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CD70 defines a subset of proinflammatory and CNSpathogenic TH1/TH17 lymphocytes and is overexpressed in multiple sclerosis

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Cellular & Molecular Immunology 2019年第7期16卷 652-665页

作者： Tessa Dhaeze Laurence Tremblay Catherine Lachance Evelyn Peelen Stephanie Zandee Camille Grasmuck Lyne Bourbonnière Sandra Larouche Xavier Ayrignac Rose-Marie Rébillard Josée Poirier Boaz Lahav Pierre Duquette marc girard Robert Moumdjian Alain Bouthillier Catherine Larochelle Alexandre Prat Department of Neuroscience Faculty of MedicineUniversitéde Montréaland Centre de Recherche du CHUM(CRCHUM)MontréalQC H2X0A9Canada Multiple Sclerosis Clinic Division of NeurologyCHUMMontréalQC H2X0A9Canada Division of Neurosurgery CHUMMontréalQC H2X0A9Canada CD70 is the unique ligand of CD27 and is expressed on immune cells only upon

***,engagement of the costimulatory CD27/CD70 pathway is solely dependent on upregulation of ***,the T cell-intrinsic effect and function of human CD70 remain ***,we describe that CD70 expression distinguishes proinflammatory CD4^(+)T lymphocytes that display an increased potential to migrate into the central nervous system(CNS).Upregulation of CD70 on CD4^(+)T lymphocytes is induced by TGF-β1 and TGF-β3,which promote a pathogenic *** addition,CD70 is associated with a TH1 and TH17 profile of lymphocytes and is important for T-bet and IFN-γexpression by both T helper ***,adoptive transfer of CD70−/−CD4^(+)T lymphocytes induced less severe experimental autoimmune encephalomyelitis(EAE)disease than transfer of WT CD4^(+)T ***70+CD4^(+)T lymphocytes are found in the CNS during acute autoimmune inflammation in humans and mice,highlighting CD70 as both an immune marker and an important costimulator of highly pathogenic proinflammatory TH1/TH17 lymphocytes infiltrating the CNS.

关键词： CD70+CD4^(+)T lymphocytes multiple sclerosis CD27/CD70 pathway TGF-β1 TGF-β3 soluble CD70 blood-brain barrier endothelial cells experimental autoimmune encephalitis TCR1640 transgene mouse model

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沙漠中的“北非好莱坞” 柏柏尔人的“金字塔”村庄

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环球人文地理 2021年第9期 92-99页

作者：祁斐 marc girard Valentin Munitsa Tatiana Zanon 这儿没有好小的那只熊

在摩洛哥中部的沙漠腹地,有一座古老的柏柏尔人原始村庄,充满独特的异域风情。同时,这里也先后成为众多影视大片的取景地,有着"北非好莱坞"的别称。阿伊特·本·哈杜筑垒村,位于摩洛哥中部的瓦尔扎扎特省,雄伟的阿特拉斯山脉间。它修建...

在摩洛哥中部的沙漠腹地,有一座古老的柏柏尔人原始村庄,充满独特的异域风情。同时,这里也先后成为众多影视大片的取景地,有着"北非好莱坞"的别称。阿伊特·本·哈杜筑垒村,位于摩洛哥中部的瓦尔扎扎特省,雄伟的阿特拉斯山脉间。它修建于12世纪柏柏尔人穆瓦希德王朝的鼎盛时期,历经几百年岁月洗礼,仍保存完好。最初,这座村庄的建立是为进行军事防御,因此内部除了平房和住宅之外,还有指挥所、马厩,以及粮草和弹药库房等。

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Prognostication algorithm for non-cirrhotic non-B non-C hepatocellular carcinoma-a multicenter study under the aegis of the French Association of Hepato-Biliary Surgery and liver Transplantation

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Hepatobiliary Surgery and Nutrition 2023年第2期12卷 192-204,I0002-I0004页

作者： Charlotte Maulat Stéphanie Truant Christian Hobeika Louise Barbier Astrid Herrero Alexandre Doussot Johan Gagnière Édouard girard Hadrien Tranchart Jean-marc Regimbeau David Fuks François Cauchy Mathieu Prodeau Antoine Notte Cyprien Toubert Ephrem Salamé Mehdi El Amrani Sandrine Andrieu Fabrice Muscari Jason Shourick Bertrand Suc Department of Digestive Surgery Hepatobiliary and Pancreatic Surgery and Liver Transplantation UnitToulouse University HospitalToulouseFrance Department of Digestive Surgery and Transplantation Claude-HuriezHospitalCHRU LilleLilleFrance CANTHER laboratory“Cancer Heterogeneity Plasticity and Resistance to Therapies”Inserm UMR-S1277 Teams“MucinsCancer and Drug Resistance”LilleFrance Department of Hepato-bilio-pancreatic Surgery and Liver Transplantation Beaujon HospitalAPHPClichyFrance Department of Digestive Surgery and Liver Transplantation Trousseau HospitalTours University HospitalToursFrance Department of Digestive Surgery and Liver Transplantation Saint Eloi HospitalMontpellier University HospitalMontpellierFrance Department of Digestive Surgery and Liver Transplantation Besançon University HospitalBesançonFrance Department of Digestive and Hepatobiliary Surgery University Hospital of Clermont-FerrandClermont-FerrandFrance U1071 Inserm/UniversitéClermont-Auvergne Clermont-FerrandFrance Department of Digestive Surgery and Emergency CHU Grenoble-AlpesGrenobleFrance Department of Mini-invasive Surgery Antoine Béclère HospitalAPHPClamartFrance Department of Digestive Surgery Amiens Picardie University Hospital and Picardie Jules Verne UniversityAmiensFrance Department of Digestive Surgery Institut Mutualiste MontsourisParisFrance Department of Epidemiology Toulouse University HospitalToulouseFrance

Background:Liver resection and local ablation are the only curative treatment for non-cirrhotic hepatocellular carcinoma(HCC).Few data exist concerning the prognosis of patients resected for non-cirrhotic *** objectives of this study were to determine the prognostic factors of recurrence-free survival(RFS)and overall survival(OS)and to develop a prognostication algorithm for non-cirrhotic ***:French multicenter retrospective study including HCC patients with non-cirrhotic liver without underlying viral hepatitis:F0,F1 or F2 ***:A total of 467 patients were included in 11 centers from 2010 to ***-cirrhotic liver had a fibrosis score of F0(n=237,50.7%),F1(n=127,27.2%)or F2(n=103,22.1%).OS and RFS at 5 years were 59.2%and 34.5%,*** multivariate analysis,microvascular invasion and HCC differentiation were prognostic factors of OS and RFS and the number and size were prognostic factors of RFS(P10 cm(n=176,Group 2);>2 HCC regardless of size Conclusions:We developed a prognostication algorithm based on the number(≤or>2)and size(≤or>10 cm),which could be used as a treatment decision support concerning the need for perioperative *** case of bifocal HCC,surgery should not be a contraindication.

关键词： Hepatocellular carcinoma(HCC) non-cirrhotic liver prognostic factors recurrence-free survival(RFS) prognostication algorithm

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