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Viral hepatitis update: Progress and perspectives

World Journal of Gastroenterology 2021年第26期27卷 4018-4044页

作者： mar.a B Pisano Cecilia G Giadans Diego M Flichman Viviana E ré mar.a V Preciado Pamela Valva Virology Institute CONICETSchool of Medical SciencesNational University of CórdobaCordoba X5016Argentina Multidisciplinary Institute for Investigation in Pediatric Pathologies(IMIPP)CONICET-GCBA Laboratory of Molecular BiologyPathology DivisionRicardo Gutiérrez Children’s HospitalCABA C1425Buenos AiresArgentina Institute of Biomedical Investigations in retrovirus and AIDS(INBIrS) School of MedicineUniversity of Buenos AiresCONICETCABA C1121ABGBuenos AiresArgentina

Viral hepatitis,secondary to infection with hepatitis A,B,C,D,and E viruses,are a major public health problem and an important cause of morbidity and *** the huge medical advances achieved in recent years,there are still points of conflict concerning the pathogenesis,immune response,development of new and more effective vaccines,therapies,and *** review focuses on the most important research topics that deal with issues that are currently being solved,those that remain to be solved,and future research *** hepatitis A virus we will address epidemiology,molecular surveillance,new susceptible populations as well as environmental and food *** the case of hepatitis B virus,we will discuss host factors related to disease,diagnosis,therapy,and vaccine *** hepatitis C virus,we will focus on pathogenesis,immune response,direct action antivirals treatment in the context of solid organ transplantation,issues related to hepatocellular carcinoma development,direct action antivirals resistance due to selection of resistanceassociated variants,and *** hepatitis D virus,we describe diagnostic methodology,pathogenesis,and ***,for hepatitis E virus,we will address epidemiology(including new emerging species),diagnosis,clinical aspects,treatment,the development of a vaccine,and environmental surveillance.

关键词： Viral hepatitis Hepatitis A virus Hepatitis B virus Hepatitis C virus Hepatitis D virus Hepatitis E virus

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Key Factors Involved in Lamb Quality from Farm to Fork in Europe

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Journal of Integrative Agriculture 2013年第11期12卷 1919-1930页

作者： Carlos Saudo Erica Muela mar.a del mar Campo Department of Animal Production and Food Science University of Zaragoza

World lamb consumption is approximately 2 kg per capita with large variations between continents, e.g., 17 kg in Oceania vs. 0.7 kg in North America. With less than one million tonnes, the international trade of sheep meat contributes to a small percentage of the total meat exchanged between countries. On the other hand, lamb represents the highest rate of species trading in relation to the total sheep meat produced. It is therefore likely to ifnd a wide variability of different lamb products in the same market, and that the conservation procedures （such as refrigeration, packaging or freezing）, chemical composition, especially the fat due to its implication in human health, lfavour development and juiciness perception （affected, i.e., by the feeding or the age or slaughter weight of the animal） and acceptability （based on culinary background） could be considered important indicators of this advantageous situation. In this paper some studies related to the aforementioned indicators are discussed.

关键词： technology chemical composition consumer preferences

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Vector-valued operators, optimal weighted estimates and the C_p condition

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Science China Mathematics 2020年第7期63卷 1339-1368页

作者： mar.a Eugenia Cejas Kangwei Li Carlos Pérez Israel Pablo rivera-ríos BCAM—Basque Center for Applied Mathematics Bilbao 48009Spain CONICET Departamento de MatematicaFacultad de Ciencias ExactasUniversidad Nacional de La PlataLa Plata 1900Argentina Department of Mathematics University of the Basque CountryBilbao 48080Spain Ikerbasque Basque Foundation of ScienceBilbao 48013Spain INMABB CONICETDepartamento de MatematicaUniversidad Nacional del SurBahia Blanca 8000Argentina

In this paper some new results concerning the C_p classes introduced by Muckenhoupt(1981)and later extended by Sawyer(1983),are *** particular,we extend the result to the full expected range p>0,to the weak norm,to other operators and to their vector-valued *** of those results rely upon sparse domination,which in the vector-valued case are provided as *** will also provide sharp weighted estimates for vector-valued extensions relying on those sparse domination results.

关键词： A_p weights quantitative estimates C_p estimates vector-valued extensions sparse domination maximal functions Calderon-Zygmund operators commutators

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review on signal-by-wire and power-by-wire actuation for more electric aircraft

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Chinese Journal of Aeronautics 2017年第3期30卷 857-870页

作者： Jean-Charles mar Jian FU Institut National des Sciences Appliquees Institut Clement Ader (CNRS UMR 5312) Toulouse 31077 France School of Mechanical Engineering and Automation Beihang University Beijing 100083 China

The huge and rapid progress in electric drives offers new opportunities to improve the performances of aircraft at all levels：fuel burn,environmental footprint,safety,integration and production,serviceability,and *** for safety-critical applications like flight-controls,landing gears,and even engines is one of the major consumers of non-propulsive *** actuation with centralized hydraulic power generation and distribution and control of power by throttling has been well established for decades,but offers a limited potential of *** this context,electric drives become more and more attractive to remove the natural drawbacks of conventional actuation and to offer new opportunities for improving *** paper takes the stock,at both the signal and power levels,of the evolution of actuation for safety-critical applications in *** focuses on the recent advances and the remaining challenges to be taken toward full electrical actuation for commercial and military aircraft,helicopters,and *** logically starts by emphasizing the specificity of safety-critical actuation for *** following section addresses in details the evolution of aerospace actuation from mechanically-signaled and hydraulically-supplied to all electric,with special emphasis on research and development programs and on solutions entered into ***,the last section reviews the challenges to be taken to generalize the use of all-electric actuators for future aircraft programs.

关键词： Actuator Aerospace Electrohydrostatic Electromechanical Hydraulic More electric aircraft Power-by-wire Signal-by-wire

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Inter-population variabilities in seed mass and germination of Panicum turgidum and Pennisetum divisum in the desert of Kuwait

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Journal of Arid Land 2020年第1期12卷 144-153页

作者： Arvind BHATT Narayana r BHAT Afaf AL-NASSEr mar.a M CArÓN AndreaSANTO Kuwait Institute for Scientific research Safat 24885Kuwait Laboratory of Botanical research(LABIBO) Faculty of Natural SciencesNational University of Salta-CONICETSalta 4400Argentina Independent researcher Selargius 09047Italy

Understanding variability in seed germination among populations is essential for planning an effective germplasm collection for restoration and conservation *** knowledge of germination and dormancy patterns among populations of desert grasses is crucial for determining the potential of the species and populations to be used for restoration and conservation as well as forage *** in seed germination of Panicum turgidum Forssk and Pennisetum divisum(Gmel.)*** the desert of Kuwait was evaluated in different populations in May *** of seed germination(25 seeds and 4 replicates)was conducted for each population at night/day temperatures of 15℃/20℃and 20℃/30℃under the following light condition:continuous darkness or 12 h/12 h light/*** showed that seed masses of both species strongly varied according to their seed provenances,and both species produced heavier seeds in population with a higher soil electrical *** germination percentage considerably varied between two species,and the variation in *** was greater(17%–49%)than that of ***(72%–93%).Germination percentage in *** was greater at high temperature(20℃/30℃)than at low temperature(15℃/20℃).However,temperature regimes had no effect on germination percentage of *** *** germination time of both species exhibited significant inter-population *** result is especially relevant to assure the selection of the best population of each species and the regeneration success of the *** this,inter-population variability also provides valuable information for enhancing our understanding of the mechanisms that regulate seed germination and how they might be related to seed provenance.

关键词： desert grass seed germination inter-population variability seed provenance seed dormancy

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Neurotrophin receptors,gamma-secretase inhibitors,and neurodegeneration of basal forebrain cholinergic neurons

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Neural regeneration research 2022年第7期17卷 1493-1494页

作者： mar.al Vilar Instituto de Biomedicina de València del CSIC ValènciaSpain

The amyloid hypothesis of Alzhemer’s disease(AD)postulates that the generation of amyloid-beta(Aβ)peptide from the amyloid precursor protein(APP)by the action of theγ-secretase complex is one of the principal causes of *** idea is supported by the identification of several hereditary mutations in the APP gene or in the PSEN1 and PSEN2 genes that encode Presenilin-1 and Presenilin-2.

关键词： amyloid Aβ cholinergic

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Potential of Bamboo Species Guadua trinii and Guadua angustifolia for Nanocellulose Production

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Journal of renewable Materials 2024年第9期12卷 1541-1555页

作者： Agatha E.r.Prado Gárate Fernando E.Felissia mar.a Cristina Area Teresa Suirezs mar.a Evangelina Vallejos Círculo de Investigación del Bambú Universidad Nacional Agraria La Molina(UNALM)Lima15026Perú Instituto de Materiales de Misiones(IMAM) Universidad Nacional de Misiones(UNaM)Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Facultad de Ciencias ExactasQuímicas y Naturales(FCEQYN)Programa de Celulosa y Papel(PROCyP)Posadas3300Argentina Instituto de Materiales de Misiones(IMAM) Universidad Nacional de Misiones(UNaM)Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Facultad de Ciencias Forestales(FCF)Eldorado3380Argentina

Non-traditional lignocellulosic materials are a significant resource for producing high-value products,including *** work studied the nanocellulose obtention from chemical pulps of the two fast-growing bamboo species,Guadua trinii,and Guadua *** pulps were produced by soda-anthraquinone(S)pulping from both autohydrolysis-pretreated(H)and unpretreated bamboo ***-pretreated(SHP)and unpretreated soda-anthraquinone(AQ)(SP)pulps were characterized by yield,Kappa number,alpha,beta,and gamma cellulose,degree of polymerization,water retention value,and *** nanocellulose was produced by a sequential chemical oxidation treatment(2,2,6,6-tetramethylpiperidine-1-oxyl,TEMPO reagent)and mechanical *** was characterized by carboxylic group content and *** results revealed that autohydrolysis pretreatment resulted in a higher hemicelluloses extraction in *** contrast,the pulping yield of unpretreated samples was higher for ***,and the soda-AQ pulps from this species exhibited better delignification than the autohydrolysis-pretreated *** crystallinity index values of the obtained pulps were high(>80%),and the alpha-cellulose contents were *** viscosities of the aqueous nanocellulose suspensions were higher for the nanocellulose solutions obtained from the unpretreated soda-AQ ***,nanocellulose from *** unpretreated soda-AQ pulps had a higher rate of carboxylic *** results of this work are significant in assessing the potential of both bamboo species as a source of high-value products within the biorefinery framework because the viscosities of the aqueous nanocellulose suspensions depend on the size and shape of *** has significant importance for industrial unit operations and potential applications.

关键词： Natural fiber Guadua angustifolia Guadua trinii soda-anthraquinone pulp nanocellulose

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Contribution of galectin-1, a glycan-binding protein, to gastrointestinal tumor progression

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World Journal of Gastroenterology 2017年第29期23卷 5266-5281页

作者： mar.a l bacigalupo pablo carabias mar.a f troncoso Facultad de Farmacia y Bioquímica Instituto de Química y Fisicoquímica Biológicas (IQUIFIB) Consejo Nacional de lnvestigaciones Científicas y Técnicas Universidad de Buenos Aires

Gastrointestinal cancer is a group of tumors that affect multiple sites of the digestive system, including the stomach, liver, colon and pancreas. These cancers are very aggressive and rapidly metastasize, thus identifying effective targets is crucial for treatment. Galectin-1(Gal-1) belongs to a family of glycan-binding proteins, or lectins, with the ability to cross-link specific glycoconjugates. A variety of biological activities have been attributed to Gal-1 at different steps of tumor progression. Herein, we summarize the current literature regarding the roles of Gal-1 in gastrointestinal malignancies. Accumulating evidence shows that Gal-1 is drastically up-regulated in human gastric cancer, hepatocellular carcinoma, colorectal cancer and pancreatic ductal adenocarcinoma tissues, both in tumor epithelial and tumor-associated stromal cells. Moreover, Gal-1 makes a crucial contribution to the pathogenesis of gastrointestinal malignancies, favoring tumor development, aggressiveness, metastasis, immunosuppression and angiogenesis. We also highlight that alterations in Gal-1-specific glycoepitopes may be relevant for gastrointestinal cancer progression. Despite the findings obtained so far, further functional studies are still required. Elucidating the precise molecular mechanisms modulated by Gal-1 underlying gastrointestinal tumor progression, might lead to the development of novel Gal-1-based diagnostic methods and/or therapies.

关键词： Galectin-1 Gastric cancer Hepatocellular carcinoma Colorectal carcinoma Pancreatic cancer β1 6-N-acetylglucosaminyltransferase V

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Mesenchymal stem cells from different sources and their derived exosomes: A pre-clinical perspective

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World Journal of Stem Cells 2020年第2期12卷 100-109页

作者： mar.a álvarez-Viejo Unidad de Terapia Celulary Medicina regenerativa Servicio de Hematologíay Hemoterapia Hospital Universitario Central de Asturias Plataforma de Terapias Avanzadas Instituto de Investigación Sanitaria del Principado de Asturias

Since the introduction of cell therapy as a strategy for the treatment of many diseases,mesenchymal stem cells have emerged as ideal candidates,yet the underlying mechanisms of their beneficial effects are only partially *** the start of the 21st century,a paracrine effect was proposed as a mechanism of tissue repair by these *** addition,a role was suggested for a heterogeneous population of extracellular vesicles in cell-to-cell *** of these vesicles including exosomes have been isolated from most fluids and cells,as well as from supernatants of in vitro cell *** research in the field of regenerative medicine suggests that exosomes derived from mesenchymal stem cells could be a powerful new therapeutic *** review examines the therapeutic potential of these exosomes obtained from the sources most used in cell therapy:bone marrow,adipose tissue,and umbilical cord.

关键词： Mesenchymal stem cells Exosomes Cellular therapy

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Existence and Uniqueness to a Fully Nonlinear Version of the Loewner–Nirenberg Problem Dedicated to Celebrate the Sixtieth Anniversary of USTC

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Communications in Mathematics and Statistics 2018年第3期6卷 269-288页

作者： mar.a del mar González YanYan Li Luc Nguyen Departamento de Matemáticas Universidad Autónoma de MadridCampus de Cantoblanco28049 MadridSpain Department of Mathematics Hill CenterBusch CampusRutgers University110 Frelinghuysen RoadPiscatawayNJ 08854USA Mathematical Institute and St Edmund Hall University of OxfordAndrew Wiles BuildingRadcliffe Observatory QuarterWoodstock RoadOxford OX26GGUK

We consider the problem of finding on a given Euclidean domainof dimension n≥3 a complete conformally flat metric whose Schouten curvature A satisfies some equations of the form f(λ(−A))=*** generalizes a problem considered by Loewner and Nirenberg for the scalar *** prove the existence and uniqueness of such metric when the boundary δΩ is a smooth bounded hypersurface(of codimension one).When δΩ contains a compact smooth submanifold ∑ of higher codimension with δΩ\∑ being compact,we also give a‘sharp’condition for the divergence to infinity of the conformal factor near ∑ in terms of the codimension.

关键词： Fully nonlinear Loewner-Nirenberg problem Singular fully nonlinear Yamabe metrics Conformal invariance

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