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有时彩虹也徒有虚名

中国新时代 2003年第1期 33-38页

作者： mara

一道红光,闪耀在眼前。原来彩虹也徒有虚名。梦幻其实有另外的名字。美丽,其实可能为一个色彩占据。

关键词：彩虹

Testicular fine-needle aspiration for the assessmen＇ of intratesticular hormone concentrations

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Asian Journal of Andrology 2016年第1期18卷 21-24页

作者： Ada P Lee mara Y Roth Jean-Jacques Nya-Ngatchou Kat Lin Thomas J Walsh Stephanie T Page Alvin M Matsumoto William J Bremner John K Amory Bradley D Anawalt Department of Medicine University of California San Francisco San Francisco CA USA Department of Medicine and Center for Research in Reproduction and Contraception University of Washington Seattle WA USA Department of Obstetrics and Gynecology University of Washington Seattle WA USA Department of Urology University of Washington Seattle WA USA Department of Medicine Geriatric Research Education and Clinical Center VA Puget Sound Health Care System Seattle WA USA.

Measurement of intratesticular sex steroid concentrations in men informs both the development of male hormonal contraceptives and the understanding of male infertility. Given the challenges of using invasive techniques to measure testicular hormone physiology, our group has used a minimally-invasive fine-needle aspiration technique to measure intratesticular hormones in normal healthy men. Herein, we present a post-hoc analysis of the safety and efficacy of testicular fine-needle aspiration （FNA） completed as part of six clinical trials. From 2001 through 2011, a total of 404 procedures were conducted among 163 research volunteers, 85.9% of which were successful in obtaining sufficient fluid for the measurement of intratesticular steroid concentrations. Pain was the most common side effect, with 36.8% of procedures associated with moderate procedural pain and 4.7% with severe procedural pain. Postprocedural pain was uncommon and abated within a few days. Mild local bruising occurred with 14.9% of procedures. Two serious adverse events （0.5%） required surgical intervention. The risk of an adverse event was not associated with age, body mass index, testicular size, or the volume of fluid aspirated. Testicular FNA to obtain fluid for measurement of intratesticular steroid concentrations frequently causes mild to moderate procedural pain, but serious adverse events occur rarely. Testicular FNA has been instrumental for defining human intratesticular hormone physiology and is a minimally-invasive, safe, effective method for obtaining fluid for research on testicular physiology and pathology.

关键词： male contraception physiology reproductive and urinary testis

The emerging TDP-43 proteinopathy

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Neuroimmunology and Neuroinflammation 2018年第5期5卷 4-6页

作者： George P.Paraskevas mara Bourbouli Ioannis Zaganas Elisabeth Kapaki Cognitive and Movement Disorders Clinic and Neurochemistry Unit 1st Department of NeurologySchool of MedicineNationaland Kapodistrian University of AthensAthens11528Greece Neurology Laboratory of the Department of Neurology School of MedicineUniversity of CreteCrete71003Greece

Currently, neurodegenerative diseases are viewed as proteinopathies. In this context, a specific protein or peptide is involved in the pathogenesis of the disease by missfolding, polymerization, reduced degradation and final accumulation in the form of insoluble inclusions leading to neurodegeneration by various interacting mechanisms[1,2].

关键词： The emerging TDP-43 neurodegenerative diseases

Assessing radiation dose for postoperative radiotherapy in prostate cancer: Real world data

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World Journal of Clinical Oncology 2022年第7期13卷 652-662页

作者： Asunción Hervás-Morón Jose Domínguez-Rullán Victor Duque Santana Mireia Valero Carmen Vallejo Sonsoles Sancho Juan David García Fuentes Miguel Cámara Gallego Fernando López-Campos Department of Radiation Oncology Hospital Universitario Ramón Y CajalMadrid 28034Spain Department of Medical Physics Hospital Universitario Ramón Y CajalMadrid 28034Spain

BACKGROUND Approximately 30%of patients with localized prostate cancer(PCa)who undergo radical prostatectomy will develop biochemical *** these patients,the only potentially curative treatment is postoperative radiotherapy(PORT)with or without hormone ***,the optimal radiotherapy dose is unknown due to the limited data *** To determine whether the postoperative radiotherapy dose influences biochemical failure-free survival(BFFS)in patients with *** Retrospective analysis of patients who underwent radical prostatectomy for PCa followed by PORT-either adjuvant radiotherapy(ART)or salvage radiotherapy(SRT)-between April 2002 and July *** 2002 to 2010,the prescribed radiation dose to the surgical bed was 66-70 Gy in fractions of 2 Gy;from 2010 until July 2015,the prescribed dose was 70-72 *** were grouped into three categories according to the total dose administered:66-68 Gy,70 Gy,and 72 *** primary endpoint was BFFS,defined as the post-radiotherapy prostatespecific antigen(PSA)nadir+0.2 ng/*** endpoints were overall survival(OS),cancer-specific survival(CSS),and metastasis-free survival(MFS;based on conventional imaging tests).Treatment-related genitourinary(GU)and gastrointestinal(GI)toxicity was evaluated according to Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer ***,we aimed to identify potential prognostic ***,OS,CSS,and MFS were calculated with the Kaplan-Meier method and the log-rank *** and multivariate Cox regression models were performed to explore between-group differences in survival outcome *** A total of 301 consecutive patients were *** these,93(33.6%)received ART and 186(66.4%)SRT;22 patients were excluded due to residual macroscopic disease or local recurrence in the surgical *** this subgroup(n=93),43 patients(46.2%)were Gleason score(GS)≤6,44(47.3%)GS 7,and 6(6.5%)GS≥8;clinical stage

关键词： Prostate cancer Postoperative radiotherapy Dose intensified Radiation dose Biochemical relapse free survival

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亚勒坦的神秘女性世界

世界知识画报（艺术视界） 2009年第4期 20-25页

作者： mara Ferloni

2009年3月20日至26日，意大利女艺术家安娜丽塔·亚勒坦在中央美术学院美术馆举办《思想的泉涌——安娜丽塔·亚勒坦的神秘女性世界》个人作品展。展览由中央美术学院造型学院主办，展出了艺术家近年来创作的40幅油画、丙烯作品。意大... 详细信息

2009年3月20日至26日，意大利女艺术家安娜丽塔·亚勒坦在中央美术学院美术馆举办《思想的泉涌——安娜丽塔·亚勒坦的神秘女性世界》个人作品展。展览由中央美术学院造型学院主办，展出了艺术家近年来创作的40幅油画、丙烯作品。意大利驻华使馆文化参赞，中央美术学院领导、师生以及国内外美术界、音乐界、影视界的嘉宾朋友出席了开幕式。

关键词：女性世界神秘中央美术学院个人作品女艺术家文化参赞驻华使馆意大利

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新不了配饰情

中国新时代 2002年第11期 26-27页

作者： mara

2002/2003秋冬,时尚变换纷繁。配饰,无疑又是挑大梁的重头戏,注重细节的高档时装品牌都在配饰这个细节上下足了功夫。把握住配饰的走向,从某种程度上也就把握住了时尚的脉搏。与其倾囊添置高档时装,让人心有余而力不足,不如把精力更... 详细信息

2002/2003秋冬,时尚变换纷繁。配饰,无疑又是挑大梁的重头戏,注重细节的高档时装品牌都在配饰这个细节上下足了功夫。把握住配饰的走向,从某种程度上也就把握住了时尚的脉搏。与其倾囊添置高档时装,让人心有余而力不足,不如把精力更多地投向配饰的选择。时尚,其实真的还是在细节。

关键词：配饰高跟鞋山茶花观花树木

Chemical Characterization of PM10 Particulate Matter in the Ambient Air of a Region of Central Italy (Umbria)

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International Journal of Analytical Mass Spectrometry and Chromatography 2015年第3期3卷 47-53页

作者： mara Galletti Silvia Castellini Andrea Pileri Caterina Austeri Marco Pompei Monica Angelucci ARPA Umbria Perugia Italy Department of Chemistry Biology and Biotechnology University of Perugia Perugia Italy

Atmospheric particulate matter is a critical factor for many regional urban areas of Umbria (Central Italy region). During 2013 the monitoring air quality network, managed by ARPA Umbria, has been upgraded to Legislative Decree of 13 August 2010, n.155 and an analytical study about chemical composition of PM10 (Particulate Matter with diameter of 10 micrometres or less) over all the region has been started. The PM10 filters have been analyzed for Benzo(α)Pyrene, Pb, Cr, Ni and Cd to check compliance with limits or target values defined in Italian regulation (Legislative Decree of 13 August 2010, n.155);other parameters, like US-EPA list Polycyclic Aromatic Hydrocarbons (PAHs), Polychlorinated Dibenzo-p-Dioxins and Polychlorinated Dibenzo Furans (PCDD/ Fs), Polychlorinated Biphenyls (PCBs), Organic Carbon/Elemental Carbon (OC/EC) and Levoglucosan were analyzed because they are toxic or because they identify particular pollutant sources. The data obtained showed a large and diffusive biomass burning contribution, widely used in the Umbria Region both for domestic heating in traditional fireplaces and for combustion of pruning residues. In particular the urban sites of Terni and suburban site near Terni (Narni), both lying in the Terni basin called “Conca Ternana”, showed a chemical composition of PM10 that suggests a very large anthropization. This area is the principal industrial reality in the Central Italy because there is a steel production plant, a Municipal solid waste (MSW) burning plant and a chemical plant.

关键词： Particulate Matter Chemical Composition Biomass Burning

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宫崎骏:沉溺于无法探究的惟一

中国新时代 2002年第10期 128-129页

作者： mara

2002年,宫崎骏的《千与千寻》公映,作为商业奇才的宫崎依然是票房神话的保持者。看着卖盗版的小贩在人群中肆无忌惮地推销着《千与千寻》,看着那些抱着“看大片”想法而略带疯狂的人群。与以往的任何一部电影比,《千与千寻》依然是对... 详细信息

2002年,宫崎骏的《千与千寻》公映,作为商业奇才的宫崎依然是票房神话的保持者。看着卖盗版的小贩在人群中肆无忌惮地推销着《千与千寻》,看着那些抱着“看大片”想法而略带疯狂的人群。与以往的任何一部电影比,《千与千寻》依然是对人类的失望与希望、少女、飞行、战斗以及“活下去”,结尾依然喜悦的大团圆。然而,隐藏的离别与隐密的深意中,更多的是对人性、对现实的深深失望。

关键词：宫崎骏失望人类结尾情节《千与千寻》

Combined Use of NMR, LC-ESI-MS and Antifungal Tests for Rapid Detection of Bioactive Lipopeptides Produced by Bacillus

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Advances in Microbiology 2016年第10期6卷 788-796页

作者： mara Silva António Pereira Dora Teixeira António Candeias Ana Teresa Caldeira Chemistry Department School of Science and Technology évora University évora Portugal HERCULES Laboratory évora University évora Portugal

The science and technology interact with the art in several ways. Biotechnological coupled with analytical approaches can play an important role in protecting and preserving cultural heritage for future generations. Many microorganisms influenced by environmental conditions are the main responsible for biological contamination in built heritage. Biocides based on chemical compounds have been used to mitigate this problem. Thus, it is vitally important to develop proper remediation actions based on environmentally innocuous alternative. Bacillus specie is emerging as an optimistic alternative for built heritage treatment due to their capacity to produce secondary metabolites with antagonistic activities against many fungal pathogens. Therefore, the intent of this work was to access a rapid evaluation of antifungal potential of bioactive metabolites produced by Bacillus strains and simultaneously their characterization using spectroscopic (NMR) and chromatographic techniques (LC-ESI-MS). The high antifungal activity obtained for Bacillus sp. active compounds produced in this study confirms the great potential to suppress biodeteriogenic fungi growth on historical artworks. Additionally, the proposed methodology allowed to access bioactive metabolites produced without need of the laborious total previous isolation and could be used as a viable alternative to be employed for screening and production of new green biocides.

关键词： Lipopeptides Bacillus sp. Biodegradation/Biodeterioration Natural Biocides Nuclear Magnetic Resonance Liquid Chromatography Coupled to Mass Spectrometry