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Maternal supplementation with n-3 fatty acids affects placental lipid metabolism, inflammation, oxidative stress, the endocannabinoid system, and the neonate cytokine concentrations in dairy cows

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Journal of Animal Science and Biotechnology 2024年第5期15卷 2012-2030页

作者： Priscila dos Santos Silva Gitit Kra Yana Butenko Jayasimha Rayalu Daddam Yishai levin Maya Zachut Department of Ruminant Science Institute of Animal SciencesARO Volcani InstituteRishon LeZionIsrael Department of Animal Science The Robert H.Smith Faculty of AgricultureFood and EnvironmentThe Hebrew University of JerusalemRehovotIsrael Department of Animal Sciences Michigan State UniversityEast LansingMIUSA The Nancy and Stephen Grand Israel National Center for Personalized Medicine Weizmann Institute of ScienceRehovotIsrael

Background The placenta plays a crucial role in supporting and influencing fetal *** compared the effects of prepartum supplementation with omega-3(n-3)fatty acid(FA)sources,flaxseed oil(FLX)and fish oil(FO),on the expression of genes and proteins related to lipid metabolism,inflammation,oxidative stress,and the endocannabinoid system(ECS)in the expelled placenta,as well as on FA profile and inflammatory response of ***-pregnant Holstein dairy cows were supplemented with saturated fat(CTL),FLX,or *** cotyledons(n=5)were collected immediately after expulsion,and extracted RNA and proteins were analyzed by RTPCR and proteomic *** blood was assessed for FA composition and concentrations of inflammatory *** FO increased the gene expression of fatty acid binding protein 4(FABP4),interleukin 10(IL-10),catalase(CAT),cannabinoid receptor 1(CNR1),and cannabinoid receptor 2(CNR2)compared with CTL *** expression of ECS-enzyme FA-amide hydrolase(FAAH)was lower in FLX and FO than in *** analysis identified 3,974 proteins;of these,51–59 were differentially abundant between treatments(P≤0.05,|fold change|≥1.5).Top canonical pathways enriched in FLX *** and in FO *** were triglyceride metabolism and inflammatory *** n-3 FA increased the placental abundance of FA binding proteins(FABPs)3 and *** abundance of CNR1 cannabinoid-receptor-interacting-protein-1(CNRIP1)was reduced in FO *** silico modeling affirmed that bovine FABPs bind to *** FLX increased the abundance of inflammatory CD44-antigen and secreted-phosphoprotein-1,whereas prostaglandin-endoperoxide synthase 2 was decreased in FO *** *** FO enriched neonatal plasma with n-3 FAs,and both FLX and FO reduced interleukin-6 concentrations compared with *** Maternal n-3 FA from FLX and FO differentially affected the bovine placenta;both enhanced lipid metabolism and modulated oxidative s

关键词： Antioxidants Dairy cows Endocannabinoid system Inflammation Omega-3 fatty acids Placenta

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Coupled thermo-hydro-mechanical modeling of frost heave and water migration during artificial freezing of soils for mineshaft sinking

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Journal of Rock Mechanics and Geotechnical Engineering 2022年第2期14卷 537-559页

作者： M.Zhelnin A.Kostina A.Prokhorov O.Plekhov M.Semin L.levin Institute of Continuous Media Mechanics of the Ural Branch of the Russian Academy of Sciences Perm614013Russia Mining Institute of the Ural Branch of the Russian Academy of Sciences Perm614007Russia

Artificial freezing of water-bearing soil layers composing a sedimentary deposit can induce frost heave and water migration that affect the natural stress-strain state of the soil layers and freezing *** the present paper,a thermo-hydro-mechanical(THM)model for freezing of water-saturated soil is proposed to study the effects of frost heave and water migration in frozen soils on the formation of a frozen wall and subsequent excavation activity for sinking a vertical *** governing equations of the model are formulated relative to porosity,temperature,and displacement which are considered as primary *** relationship between temperature,pore water,and ice pressure in frozen soil is established by the Clausius-Clapeyron equation,whereas the interaction between the stress-strain behavior and changes in porosity and pore pressure is described with the poromechanics ***,constitutive relations for additional mechanical deformation are incorporated to describe volumetric expansion of soil during freezing as well as creep strain of soil in the frozen *** ability of the proposed model to capture the frost heave of frozen soil is demonstrated by a comparison between numerical results and experimental data given by a one-sided freezing *** to validate the model in other freezing conditions,a radial freezing experiment is *** the validation procedure,the model is applied to numerical simulation of artificial freezing of silt and sand layers for shaft sinking at Petrikov potash mine in *** of calculated temperature with thermal monitoring data during active freezing stage is *** analysis of deformation of unsupported sidewall of a shaft inside the frozen wall is conducted to account for the change in natural stress-strain state of soil layers induced by artificial freezing.

关键词： Artificial ground freezing(AGF) Thermo-hydro-mechanical(THM)modeling Frost effects Frozen wall Shaft sinking

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Zero-emission public transit could be a catalyst for decarbonization of the transportation and power sectors

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Clean Energy 2021年第3期5卷 492-504页

作者： Anthony Y.Ku Andrew de Souza Jordan McRobie Jimmy XLi Jaimie levin NICE America Research Mountain ViewCA 94043USA National Institute of Clean-and-Low-Carbon Energy Beijing 102209P.R.China Center for Transportation and the Environment BerkeleyCA 94704USA

Reaching carbon neutrality will require investment on an unprecedented *** we suggest that there is an underappreciated opportunity to leverage public funds to mobilize private capital in support of these *** illustrate the point using examples from public *** the fuelling energy requirements of public fleets represent a small fraction of the eventual total demand across the transportation sector,the predictable and long-term nature of the refuelling profiles can reduce the financing *** appropriate coordination across the energy supply chain,near-term investments can be used to support scale-up of wider efforts to decarbonize the transportation sector and electric *** present two examples from California-one related to overnight power for battery electric bus charging and the other related to medium-scale supply chains for zero-carbon hydrogen production-to illustrate how this might be achieved.

关键词： carbon neutrality electric vehicles fuel-cell vehicles hydrogen infrastructure net-zero emissions public transit transition

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Toll-like receptors in inflammatory bowel disease-stepping into uncharted territory

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World Journal of Gastroenterology 2008年第33期14卷 5149-5153页

作者： Avi levin Oren Shibolet Liver and Gastroenterology Units Division of Medicine Hadassah-Hebrew University Medical CenterJerusalem 91120 Israel

Ulcerative colitis and Crohn's disease are chronic relapsing-remitting inflammatory processes of the intestinal tract. The etiology of these diseases is currently unknown. However, inflammation is hypothesized to result from inappropriate activation of mucosal immunity by luminal antigens in genetically susceptible individuals. Toll-like receptors (TLRs) are a family of transmembrane proteins that act as microbial pattern recognition receptors. They are crucial initiators of innate immune responses. The role of TLRs in the pathogenesis of inflammatory bowel disease (IBD) has not been fully elucidated. In this review, we aim to analyze the available data connecting individual TLRs to intestinal inflammation and IBD.

关键词： Toll-like receptors Inflammatory bowel disease Intestinal inflammation

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Compensation Method： New Perspectives

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Journal of Physical Science and Application 2014年第2期4卷 119-129页

作者： Boris levin Holon Institute of Technology Holon 58102 Israel

The compensation method aiming to reduce the irradiation on the user＇s body and to form a weak field area （a dark spot） in an antenna near region is considered. The results of the method development for the use in a narrow frequencies range are given. They show that under realistic conditions the compensation method allows reducing the irradiation power by a factor of 3-4 and more. The pattern changes are predictable and small, if the points of antennas placement are selected correctly. The dark spot necessity near the transmitter is not limited by mobile communication. A man often uses a low-power radio station, which is placed nearby in a vehicle, and it is necessary to protect from irradiation not only user but also other passengers. In the paper, it is shown that broadband field compensation can be achieved in various structures where the needed anti-phase fields are created either by identical antennas or by radiators located at equal distance from the compensation point, or by flat reflectors.

关键词： Antenna theory compensation mobile antennas mutual coupling near fields

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Quantifying relations between altered hydrology and fish community responses for streams in Minnesota

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Ecological Processes 2022年第1期11卷 536-560页

作者： Jeffrey R.Ziegeweid Gregory D.Johnson Aliesha L.Krall Kara Fitzpatrick Sara B.levin U.S.Geological Survey California Water Science Center6000 J StPlacer HallSacramentoCA 85819USA U.S.Geological Survey Upper Midwest Water Science Center2280 Woodale DrMounds ViewMN 55112USA Minnesota Pollution Control Agency 520 Lafayette RdSt.PaulMN 55155USA Minnesota Pollution Control Agency 7678 College RoadSuite 105BaxterMN 56425USA

Background:Altered hydrology is a stressor on aquatic life,but quantitative relations between specific aspects of streamflow alteration and biological responses have not been developed on a statewide scale in *** sub-sets regression analysis was used to develop linear regression models that quantify relations among five categories of hydrologic metrics(i.e.,duration,frequency,magnitude,rate-of-change,and timing)computed from streamgage records and six categories of biological metrics(i.e.,composition,habitat,life history,reproductive,tolerance,trophic)computed from fish-community samples,as well as fish-based indices of biotic integrity(FIBI)scores and FIBI scores normalized to an impairment threshold of the corresponding stream class(FIBI_BCG4).Relations between hydrology and fish community responses were examined using three hydrologic datasets that represented periods of record,long-term changes,and short-term changes to flow regimes in streams of ***:Regression models demonstrated significant relations between hydrologic explanatory metrics and fish-based biological response metrics,and the five regression models with the strongest linear relations explained over 70%of the variability in the biological metric using three hydrologic metrics as explanatory ***-based biological metrics demonstrated the strongest linear relations to hydrologic *** most commonly used hydrologic metrics were related to bankfull flows and aspects of flow ***:Final regression models represent paired streamgage records and biological samples throughout the State of Minnesota and encompass differences in stream orders,hydrologic landscape units,and watershed *** methods can support evaluations of stream fish communities and facilitate targeted efforts to improve the health of fish *** also can be applied to locations outside of Minnesota with continuous streamgage data and fish-community sampl

关键词： EflowStats Best subset regression Altered hydrology Fish community Indices of biotic integrity Ecological flows

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Coldplay＇s Chris Martin

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空中英语教室（高级版．彭蒙惠英语） 2009年第11期 21-23,43,44页

作者： Jordan levin

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Lower extremity amputation:the emerging role of targeted muscle reinnervation(TMR)and regenerative peripheral nerve interface(RPNI)

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Plastic and Aesthetic Research 2022年第1期9卷 334-350页

作者： Yoshiko Toyoda Said Azoury Andrew Bauder L.Scott levin Stephen Kovach Division of Plastic and Reconstructive Surgery University of PennsylvaniaPhiladelphiaPA 19104USA Department of Plastic and Reconstructive Surgery Memorial Sloan Kettering Cancer CenterNew YorkNY 10065USA Department of Orthopedic Surgery University of PennsylvaniaPhiladelphiaPA 19104USA

Lower extremity amputation is increasingly prevalent in the United States,with growing numbers of patients suffering from diabetes and peripheral vascular *** has significant functional sequelae as more than half of patients are unable to ambulate at one year *** mobility and decreasing chronic post-amputation pain can significantly improve the quality of life for these patients and reduce the cost burden on the healthcare *** and reconstructive surgery has been at the forefront of“reconstructive amputation”,in which nerve pedicles can be surgically guided to decrease painful neuroma formation as well as provide targets for myoelectric prosthesis *** herein review post-amputation outcomes,epidemiology of chronic,post-amputation pain,and current treatments,including total muscle reinnervation and regenerative peripheral nerve interface,which are at the forefront of multidisciplinary treatment of lower extremity amputees.

关键词： Lower extremity amputation post-amputation pain neuroma targeted muscle reinnervation regenerative peripheral nerve interface

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Thirty-two essential questions for understanding the social-ecological system of forage fish:the case of pacific herring

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Ecosystem Health and Sustainability 2016年第4期2卷 44-55页

作者： Phillip S.levin Tessa B.Francis Nathan G.Taylor Conservation Biology Division Northwest Fisheries Science CenterNOAA Fisheries2725 Montlake Boulevard EastSeattleWashington 98112USA Puget Sound Institute University of Washington Tacoma326 East D StreetTacomaWashington 98421USA Fisheries and Oceans Canada 3190 Hammond Bay RoadNanaimoBritish Columbia V9T 1K6Canada

Forage fishes are ecologically and economically important low trophic level species,and in recent years interest in their biology and management has *** Herring are emblemat-ic of the management issues facing forage species-they are central components of the Northeast Pacific pelagic food web and support important commercial *** addition,the importance of Herring to indigenous peoples have made them cultural keystone *** employed a participatory process to promote collaborative priority-setting for this critical forage *** with managers,the fisher-ies industry,indigenous peoples,and scientists,we co-constructed a conceptual model of the Pacific Her-ring social-ecological system(SES)in the Northeast *** then identified a set of questions,that,if answered,would significantly increase our ability to sustainably manage the Herring *** objective was to generate a road map for scientists who wish to conduct useful forage fish research,for resource managers who wish to develop new research efforts that could fill critical gaps,and for public agencies and private foundations seeking to prioritize funding on forage fish issues in the *** this socio-cultural centrality comes complexity for fisheries *** participatory process highlighted the value of conceptualizing the full SES,overcame disciplinary differences in scientific approaches,research philos-ophy,and language,and charted a path forward for future research and management for forage species.

关键词： fisheries forage fish interdisciplinary science Pacific Herring Pacific Ocean social-ecological system

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Rain Music

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小学生时代（大嘴英语） 2022年第6期 20-23页

作者： Neal levin Shannon Day(图) 不详

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