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Breaking paradigms: Long non-coding RNAs forming gene fusions with potential implications in cancer

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Genes & Diseases 2024年第3期11卷 311-323页

作者： David Sanchez-marin Macrina Beatriz Silva-Cazares Fany Iris Porras-Reyes Rebeca Garcia-Roman Alma D.Campos-Parra Posgrado en Ciencias Biologicas Facultad de MedicinaUniversidad Nacional Autonoma de MexicoCiudad de MexicoC.P.04360Mexico Unidad Academica Multidisciplinaria Region Altiplano Universidad Autonoma de San Luis Potost(UASLP)Carretera a Cedral Km 5+600Ejido San Jose de la TrojesMatehualaSan Luis PotosiC.P.78760Mexico Servicio de Anatomia Patologica Instituto Nacional de Cancerologia(INCan)Nino JesuisTlalpanCiudaddeMexicoC.P.14080Mexico Instituto de Salud Publica Universidad Veracruzana(UV)Av.Dr LuisDr.Castelazo Ayala s/nCol.Industrial AnimasXalapaVeracruzC.P.91190Mexico

Long non-coding RNAs(lncRNAs)are non-coding RNAs longer than 200 nucleotides with dynamic regulatory *** interact with a wide range of molecules such as DNA,RNA,and proteins to modulate diverse cellular functions through several mechanisms and,if deregulated,they can lead to cancer development and ***,it has been described that IncRNAs are susceptible to form gene fusions with mRNAs or other IncRNAs,breaking the paradigm of gene fusions consisting mainly of protein-coding ***,their biological significance in the tumor phenotype is still ***,their recent identification opens a new line of research to study their biological role in tumor-igenesis,and their potential as biomarkers with clinical relevance or as therapeutic *** present study aimed to review the IncRNA fusions identified so far and to know which of them have been associated with a potential *** address the current challenges to deepen their study as well as the reasons why they represent a future therapeutic window incancer.

关键词： Cancer Genefusions IncRNAs ncRNAs Therapy

Ductal carcinoma in situ within a fibroadenoma:A case report and review of literature

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World Journal of Radiology 2024年第3期16卷 58-68页

作者： Yazmin Olivares-Antúnez Yesika Janett Dávila-Zablah JoséRaúl Vázquez-Ávila Gabriela Sofía Gómez-Macías mar.a Teresa Mireles-Aguilar mar.arita Lilia Garza-Montemayor Department of Diagnostic Breast Imaging Center Hospital Zambrano HellionTecnológico de MonterreyNuevo León 66260Mexico Department of Patology Service Hospital San JoséTecnológico de MonterreyNuevo León 64710Mexico Department of Faculty of Medicine Hospital Universitario de la UANLNuevo León 64710Mexico. Department of Breast Surgery Center Hospital Zambrano HellionTecnológico de MonterreyNuevo León 66260Mexico

BACKGROUND Fibroadenoma(FA)is the most common tumor found in young women,although it can occur in any age *** carcinoma in situ(DCIS)that is confined in a FA is rare;it is most frequently reported as an incidental *** SUMmarY We report a case of DCIS within a FA in a 46-year-old female without cancerrelated personal and family *** patient was diagnosed with a breast conglomerate of nodules and was followed for 1 *** the current control image study,we found suspicious microcalcification,as a new finding,within one of the ***,a core biopsy of the tumor,which appeared hypoechoic,oval,and circumscribed,was *** pathological diagnosis was ductal carcinoma in situ within a fibroepithelial *** patient underwent breastconserving surgery and received radiotherapy as well as endocrine therapy(tamoxifen).CONCLUSION We recommend a multidisciplinary approach for adequate treatment and followup.

关键词： Carcinoma in situ Fibroadenoma Mammography Ultrasound Magnetic resonance imaging Radiology Case report

The Iberian Roma Population Variant Server(IRPVS)

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Journal of Genetics and Genomics 2024年第7期51卷 769-773页

作者： Fabiola Mavillard Javier Perez-Florido Francisco M.Ortuño Amador Valladares Miren L.Álvarez-Villegas Gema Roldán Rosario Carmona Manuel Soriano Santiago Susarte Pilar Fuentes Daniel López-López Ana mar.a Nuñez-Negrillo Alejandra Carvajal Yolanda Morgado Daniel Arteaga Rosa Ufano Pablo Mir Juan F.Gamella Joaquín Dopazo Carmen Paradas Macarena Cabrera-Serrano Instituto de Biomedicina de Sevilla(IBiS) Hospital Universitario Virgen del Rocío/CSIC/Universidad de SevillaSevillaSpain Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas(CIBERNED) Instituto de Salud CarlosⅢSevillaSpain Plataforma Andaluza de Medicina Computacional Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevillaSpain Grupo de medicina computacional de sistemas Instituto de Biomedicina de Sevilla(IBiS)Hospital Virgen del RocíoSevillaSpain Nodo de Genómica Funcional (INB-ELIXIR-es)Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevilla 41013Spain Bioinformática en Enfermedades raras(BiER) Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER)Instituto de salud CarlosⅢSevillaSpain Departamento de Ingeniería de Computadores Automática y RobóticaUniversidad de GranadaGranadaSpain Servicio de Urgencias de Atención Primar.a Distrito SevillaSevillaSpain Centro de Servicios Sociales Negociado de Servicios EspecializadosAyuntamiento de SevillaSevillaSpain Departamento de Enfermería Facultad de Ciencias de la SaludUniversidad de GranadaGranadaSpain Departamento de Neurología Hospital Virgen de las NievesGranadaSpain Departamento de Neurología Hospital Virgen de ValmeSevillaSpain Centro de Salud Utrera Sur SevillaSpain Centro de Salud Polígono Sur SevillaSpain Unidad de Trastornos del Movimiento Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain Departamento de Medicina Facultad de MedicinaUniversidad de SevillaSevilleSpain Departamento de Antropología Social Universidad de GranadaSpain Unidad Enfermedades Neuromusculares Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain

In recent years,the number of known disease genes has exponentially grown due to the widespread adoption of cost-effective massive parallel *** identify new disease variants,especially in monogenic disorders,a frequen... 详细信息

关键词： Server filtering massive

Neurotrophin receptors,gamma-secretase inhibitors,and neurodegeneration of basal forebrain cholinergic neurons

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Neural Regeneration Research 2022年第7期17卷 1493-1494页

作者： mar.al Vilar Instituto de Biomedicina de València del CSIC ValènciaSpain

The amyloid hypothesis of Alzhemer’s disease(AD)postulates that the generation of amyloid-beta(Aβ)peptide from the amyloid precursor protein(APP)by the action of theγ-secretase complex is one of the principal causes of *** idea is supported by the identification of several hereditary mutations in the APP gene or in the PSEN1 and PSEN2 genes that encode Presenilin-1 and Presenilin-2.

关键词： amyloid Aβ cholinergic

Key Factors Involved in Lamb Quality from Farm to Fork in Europe

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Journal of Integrative Agriculture 2013年第11期12卷 1919-1930页

作者： Carlos Saudo Erica Muela mar.a del mar Campo Department of Animal Production and Food Science University of Zaragoza

World lamb consumption is approximately 2 kg per capita with large variations between continents, e.g., 17 kg in Oceania vs. 0.7 kg in North America. With less than one million tonnes, the international trade of sheep meat contributes to a small percentage of the total meat exchanged between countries. On the other hand, lamb represents the highest rate of species trading in relation to the total sheep meat produced. It is therefore likely to ifnd a wide variability of different lamb products in the same market, and that the conservation procedures （such as refrigeration, packaging or freezing）, chemical composition, especially the fat due to its implication in human health, lfavour development and juiciness perception （affected, i.e., by the feeding or the age or slaughter weight of the animal） and acceptability （based on culinary background） could be considered important indicators of this advantageous situation. In this paper some studies related to the aforementioned indicators are discussed.

关键词： technology chemical composition consumer preferences

Review on signal-by-wire and power-by-wire actuation for more electric aircraft

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Chinese Journal of Aeronautics 2017年第3期30卷 857-870页

作者： Jean-Charles mar Jian FU Institut National des Sciences Appliquees Institut Clement Ader (CNRS UMR 5312) Toulouse 31077 France School of Mechanical Engineering and Automation Beihang University Beijing 100083 China

The huge and rapid progress in electric drives offers new opportunities to improve the performances of aircraft at all levels：fuel burn,environmental footprint,safety,integration and production,serviceability,and *** for safety-critical applications like flight-controls,landing gears,and even engines is one of the major consumers of non-propulsive *** actuation with centralized hydraulic power generation and distribution and control of power by throttling has been well established for decades,but offers a limited potential of *** this context,electric drives become more and more attractive to remove the natural drawbacks of conventional actuation and to offer new opportunities for improving *** paper takes the stock,at both the signal and power levels,of the evolution of actuation for safety-critical applications in *** focuses on the recent advances and the remaining challenges to be taken toward full electrical actuation for commercial and military aircraft,helicopters,and *** logically starts by emphasizing the specificity of safety-critical actuation for *** following section addresses in details the evolution of aerospace actuation from mechanically-signaled and hydraulically-supplied to all electric,with special emphasis on research and development programs and on solutions entered into ***,the last section reviews the challenges to be taken to generalize the use of all-electric actuators for future aircraft programs.

关键词： Actuator Aerospace Electrohydrostatic Electromechanical Hydraulic More electric aircraft Power-by-wire Signal-by-wire

Post-traumatic hepatic artery pseudoaneurysm treated with endovascular embolization and thrombin injection

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World Journal of Hepatology 2010年第2期2卷 87-90页

作者： lloret Esta Francisco López Conesa Asunción Capel Alemán Antonio Robles Campos Ricardo Reus Pintado Manuel marín Hernández Caridad Section of Vascular and Interventional Radiology Department of RadiologyUniversity General Hospital Virgen de la Arrixaca.Ctra Murcia-Cartagena30120 El PalmarMurcia Spain Division of Hepatobiliary Surgery Depart-ment of General SurgeryUniversity General Hospital Virgen de la ArrixacaCtra Murcia-Cartagena30120 El PalmarMurcia Spain

Post-traumatic hepatic artery pseudoaneurysm is unc-ommon,appearing in approximately 1%of hepatic trauma *** are extrahepatic(80%)and have a late *** they are usually asymptomatic, they should always be treated becasue of the high risk of complications,especially *** the treatment of choice is endovascular embolization with coils or the exclusion of the pseudoaneurysm using other intravascular *** there have been accounts of a treatment that combines embolization with coils and image-guided percutaneous human thrombin *** present a case of post-traumatichepatic artery pseudoaneurysm that was successfully treated using this combined technique.

关键词： Pseudoaneurysm Hepatic trauma Hepatic artery Endovascular treatment Thrombin

Scoring and Consequential Validity Evidence of Computer-and Paper-Based Writing Tests in Times of Change

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Chinese Journal of Applied Linguistics 2024年第3期47卷 450-480,525页

作者： mar.a GUAPACHA-CHAMORRO Orlando CHAVES-VARÓN Universidad del Valle Colombia

Little is known about how the assessment modality,i.e.,computer-based(CB)and paper-based(PB)tests,affects language teachers’scorings,perceptions,and preferences and,therefore,the validity and fairness of classroom writing *** present mixed-methods study used Shaw and Weir’s(2007)sociocognitive writing test validation framework to examine the scoring and consequential validity evidence of CB and PB writing tests in EFL classroom assessment in higher *** handwritten and word-processed texts of 38 EFL university students were transcribed to their opposite format and assessed by three language lecturers(N=456 texts,152 per teacher)to examine the scoring validity of CB and PB *** teachers’perceptions of text quality and preferences for assessment modality accounted for the consequential validity evidence of both *** revealed that the assessment modality impacted teachers’scorings,perceptions,and *** teachers awarded higher scores to original and transcribed handwritten texts,particularly text organization and language *** teachers’perceptions of text quality differed from their ratings,and physical,psychological,and experiential characteristics influenced their preferences for assessment *** results have implications for the validity and fairness of CB and PB writing tests and teachers’assessment practices.

关键词： scoring validity consequential validity CB and PB writing tests classroom assessment

Global wild rice germplasm resources conservation alliance:World Wild-Rice Wiring

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Molecular Plant 2024年第4期17卷 516-518页

作者： Xiaoming Zheng Disna Ratnasekera Jiayu Fan Robert J.Henry Beng-Kah Song Kenneth M.Olsen Bal Krishna Joshi mar.a Celeste N.Banaticla-Hilario Tonapha Pusadee Adane Getachew Melaku Yeyinou Laura Estelle Loko Koukham Vilayheuang Gavers K.Oppong Samuel Aduse Poku Peterson W.Wambugu Song Ge Aldo Merotto Junior Ohn mar.aung Ramaiah Venuprasad Ajay Kohli Wenbin Zhou Qian Qian National Key Facility for Crop Gene Resources and Genetic Improvement Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China Sanya National Research Institute of Breeding in Hainan Chinese Academy of Agricultural SciencesBeijing 100081China International Rice Research Institute DAPO Box 7777Metro Manila 4031Philippines Department of Agricultural Biology Faculty of AgricultureUniversity of RuhunaMatara 81000Sri Lanka Yazhouwan National Laboratory No.8 Huanjin RoadYazhou DistrictSanya CityHainan Province 572024China Hainan University Haikou 570228China ARC Centre of Excellence for Plant Success in Nature and Agriculture University of QueenslandBrisbaneQLD4072Australia School of Science Monash University Malaysia47500 Bandar SunwaySelangor 47500Malaysia Department of Biology Washington University in St.LouisSt.LouisMO 63130-4899USA National Agriculture Genetic Resources Center(Genebank) KhumaltarPO Box 3055KathmanduNepal Plant Biology Division Insttute of Biological SciencesUniversity of the Pilippines Los BanosLos BanosLaguna 4031Philippines Division of Agronomy Department of Plant and Soil SciencesFaculty of AgricultureChiang Mai UniversityChiang Mai 50200Thailand Bio and Emerging Technology Institute Addis Ababa 1165Ethiopia National University of Sciences TechnologiesEngineering and Mathematics(UNSTIM)Dassa-ZouméBP 14Benin National Genebank Rice and Cash Crops Research CenterNAFRIVientiane 0605Lao PDR Plant Sciences and the Bioeconomy Rothamsted ResearchHarpenden AL52JQUK UK Future Food Beacon of Excellence and School of Biosciences and University of Nottingham Nottingham LE125RDUK Department of Plant and Environmental Biology University of GhanaAccraGhana Kenya Agricultural and Livestock Research Organization Genetic Resources Research InstituteNairobi 00200Kenya Institute of Botany Chinese Academy of SciencesBeijing 100093China Federal University of Rio Grande do Sul UFRGSPorto Alegre 91501-970RSBrazil Department of Agricultur

Wild relatives of crop are key genetic resources serving as diversity reservoirs for crop improvement under changing ***(Oryza sativa)is one of the most important crops in the world,providing staple food for half of the world's *** rice is thus a critical germplasm resource for sustained global food security,ensuring high production yields,improved quality,and stress resistance in the face of climate *** rice is closely related to domesticated rice and has a rich genetic diversity and exceptional adaptability to extreme *** has played a pivotal role in the history of rice hybridization and has become a key resource for rice breeding *** identification of wild-type cytoplasmic male sterility resources paved the way for the achievement of the“three lines”goal in hybrid rice,leading to a significant increase in rice *** addition,the use of resistance alleles found in wild rice is making rice production more resilient to losses caused by environmental ***,wild rice germplasm resources are threatened due to habitat destruction and other anthropogenic *** the same time,the lack of centralized distribution of wild rice has hampered the sharing of basic information on wild rice resources and the utilization and conservation of wild rice in each country,as well as collaboration among scientists.

关键词： germplasm breeding crops