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Engineering hyaluronic acid-based nanoassemblies for monoclonal antibody delivery-design,characterization,and biological insights

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Nano Research 2024年第10期17卷 9111-9125页

作者： Ana M.López-Estévez Y.Zhang mar.a Medel Iker Arriaga Lucía sanjurjo Cristian Huck-Iriart Nicola G.A.Abrescia mar.a j.Vicent Defang Ouyang Dolores Torres mar.a j.sé Alonso Center for Research in Molecular Medicine and Chronic Diseases(CiMUs) University of Santiago de CompostelaSantiago de Compostela 15782Spain Department of Pharmacology Pharmacy and Pharmaceutical TechnologySchool of PharmacyUniversity of Santiago de CompostelaSantiago de Compostela 15782Spain Health Research Institute of santiago de Compostela(IDIs) Santiago de Compostela 15782Spain state Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences(ICMS)University of MacaoMacao 999078China Polymer Therapeutics Laboratory and CIBeroNC Prince Felipe Research Centre Valencia E-46012Spain structure and Cell Biology of Viruses Lab CIC bioGUNEBasque Research and Technology Alliance(BRTA)Derio 48160Spain ALBA synchrotron Light source Experiments DivisionCerdanyola del VallèsBarcelona 08290Spain IKERBAsQUE Basque Foundation for ScienceBilbao 48009Spain

The current spotlight of cancer therapeutics is shifting towards personalized medicine with the widespread use of monoclonal antibodies(mAbs).Despite their increasing potential,mAbs have an intrinsic limitation related to their inability to cross cell membranes and reach intracellular *** offers promising solutions to overcome this limitation,however,formulation challenges *** challenges are the limited loading capacity(often insufficient to achieve clinical dosing),the complex formulation methods,and the insufficient characterization of mAb-loaded ***,we present a new nanocarrier consisting of hyaluronic acid-based nanoassemblies(HANAs)specifically designed to entrap mAbs with a high efficiency and an outstanding loading capacity(50%,w/w).HANAs composed by an mAb,modified HA and phosphatidylcholine(PC)resulted in sizes of~100 nm and neutral surface *** modeling identified the principal factors governing the high affinity of mAbs with the amphiphilic HA and *** composition and structural configuration were analyzed using the orthogonal techniques cryogenic transmission electron microscopy(cryo-TEM),asymmetrical flow field-flow fractionation(AF4),and small-angle X-ray scattering(sAXs).These techniques provided evidence of the formation of core-shell nanostructures comprising an aqueous core surrounded by a bilayer consisting of phospholipids and amphiphilic *** vitro experiments in cancer cell lines and macrophages confirmed HANAs’low toxicity and ability to transport mAbs to the intracellular *** reproducibility of this assembling process at industrial-scale batch sizes and the long-term stability was *** conclusion,these results underscore the suitability of HANAs technology to load and deliver biologicals,which holds promise for future clinical translation.

关键词： monoclonal antibody nanoparticles hyaluronic acid characterization particle size computational modeling

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American tegumentary leishmaniasis mimicking myiasis and granulomatous vasculitis:A case report

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Asian Pacific journal of Tropical Medicine 2024年第10期17卷 473-476,I0001,I0002页

作者： Victoria j Arrieta Gastón Morea Leticia M Tennerini mar.a Vsanchez Esteban s Lozano Diego E Cargnelutti Instituto de Medicina y Biología Experimental de Cuyo(IMBECU) Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Universidad Nacional de Cuyo(UNCuyo)MendozaArgentina Hospital Luis C.Lagomaggiore MendozaArgentina Facultad de Ciencias Médicas(FCM) Universidad Nacional de Cuyo(UNCuyo)MendozaArgentina

Rationale:American tegumentary leishmaniasis comprises cutaneous and mucocutaneous manifestations caused by parasitic infections by various Leishmania *** report details the clinical interventions for a patient with American tegumentary leishmaniasis in Mendoza,Argentina,a non-endemic *** concerns:A 43-year-old male was admitted to a tertiary care hospital in Mendoza,Argentina Republic with a history of progressive nasal discharge,septal perforation,facial pain,and *** treatment for presumed nasal myiasis and vasculitis with granulomatosis,symptoms ***:American tegumentary ***:Intravenous liposomal amphotericin ***:Follow-up at 30 days showed no recurrence of symptoms with a remar.able clinical improvement of the nasal ***:This case sheds light on the necessity of accurate identification for timely intervention and the need to recognize the diverse manifestations of American tegumentary leishmaniasis to avoid misdiagnosis.

关键词： Leishmania American tegumentary leishmaniasis Diagnosis methods Myasis Vasculitis and granulomatosis Case report

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Reuse of port industrial heritage in tourist cities:shipyards as case studies

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Frontiers of Architectural Research 2024年第1期13卷 164-183页

作者： mar.a j.Andrade Eduardo jiménez-Morales Rachel Rodríguez-Ramos Pablo martínez-Ramírez Department of Art and Architecture School of ArchitectureMalaga UniversityMalaga 29013Spain

The progressive deindustrialisation of many western cities since the 1980s has led to many industrial zones linked to port activities being abandoned or falling into *** such as Barcelona,Naples,Lisbon,Amsterdam,and Hamburg have port industrial complexes of high tangible and intangible heritage value that could totally or partially disappear,resulting in an irreparable loss of their scientific,architectural,social,technological,and historical *** that in mind,Adaptive Reuse(AR)of the built heritage allows the industrial memory of the ports to be preserved by turning them into new functional centres within the existing urban *** occurs in the context of the contemporary challenges of those cities,such as touristification,the circular economy and climate change,while guaranteeing the life cycle of those *** article analyses two case studies—the Nederlandsche scheepsbouw Maatschappij(NDsM)and the Rotterdamsche Droogdok Maatschappij(RDM)shipyards,both in the Netherlands—in order to contribute to the knowledge of AR of Port Industrial *** are two examples of good practices in port industrial heritage interventions,where the factors behind their acclaim can be easily highlighted.A multi-scale methodology is therefore used and tailored to the case of port industrial heritage,based on analysing previous studies of the heritage in different spheres and on different scales.A relationship matrix tool is thus *** enables a comparative study to be conducted,using key variables and indicators,and considering qualitative and quantitative *** provides extensive output information for each case study,which is summarised in the most favourable factors for the success of the AR of this port industrial heritage.

关键词： Industrial heritage Port-city Adaptive reuse Best practices Circular economy HUL Touristification

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Intestinal anti-inflammatory effect of a plant sterol food supplement in experimental murine colitis and cell co-culture models

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Food science and Human Wellness 2024年

作者： Mussa Makran Antonio Cilla Rosa mar.a Giner mar.a Carmen Recio Luisa Tesoriere Alessandro Attanzio Guadalupe Garcia-Llatas Nutrition and Food science Area， Faculty of Pharmacy and Food sciences， University of Valencia.Av.Vicente Andrés Estellés s/n Department of Pharmacology， Faculty of Pharmacy and Food sciences， University of Valencia.Av.Vicente Andrés Estellés s/n Department of Biological， Chemical and Pharmaceutical sciences and Technologies， University of Palermo

The potential of a plant sterol food supplement （Ps-Fs） in addressing intestinal inflammation in vivo and in vitro was evaluated. As in vivo model， C57BL/6j mice were exposed to 1.5% dextran sulfate sodium in three 5-day periods， with 10-day rest intervals in between， daily reciving Ps-Fs （35 mg Ps/kg）. The in vitro approach involved a bi-cameral system with 8-day-differentiated Caco-2 （apical） and RAW264.7 cells （basolateral）. The bioaccessible fraction of Ps-Fs， obtained after INFOGEsT 2.0 simulated gastrointestinal digestion， was added to the apical part （90 min）， followed by stimulation with lipopolysaccharide （1 μg/mL， 24 h）. Ps-Fs alleviated rectal bleeding and rebalanced pro- (tumor necrosis factor α， interleukin （IL）-6， and IL-8) and anti-inflammatory cytokines （IL-10）. Additionally， Ps-Fs ameliorated histopathological damage and enhancing occludin expression. A reduction in oxidative stress was evidenced by decreased myeloperoxidase activity and reactive oxygen species production. The anti-inflammatory mechanism included suppressing cyclooxygenase 2 expression， reducing prostaglandin E2production， and inhibiting the phosphorylation and nuclear translocation of the nuclear factor κB p65 subunit. This study reveals the potential of Ps-Fs as a therapeutic intervention for colitis. The alignment between in vivo and in vitro outcomes substantiates the appropriateness of the co-culture model to evaluate the anti-inflammatory activity of foods.

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Multiplexed Biosensing Diagnostic Platforms Detecting Autoantibodies to Tumor-Associated Antigens from Exosomes Released by CRC Cells and Tissue samples showed High Diagnostic Ability for Colorectal Cancer

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Engineering 2021年第10期7卷 1393-1412页

作者： Ana Montero-Calle Itziar Aranguren-Abeigon mar.a Garranzo-Asensio Carmen Poves mar.a j.sús fernández-aceñero javier martínez-Useros Rodrigo sanz jana Dziaková javier Rodriguez-Cobos Guillermo solís-fernández Eloy Povedano mar.a Gamella Rebeca Magnolia Torrente-Rodríguez Miren Alonso-Navarro Vivian de los Ríos j.Ignacio Casal Gemma Domínguez Ana Guzman-Aranguez Alberto Peláez-García j.séManuel Pingarrón susana Campuzano Rodrigo Barderas Chronic Disease Program(UFIEC) Carlos III Health InstituteMadrid E-28220Spain Department of Biochemistry and Molecular Biology Faculty of Optics and OptometryComplutense University of MadridMadrid E-28040Spain Gastroenterology Unit San Carlos Clinical HospitalMadrid E-28040Spain surgical Pathology Department San Carlos Clinical HospitalMadrid E-28040Spain Translational Oncology Division OncoHealth InstituteJimenez Diaz Foundation University HospitalMadrid E-28040Spain Department of Biochemistry Faculty of MedicineAlberto Sols Institute of Biomedical ResearchCSIC-UAMMadrid E-28029Spain Department of Analytical Chemistry Faculty of Chemical SciencesComplutense University of MadridMadrid E-28040Spain Center for Biological Research Spanish National Research Council(CSIC)MadridE-28040Spain Molecular Pathology and Therapeutic Targets Group La Paz University Hospital(IdiPAZ)Madrid E-28046Spain

Colorectal cancer(CRC)is the second leading cause of cancer-related death *** five-year survival rate of CRC patients depends on the stage at diagnosis,being higher than 80%when CRC is diagnosed in the early stages but lower than 10%when CRC is diagnosed in advanced *** against specific CRC autoantigens(tumor-associated antigens(TAAs))in the sera of patients have been widely demonstrated to aid in early ***,we herein aim to identify autoantigens target of autoantibodies specific to CRC that possess a significant ability to discriminate between CRC patients and healthy individuals by means of liquid *** that end,we examined the protein content of the exosomes released by five CRC cell lines and tissue samples from CRC patients by means of immunoprecipitation coupled with mass spectrometry analysis.A total of 103 proteins were identified as potential autoantigens specific to *** bioinformatics and meta-analysis,we selected 15 proteins that are more likely to be actual CRC autoantigens in order to evaluate their role in CRC prognosis by Western blot(WB)and immunohistochemistry(IHC).We found dysregulation at the protein level for 11 of these proteins in both tissue and plasma exosome samples from patients,along with an association of nine of these proteins with CRC *** validation,all but one showed a statistically significant high diagnostic ability to distinguish CRC patients and individuals with premalignant lesions from healthy individuals,either by luminescence Halotag-based beads,or by a multiplexed biosensing platform involving the use of magnetic microcarriers as solid support modified with covalently immobilized Halotag fusion proteins constructed for CRC *** together,our results highlight the usefulness of the approach defined here to identify the TAAs specific to chronic diseases;they also demonstrate that the measurement of autoantibody levels in plasma against the TAAs identified here

关键词： Autoantibodies Diagnosis Colorectal cancer Exosomes Tumor microenviroment Humoral immune response Point of care Biosensors

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Influence of biomass burning on ozone levels in the Megalopolis of Central Mexico during the COVID-19 lockdown

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journal of Environmental sciences 2024年第9期143卷 99-115页

作者： Victor Almanza Luis Gerardo Ruiz-suárez Ricardo Torres-jardón Agustín García-Reynoso Iván Y.Hernández-Paniagua Institute for Atmospheric sciences and Climate Change National Autonomous University of MexicoCoyoacan 04510Mexico CityMexico

The massive reductions in anthropogenic emissions resulting from the COVID-19 lockdown provided a unique opportunity to evaluate the effect of mitigation measures aiming to abate air *** Mexico,the total lockdown period took place during the dry-hot season when biomass burning activity is ***,we investigate the role of biomass burning emissions on regional ozone levels in the Megalopolis of Central *** studied period covers the lockdown phases 2 and 3,and the first month of the New *** applied a factor separation technique and process analysis to estimate the pure and synergistic contributions of emission reductions under lockdown and that from biomass burning to daily ozone maximum concentrations in 7 metropolitan areas of different states in the *** results revealed that biomass burning plumes likely masked the effect of massive reductions from mobile emissions,impacted the PBL development during phase 3 and favored transition and mixed NO_(x)-limited and VOC-limited regional *** contributed to increased ozone production in the middle to lower PBL by changing the regional background levels which potentially could bias high ozone production efficiency *** the Megalopolis contribution to economic and societal development at national scale,our study suggests that ozone mitigation measures during the dry-hot season targeting mainly mobile emissions will likely be offset by biomass burning plumes.A regional and synergic policy aiming to control biomass burning would help to reduce the occurrence of high ozone levels in Central Mexico with the co-benefit of tackling short-lived climate pollutants.

关键词： COVID-19 Mexico Megalopolis Ozone Factor separation Process Analysis

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Provenance and tectonic setting of sandstones of the Lomas Coloradas Formation, Cabullona Group, sonora, México: Constraints on petrography and geochemistry

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journal of Palaeogeography 2024年第4期13卷 839-861页

作者： j.Madhavaraju D.G.Noriega-Montoya E.Ramirez-Montoya C.M.Gonz alez-Le on john s.Armstrong-Altrin Estaci on Regional del Noroeste Instituto de GeologíaUniversidad Nacional Aut onoma de Mexico Ingeniería en Geociencias Universidad Estatal de Sonora Posgrado en Ciencias de la Tierra Estaci on Regional del NoroesteInstituto de GeologíaUniversidad Nacional Aut onoma de Mexico Universidad Nacional Aut onoma de Mexico Instituto de Ciencias del Mar y LimnologíaUnidad de Procesos Oce anicos y CosterosCiudad Universitaria

The sedimentary rocks of the Cabullona Group are well exposed in the Cabullona Basin of northeastern sonora, Mexico, which represent syntectonic sedimentation associated with Laramide-style deformation during the Campanian-early Maastrichtian. The sandstones of the Lomas Coloradas Formation deposited at the upper part of the Cabullona Group. Petrography and geochemical(major, trace, and rare earth elements) studies were carried out on the sandstones to interpret the palaeoweathering, provenance,and tectonic setting of the Lomas Coloradas Formation sandstones. Most of the sandstone modal analysis data plotted in the QFL and Qm FLt ternary diagrams fall into the fields of dissected arcs and recycled orogens,respectively. Geochemically the sandstones are classified as litharenites while few samples plot into the arkosic field. The chondrite-normalized REE diagrams for sandstones have LREE-enriched, relatively flat HREE patterns with negative Eu anomalies. CIA values and the A-CN-K diagram indicate a low intensity of chemical weathering in the source area. The tectonic setting diagram suggests both arc and rift settings for the studied sandstones. The bivariate and ternary diagrams and elemental ratios suggest a felsic source for the Lomas Coloradas Formation. The average REE patterns of the studied sandstones are comparable with REE patterns of the granite from the Caborca block, the rhyolite and granite of the Tarahumara Formation, and the Mesozoic felsic volcanic rocks. The modeled mixture of 40% Proterozoic granite, 30% Triassic arc, 10% jurassic arc, and 20% Laramide arc represents the probable source rocks for the Lomas Coloradas Formation.

关键词： Provenance Petrography Geochemistry Lomas Coloradas Formation Cabullona Group México

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重症监护室护士限制治疗努力的能力:整合性综述

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International journal of Nursing sciences 2024年第1期11卷 143-154,I0003页

作者： Elvia R.Lopez-Panza Vanessa C.Pacheco-Roys Kelly j.fernandez-Ahumada Diana C.Díaz-Mass mar.a Y.Exposito-Concepcion Elizabeth Villarreal-Cantillo Cesar I.Aviles Gonzalez Nursing Department Universidad del NorteBarranquillaColombia Nursing Program Faculty of Health SciencesUniversidad Popular del CesarValleduparColombia Clínica Valledupar ValleduparColombia Hospital Universidad del Norte SoledadColombia Department of Medical sciences and Public Health University of CagliariCittadella Universitaria di MonserratoCagliariItaly

目的在重症监护病房(IntensiveCareUnit,ICU),护土难免会遇到需要限制治疗努力(limiting therapeutie efort,LTE)的患者,尽管多数护士还缺乏为这些临终患者及其家庭提供支持的准备。本综述旨在描述ICU护士在LTE中需要具备的能力。方法对... 详细信息

目的在重症监护病房(IntensiveCareUnit,ICU),护土难免会遇到需要限制治疗努力(limiting therapeutie efort,LTE)的患者,尽管多数护士还缺乏为这些临终患者及其家庭提供支持的准备。本综述旨在描述ICU护士在LTE中需要具备的能力。方法对2010年--2023年发表的文献进行综述。系统检索了5个数据库:Medline、Wiley Online Library、sciELO、scienceDirect和Web of science。使用关键评估项目工具西班牙语版(Critical Appraisal skills Programme in spanish,CAsPe)作为评判性阅读工具。使用牛津循证医学中心(Center for Evidence-Based Medicine.,CEBM)评估工具确定证据级别和推荐强度。结果共纳入25篇文献。ICU护士LTE护理的能力包括对患者的直接护理、以家庭为中心的护理以及护士在团队中的作用。该综述确定了3个类别的能力:作为患者、家庭与跨学科团队之间维护者的能力,在LTE方面的决策能力,在患者生命末期治疗和护理干预的能力。结论ICU护士在LTE方面需要具备相应的能力,这对患者的生活质量死亡尊严以及患者家庭应对悲伤的全面支持至关重要。

关键词：重症监护家庭支持重症监护病房护士的作用安宁疗护专业能力

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Prevalence of and risk factors for erectile dysfunction in young nondiabetic obese men:results from a regional study

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Asian journal of Andrology 2020年第4期22卷 372-378页

作者： mar.a Molina-Vega Maite Asenjo-Plaza mar.a j.séBanderas-Donaire mar.a Dolores Hernández-Ollero silvia Rodríguez-Moreno juan jálvarez-Millán Pablo Cabezas-sanchez fernando Cardona-Díaz juan Alcaide-Torres Lourdes Garrido-sánchez Daniel Castellano-Castillo Francisco j Tinahones j.séC fernández-García Department of Endocrinology and Nutrition Virgen de la Victoria University Hospital(IBIMA)Málaga UniversityMálaga 29010Spain Centro de Investigación Biomédica en Red de la Fisiopatología de la Obesidad y Nutrición(CIBeroBN) Instituto de Salud Carlos IIIMadrid 28029Spain Cruz de Humilladero Primary Care Center Málaga 29010Spain Teatinos Primary Care Center Málaga 29010Spain Chemical sanitary Consulting(CQs Lab) Madrid 28003Spain

Erectile dysfunction(ED),a condition closely related to cardiovascular morbidity and mortality,is frequently associated with *** this study,we aimed to determine the prevalence of ED and evaluate the associated risk factors in a cohort of 254 young(18–49 years)nondiabetic obese(body mass index[BMI]≥30 kg m−2)men from primary *** function(International Index of Erectile Function[IIEF-5]questionnaire),quality of life(Aging Males'symptoms[AMs scale]),and body composition analysis(Tanita MC-180MA)were *** testosterone was determined using high-performance liquid chromatography–mass *** logistic regression analysis was used to study the factors associated with *** prevalence was 42.1%.subjects with ED presented higher BMI,waist circumference,number of components of the metabolic syndrome,AMs score,insulin resistance,and a more unfavorable body composition than those without *** logistic regression analysis showed that a pathological AMs score(odds ratio[OR]:4.238,Psity(BMI≥40 kg m−2,OR:2.602,P=0.005,compared with BMI 30–34.9 kg m−2),high-density lipoprotein(HDL)-cholesterol levels(OR:0.956,P=0.004),and age(OR:1.047,P=0.016)were factors independently associated with *** conclusion,we demonstrate that,in a primary care-based cohort of nondiabetic young obese men,ED affected>40%of subjects.A pathological AMs score,the degree of obesity,and age were positively associated with ED,while elevated HDL-cholesterol levels were inversely associated with the odds of presenting *** prospective studies are needed to evaluate the long-term consequences of ED in this population.

关键词： Aging Males'symptoms score erectile dysfunction International Index of Erectile Function-5 questionnaire obesity testosterone

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重症监护室护士限制治疗努力的能力:整合性综述（英文）

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International journal of Nursing sciences 2024年第1期 143-154+160页

作者： Elvia R.López-Panza Vanessa C.Pacheco-Roys Kelly j.fernández-Ahumada Diana C.Díaz-Mass mar.a Y.Expósito-Concepción Elizabeth Villarreal-Cantillo Cesar I.Aviles Gonzalez Nursing Department Universidad del Norte Nursing Program Faculty of Health Sciences Universidad Popular del César Clínica Valledupar Hospital Universidad del Norte Department of Medical sciences and Public Health University of Cagliari Cittadella Universitaria di Monserrato

目的在重症监护病房(Intensive Care Unit,ICU),护士难免会遇到需要限制治疗努力(limiting therapeutic effort,LTE)的患者,尽管多数护十还缺乏为这些临终患者及其家庭提供支持的准备。本综述旨在描述ICU护士在LTE中需要具备的能力。方... 详细信息

目的在重症监护病房(Intensive Care Unit,ICU),护士难免会遇到需要限制治疗努力(limiting therapeutic effort,LTE)的患者,尽管多数护十还缺乏为这些临终患者及其家庭提供支持的准备。本综述旨在描述ICU护士在LTE中需要具备的能力。方法对2010年—2023年发表的文献进行综述。系统检索了5个数据库:Medline、Wiley Online Library sciELO、scienceDirect和Web of science。使用关键评估项目工具西班牙语版(Critical Appraisal skills Programme in spanish,CAsPe)作为评判性阅读工具。使用牛津循证医学中心(Center for Evidence-Based Medicine,CEBM)评估工具确定证据级别和推荐强度。结果共纳入25篇文献。ICU护士LTE护理的能力包括对患者的直接护理、以家庭为中心的护理以及护士在团队中的作用。该综述确定了3个类别的能力:作为患者、家庭与跨学科团队之间维护者的能力,在LTE方面的决策能力,在患者生命末期治疗和护理干预的能力。结论 ICU护十在LTE方面需要具备相应的能力,这对患者的生活质量、死亡尊严以及患者家庭应对悲伤的全面支持至关重要。

关键词：重症监护家庭支持重症监护病房护士的作用安宁疗护专业能力

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