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Role of endoscopy in predicting the disease course in inflammatory bowel disease

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World Journal of Gastroenterology 2010年第21期16卷 2626-2632页

作者： Matthieu Allez marc lémann Department of Gastroenterology and Equipe AVENIR INSERM Saint-Louis HospitalAPHPUniversité Denis Diderot Paris 775010 ParisFrance

Endoscopy provides a direct evaluation of mucosal lesions in inflammatory bowel disease(IBD),permitting the description of elementary lesions,their surface extent and *** severity of mucosal lesions directly reflects disease activity and may help to identify an aggressive behavior of the *** studies have recently pointed out the potential role of endoscopy in the prediction of IBD ***,severe endoscopic lesions in Crohn's disease(CD) patients,defined by deep and extensive ulcerations on at least one part of the colon,are associated with an increased risk of penetrating complication and *** endoscopic lesions during severe attacks of ulcerative colitis(UC) are associated with an increased risk of colectomy in the short and long *** of postoperative recurrence in CD may help to predict the risk of clinical relapse and need for further *** of mucosal healing,which can be obtained by administration of several types of drugs,is associated with a better outcome,less surgery and *** review focuses on the assessment of endoscopic severity in CD and UC and on the impact of endoscopic severity on disease *** specifically,we discuss how endoscopy can be used at different stages of IBD to predict the disease course and/or to adapt treatment strategies.

关键词： Crohn’s disease Ulcerative colitis Inflammatory bowel disease Colonoscopy Natural history Outcome Medical therapy Surgery

Beginning from the end:the presynaptic terminal as a pathomechanism hub in frontotemporal dementia and amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3217-3218页

作者： laura Huggon Emma l.Clayton UK Dementia Research Institute at King’s College london LondonUK Department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F T D)and amyo t rophic lateral sclerosis(AlS)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with FTD affecting neurons of the frontal and temporal lobes,and AlS affecting upper and lower motor neurons),these two diseases are complexly *** and AlS exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

3D topological relationships of landforms and their spatial schema-based representation

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Geo-Spatial Information Science 2013年第4期16卷 238-246页

作者： marc-O.lÖWNER Institute for Geodesy and Photogrammetry Technische Universität BraunschweigPockelsstraβe 330106 BraunschweigGermany

The science of geomorphology works on natural 3D *** includes the change of landforms as well as the processes causing these *** transport processes lead to a composition of a geomorphic system that follows a certain spatial *** analysis of 3D topological relations of landforms can help to investigate geomorphic systems in two ***,chronological order of geomorphic genesis can be derived and,second,indications of material source can be ***,at least some 3D geometric information is needed if topology is supposed to be derived and *** cannot simply be reconstructed by surface *** capture is a major problem when buried features are under *** information is gathered by drillings or geophysical methods that reveal point or line ***,the ISO 19107 Spatial Schema does not offer a valid representation of 3D geometry from sparse data,either by aggregating a surface and one or few points or by aggregating a surface and a ***,we discuss the possibilities for the analysis of chronological order of landform genesis and material dependencies that arise from applying 3D topological relationships to geomorphic system *** show five relationships that are able to be observed in ***,we introduce a new class for the representation of 3D objects with under-specified geometry.A_UG_Solid mediates between the Spatial Schema’s geometric primitives with a dimension less than three on the one side and a GM_Solid on the other *** to aggregate such a_UG_Solid are *** introduction of a_UG_Solid facilitates the application of 3D topological concepts to geometric objects that are known to be volumetric but have to be modeled from sparse data.

关键词： 3D Topology geomorphology landform ISO 19107 spatial schema under-specified geometries

Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon C.Smith Jessica l.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(CNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael J.lee Ryota l.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

Force and impulse multi-sensor based on flexible gate dielectric field effect transistor

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 214-220页

作者： Chao Tan Junling lü Chunchi Zhang Dong liang lei Yang Zegao Wang College of Materials Science and Engineering Sichuan UniversityChengdu 610065China The 54th Research Institute of China Electronics Technology Group Corporation Shijiazhuang 050081China

Nowadays,force sensors play an important role in industrial production,electronic information,medical health,and many other ***-dimensional material-based filed effect transistor(2D-FET)sensors are competitive with nano-level size,lower power consumption,and accurate ***,few of them has the capability of impulse detection which is a path function,expressing the cumulative effect of the force on the particle over a period of *** we fabricated the flexible polymethyl methacrylate(PMMA)gate dielectric MoS_(2)-FET for force and impulse sensor *** systematically investigated the responses of the sensor to constant force and varying forces,and achieved the conversion factors of the drain current signals(I_(ds))to the detected impulse(I).The applied force was detected and recorded by I_(ds)with a low power consumption of~30 *** sensitivity of the device can reach~8000%and the 4×1 sensor array is able to detect and locate the normal force applied on ***,there was almost no performance loss for the device as left in the air for two months.

关键词： flexible gate dielectric transistor force sensor impulse sensor force sensor array

Viscosity and structure relationship with equimolar substitution of CaO with MgO in the CaO–MgO–Al_(2)O_(3)–SiO_(2)slag melts

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 70-79页

作者： Yong Hou Shuo Zhang Jie Dang Jia Guo Hanghang Zhou Xuewei lü College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Chongqing Key laboratory of Vanadium-Titanium Metallurgy and New Materials Chongqing UniversityChongqing 400044China

Currently,the Al_(2)O_(3)content in the high-alumina slag systems within blast furnaces is generally limited to 16wt%–18.5wt%,making it challenging to overcome this *** most studies that concentrated on managing the MgO/Al_(2)O_(3)ratio or basicity,this paper explored the effect of equimolar substitution of MgO for CaO on the viscosity and structure of a high-alumina CaO-MgO-Al_(2)O_(3)-SiO_(2)slag system,providing theoretical guidance and data to facilitate the application of high-alumina *** results revealed that the viscosity first decreased and then increased with higher MgO substitution,reaching a minimum at 15mol%MgO *** transform infrared spectroscopy(FTIR)results found that the depths of the troughs representing[SiO_(4)]tetrahedra,[AlO_(4)]tetrahedra,and Si-O-Al bending became progressively deeper with increased MgO *** of the Raman spectra showed that the average number of bridging oxygens per Si atom and the X_(Q^(3))/X_(Q^(2))(X_(Q^(i))is the molar fraction of Q^(i) unit,and i is the number of bridging oxygens in a[SiO_(4)]tetrahedral unit)ratio increased from 2.30 and 1.02 to 2.52 and 2.14,respectively,indicating a progressive polymerization of the silicate structure.X-ray photoelectron spectroscopy(XPS)results highlighted that non-bridging oxygen content decreased from 77.97mol% to 63.41mol% with increasing MgO concentration,whereas bridging oxygen and free oxygen contents *** analysis demonstrated a gradual increase in the polymerization degree of the tetrahedral structure with the increase in MgO ***,bond strength is another important factor affecting the slag *** occurrence of a viscosity minimum can be attributed to the complex evolution of bond strengths of non-bridging oxygens generated during depolymerization of the[SiO_(4)]and[AlO_(4)]tetrahedral structures by CaO and MgO.

关键词： aluminosilicate viscosity structure spectroscopy

Bound and Resonating Multiquark Configurations

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Chinese Physics letters 2024年第8期41卷 8-12页

作者： Jean-marc Richard Institut de Physique des 2 Infinis de lyon Université Claude Bernard(lyon 1) CNRS-IN2P34 rue Enrico Fermi69622 VilleurbanneFrance

We review the predictions of quark models for multiquark configurations that are bound or resonant states,and compare different methods for estimating the properties of resonances.

关键词： quark Configuration resonant

Fibre optic distributed scattering sensing system:perspectives and challenges for high performance applications

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仪器仪表学报 2007年第8期28卷 1345-1352页

作者： marc Niklès Omnisens SA Riond-Bosson 3CH-1110 MorgesSwitzerland

As fiber optic distributed scattering sensing systems are providing innovative solutions for the monitoring of large structures,the comparison of different techniques and solutions is difficult because of the lack of standardized specifications and the difficulty associated to the characterization of such *** article presents a tentative definition of performance specifications and qualification procedures applicable to fiber optic distributed sensing systems aiming at providing clear guidelines for their design,specifications,qualification,application and selection.

关键词：纤维光学传感器分布式散射传感系统发展前景应用布里渊散射空间分辨率温度