检索结果-南通市图书馆

Taking advantage of the potential of mesenchymal stromal cells in liver regeneration:Cells and extracellular vesicles as therapeutic strategies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2018年第23期24卷 2427-2440页

作者： Esteban Juan fiore Luciana María Domínguez Juan Bayo Mariana Gabriela García Guillermo Daniel Mazzolini Laboratory of Gene Therapy Instituto de Investigaciones en Medicina TraslacionalCONICET-Universidad Austral

Cell-based therapies for acute and chronic liver diseases are under continuous progress. Mesenchymal stem/stromal cells(MSCs) are multipotent cells able to migrate selectively to damaged tissue and contribute to its healing and regeneration. The MSC pro-regenerative effect occurs due to their immunomodulatory capacity and their ability to produce factors that promote cell protection and survival. Likewise,it has been observed that part of their paracrine effect is mediated by MSC-derived extracellular vesicles(EVs). EVs contain proteins,lipids and nucleic acids(DNA,m RNA,mi RNA,lnc RNA) from the cell of origin,allowing for intercellular communication. Recently,different studies have demonstrated that MSC-derived EVs could reproduce,at least in part,the biological effects obtained by MSCbased therapies. Moreover,due to EVs' stability for long periods of time and easy isolation methods they have become a therapeutic option to MSCs treatments. This review summarizes the latest results achieved in clinical trials using MSCs as cell therapy for liver regeneration,the role of EVs in liver physiopathology and the potential of MSC-derived EVs as intercellular mediators and therapeutic tools in liver diseases.

关键词： Mesenchymal stem cells Extracellular vesicles Cirrhosis Liver Acute damage Regeneration

Ultrastructural characters of a Physarum melleum on living leaves of Dendrobium candidum in China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2007年第12期8卷 896-899页

作者： ZHANG Jing-ze LIU Lu-ning fiore-DONNO Anna-Maria XU Tong Biotechnology Institute Zhejiang University Hangzhou 310029 China Department of Biology University of York PO Box 373 York YOIO 5YW UK

A known species, Physarum melleum, was found fruiting on living leaves of Dendrobium candidum, which was collected in China in 2004. Its morphological characters were revealed by light microscopy (LM), environmental scanning elec- tron microscopy (ESEM) and scanning electron microscopy (SEM). Character variations were distinguished by its olive-yellow peridium and its always thinner capillitium containing globulose granular material between the large calcareous nodes. The cal- cium carbonate granules, deposited on stalks, peridium and hypothallus as well as within stalks, were globose and smooth.

关键词： Myxomycete Physarum Ultrastructure Fruiting site Peridium

Medicinal cannabis products for the treatment of acute pain

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2023年第12期11卷 2670-2676页

作者： marc. fiore Aniello Alfieri Sveva Di Franco Stephen Petrou Giovanni Damiani Maria Caterina Pace Department of Women Child and General and Specialized SurgeryUniversity of Campania“Luigi Vanvitelli”Naples 80138Italy Department of Emergency Medicine University of California San FranciscoSan FranciscoCA 94143United States Department of Biomedical Surgicaland Dental SciencesUniversity of MilanMilan 20122Italy

For thousands of years,medicinal cannabis has been used for pain treatment,but its use for pain management is still ***-analysis of the literature has shown contrasting results on the addition of cannabinoids to opioids compared with placebo/other active agents to reduce *** studies are mainly focused on medicinal cannabis use in chronic pain management,for which the analgesic effect has been proven in many *** review focuses on the potential use of medical cannabis for acute pain management in preclinical studies,studies on healthy subjects and the few pioneering studies in the clinical setting.

关键词： Cannabis Cannabinoids Endocannabinoid system 2-arachidonoylglycerol Anandamide Analgesia Acute pain

Tissue with high intelligence quotient Adipose-derived stem cells in neural regeneration

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2009年第12期4卷 1116-1120页

作者： George N.Chaldakov marc. fiore Anton B.Tonchev Mariyana G.Hristova Vesselka Nikolova Luigi Aloe Division of Cell Biology Medical University Institute of Neurobiology and Molecular Medicine National Research Council and Rita Levi-Montalcini European Brain Research Institute Department of Endocrinology Medical Center Third Clinic of Cardiology Intensive Cardiac Care UnitUniversity St Marina Hospital

The aim of the present review is to highlight the possible neuroregenerative potential ol adipose-derived stem cells. The key property of stem cells is plasticity including self-renewal, multilineage differentiation, and migration, whereas the required property is transplantability. For a long time, embryonic stem cells were thought to be the only source of pluripotency, a dogma that has been challenged during the last decade. Today, an alternative option might be adipose-derived stem cells, as easily accessible, ethical and autologous cellular source. Recent knowledge of adipobiology increasingly recognizes that adipose tissue is the major endo- and paracrine organ of the human body. Likewise, numerous neuropetides, neurotrophic factors, neurotransmitters, hypothalamic and steroid hormones and their receptors are shared by adipose tissue and brain. Accordingly, the regenerative potential of neuroprotective factor-secreting adipose-derived stem cells is outlined. Whether the possible benefits of adipose stem cell-based therapy may be mediated via cell transdifferentiation and/or paracrine mechanisms remains to further be evaluated.

关键词： adipose tissue neurodegeneration neurotrophic factors regeneration stem cells

Burden of severe infections due to carbapenem-resistant pathogens in intensive care unit

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2023年第13期11卷 2874-2889页

作者： Maria Caterina Pace Antonio Corrente Maria Beatrice Passavanti Pasquale Sansone Stephen Petrou Sebastiano Leone marc. fiore Department of Women Child and General and Specialized SurgeryUniversity of Campania"Luigi Vanvitelli"Naples 80138Italy Department of Emergency Medicine University of California San FranciscoSan FranciscoCA 94143United States Division of Infectious Diseases “San Giuseppe Moscati”HospitalAvellino 83100Italy

Intensive care units(ICU)for various reasons,including the increasing age of admitted patients,comorbidities,and increasingly complex surgical procedures(e.g.,transplants),have become"the epicenter"of nosocomial infections,these are characterized by the presence of multidrug-resistant organisms(MDROs)as the cause of ***,the perfect match of fragile patients and MDROs,as the cause of infection,makes ICU mortality very ***,carbapenems were considered for years as last-resort antibiotics for the treatment of infections caused by MDROs;unfortunately,nowadays carbapenem resistance,mainly among Gram-negative pathogens,is a matter of the highest concern for worldwide public *** comprehensive review aims to outline the problem from the intensivist's perspective,focusing on the new definition and epidemiology of the most common carbapenem-resistant MDROs(Acinetobacter baumannii,Pseudomonas aeruginosa and Enterobacterales)to emphasize the importance of the problem that must be permeating clinicians dealing with these diseases.

关键词： Antimicrobial resistance Multidrug-resistant PDR Carbapenem-resistance Multidisciplinary critical care Intensive care unit

Preface:Special Issue on Modeling,Simulation,and Optimization in Operational Research

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of the Operations Research Society of China 2022年第4期10卷 685-688页

作者： Gerhard-Wilhelm Weber J.Joshua Thomas José Antonio Marmolejo Saucedo Ugo fiore Igor Litvinchev Pandian Vasant Poznan University of Technology PoznanPoland Institute of Applied Mathematics Middle East Technical UniversityAnkaraTurkey UOW Malaysia KDU Penang University CollegePetaling JayaMalaysia Facultad de Ingeniería Universidad PanamericanaMexico CityMexico Parthenope University and at Federico II University NaplesItaly Nuevo Leon State University San Nicolás de los GarzaMexico MERLIN Research Centre Ton Duc Thang UniversityHo Chi Minh CityVietnam

“Operational Research”(OR)is“the discipline of applying advanced analytical methods to help make better decisions”.By using techniques such as problem structuring methods and mathematical modeling to analyze nontr... 详细信息

关键词： Simulation applying productive

Tadalafil treatment had a modest effect on endothelial cell damage and repair ability markers in men with erectile dysfunction and vascular risk

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2014年第2期16卷 290-294,I0011页

作者： fiore Pelliccione Anatolia D'ngeli Settimio D'ndrea Arcangelo Barbonetti Alfonso Pezzella Stefano Necozione Stefano Falone Fernanda Amicarelli Felice Francavilla Sandro Francavilla Department of Life Health and Environmental Sciences Section of Andrology Department of Life Health and Environmental Sciences Section of Epidemiology Department of Life Health and Environmental Sciences Section of Biological and Biotechnological Sciences University of UAquila L'Aquila Italy.

The number of the circulating angiogenic cells （CACs） and colony forming units （CFUs） derived from cultured circulating mononuclear cells （MNCs） represents a laboratory surrogate for endothelial cell repair ability. The serum of men with erectile dysfunction （ED） and vascular risk factors （VRFs） showed an increased level of endothelial cell damage/dysfunction markers and reduced the numbers of CACs and CFUs derived from the cells of healthy men. We analyzed whether treating men with ED and VRFs with the selective phosphodiesterase type 5 inhibitor tadalafil improved the endothelial cell repair ability and reduced the levels of the serum markers of endothelial cell damage/dysfunction. MNCs from healthy men were cultured with 20% serum from 36 ED patients to obtain CACs and CFUs. The ED patients were evaluated before and after 4weeks of treatment with tadalafil （20 mg every other day） or with a placebo. The tadalafil treatment improved erectile function （P = 0.0028）, but had no effect on the inhibitory effects of serum from ED patients on the CACs and CFUs derived from healthy men. The levels of endothelin-1 （P = 0.011） and tissue type plasminogen activator （P = 0.005） were reduced after treatment compared to baseline and those of the placebo group, whereas no changes were observed in the E-selectin levels. The tadalafil treatment in the ED patients with VRFs resulted in only a modest effect on the laboratory measures of the endothelial cell damage/dysfunction and repair ability. The proposed beneficial effect of phosphodiesterase type 5 inhibition on vascular homeostasis requires further analysis.

关键词： cardiovascular risk circulating angiogenic cells endothelial cell erectile dysfunction tadalafil

Differences in Morphological, Physiological and Growth Traits between Two Endemic Subspecies of <i>Brassica rupestris</i>Raf.: Implications for Their Conservation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

American Journal of Plant Sciences 2013年第6期4卷 42-50页

作者： Maria fiore Crescente Loretta Gratani Department of Environmental Biology Sapienza University of Rome Rome Italy.

The goal of this work was to analyze the phenological and physiological responses of Brassica rupestris Raf. subsp. hispida Raimondo & Mazzola and Brassica rupestris Raf. subsp. rupestris to environmental factors also in consideration of global change. We used seedlings of the two subspecies originated from wild plants from the natural habitats in Sicily and cultivated in the Botanical Garden of Rome. Leaf morphological and physiological traits and growth dynamic were analyzed as well as the response to an imposed water stress experiment. The results underlined a higher relative growth rate in plant height (RGRH, cm·cm-1·d-1) in B. rupestris subsp. rupestris also attested by the highest plant height (H, cm), leaf area (LA, cm2), specific leaf area (SLA, cm·g-1), total leaf area per plant (TLA, cm2) and total plant dry mass (PDM, g plant-1). Moreover, the significantly highest net photosynthetic rates (A, μmol CO2 m-2·s-1) during the study period of this subspecies was related to the high Chlorophyll content (Chl, SPAD units). B. rupestris subsp. rupestris was also the most tolerant subspecies to imposed water stress showing the highest relative water content (RWC, %), A and water use efficiency (WUE, μmol·mmol-1).

关键词： Brassica rupestris Raf. subsp. hispida Raimondo & Mazzola Brassica rupestris Raf. subsp. rupestris Conservation Drought Stress Endemism Global Change Growth Analysis Physiological Traits Red-Listed Species

Spontaneous fungal peritonitis: Epidemiology, current evidence and future prospective

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2016年第34期22卷 7742-7747页

作者： marc. fiore Sebastiano Leone Department of Anesthesiological Surgical and Emergency SciencesSecond University of Naples Division of Infectious Diseases "San Giuseppe Moscati" Hospital

Spontaneous bacterial peritonitis is a complication of ascitic patients with end-stage liver disease(ESLD); spontaneous fungal peritonitis(SFP) is a complication of ESLD less known and described. ESLD is associated to immunodepression and the resulting increased susceptibility to infections. Recent perspectives of the management of the critically ill patient with ESLD do not specify the rate of isolation of fungi in critically ill patients,not even the antifungals used for the prophylaxis,neither optimal treatment. We reviewed,in order to focus the epidemiology,characteristics,and,considering the high mortality rate of SFP,the use of optimal empirical antifungal therapy the current literature.

关键词： Cirrhosis Critically ill patient Spontaneous fungal peritonitis Life-threatening infections Fungal ascitis Nosocomial spontaneous peritonitis