology 2014年第19期20卷 5625-5631页

作者： marcela Kopacova Ilona Koupil Bohumil Seifert Miluska Skodova Fendrichova Jana Spirkova Viktor Vorisek Stanislav Rejchrt Tomas Douda Ilja Tacheci Jan Bures 2~(nd)Department of Internal Medicine-Gastroenterology Charles University in PrahaFaculty of Medicine at Hradec KraloveUniversity Teaching Hospital50005 Hradec KraloveCzech Republic Centre for Health Equity Studies Stockholm UniversityKarolinska Institute17177 StockholmSweden Institute of General Practice First Faculty of MedicineCharles University12002 PrahaCzech Republic Institute of Clinical Biochemistry and Diagnostics Charles University in PrahaFaculty of Medicine at Hradec KraloveUniversity Teaching Hospital50005 Hradec KraloveCzech Republic

To evaluate vital signs and body indices in Helicobacter pylori (H. pylori) positive and negative persons. A total of 22 centres entered the study. They were spread over the whole country, corresponding well to the geographical distribution of the Czech population. A total of 1818 subjects (aged 5-98 years) took part in the study, randomly selected out of 38147 subjects. H. pylori infection was investigated by means of a 13C-urea breath test. Data on height, weight, systolic and diastolic blood pressure and heart rate were collected at the clinics of general practitioners. The overall prevalence of H. pylori infection was 30.4% (402/1321) in adults (≥ 18 year-old) and 5.2% (26/497) in children and adolescents (≤ 17 year-old). Once adjusted for age and gender, only a difference in body mass index remained statistically significant with H. pylori positive adults showing an increase of 0.6 kg/m2 in body mass index. Once adjusted for age and gender, we found a difference in height between H. pylori positive and H. pylori negative children and adolescents. On further adjustment for place of residence, this difference became statistically significant, with H. pylori positive children and adolescents being on average 3.5 cm shorter. H. pylori positive adults were significantly older compared to H. pylori negative subjects. Once adjusted for age and gender, H. pylori infection had no impact on body weight, body mass index and vital signs either in adults or children and adolescents. Chronic H. pylori infection appeared to be associated with short stature in children. H. pylori infection did not influence blood pressure, body weight and body mass index either in adults or children and adolescents.

关键词： Epidemiology Helicobacter pylori Czech Republic 13C-urea breath test Blood pressure Heart rate Weight Stature Body mass index

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Magnesium: The Neglected Electrolyte? A Clinical Review

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Pharmacology & Pharmacy 2014年第7期5卷 762-772页

作者： Pranev Sharma Christine Chung marcela Vizcaychipi Imaging & Anaesthetics Chelsea & Westminster Hospital London UK Magill Department of Anaesthesia Chelsea & Westminster Hospital London UK

Magnesium, Mg2+, is the second most abundant intracellular cation after potassium and the fourth most abundant in the body. It was first isolated in 1808 by the English chemist, Sir Humphrey Davy. Magnesium is essential to numerous biochemical reactions. It modulates key physiological processes such as metabolic biochemistry, nucleic acid synthesis, receptor-binding and ion flux. The western diet falls short of the recommended daily allowance of 4.5 mg/Kg/day and important dietary sources are seeds, grains, nuts and green vegetables. It is used as a therapeutic agent in a broad range of pathologies: neurological, cardiovascular, respiratory, gastrointestinal and obstetric. The pharmacokinetics and pharmacodynamics of magnesium, as a drug, are not well understood. Despite its fundamental importance to human physiology, it remains an electrolyte that is not routinely measured as part of the “urea & electrolytes” test and is the most overlooked electrolyte deficiency in hospital inpatients. This review will summarise the importance of magnesium homeostasis, its pharmacological effects and clinical applications.

关键词： Magnesium Pharmacology Pharmacodynamics Pharmacokinetics Physiology Arrhythmias Eclampsia Pre-Eclampsia Phaeochromocytoma

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Ibuprofen-Maltodextrin Interaction: Study of Enantiomeric Recognition and Complex Characterization

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Pharmacology & Pharmacy 2013年第1期4卷 18-30页

作者： Claudia Garnero Carolina Aloisio marcela Longhi Departamento de Farmacia Facultad de Ciencias Químicas Universidad Nacional de Córdoba Ciudad Universitaria Córdoba Argentina

The interaction between ibuprofen and maltodextrins with different dextrose equivalent was studied in solution and solid state in order to investigate the effect on the solubility of ibuprofen and to determine their usefulness in terms of chiral recognition. Apparent binding constants were calculated using nuclear magnetic resonance spectroscopy experiments and solubility studies. The results showed an increase in the apparent solubility of ibuprofen in the presence of maltodextrins that depended on their ionization state. The freeze-drying method was used to prepare solid complexes, while physical mixtures were obtained by simple blending. These solid systems were characterized in the solid state using differential scanning calorimetry, thermogravimetric analysis, Fourier Transform-Infrared spectroscopy, scanning electron microscopy and X-ray diffractometry. Detailed nuclear magnetic resonance studies provided evidence of the influence of the type and concentration of the maltodextrin host on the chiral recognition of racemic ibuprofen, indicating that these linear ligands act as chiral selectors.

关键词： Ibuprofen Maltodextrin Chiral Recognition Complex Characterization Nuclear Magnetic Resonance Spectroscopy Solubility Studies

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Description of Four New Species for the Genus Damasippus Stål, 1875 (Phasmida: Prisopodidae)

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Advances in Entomology 2023年第2期11卷 105-123页

作者： marcela Sánchez-Ocampo Diego Monge-Villegas Natural History Entomology Costa Rica National Museum San José Costa Rica Heredia Costa Rica

During the review and identification of specimens of the genus Damasippus Stål, 1875 deposited in the National Museum of Costa Rica, some specimens were found that corresponded to four non-described species: D. sepia ***., D. viridicorpus ***, D. duoviridis *** and D. viridilabrum n. sp. Due to the above, a review of the literature describing the species of this group was carried out, with which an illustrated dichotomous key was developed to identify the 16 species, in addition to a partial phylogenetic analysis to corroborate that they do not correspond to the species D. fuscipes, due to its morphological similarity.

关键词： Costa Rica Stick Insects Taxonomic Key

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An Experimental Study of Self-Compacting Concrete Made with Filler from Construction and Demolition Waste

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Open Journal of Civil Engineering 2020年第4期10卷 364-384页

作者： Mônica Batista Leite marcela Crusoé Figueiredo Civil and Environmental Engineering Graduate Program Department of Technology State University of Feira de Santana Feira de Santana Brazil UNIFACS Feira de Santana Brazil

This study evaluated the influence of the Portland cement replacement by 0, 5%, 10%, 15% and 20% of Construction and Demolition Waste (CDW) filler contents in the production of self-compacting concrete (SCC). The SCC mixtures were evaluated on fresh state by slump flow, J-ring, resistance of segregation, specific gravity, and on hardened state by compressive and splitting tensile strength, specific gravity, air voids and absorption rate. The results indicated that all SCC produced with CDW filler met the limits established at any level of substitution without changes of the w/c ratio or superplasticizer content. It was possible to verify that the presence of CDW filler, in substitution of cement, by volume, improves the resistance to segregation and up to 5% of CDW filler decreases the loss of fluidity with time as compared to reference. It was found that all SCC mixtures, at 28 days, had the average compressive strength above 50 MPa, without showing significant loss with up to 20% of CDW filler. For splitting tensile strength, SCC recycled mixtures reached up to 92.5% of the SCC used as referenc

关键词： Self-Compacting Concrete Construction and Demolition Waste Filler Mineral Admixtures Slump Flow

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What can natural edges of gallery forests teach us about woody community performance in sharp ecotones?

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Journal of Plant Ecology 2017年第6期10卷 937-948页

作者： Gabriela Aparecida de Oliveira Coelho marcela de Castro Nunes Santos Terra Hisaias de Souza Almeida Eduardo van den Berg Departamento de Ciências Florestais Universidade Federal de LavrasC.Postal 3037LavrasMG 37200-000Brazil Instituto de Recursos Naturais Universidade Federal de ItajubáC.Postal 50ItajubáMG 37500-903Brazil Departamento de Biologia Universidade Federal de LavrasC.Postal 3037LavrasMG 37200-000Brazil

Aims The diversity and structure of forest edges are a central issue in ***,most studies have focused on anthropogenic for-est edges,being natural ones least *** studied the com-munities of shrubs and trees in natural edges of gallery forests with the main goal of learning what are the main factors that shape the structure and diversity of these natural sharp *** We evaluated 10 gallery forest sites,allocating in each of them three 15×20 m *** plots were laid out in relatively rectilinear stretches of forest edges,respecting a minimal distance of 10 m between each *** they are permanent plots and meant to study eventual fluctuations in the forest-grasslands limits,we allocated the plots with their longest side parallel to the forest edge and covering perpendicularly 5 m of the grassland and 10 m of *** the plots we identified,mapped and measured all shrub and tree individuals with diameter at breast height(DBH)≥1 *** Findings Although many differences exist among the communities in terms of density and basal area,all of them were highly dense and had relatively low basal *** addition,both the number of individu-als and the basal area increased rapidly towards the forest *** results also revealed that the edge communities are composed mainly by small individuals that demand a great amount of *** the vertical stratification and the proportion of the functional groups are similar among the sites yet change quickly in the first 10 m of the forest ***,the floristic similarities were low among the communities mainly due to the species turnover within each ***,although the overall structure is constant in the studied edges,the low floristic similarity among them possibly indicates that the species within the same functional groups are sub-stituting each other across the *** older and seemingly stable,our results showed the gallery forest edges are quite simila

关键词： beta diversity edge effects ecotone forest-grassland transition functional groups.

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