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Acceptance of living liver donation among medical students: A multicenter stratified study from Spain

World Journal of Gastroenterology 2016年第25期22卷 5800-5813页

作者： Antonio Ríos Ana Isabel López-Navas Ana Isabel López-López Francisco Javier Gómez Jorge Iriarte Rafael Herruzo Gerardo Blanco Francisco Javier Llorca Angel Asunsolo Pilar Sánchez-Gallegos Pedro Ramón Gutiérrez Ana Fernández mar.a Teresa de Jesús Laura martínez-Alarcón Alberto Lana Lorena Fuentes Juan Ramón Hernández Julio Virseda José Yelamos José Antonio Bondía Antonio Miguel Hernández marco Antonio Ayala Pablo Ramírez Pascual Parrilla International Collaborative Donor Project ('Proyecto Colaborativo Internacional Donante' 30007 Casillas Murcia Spain department of Surgery Paediatrics Obstetrics and Gynaecology University of Murcia Avenida de las Fuerzas Armadas 30800 Espinardo Murcia Spain Transplant Unit Surgery Service IMIB - Virgen de la Arrixaca University Hospital Carretera Madrid-Cartagena s/n 30120 El Palmar Murcia Spain Regional Transplant Centre Consejeria de Sanidad y Consumo de la Region de Murcia 30008 Ronda de Levante Murcia Spain Hospital Clinico Universitario Virgen de la Arrixaca Departamento de Cirugia General y del Aparato Digestivo Unidad de Trasplantes 30007 Casillas Murcia Spain department of Psychology Universidad Catolica San Antonio (UCAM) Avenida de los Jeronimos 30107 Guadalupe Murcia Spain department of Urology San Juan University Hospital of Alicante 03010 Calle Pintor Baeza Alicante Spain Universidad de Granada Avenida del Hospicio s/n 18010 Granada Spain Universidad de Navarra Campus Universitario 31080 Pamplona Navarra Spain Universidad Autonoma de Madrid Ciudad Universitaria de cantoblanco 28049 Madrid Spain Servicio de Cirugia HBP y Trasplante Hepatico Complejo Hospitalario Universitario de Badajoz Hospital Infanta Cristina Avenida Elvas s/n 06006 Badajoz Spain Universidad de Cantabria Avenida los Castros s/n 39005 Santander Cantabria Spain departamento de Cirugia Ciencias Medicas y Sociales Facultad de Medicina y Ciencias de la Salud Universidad de Alcala Campus Cientifico-Tecnologico Plaza de San Diego s/n 28801 Alcala de Henares Madrid Spain Facultad de Medicina Universidad de Malaga 29071 Avenida de Cervantes Malaga Spain Servicio de Urologia (Complejo Hospitalario Universitario de Canarias CHUC) y Departamento de Cirugia (Universidad de La Laguna ULL) Calle Molinos de Agua s/n 38207 San Cristobal de La Laguna Santa Cruz de Tenerife Spain departamento de Ciencias Biomedicas Basicas Facultad de Ciencias Biomedicas Universidad Europea de

AIM: To analyze the attitude of Spanish medical students toward living liver donation (LLD) and to establish which factors have an influence on this ***: Study type: A sociological, interdisciplinary, multicenter and observational study. Study population: Medical students enrolled in Spain (n = 34000) in the university academic year 2010-2011. Sample size: A sample of 9598 students stratified by geographical area and academic year. Instrument used to measure attitude: A validated questionnaire (PCID-DVH RIOS) was self-administered and completed anonymously. Data collection procedure: Randomly selected medical schools. The questionnaire was applied to each academic year at compulsory sessions. Statistical analysis: Student´s t test, χ2 test and logistic regression ***: The completion rate was 95.7% (n = 9275). 89% (n = 8258) were in favor of related LLD, and 32% (n = 2937) supported unrelated LLD. The following variables were associated with having a more favorable attitude: (1) age (P = 0.008); (2) sex (P demic year (P de toward deceased donation (P de toward living kidney donation (P ded (P ruistic nature; and (12) fear of the possible mutilation of the body after donation (P dents have a favorable attitude toward LLD.

关键词： Attitude Living liver donation Medical students Transplantation Organ donation Psychosocial variables Spain

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翼状胬肉术后结膜印记细胞学及临床疗效观察

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中华眼科杂志 2010年第4期46卷 323-327页

作者：刘俊茹李学民王薇石家庄市中心医院眼科 050011 北京大学第三医院眼科中心

目的观察翼状胬肉不同术式后眼表的病理学变化，同时对比观察不同术式的复发和眼表损伤情况，为临床医师设计针对性治疗方法提供理论依据。方法前瞻性研究。筛选2006年3月至2008年3月于石家庄市中心医院眼科就诊的原发性翼状胬肉患者84... 详细信息

目的观察翼状胬肉不同术式后眼表的病理学变化，同时对比观察不同术式的复发和眼表损伤情况，为临床医师设计针对性治疗方法提供理论依据。方法前瞻性研究。筛选2006年3月至2008年3月于石家庄市中心医院眼科就诊的原发性翼状胬肉患者84例（93只眼），按患者的临床特点分为4组：单纯翼状胬肉切除组24例（27只眼）、自体结膜移植组21例（22只眼）、自体角膜缘干细胞移植组18例（20只眼）、单纯翼状胬肉切除加用0．02％丝裂霉素C（MMC）组21例（24只眼）。分别于术前1d、术后30d、术后90d应用醋酸纤维膜滤纸片取4组患者眼表结膜上皮组织，行结膜印记细胞学对杯状细胞、炎性细胞等进行定性检查，同时观察术眼有无异物感、眼睑红肿、结膜水肿、角膜创面愈合情况、复发倾向等指标。采用多变量方差分析对实验结果进行统计学分析。结果4组患者术前胬肉区结膜上皮细胞可见上皮细胞角化较轻，细胞间隙加大，杯状细胞减少，4组杯状细胞密度分别为248．8±97．3，256．2±75．1，236．1±87．9，245．1±81．0，差异无统计学意义（F=0．029，P=0．993）。术后1个月，所有患者上皮细胞角化减轻，细胞间隙减小，核质比减少；术中加用MMC组杯状细胞数较其他3组有所增加，但差异无统计学意义（F=0．747，P=0．554）。术后3个月，加用MMC组，上皮细胞角化加重，细胞间隙增加，核质比增加，杯状细胞数明显减少，密度为112．14-56．8，与其他3组（309．6±77．0，314．1±68．9，317．4±73．2）相比差异有统计学意义（F=6．337，P=0．017），但另外3组之间差异无统计学意义。4组患者中单纯翼状胬肉组5例复发；自体结膜移植组无1例复发；干细胞移植组1例复发；单纯切除加用MMC组3例复发。结论翼状胬肉切除联合自体结膜移植和翼状胬肉切除联合角膜缘干细胞移植较单纯切除均能有效地降低复发率，有效促进创面愈合，改善眼表状态。MMC对眼表环境有明显的损伤。

关键词：翼状胬肉细胞诊断学干细胞

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Immunotherapy combinations and chemotherapy sparing schemes in first line non-small cell lung cancer

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World Journal of Clinical Oncology 2021年第12期12卷 1182-1192页

作者： mar.a Sereno Oliver Higuera Patricia Cruz Castellanos Sandra Falagan Xabier Mielgo-rubio Juan Carlos Trujillo-Reyes Felipe Couñago Medical Oncology department Hospital Universitario Infanta SofíaSan Sebastián de los Reyes 28702MadridSpain Medical Oncology department Hospital Universitario La PazMadrid 28046Spain Medical Oncology department Hospital Universitario Fundación AlcorcónAlcorcón 28922MadridSpain department of Thoracic Surgery Hospital de la Santa Creu I Sant PauBarcelona 08029CataloniaSpain department of Surgery Universitat Autonoma de BarcelonaBarcelona 08029CataloniaSpain department of Radiation Oncology Hospital Universitario Quirónsalud MadridPozuelo de Alarcón 28223MadridSpain department of Radiation Oncology Hospital La LuzMadrid 28003Spain Medicine department School of Biomedical SciencesUniversidad Europea de MadridVillaviciosa de Odón 28670MadridSpain

In recent years,studies have explored different combinations of immunotherapy and *** rationale behind these is the improved survival outcomes of new immunologic therapies used in first-line-treatment of advanced non-small cell lung ***,for the most-studied combinations of anti-programed death-1(PD-1)/programed death ligand-1(PD-L1)with the addition of platinumbased chemotherapy,recent research is investigating whether combining different immunologic antitumoral mechanisms of action,such as anti-PD-1/PD-L1 and anti-CTLA-4,or anti-PD-L1 and anti-TIGIT,with or without chemotherapy,can improve efficacy outcomes compared with more classical combinations,or compared with standard chemotherapy ***,we present the data of the main randomized studies that have evaluated these combinations,focusing on the basic rationale behind the different combinations,and the efficacy and tolerability data available to date.

关键词： Immunotherapy combinations Anti-programmed cell death protein Antiprogrammed cell death ligand 1 anti-TIGIT anti-CTLA-4 Combo Non-small cell lung cancer

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Chemical Study and determination of the Antioxidant Activity of Three Varieties <i>Tropaeolum tuberosum</i>(Mashua)

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American Journal of Plant Sciences 2019年第12期10卷 2279-2297页

作者： Jiménez Heinert mar.a Elena Gutiérrez Gaitén Yamilet Irene Yamilet Guaranda Iván Miranda martínez Migdalia Jiménez Heinertmar.a Elena Chemical Sciences Faculty Guayaquil University Guayaquil Ecuador Gutiérrez GaiténYamilet Pharmacy and Food Institute Havana University Havana Cuba ChóezGuarandaIván Biotechnological Research Center of Ecuador Polytechnic School of the Coast ESPOL Guayaquil Ecuador Miranda martínez Migdalia Chemical and Environmental Sciences Department Natural Sciences and Mathematics Faculty Higher Polytechnic School of the Coast ESPOL Guayaquil Ecuador

Ecuador has among its foods a number of potatoes and tubers that are not only nutritious, but are also attributed properties as coadjutant in the treatment of different illnesses. The objective of this study was to conduct a comparative study of the mashua tuber (Tropaeolum tuberosum spp tuberosum ruíz & Pavón, Kuntze), in its three pink, yellow and black varieties, by comparing the physicochemical characteristics and antioxidant activity. The comparative study was carried out on tubers obtained in the province of Pichincha, Quito-Ecuador. The physicochemical parameters were determined by the identification of the secondary metabolites present in the hydroalcoholic extracts, the quantification of phenols and flavonoids, and the characterization of the extracts by gas chromatography coupled to mass spectrometry and the antioxidant activity by three test methods. As a result, significant differences were found between the three varieties studied.

关键词： Antioxidant Activity Chemical Composition Gas Chromatography-Mass Spectrometry

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Removal of the Methylene Blue Dye (MB) with Catalysts of Au-TiO<sub>2</sub>: Kinetic and degradation Pathway

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Modern Research in Catalysis 2021年第1期10卷 1-14页

作者： mar.a-Cruz Arias Claudia Aguilar Mohamad Piza Elvira zarazua Francisco Anguebes Francisco Anguebes Francisco Anguebes Francisco Anguebes Víctor Cordova Faculty of Chemistry Autonomous University of Carmen City of Carmen Mexico department of Ecomaterials and Energy Autonomous University of Nuevo León San Nicolás de los Garza México

Au-TiO2 catalysts were used in the photocatalytic degradation of the methylene blue dye (MB). The synthesis of titanium oxide (TiO2) was carried out by sol-gel method. Subsequently, particles of Au were deposited on the surface of the semiconductor by photo-deposition, thus modifying the surface of the semiconductor. For the characterization of the catalyst obtained, the techniques of X-ray Diffraction (DRX), Scanning Electron Microscopy (SEM), Spectroscopy with Diffuse Reflectance (DR) and Surface Area by the BET (Brunauer, Emmett y Teller) were used. The solid obtained was tested experimentally as a catalyst in the photocatalytic degradation of a solution of MB. The data obtained were analyzed by UV-vis Spectroscopy and Total Organic Carbon (TOC) and the results indicated conversions were greater than 80%. The intermediate products were evaluated by mass coupled gas chromatography (GC-MS) and the MB decomposition route was by hydroxylation, obtaining aromatic intermediates, esters and products of the chemical degradation of the molecule.

关键词： Titanium Oxide Water Pollution Methylene Blue Dye Heterogeneous Photocatalysis

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经胼胝体入路切除第三脑室肿瘤

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中华神经外科杂志 2009年第5期25卷 421-424页

作者：王向宇徐如祥南方医科大学珠江医院神经外科广州510280

目的探讨31例第三脑室内肿瘤经胼胝体入路手术治疗的临床与神经心理结果。方法31例第三脑室前部肿瘤采用经胼胝体-穹隆间、胼胝体-室间孔、胼胝体-脉络膜裂结合室间孔入路手术治疗，患者在术前和术后用RancholosAmigos认识功能评定量表... 详细信息

目的探讨31例第三脑室内肿瘤经胼胝体入路手术治疗的临床与神经心理结果。方法31例第三脑室前部肿瘤采用经胼胝体-穹隆间、胼胝体-室间孔、胼胝体-脉络膜裂结合室间孔入路手术治疗，患者在术前和术后用RancholosAmigos认识功能评定量表进行神经心理测试，术后行影像学复查和GOS评估。结果采用纵裂胼胝体-室间孔入路14例，纵裂胼胝体-穹隆间入路12例，纵裂胼胝体-脉络膜裂（脉络膜上、下）结合室间孔入路5例；全切26例，次全切除5例。手术死亡1例。8例垂体柄因肿瘤侵犯被切除后尿崩7例，5例完全恢复，2例持续尿崩。Rancho losAmigos认识功能评定术后有明显改善。84％（26／31）术后GOS评估优秀（V级）。术后2例出现意识障碍超过24h，约72h恢复。术后2例出现失联系综合征，1例有明显记忆障碍，经康复治疗有好转。结论主体位于第三脑室内、后界未达到松果体的肿瘤都可以经上述胼胝体入路进行手术切除。选择经室间孔、经穹隆间、经脉络膜上下进入第三脑室可因病变的具体方位和周围血管布局而定。但是胼胝体、穹隆问、脉络膜上下可以切开的范围有限且值得进一步探讨，严格切开范围和控制牵拉幅度可以最大限度减少脑功能损害。

关键词：第三脑室外科手术脑肿瘤

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High-density mapping suggests cytoplasmic male sterility with two restorer genes in almond×peach progenies

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Horticulture Research 2015年第1期2卷 234-241页

作者： JoséManuel Donoso Iban Eduardo Roger Picañol Ignasi Batlle Werner Howad mar.a JoséAranzana Pere Arús IRTA Centre de Recerca en Agrigenòmica CSIC-IRTA-UAB-UB Campus UAB Bellaterra(Cerdanyola del Vallès)08193 BarcelonaSpain IRTA.Centre de Mas de Bover.Crta.de Reus–El Morell Km 3.8.43120 Constantί TarragonaSpain INIA Av.Salamanca s/nSector Los ChoapinosRengoChile Rijk zwaan Finca La Marina-Pj Lo Contreras s/n30395 La PueblaCartagenaSpain

Peach(Prunus persica)and almond(Prunus dulcis)are two sexually compatible species that produce fertile ***,a highly polymorphic species,is a potential source of new genes for peach that has a strongly eroded gene *** we describe the genetics of a male sterile phenotype that segregated in two almond(‘Texas’)×peach(‘Earlygold’)progenies:an F2(T×E)and a backcross one(T1E)to the‘Earlygold’***-density maps were developed using a 9k peach SNP chip and 135 simple-sequence *** highly syntenic and collinear maps were obtained:one for the F2(T×E)and two for the backcross,T1E(for the hybrid)and E(for‘Earlygold’).A major reduction of recombination was observed in the interspecific maps(T×E and T1E)compared to the intraspecific parent(E).The E map also had extensive monomorphic genomic regions suggesting the presence of large DNA fragments identical by *** data for the male sterility character were consistent with the existence of cytoplasmic male sterility,where individuals having the almond cytoplasm required the almond allele in at least one of two independent restorer genes,Rf1 and Rf2,to be *** restorer genes were located in a 3.4 Mbp fragment of linkage group 2(Rf1)and 1.4 Mbp of linkage group 6(Rf2).Both fragments contained several genes coding for pentatricopeptide proteins,demonstrated to be responsible for restoring fertility in other *** implications of these results for using almond as a source of novel variability in peach are discussed.

关键词： linkage restore mapping

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冠心病患者急诊PCI术后医院感染病原菌特点及相关因素分析

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中华医院感染学杂志 2018年第20期28卷 3080-3083页

作者：温书敏林德智袁权李刘菲吕燕茹内江市第一人民医院心血管内科四川内江641000

目的探讨冠心病患者急诊经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)术后医院感染病原菌特点与相关因素。方法选择2012年3月-2017年4月于医院心导管室接受急诊PCI治疗的患者782例为研究对象,采集急诊PCI术后发生医... 详细信息

目的探讨冠心病患者急诊经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)术后医院感染病原菌特点与相关因素。方法选择2012年3月-2017年4月于医院心导管室接受急诊PCI治疗的患者782例为研究对象,采集急诊PCI术后发生医院感染患者感染部位的分泌物或血液样本,分析病原菌特点,详细记录患者年龄、性别、体重指数、合并高血压、糖尿病等相关基础疾病、营养状况等临床资料,归纳冠心病患者急诊PCI术后医院感染的相关因素。结果 782例急诊患者PCI治疗术后发生医院感染43例,感染率为5.50%,感染部位以呼吸道和泌尿道为主;43例发生医院感染的患者,共培养分离病原菌57株,其中革兰阳性菌32株占56.14%,革兰阴性菌21株占36.84%,真菌4株占7.02%;年龄、合并基础疾病、侵入性操作、支架植入数量、PCI时段及住院时间均是导致冠心病患者急诊PCI术后医院感染的相关因素(P<0.05)。结论导致冠心病患者急诊PCI术后医院感染的病原菌主要以革兰阳性菌为主,临床应依据病原菌特点和导致其发生感染的相关因素采取相关干预措施进行综合性干预,对于降低其医院感染的发生率和改善患者预后有着重要意义。

关键词：冠心病急诊经皮冠状动脉介入医院感染相关因素病原菌

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太平洋东南海域海面高度的季节及年际变化特征

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海洋科学 2005年第2期29卷 37-42页

作者：林丽茹胡建宇厦门大学海洋系亚热带海洋研究所福建厦门361005

利用1992～2001年Topex/Poseidon卫星高度计遥感资料分析了太平洋东南海域 (5°～55°S ,70°～110°W)海面高度的季节及年际变化特征。研究结果表明 ,海区海面高度的季节变化总体上受太阳辐射季节变化的影响 ,南半球夏季 (1～3月 )和秋... 详细信息

利用1992～2001年Topex/Poseidon卫星高度计遥感资料分析了太平洋东南海域 (5°～55°S ,70°～110°W)海面高度的季节及年际变化特征。研究结果表明 ,海区海面高度的季节变化总体上受太阳辐射季节变化的影响 ,南半球夏季 (1～3月 )和秋季 (4～6月 )大致为正距平 ,而冬季 (7～9月 )和春季 (10～12月 )大致为负距平 ,1996～1998年除外 ;同时 ,受季节性风场、海区罗斯贝波等的影响 ,海面高度变化的区域特征性很强。海面高度的年际变化在低纬处和沿岸还受ElNino影响。

关键词：太平洋东南海域 Topex/Poseidon 海面高度距平

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Clinical epidemiology and disease burden of bronchiolitis in hospitalized children in China:a national cross-sectional study

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World Journal of Pediatrics 2023年第9期19卷 851-863页

作者： Jiao Tian Xin‑Yu Wang Lin‑Lin zhang Meng‑Jia Liu Jun‑Hong Ai Guo‑Shuang Feng Yue‑Ping zeng Ran Wang zheng‑de Xie Beijing Key Laboratory of Pediatric Respiratory Infectious Diseases Key Laboratory of Major Diseases in ChildrenMinistry of EducationNational Clinical Research Center for Respiratory DiseasesResearch Unit of Critical Infection in ChildrenChinese Academy of Medical Sciences2019RU016Laboratory of Infection and VirologyBeijing Pediatric Research InstituteBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthNan Li Shi Lu 56#Beijing 100045China Big Data Center Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina Medical Record Management Ofce Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina

Background Bronchiolitis is a common acute lower respiratory tract infection(ALRTI)and the most frequent cause of hospitalization of infants and young children with *** syncytial virus is the main pathogen that leads to severe *** disease burden is relatively *** date,few descriptions of the clinical epidemiology and disease burden of children hospitalized for bronchiolitis are *** study reports the general clinical epidemiological characteristics and disease burden of bronchiolitis in hospitalized children in *** This study included the face sheet of discharge medical records collected from 27 tertiary children’s hospitals from January 2016 to december 2020 that were aggregated into the FUTang Update medical REcords(FUTURE)*** sociodemographic variables,length of stay(los)and disease burden of children with bronchiolitis were analyzed and compared using appropriate statistical *** In total,42,928 children aged 0–3 years were hospitalized due to bronchiolitis from January 2016 to december 2020,accounting for 1.5%of the total number of hospitalized children of the same age in the database during the period and 5.31%of the hospitalizations for *** male to female ratio was 2.01:***,more boys than girls were observed in different regions,age groups,years,and *** 1–2 year age group had the greatest number of hospitalizations for bronchiolitis,while the 29 days–6 months group had the largest proportion of the total inpatients and inpatients with ALRTI in the same age *** terms of region,the hospitalization rate of bronchiolitis was the highest in East ***,the number of hospitalizations from 2017 to 2020 showed a decreasing trend from that in ***,the peak hospitalizations for bronchiolitis occurred in *** rates in North China in autumn and winter were higher than those in South China,while hospitalization rates in South China were h

关键词： Bronchiolitis Children Clinical epidemiology Disease burden Respiratory syncytial virus

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