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电力情报 1990年第2期 105-108页

作者： marc.,pa 李祖培

A new endophytic insect-associated Daldinia species, recognised from a comparison of secondary metabolite profiles and molecular phylogeny

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Fungal Diversity 2013年第3期60卷 107-123页

作者： Sylvie pažoutová Stefanie Follert Jens Bitzer Matthias Keck Frank Surup PetrŠrůtka Jaroslav Holuša marc.Stadler Institute of Microbiology of the ASCR v.v.i.Vídeňská108314220 Prague 4Czech Republic Department Microbial Drugs Helmholtz-Zentrum für Infektionsforschung GmbHInhoffenstrasse 738124 BraunschweigGermany IMD Natural Solutions GmbH Otto-Hahn-Strasse 1544227 DortmundGermany Faculty of Forestry and Wood Sciences Czech University of Life SciencesKamýcká12916521 Prague 6Czech Republic

Xylariaceous endophytes are commonly encountered in plants,and it has recently been found out that insect vectors play a major role in their life cycle,as well as in the apparent host-specificity of the fungal *** this study,a new insect-associated,endophytic anamorph species of Daldinia is recognised from a comparison of (a)morphological and ecological data;(b)molecular phylogenetic data based on rDNA,alpha-actin and beta-tubulin genes;and (c)secondary metabolite profiles based on high performance liquid chromatography/diode array/mass spectrometry(HPLC-DAD/MS)and gas chromatography/mass spectrometry(GC-MS)in comparison with authentic strains of Daldinia and other *** new species,Daldinia hawksworthii,is a symbiont of the willow woodwasp,Xiphydria prolongata,which is in turn preferentially associated with Salix.A comparison of HPLCDAD/MS profiles from standardised cultures revealed the presence of a specific compound,which was not encountered in any of the ca.250 Daldinia strains studied for *** compound was isolated after fermentation of the fungus in 10 l scale by preparative *** elucidation by NMR spectroscopy revealed a novel pyrone,for which the name dalsymbiopyrone is *** compound showed weak antimicrobial and cytotoxic effects and might be a signal molecule involved in the trilateral ecological interaction between the host plant,the insect,and its fungal symbiont.

关键词： Fungi Endophytes Evolution Xylariales Bioactive metabolites Natural products Alpha-pyrones

parametric simulation of electron backscatter diffraction patterns through generative models

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npj Computational Materials 2023年第1期9卷 285-294页

作者： Zihao Ding marc.De Graef Department of Materials Science and Engineering Carnegie Mellon UniversityPittsburghPA 15213USA

Recently,discriminative machine learning models have been widely used to predict various attributes from Electron Backscatter Diffraction(EBSD)***,there has never been any generative model developed for EBSD pattern *** one hand,the training of generative models is much harder than that of discriminative ones;On the other hand,numerous variables affecting EBSD pattern formation make the input space high-dimensional and its relationship with the distribution of backscattered electrons *** this study,we propose a framework(EBSD-CVAE/GAN)with great flexibility and scalability to realize parametric simulation of EBSD *** with the frequently used forward model,EBSD-CVAE/GAN can take variables more than just orientation and generate corresponding EBSD patterns in a single *** accuracy and quality of generated patterns are systematically *** model does not only summarize a distribution of backscattered electrons at a higher level,but also mitigates data scarcity in this field.

关键词： EBSD distribution pattern

Does white-tailed deer density affect tree stocking in forests of the Eastern United States?

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Ecological Processes 2019年第1期8卷 371-382页

作者： Brice B.Hanberry marc.D.Abrams USDA Forest Service Rocky Mountain Research StationRapid CitySD 57702USA Department of Ecosystem Science and Management Pennsylvania State University307 Forest Resources BldgUniversity ParkPA16802USA

Background:White-tailed deer(Odocoileus virginianus)have increased during the past century in the *** deer densities may reduce tree regeneration,leading to forests that are understocked,where growing space is not filled completely by *** deer pressure,a major transition in eastern forests has resulted in increased tree ***:To reconcile conflicting trends,we applied generalized linear mixed models to compare deer densities during 1982 and then 1996 to tree stocking after about 30 years and 15 years of potential reductions of small trees by deer,for the entire eastern US and 11 ecological *** also compiled deer browse preferences and compared preferred browse with trends in tree species composition from historical(1620–1900)and current tree ***:The forested area of the eastern US,including a prairie ecological province,was equally well-stocked(52%)and understocked(48%)during 2011–2017 tree *** 1982 deer densities,38%of area had deer densities>5.8 deer/km2 and for 1996,66%of area had deer densities>5.8 deer/*** densities and tree stocking were not related significantly for the entire eastern *** may reduce tree stocking in the Laurentian Mixed Forest;however,this province had both lower deer densities and greater tree stocking than other ***,major tree species trends did not match tree browse ***:Rather than too few trees,too many trees is an ecological problem where historical open oak and pine forests had herbaceous understories,and currently,trees have captured growing *** attribute other drivers than deer to explain this transition.

关键词： Driver Fire Herbivory Open forests Transition Tree density

Model-independent constraints on spin observables

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Chinese Physics C 2009年第12期33卷 1153-1158页

作者： Jean-marc.Richard Xavier Artru Mokhtar Elchikh Jacques Soffer Oleg Teryaev LPSC Université Joseph Fourier CNRS/IN2P3 INPG Grenoble France Université de Lyon IPNL Université Lyon 1 and CNRS/IN2P3 Villeurbanne France Université des Sciences et de Technologie d'Oran El Menauoer Oran Algeria Physics Department Temple University Philadelphia PA 19122 -6082 USA Bogoliubov Laboratory of Theoretical Physics JINR 141980 Dubna Russia

We discuss model-independent constraints on spin observables in exclusive and inclusive reactions, with special attention to the case of photoproduction.

关键词： spin observables positivity exclusive reactions inclusive reactions

Photoacoustic detection of circulating melanoma cells in late stage patients

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Journal of Innovative Optical Health Sciences 2020年第6期3卷 47-54页

作者： John A.Viator marc.Hazur Andrea Sajewski Ahmad Tarhini Martin E.Sanders Robert H.Edgar Department of Engineering Duquesne University 600 Forbes Avenue PittsburghPennsylvania 15282USA Department of Bioengineering University of Pittsburgh 3700 O'Hara Street PittsburghPA 15260USA Moffitt Comprehensive Cancer Center and Research Institute 10920 McKinley Drive TampaFlorida 33612USA Acousys Biodevices Inc 1777 Highland Drive Ann ArborMichigan 48108USA

Melanoma is the deadliest skin cancer and is responsible for over 7000 deaths in the US *** spread of cancer,or metastasis,is responsible for these deaths,as secondary tumors interrupt normal organ *** tumor cells,or those cells that spread throughout the body from the primary tumor,are thought to be responsible for *** developed an optical method,photoacoustic flow cytometry,in order to detect and enumerate circulating melanoma cells(CMCs)from blood samples of *** tested the blood of StageⅣmelanoma patients to show the ability of the photoacoustic flow cytometer to detect these rare cells in *** then tested the system on archived blood samples from StageⅢmelanoma patients with known outcomes to determine if detection of CMCs can predict future *** detected between 0 and 66 CMCs in StageⅣ*** the StageⅢstudy,we found that of those samples with CMCs,two remained disease free and five developed *** those without CMCs,six remained disease free and one developed *** believe that photoacoustic detection of CMCs provides valuable information for the prediction of metastasis and we postulate a system for more accurate prognosis.

关键词： Diagnosis metastasis optoacoustics

Heterogeneity and renal mass biopsy:a review of its role and reliability

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Cancer Biology & Medicine 2014年第3期11卷 162-172页

作者： Jeffrey J.Tomaszewski Robert G.Uzzo marc.C.Smaldone Division of Urology Department of SurgeryMD Anderson Cancer Center at CooperRowan University School of MedicineCamdenNJ08103USA Division of Urologic Oncology Department of Surgical OncologyFox Chase Cancer Center-Temple University Health SystemPhiladelphiaPA19111USA

Increased abdominal imaging has led to an increase in the detection of the incidental small renal mass(SRM). With increasing recognition that the malignant potential of SRMs is heterogeneous, ranging from benign(15%-20%) to aggressive(20%), enthusiasm for more conservative management strategies in the elderly and infirmed, such as active surveillance(AS), have grown considerably. As the management of the SRM evolves to incorporate ablative techniques and AS for low risk disease, the role of renal mass biopsy(RMB) to help guide individualized therapy is evolving. Historically, the role of RMB was limited to the evaluation of suspected metastatic disease, renal abscess, or lymphoma. However, in the contemporary era, the role of biopsy has grown, most notably to identify patients who harbor benign lesions and for whom treatment, particularly the elderly or frail, may be avoided. When performing a RMB to guide initial clinical decision making for small, localized tumors, the most relevant questions are often relegated to proof of malignancy and documentation(if possible) of grade. However, significant intratumoral heterogeneity has been identified in clear cell renal cell carcinoma(ccRCC) that may lead to an underestimation of the genetic complexity of a tumor when single-biopsy procedures are used. Heterogeneous genomic landscapes and branched parallel evolution of ccRCCs with spatially separated subclones creates an illusion of clonal dominance when assessed by single biopsies and raises important questions regarding how tumors can be optimally sampled and whether future evolutionary tumor branches might be predictable and ultimately targetable. This work raises profound questions concerning the genetic landscape of cancer and how tumor heterogeneity may affect, and possibly confound, targeted diagnostic and therapeutic interventions. In this review, we discuss the current role of RMB, the implications of tumor heterogeneity on diagnostic accuracy, and highlight promi

关键词： Renal cell carcinoma(RCC) renal mass biopsy(RMB) tumor heterogeneity

Tenecteplase Reperfusion therapy in Acute ischaemic Cerebrovascular Events-Ⅱ (TRACE Ⅱ): rationale and design

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Stroke & Vascular Neurology 2022年第1期7卷 71-76页

作者： Shuya Li Bruce C V Campbell Lee H Schwamm marc.Fisher Mark parsons Hao Li Yuesong pan Yongjun Wang China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Medicine and Neurology University of MelbourneMelbourneVictoriaAustralia Department of Neurology and Comprehensive Stroke Center Massachusetts General HospitalHarvard Medical SchoolBostonMassachusettsUSA Neurology Beth Israel Deaconess Medical CenterBostonMassachusettsUSA Department of Neurology Liverpool HospitalSouth Western Sydney Clinical SchoolSydneyNew South WalesAustralia

Background and purpose Tenecteplase(TNK)is a promising agent for treatment of acute ischaemic stroke(AIS).We hypothesised that recombinant human TNK tissue-type plasminogen activator(rhTNK-tpa)is non-inferior to rt-pa in achieving excellent functional outcome at 90 days,when administered within 4.5 hours of ischaemic stroke *** and design Tenecteplase Reperfusion therapy in Acute ischemic Cerebrovascular Events(TRACE)is a phase Ⅲ,multicentre,prospective,randomised,open-label,blinded-end point non-inferiority *** eligible for intravenous thrombolysis therapy are randomised to rhTNK-tpa 0.25 mg/kg(single bolus)to a maximum of 25 mg or rt-pa 0.9 mg/kg(10%bolus+90%infusion/1 hour)to a maximum of 90 *** considered necessary for the patient’s health may be given at the discretion of the investigator during 90-day *** outcomes The primary study outcome is excellent functional outcome defined as modified Rankin Scale(mRS)0–1 at 90 *** efficacy outcomes include favourable functional outcome defined as mRS≤2 at 90 days,ordinal distribution of mRS and major neurological improvement on the National Institutes of Health Stroke *** outcomes are symptomatic intracranial haemorrhage within 36 hours and death from any *** There is no completed registration study of TNK in AIS *** Ⅱ strives to provide evidence for a new drug application for rhTNK-tpa in AIS within 4.5 hours through a well-designed and rigorously executed randomised trial in China.

关键词： infusion acute rational

A Lazarus effect： A case report of Bupropion overdose mimicking brain death

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World Journal of Emergency Medicine 2018年第1期9卷 67-69页

作者： Douglas Stranges Alan Lucerna James Espinosa Neveen Malik marc.Mongeau Kelly Schiers Syed Omar Shah Joan Wiley Philip Willsie Department of Emergency Medicine Department of Internal Medicine Rowan University SOM Kennedy University Hospital Washington Twp N J USA Department of Emergency Medicine Rowan University SOM Kennedy University Hospital Stratford NJ USA Department of Pulmonaryy/Critical Care/Sleep Medicine Kennedy Health Alliance Kennedy University Hospital Washington Twp N J USA Department of Pulmonary and Critical Care Medicine Rowan University SOM Kennedy University Hospital Washington Twp N J USA Department of Neurocritical Care Thomas Jefferson University Hospital Philadelphia PA USA

Dear editor, We report a case of a 47-year-old female who presented with a toxic bupropion ingestion leading to cardiac arrest. She initially exhibited a loss of brainstem reflexes in conjunction with burst-suppression pattern on EEG. Burst suppression is an EEG waveform pattern of alternating isoelectric suppressions and high voltage bursts, Our patient ultimately made a full neurologic recovery a few days later. While there are two other cases in the literature of bupropion overdose resulting in EEG burst-suppression and loss of brainstem reflexes, we believe this is the only reported adult case complicated by cardiac arrest.

关键词： A Lazarus effect A case report of Bupropion overdose mimicking brain death

Molecular genetics of early-onset colorectal cancer

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World Journal of Biological Chemistry 2023年第2期14卷 13-27页

作者： Olivia Marx marc.Mankarious Gregory Yochum Department of Biochemistry&Molecular Biology Pennsylvania State University College of MedicineHersheyPA 17033United States Department of Surgery Division of Colon&Rectal SurgeryPennsylvania State University Milton S.Hershey Medical CenterHersheyPA 17033United States Department of Biochemistry&Molecular Biology&Surgery Pennsylvania State University College of MedicineHersheyPA 17033United States

Early-onset colorectal cancer(EOCRC)has been rising in global prevalence and incidence over the past several *** influences,including generational lifestyle changes and rising obesity,contribute to these increased *** the rise in EOCRC is best documented in western countries,it is seen throughout the world,although EOCRC may have distinct genetic mutations in patients of different ethnic *** and molecular characterizations show that EOCRC has a distinct presentation compared with later-onset colorectal cancer(LOCRC).Recent studies have identified DNA,RNA,and protein-level alterations unique to EOCRC,revealing much-needed biomarkers and potential novel therapeutic *** molecular EOCRC studies have been performed with Caucasian and Asian EOCRC cohorts,however,studies of other ethnic backgrounds are *** addition,certain molecular characterizations that have been conducted for LOCRC have not yet been repeated in EOCRC,including high-throughput analyses of histone modifications,mRNA splicing,and proteomics on large *** propose that the complex relationship between cancer and aging should be considered when studying the molecular underpinnings of *** this review,we summarize current EOCRC literature,focusing on sporadic molecular alterations in tumors,and their clinical *** conclude by discussing current challenges and future directions of EOCRC research efforts.

关键词： Early-onset colorectal cancer Later-onset colorectal cancer Mutations oncogenes Molecular characteristics Transcriptomics