检索结果-南通市图书馆

Journal of Biosciences and Medicines 2014年第2期2卷 67-73页

作者： mara Shepherd Misty Lutes Gene Scalarone Department of Biological Sciences Idaho State University Pocatello USA

The systemic fungal organism, Blastomyces dermatitidis causes blastomycosis in animals and hu-mans. This study was designed to evaluate antibody detection in 55 serial serum specimens from 9 dogs with blastomycosis using B. dermatitidis yeast lysate antigens produced from two human isolates (B5896;B5931) and two dog isolates (ERC-2;T-58) with the indirect enzyme linked im-munosorbent assay (ELISA;peroxidase system) to determine an optimal lysate antigen(s) for use in the ELISA to detect antibody in the dog serum specimens. The mean absorbance values when the lysate antigens were compared with respect to their ability to detect antibody in the day 0 sera from the 9 dogs were 1.024 (ERC-2), 1.351 (B5896), 1.700 (B5931) and 2.084 (T-58) respectively. All of the reagents exhibited a high level of sensitivity and in all instances the amount of antibody declined as the time interval post-treatment increased, but the T-58 lysate prepared from the dog isolate from Tennessee was the optimal reagent. We continue to evaluate antigens for B. derma-titidis antibody detection in different immunodiagnostic assays.

关键词： Blastomycosis Lysate Antigens Antibody Detection ELISA Serial Dog Serum Specimens

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neighbors of War

Beijing Review 2015年第46期58卷 26-27页

作者： Kathryn Lee mara Lee Durrell public health at Johns Hopkins University

Syrian refugee crisis plagues Jordan and surrounding countries As the world’s attention shifted from the impact of the Syrian refugee crisis in the Middle East itself to its effects on Europe,those countries that con... 详细信息

关键词：战争邻国海湾地区注意力难民叙利亚世界

Multiple responses optimization in the development of a headspace gas chromatography method for the determination of residual solvents in pharmaceuticals

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2015年第5期5卷 296-306页

作者： Carla M.Teglia Milagros Montemurro María M.De Zan María S.Cmara Laboratorio de Control de Calidad de Medicamentos Facultad de Bioquimica y Ciencias BiologicasUniversidad Nacional del Litoral

An efficient generic static headspace gas chromatography （HSGC） method was developed, optimized and validated for the routine determination of several residual solvents （RS） in drug substance, using a strategy with two sets of calibration. Dimethylsulfoxide （DMSO） was selected as the sample diluent and internal standards were used to minimize signal variations due to the preparative step. A gas chroma- tograph from Agilent Model 6890 equipped with flame ionization detector （FID） and a DB-624 （30 m × 0.53 mm i.d., 3.00 μm film thickness） column was used. The inlet split ratio was 5：1. The influ- encing factors in the chromatographic separation of the analytes were determined through a fractional factorial experimental design. Significant variables： the initial temperature （IT）, the final temperature （FT） of the oven and the carrier gas flow rate （F） were optimized using a central composite design. Response transformation and desirability function were applied to find out the optimal combination of the chromatographic variables to achieve an adequate resolution of the analytes and short analysis time. These conditions were 30 ℃ for IT, 158 ℃ for FT and 1.90 mL/min for F. The method was proven to be accurate, linear in a wide range and very sensitive for the analyzed solvents through a comprehensive validation according to the ICH guidelines.

关键词： Headspace gas chromatographyResidual solventsPharmaceuticalsSurface response methodologyDesirabiliW function

What will the future hold for artificial organs in the service of assisted reproduction: prospects and considerations

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Frontiers of Medicine 2019年第6期13卷 627-638页

作者： mara Simopoulou Konstantinos Sfakianoudis Petroula Tsioulou Anna Rapani Polina Giannelou Nikolaos Kiriakopoulos Agni Pantou Nikolaos Vlahos George Anifandis Stamatis Bolaris Konstantinos Pantos Michael Koutsilieri Department of Physiology Medical SchoolNational and Kapodistrian University of AthensMikras Asias11527AthensGreece Assisted Conception Unit 2nd Department of Obstetrics and GynecologyAretaieion HospitalMedical SchoolNational and Kapodistrian University of AthensVasilissis Sofias str.11528AthensGreece Centre for Human Reproduction Genesis Athens ClinicPapanikoli15232AthensGreece Department of Histology and Embryology Faculty of MedicineUniversity of Thessaly41500LarisaGreece Assisted Conception Unit General-Maternity District Hospital“Elena Venizelou”Plateia Elenas Venizelou11521AthensGreece

Assisted reproduction provides a wide spectrum of treatments and strategies addressing ***,distinct groups of infertile patients with unexplained infertility,congenital disorders,and other complex cases pose a challenge in in vitro fertilization(IVF)*** special cohort of patients is associated with futile attempts,IVF overuse,and dead ends in *** edge research on animal models introduced this concept,along with the development of artificial organs with the aim to mimic the respective physiological functions in *** on clinical application leads to the future use of infertility management in *** date,the successful clinical application of artificial reproductive organs in humans is not feasible because further animal model studies are required prior to clinical *** application of these artificial organs could provide a solution to infertility cases with no other *** manuscript presents an overview on the current status,future prospects,and considerations on the potential clinical application of artificial ovary,uterus,and gametes in *** paper presents how the IVF practice landscape may be shaped and challenged in the future,along with the subsequent concerns in assisted reproductive treatments.

关键词： artificial ovary artificial uterus artificial gametes assisted reproduction considerations in vitro fertilization

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

非正规移民政策与意大利移民政策的重塑

非正规移民政策与意大利移民政策的重塑

作者： Monteleone mara 浙江大学

学位级别：硕士

This work starts from the conviction that today,like never before,international migration reflects an important global change and significantly marks not only the internal policies of a Country but also the international relations between Nations and their foreign policies,in all their ever-changing *** conviction comes from the fact that migration is the fundamental phenomenon that characterizes the global era we live in,considering that in the second half of last century individual mobility has been constantly increasing and flow of people through national borders has been notably *** particular,in the last decades the great number of irregular immigrants is what represented the biggest challenge for some EU countries and for the Union itself;perceived as a threat,this resulted in stricter immigration policies on both national and Community *** study tries to provide a concrete solution on a national level,in Italy specifically,to reshape and improve the policy on irregular immigration,rather than providing one or more theoretical frameworks that could allow the government to face the *** securitization theory has instead been used to explainthe attitude of some of the national parties towards immigration and immigrants themselves,and the role that the discursive dimension has on the idea created by the citizens through the image received from the *** this aim,the first part of the thesis tries to give a holistic analysis of the most important measures taken by the European Union and the Italian national government on irregular immigration,with reference to the relation with the UN principles and in particular,the Convention of Geneva and the right of *** second part is made up by the analysis of the outcome of the recent general elections in Italy,that saw two populist parties gain the highest number of votes,the hypotheses on the new government and the causes and effects on the process of law-making on t

关键词：移民政策政府职能意大利

Cannabinoids drive Th17 cell differentiation in patients with rheumatic autoimmune diseases

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2021年第3期18卷 764-766页

作者： Konstantin Kotschenreuther Iris Waque Shuaifeng Yan Anja Meyer Thom Haak Julia von Tresckow Joanna Schiller Lydia Gloyer mara Dittrich-Salamon David M.Kofler Laboratory of Molecular Immunology and Division of Clinical Immunology and Rheumatology University of CologneCologneGermany DepartmentⅠof Internal Medicine University of CologneCologneGermany

The legalization of cannabinoids for medical use has reinforced their emerging role as a treatment of chronic pain in patients with cancer or rheumatic diseases.1,2 In addition to their role as pain relievers,evidence obtained from animal models suggests that cannabinoids have immunosuppressive properties.3 However,a definite immunosuppressive function of cannabinoids has not yet been confirmed in clinical trials.

关键词： rheumatic Th17 patients

Edible Coatings Based on Apple Pectin,Cellulose Nanocrystals,and Essential Oil of Lemongrass:Improving the Quality and Shelf Life of Strawberries(Fragaria Ananassa)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Renewable Materials 2019年第1期7卷 73-87页

作者： Ingrid Souza Vieira da Silva Natália Soares Prado Patrícia Gontijo de Melo Danilo Campion Arantes mara Zeni Andrade Harumi Otaguro Daniel Pasquini Instituto de Química Universidade Federal de UberlândiaCampus Santa MônicaAv.João Naves deÁvila2121Uberlândia-MG38400-902Brazil Instituto Federal do Triângulo Mineiro Campus Uberaba Rua João Batista Ribeiro4000Uberaba-MG38064-790Brazil Departamento de Ciências Naturais(DCNAT) Universidade Federal de São João Del-ReiPraça D.Helvécio74São João Del-Rei-MG36301-160Brazil Universidade de Caxias do Sul Rua Francisco Getúlio Vargas1130Caxias do Sul-RS95070-970Brazil

In this work,nine different types of edible coating based on pectin,cellulose nanocrystals,glycerol,and essential oil of lemongrass were prepared and used to coat strawberries with a film formed directly on the surface of the coated *** effects of the different edible coatings on refrigerated fruits in terms of weight loss,titratable acidity,total soluble solids,pH,and anthocyanin content was evaluated after 2 days,4 days,6 days,and 8 days of *** of the edible coatings reduced the weight loss of the coated strawberries and the anthocyanin *** total soluble solids content of or uncoated fruit increase more markedly than that of coated *** contrast,pH was maintained for both coated and uncoated *** edible coatings were effective in minimizing of the weight loss,without worsening the physical chemistry *** treatments T5 and T9 presented the best results.

关键词： Strawberry edible coating cellulose nanocrystals pectin shelf life

Natural History of a Transitional Atrioventricular Septal Defect in an Adult Patient with Down Syndrome

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Cardiovascular Diseases 2021年第7期11卷 342-346页

作者： mara Escudero-Salamanca Nilda Espinola-Zavaleta Nuclear Cardiology Department National Institute of Cardiology Ignacio Chavez Mexico City Mexico Mexican Faculty of Medicine La Salle University Mexico City Mexico Department of Echocardiography ABC Medical Center I.A.P Mexico City Mexico

Background: Atrioventricular septal defects (AVSD) are caused by a lack of development in atrioventricular endocardial cushions. Its spectrum varies from partial to transitional, or intermediate forms with a common AV valve and 2 orifices, or even the complete form. Aim: The aim of this study is to present a case of a woman in the fifth decade of life with Down syndrome and a transitional AVSD, diagnosed with echocardiography. Case presentation: This is a patient in the fifth decade of life with Down syndrome, transitional AVSD, and severe pulmonary hypertension. Her vital signs were normal, oxygen saturation of 89% on room air. Auscultation revealed pronounced pulmonary component of the second heart sound, diastolic murmur in second left intercostal space, and moderate holosystolic heart murmur that radiated to axilla. The diagnosis was made with a transthoracic echocardiogram. The patient is receiving only medical treatment and since her last consult she has New York Heart Association (NYHA) functional class II. Conclusion: This case demonstrates the natural history of a patient in her fifth decade of life with down syndrome and complex congenital heart disease, despite having received only medical treatment, she is in functional class II. Echocardiography is the noninvasive technique of choice in the diagnosis and follow-up of patients with congenital heart diseases, as seen in this case.

关键词： Transitional Atrioventricular Septal Defect Pulmonary Hypertension Echocardiography

The importance of functional diversity in the stability of Mediterranean shrubland communities after the impact of extreme climatic events

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Plant Ecology 2017年第2期10卷 281-293页

作者： Enrique Gde la Riva Francisco Lloret Ignacio MPérez-Ramos Teodoro marañón Sandra Saura-Mas Ricardo Díaz-Delgado Rafael Villar Area de Ecología Facultad de CienciasUniversidad de Cordoba.14071 CordobaSpain CREAF Cerdanyola del Vallés08193 BarcelonaSpain Unitat d’Ecologia Dept.Biologia AnimalBiologia Vegetal i EcologiaUniversitat Autònoma BarcelonaEdifici CCampus UAB08193Cerdanyola del VallèsBarcelonaSpain IRNAS CSICAv.Reina Mercedes 10PO Box 1052.41080 SevillaSpain Estación Biológica de Doñana CSIC.c/Americo Vespucios/nIsla de la Cartuja.41092 SevillaSpain

Aims Extreme climatic events may have important consequences for plant community structure and *** 2005,a severe drought together with a cold winter promoted extensive damage and mortal-ity in shrubland communities of southwest Spain(Doñana National Park).Here,we aim to identify the mechanisms underlying commu-nity stability(resistance and resilience)in response to this extreme climatic event,considering changes in the functional structure of these *** We used a trait-based approach,quantifying variations in 10 func-tional traits at the community level(community weighted means,CWM)and the functional diversity(functional richness,evenness and divergence)in 18 plots at three different times:predating the climatic event(estimated from the sum of the live and dead volume of each species in 2007),and 2 and 8 years after the 2005 *** also quantified the differences in functional traits and functional diversity between adult and recruit stages,which allowed us to bet-ter understand the contribution of the recruitment to the mainte-nance of the functional structure and diversity of the *** Findings Communities with higher functional divergence before the cli-matic event maintained nearly constant their levels of functional divergence 8 years after,but they were more prone to changes in species *** resistance in terms of vegeta-tion cover was positively correlated with root dry matter content,whereas community resilience was positively correlated with leaf chlorophyll(LChl).We also found that some values(weighted means)of functional community traits(such as root dry matter con-tent and LChl)had increased 2 years after the event,returning to the pre-event conditions after 8 *** addition,there was hardly any establishment of new species in the community and the recruits did not make substantial differences to the community functional *** seed mass differed significantly between the adult and se

关键词： climate change Doñana drought functional trait recruitment resilience resistance

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

哈尔滨档案